| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Mizuki, M Suetsugi, I Ushijima, M Yamad. Characteristics of the anxiolytic effects of buspirone in high- and low-anxious normal humans assessed by frontal midline theta activity. Methods and findings in experimental and clinical pharmacology. vol 16. issue 4. 1994-09-02. PMID:7519702. |
in the non-fmtheta group, however, there were no differences in these items except for 5-ht concentration before and after buspirone administration. |
1994-09-02 |
2023-08-12 |
human |
| C A Naranjo, K E Bremne. Serotonin-altering medications and desire, consumption and effects of alcohol-treatment implications. EXS. vol 71. 1994-08-12. PMID:8032152. |
for example, buspirone, a 5-ht1a receptor partial agonist, reduced anxiety and alcohol craving, but not ac; a 5-ht partial agonist, m-cpp, increased craving in abstinent alcoholics; modest reductions in ac were observed with a 5-ht3 antagonist, ondansetron (0.5 mg/day, but not 4 mg/day). |
1994-08-12 |
2023-08-12 |
human |
| P J Cowen, A C Power, C J Ware, I M Anderso. 5-HT1A receptor sensitivity in major depression. A neuroendocrine study with buspirone. The British journal of psychiatry : the journal of mental science. vol 164. issue 3. 1994-07-07. PMID:8199791. |
within the limitations that attend the use of buspirone as a 5-ht1a probe, our data suggest that the decrement in serotonin neurotransmission at post-synaptic 5-ht1a receptors in depression is due to decreased serotonin release rather than impaired responsivity of post-synaptic 5-ht1a receptors. |
1994-07-07 |
2023-08-12 |
Not clear |
| S E File, N Andrew. Benzodiazepine withdrawal: behavioural pharmacology and neurochemical changes. Biochemical Society symposium. vol 59. 1994-06-23. PMID:7910743. |
other treatments that reversed the anxiogenic response were the gabab agonist baclofen, the 5-ht1a receptor agonist buspirone, and the 5-ht3 receptor antagonist (r,s)-zacopride (gaba = gamma-aminobutyric acid; 5-ht = 5-hydroxytryptamine). |
1994-06-23 |
2023-08-12 |
rat |
| V Bonifati, E Fabrizio, R Cipriani, N Vanacore, G Mec. Buspirone in levodopa-induced dyskinesias. Clinical neuropharmacology. vol 17. issue 1. 1994-05-10. PMID:8149361. |
the activities of buspirone on the serotonin and dopamine systems might have led to the antidyskinetic effect we observed. |
1994-05-10 |
2023-08-12 |
Not clear |
| M Goldermann, W Hanke, W R Schlu. Modulation of K(+)-channels in p-neurones of the leech CNS by phosphorylation. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology. vol 174. issue 2. 1994-04-29. PMID:8145192. |
the 5-ht1a-receptor agonist buspirone mimics the effect of 5-ht. |
1994-04-29 |
2023-08-12 |
Not clear |
| M F Piercey, M W Smith, J T Lum-Raga. Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138943. |
the 5-ht1a receptor agonists buspirone, 8-hydroxy-n,n-dipropyl-2-aminotetralin, gepirone and ipsapirone were evaluated for their receptor binding profiles and their effects on firing rates of 5-ht, dopamine (da) and noradrenaline (na) neurons in the dorsal raphe, substantia nigra pars compacta and the locus ceruleus, respectively. |
1994-04-25 |
2023-08-12 |
Not clear |
| M F Piercey, M W Smith, J T Lum-Raga. Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics. vol 268. issue 3. 1994-04-25. PMID:8138943. |
buspirone reversed amphetamine's effects with doses similar to those for depressing 5-ht neurons, but the remaining three required much higher doses to affect da neuron function. |
1994-04-25 |
2023-08-12 |
Not clear |
| M Asberg, B Mårtensso. Serotonin selective antidepressant drugs: past, present, future. Clinical neuropharmacology. vol 16 Suppl 3. 1994-04-21. PMID:8131153. |
the availability of drugs that selectively affect the different 5-ht receptors, such as the partial 5-ht1a agonist gepirone, will presumably be helpful for modern studies of the "anatomy of melancholy." |
1994-04-21 |
2023-08-12 |
Not clear |
| J Strosznajder, M Samochocki, M Dura. Aging diminishes serotonin-stimulated arachidonic acid uptake and cholinergic receptor-activated arachidonic acid release in rat brain cortex membrane. Journal of neurochemistry. vol 62. issue 3. 1994-03-28. PMID:8113791. |
serotonin (5-ht), at 10 microm to 1 mm in the presence of pargyline and the agonist of the 5-ht1a receptor, buspirone, stimulated aa uptake into membrane lipids, mainly into phosphatidylinositol, by about 40% exclusively in adult brain synaptoneurosomes. |
1994-03-28 |
2023-08-12 |
rat |
| S E Mulroney, C Skudlarek, A Shemer, M D Lumpkin, K J Kella. Tandospirone stimulates prolactin secretion in the rat by an action at serotonin-1A receptors. The Journal of pharmacology and experimental therapeutics. vol 268. issue 2. 1994-03-28. PMID:8113999. |
this effect of tandospirone is blocked by pretreatment with the 5-ht antagonists metergoline and nan-190 and shows cross-desensitization with the 5-ht-1a agonist 8-hydroxy-2-(di-n-propyl-amino)tetralin. |
1994-03-28 |
2023-08-12 |
rat |
| F P Zemlan, A Z Murphy, M M Behbehan. 5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons. Pharmacology. vol 48. issue 1. 1994-03-14. PMID:8309982. |
this hypothesis predicts that nociceptive dorsal horn units inhibited by nrm stimulation or iontophoretic 5-ht application would also be inhibited by iontophoresis of the selective 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone. |
1994-03-14 |
2023-08-12 |
rat |
| F P Zemlan, A Z Murphy, M M Behbehan. 5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons. Pharmacology. vol 48. issue 1. 1994-03-14. PMID:8309982. |
the response of 48 dorsal horn cells to 5-ht and buspirone iontophoresis was compared. |
1994-03-14 |
2023-08-12 |
rat |
| F P Zemlan, A Z Murphy, M M Behbehan. 5-HT1A receptors mediate the effect of the bulbospinal serotonin system on spinal dorsal horn nociceptive neurons. Pharmacology. vol 48. issue 1. 1994-03-14. PMID:8309982. |
forty-four percent (21/48) of the cells were inhibited by 5-ht; 16/21 were also inhibited by buspirone. |
1994-03-14 |
2023-08-12 |
rat |
| J G Pires, A G Ramage, S R Silva, H A Futuro-Net. Effects of the 5-HT receptor antagonists cyanopindolol, ICI 169,369, cisapride and granisetron on neuroleptic-induced catalepsy in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 26. issue 8. 1994-03-07. PMID:8298521. |
buspirone, a 5-ht1a partial antagonist, cisapride, a 5-ht3/5-ht4 ligand and clomipramine, a 5-ht neuronal uptake blocker, were also employed. |
1994-03-07 |
2023-08-12 |
mouse |
| J De Vry, U Benz, R Schreiber, J Trabe. Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs. European journal of pharmacology. vol 249. issue 3. 1994-02-24. PMID:7904565. |
suppression of shock-induced ultrasonic vocalization was obtained with diazepam, chlordiazepoxide, meprobamate and pentobarbital; the serotonin (5-ht)1a receptor agonists 8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin], buspirone, ipsapirone, gepirone and tandospirone; the nonselective 5-ht receptor agonists tfmpp [1-(3-trifluoromethylphenyl)piperazin], mcpp [1-(3-chlorophenyl)piperazin] and doi (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane); the nmda antagonists pcp (phencyclidine) and mk-801; the alpha 2-adrenoceptor antagonists idazoxane, yohimbine and 1-pp (1-pyrimidinylpiperazine); and the atypical neuroleptic clozapine. |
1994-02-24 |
2023-08-12 |
rat |
| T Sharp, R McQuade, S Bramwell, S Hjort. Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7904048. |
acute administration of the 5-ht1a receptor agonists buspirone (0.1-5 mg/kg s.c.) and ipsapirone (0.03-3 mg/kg s.c.) caused a dose-dependent decrease in 5-ht output in ventral hippocampus of the chloral hydrate anaesthetized rat. |
1994-02-04 |
2023-08-12 |
rat |
| T Sharp, R McQuade, S Bramwell, S Hjort. Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7904048. |
the 5-ht response to buspirone (0.1 and 0.5 mg/kg s.c.) and ipsapirone (0.3 mg/kg s.c.) was significantly inhibited by pre-treatment with the 5-ht1/beta-adrenoceptor antagonist pindolol (8-16 mg/kg s.c.). |
1994-02-04 |
2023-08-12 |
rat |
| T Sharp, R McQuade, S Bramwell, S Hjort. Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7904048. |
the 5-ht response to buspirone (0.1 mg/kg s.c.) and ipsapirone (0.3 mg/kg s.c.) was not blocked by pretreatment with a combination of the beta 1 and beta 2-adrenoceptor antagonists metoprolol and ici 118,551 (4 mg/kg s.c.). |
1994-02-04 |
2023-08-12 |
rat |
| T Sharp, R McQuade, S Bramwell, S Hjort. Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7904048. |
the effect of an acute challenge of buspirone (0.5 mg/kg s.c.) on 5-ht output in ventral hippocampus was not attenuated in rats treated twice daily for 14 days with 0.5 or 5 mg/kg s.c. buspirone compared to saline-injected controls. |
1994-02-04 |
2023-08-12 |
rat |