| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Herdman, P J Cowen, G M Campling, R A Hockney, D Laver, A L Sharple. Effect of lofepramine on 5-HT function and sleep. Journal of affective disorders. vol 29. issue 1. 1994-01-13. PMID:8254146. |
we studied the effect of the tricyclic antidepressant lofepramine (140-210 mg daily for 16 days) on 5-hydroxytryptamine 1a (5-ht1a) receptor sensitivity in healthy volunteers, using a buspirone neuroendocrine challenge paradigm (30 mg orally). |
1994-01-13 |
2023-08-12 |
human |
| J R Herdman, P J Cowen, G M Campling, R A Hockney, D Laver, A L Sharple. Effect of lofepramine on 5-HT function and sleep. Journal of affective disorders. vol 29. issue 1. 1994-01-13. PMID:8254146. |
lofepramine treatment did not alter the hypothermic, endocrine or amnesic effects of buspirone but significantly lowered platelet 5-ht content and decreased rapid eye movement sleep. |
1994-01-13 |
2023-08-12 |
human |
| T Mennini, C Taddei, A Codegoni, M Gobbi, S Garattin. Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine. European journal of pharmacology. vol 241. issue 2-3. 1994-01-06. PMID:8243560. |
acute noise stress reduces [3h]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine. |
1994-01-06 |
2023-08-12 |
rat |
| T Mennini, C Taddei, A Codegoni, M Gobbi, S Garattin. Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine. European journal of pharmacology. vol 241. issue 2-3. 1994-01-06. PMID:8243560. |
buspirone pretreatment had no effect on [3h]5-ht uptake in resting rats but prevented the noise-induced decrease in [3h]-ht uptake. |
1994-01-06 |
2023-08-12 |
rat |
| T Mennini, C Taddei, A Codegoni, M Gobbi, S Garattin. Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine. European journal of pharmacology. vol 241. issue 2-3. 1994-01-06. PMID:8243560. |
the evidence that treatments reducing extrasynaptic 5-ht, by increasing its reuptake (tianeptine) or reducing its release (buspirone) in innervated regions are able to modify the stress-induced decrease in 5-ht uptake, further confirms the importance of serotonin in the mechanisms mediating neurochemical responses to stress. |
1994-01-06 |
2023-08-12 |
rat |
| S Maisonnette, S Morato, M L Brandã. Role of resocialization and of 5-HT1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test. Physiology & behavior. vol 54. issue 4. 1994-01-03. PMID:7902588. |
the reduction in aversiveness promoted by resocialization may be due to a recovery in the 5-ht activity depressed by isolation in a much faster way than observed with chronic gepirone administration. |
1994-01-03 |
2023-08-12 |
rat |
| S L Handley, J W McBlan. Serotonin mechanisms in animal models of anxiety. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 26. issue 1. 1993-12-21. PMID:8106074. |
immediate 'anxiogenic' and delayed 'anxiolytic' effects most closely mimic the clinical effects of recently introduced anxiolytic drugs such as the selective serotonin reuptake inhibitors and buspirone. |
1993-12-21 |
2023-08-12 |
Not clear |
| N A Kharin, A T Dolzhenko, A V Titievskiĭ, S V Naleto. [The possible neurochemical mechanisms of the neuroleptic action of buspirone-like serotonin agonists]. Eksperimental'naia i klinicheskaia farmakologiia. vol 56. issue 4. 1993-12-20. PMID:8106056. |
the experiments on animals (rats and mice) and pigeons have established that buspirone and other serotonin agonists such as 1-(2-pyrimidinyl)-piperazine derivatives such as ipsapirone (tvx q 7821), levopirone, kampirone, and sepirone have some pharmacological properties which are typical of neuroleptics. |
1993-12-20 |
2023-08-12 |
mouse |
| N A Kharin, A T Dolzhenko, A V Titievskiĭ, S V Naleto. [The possible neurochemical mechanisms of the neuroleptic action of buspirone-like serotonin agonists]. Eksperimental'naia i klinicheskaia farmakologiia. vol 56. issue 4. 1993-12-20. PMID:8106056. |
the capacity of buspirone and other serotonin antagonists of modulating dopamine release is not eliminated by 1a/b and 2 serotonin antagonists such as propranolol (3 microm) and metesergide (1 microm), but it is inhibited by ics 205-930, a selective antagonist of 3ht receptors. |
1993-12-20 |
2023-08-12 |
mouse |
| A T Dolzhenko, J Traber, T Glaser, J De Vr. [The presynaptic metabolic modulation of the impulse-dependent release of 3H-serotonin from rat brain slices by ipsapirone (TVX Q 7821) and other serotonin agonists]. Eksperimental'naia i klinicheskaia farmakologiia. vol 56. issue 4. 1993-12-20. PMID:8106062. |
the serotonin agonists ipsapirone (tvx q 7821), buspirone, gepirone, and 8-oh-dpat which mainly stimulate the type 1a serotonin receptors of somatodendritic synapses inhibit the release of [3h]-ht from the dorsal raphe nucleus slices to a greater extent rather from those of the cortex. |
1993-12-20 |
2023-08-12 |
rat |
| B Söderpalm, B Lundin, S Hjort. Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:7901030. |
sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-ht1a receptor agonist, buspirone, after prolonged chronic administration. |
1993-12-01 |
2023-08-12 |
rat |
| B Söderpalm, B Lundin, S Hjort. Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:7901030. |
the effect of prolonged administration of high doses of buspirone on its 5-hydroxytryptamine (5-ht) release-inhibitory and anxiolytic-like properties was investigated. |
1993-12-01 |
2023-08-12 |
rat |
| B Söderpalm, B Lundin, S Hjort. Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:7901030. |
the 5-ht release-inhibitory effect of a challenge dose of buspirone (0.5 mg/kg, s.c.) was identical in rats chronically treated with vehicle or buspirone (10 mg/kg, b.i.d. |
1993-12-01 |
2023-08-12 |
rat |
| B Söderpalm, B Lundin, S Hjort. Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:7901030. |
the results indicate that the functional capacity of 5-ht release-controlling 5-ht1a autoreceptors is retained upon chronic administration of buspirone, and that this effect may well be associated with the anxiolytic-like action of the compound. |
1993-12-01 |
2023-08-12 |
rat |
| C Routledge, J Gurling, I K Wright, C T Douris. Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223894. |
in contrast, the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) (0.1 mg/kg s.c.) and the partial agonists bmy 7378 (1.0 mg/kg s.c.) and buspirone (5 mg/kg s.c.) significantly decreased hippocampal 5-ht. |
1993-12-01 |
2023-08-12 |
rat |
| R T Joffe, D R Schulle. An open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression. The Journal of clinical psychiatry. vol 54. issue 7. 1993-08-26. PMID:8335654. |
an open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression. |
1993-08-26 |
2023-08-12 |
Not clear |
| R T Joffe, D R Schulle. An open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression. The Journal of clinical psychiatry. vol 54. issue 7. 1993-08-26. PMID:8335654. |
we evaluated the efficacy of buspirone in the augmentation of antidepressant response to the serotonin reuptake inhibitors. |
1993-08-26 |
2023-08-12 |
Not clear |
| S Wieland, C T Fischette, I Luck. Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology. vol 32. issue 6. 1993-08-25. PMID:8393153. |
the effects of acute and chronic treatment of rats with the tricyclic antidepressant imipramine, the 5-ht1a receptor partial agonist tandospirone, or its metabolite 1-pp were compared on behavioral responses produced by the activation of 5-ht receptors and on brain monoamine receptors. |
1993-08-25 |
2023-08-12 |
rat |
| S Wieland, C T Fischette, I Luck. Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology. vol 32. issue 6. 1993-08-25. PMID:8393153. |
the infusion of tandospirone blocked elicitation of the 5-ht behavioral syndrome when tested after 1 or 14 days of drug treatment (drug present) and 24 hr after the drug was withdrawn (drug absent). |
1993-08-25 |
2023-08-12 |
rat |
| S Wieland, C T Fischette, I Luck. Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology. vol 32. issue 6. 1993-08-25. PMID:8393153. |
when administered by injection, tandospirone blocked the production of the 5-ht syndrome 1 hr (drug present), but not 24 hr (drug absent), following either 1 day or 14 days of drug treatment. |
1993-08-25 |
2023-08-12 |
rat |