| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J D Coplan, L Tiffon, J M Gorma. Therapeutic strategies for the patient with treatment-resistant anxiety. The Journal of clinical psychiatry. vol 54 Suppl. 1993-07-13. PMID:8509358. |
patients with obsessive compulsive disorder who have failed to respond to clomipramine or fluoxetine and other serotonin reuptake blockers may benefit from augmentation strategies using combination therapies including buspirone, fenfluramine, and neuroleptics. |
1993-07-13 |
2023-08-12 |
Not clear |
| N N Bogdanov, M B Bogdano. [The role of serotonin 1A and dopamine D2 receptors in buspirone effects on the electrical activity of white rat brain]. Doklady Akademii nauk. vol 328. issue 2. 1993-06-02. PMID:8481690. |
[the role of serotonin 1a and dopamine d2 receptors in buspirone effects on the electrical activity of white rat brain]. |
1993-06-02 |
2023-08-12 |
rat |
| J C Pecknold, L Luthe, M H Scott-Fleury, S Jenkin. Gepirone and the treatment of panic disorder: an open study. Journal of clinical psychopharmacology. vol 13. issue 2. 1993-05-06. PMID:8096526. |
gepirone, an azapirone, is a potent 5-hydroxytryptamine 1a (5-ht1a) agonist. |
1993-05-06 |
2023-08-12 |
Not clear |
| C J McDougle, W K Goodman, J F Leckman, J C Holzer, L C Barr, E McCance-Katz, G R Heninger, L H Pric. Limited therapeutic effect of addition of buspirone in fluvoxamine-refractory obsessive-compulsive disorder. The American journal of psychiatry. vol 150. issue 4. 1993-05-03. PMID:8465885. |
the authors found that buspirone added to the treatment of 33 patients with obsessive-compulsive disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-compulsive, depressive, or anxiety symptoms. |
1993-05-03 |
2023-08-12 |
Not clear |
| N F Tajuddin, M J Drus. Treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring. Alcoholism, clinical and experimental research. vol 17. issue 1. 1993-04-12. PMID:7680841. |
treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring. |
1993-04-12 |
2023-08-12 |
rat |
| N F Tajuddin, M J Drus. Treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring. Alcoholism, clinical and experimental research. vol 17. issue 1. 1993-04-12. PMID:7680841. |
because of the importance of fetal serotonin (5-ht) and 5-ht1a receptors for the normal development of 5-ht containing neurons, we initiated studies to determine whether administration of a 5-ht1a agonist, buspirone, to pregnant rats could overcome the adverse effects of in utero ethanol exposure on the developing serotonergic system in offspring. |
1993-04-12 |
2023-08-12 |
rat |
| N F Tajuddin, M J Drus. Treatment of pregnant alcohol-consuming rats with buspirone: effects on serotonin and 5-hydroxyindoleacetic acid content in offspring. Alcoholism, clinical and experimental research. vol 17. issue 1. 1993-04-12. PMID:7680841. |
in contrast, the 5-ht and 5-hiaa deficiency in the somatosensory cortex of 19-day-old offspring of ethanol-fed rats was not corrected by in utero buspirone treatment. |
1993-04-12 |
2023-08-12 |
rat |
| W H Wang, T A Lovic. Inhibitory serotonergic effects on rostral ventrolateral medullary neurons. Pflugers Archiv : European journal of physiology. vol 422. issue 2. 1993-02-25. PMID:1336851. |
in rats anaesthetised with urethane, iontophoretic application of 5-hydroxytryptamine (5-ht) and the 5-ht1a agonists buspirone, flesinoxan and 8-hydroxy-2-(di-n-propylamino)-tetralin inhibited ongoing or amino-acid-evoked activity of neurons in the rostral ventrolateral medulla (rvlm) including barosensitive cells with spinally projecting axons. |
1993-02-25 |
2023-08-11 |
rat |
| A Płaźnik, R Stefański, W Pałejko, W Kostowsk. The role of accumbens serotonin in stress-induced locomotor suppression in rats. Polish journal of pharmacology and pharmacy. vol 44. issue 3. 1993-01-22. PMID:1470562. |
it was found that the deficient open field behavior, examined 24 h after learned helplessness training, was not modified by local injection of serotonin, buspirone, ipsapirone and ics 205 930, as well as by peripherally administered citalopram. |
1993-01-22 |
2023-08-11 |
rat |
| James Giordano, LaVerne Roger. Putative mechanisms of buspirone-induced antinociception in the rat. Pain. vol 50. issue 3. 1993-01-06. PMID:1454390. |
intraperitoneal administration of the serotonin 5-ht1a agonist, buspirone (1-5 mg/kg), produced dose- and time-related core hypothermia that was coincident with analgesia against a thermally noxious stimulus. |
1993-01-06 |
2023-08-11 |
rat |
| K Takao, T Nagatani, K Kasahara, S Hashimot. Role of the central serotonergic system in the anticonflict effect of d-AP159. Pharmacology, biochemistry, and behavior. vol 43. issue 2. 1992-12-22. PMID:1359579. |
the anticonflict effect of buspirone, but not that of d-ap159, was attenuated in 5-ht neuron-lesioned rats. |
1992-12-22 |
2023-08-11 |
rat |
| G Tunnicliff, J J Brokaw, J A Hausz, G K Matheson, G W Whit. Influence of repeated treatment with buspirone on central 5-hydroxytryptamine and dopamine synthesis. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1436392. |
influence of repeated treatment with buspirone on central 5-hydroxytryptamine and dopamine synthesis. |
1992-12-17 |
2023-08-11 |
rat |
| G Tunnicliff, J J Brokaw, J A Hausz, G K Matheson, G W Whit. Influence of repeated treatment with buspirone on central 5-hydroxytryptamine and dopamine synthesis. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1436392. |
in those rats which had received an acute dose of buspirone, the synthesis of 5-ht was substantially reduced in all four regions of the brain. |
1992-12-17 |
2023-08-11 |
rat |
| G Tunnicliff, J J Brokaw, J A Hausz, G K Matheson, G W Whit. Influence of repeated treatment with buspirone on central 5-hydroxytryptamine and dopamine synthesis. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1436392. |
however, in those rats which had received buspirone for 10 days, no such alterations in the synthesis of 5-ht were observed. |
1992-12-17 |
2023-08-11 |
rat |
| G Tunnicliff, J J Brokaw, J A Hausz, G K Matheson, G W Whit. Influence of repeated treatment with buspirone on central 5-hydroxytryptamine and dopamine synthesis. Neuropharmacology. vol 31. issue 10. 1992-12-17. PMID:1436392. |
these findings suggest that repeated treatment with buspirone reduces the synthesis of dopamine in the striatum but that the synthesis of 5-ht is unaffected. |
1992-12-17 |
2023-08-11 |
rat |
| G C Rigdon, J K Weatherspoo. 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex. The Journal of pharmacology and experimental therapeutics. vol 263. issue 2. 1992-12-08. PMID:1432685. |
five 5-hydroxytryptamine1a (5-ht1a, serotonin) receptor agonists: 8-hydroxy-2-(di-n-propylamino) tetraline (8-ohdpat), 5-methoxydimethyltryptamine, buspirone, gepirone and ipsapirone, were tested for effects on prepulse inhibition and startle reflex amplitude in rats. |
1992-12-08 |
2023-08-11 |
human |
| C J Fowler, P C Ahlgren, G Brännströ. GH4ZD10 cells expressing rat 5-HT1A receptors coupled to adenylyl cyclase are a model for the postsynaptic receptors in the rat hippocampus. British journal of pharmacology. vol 107. issue 1. 1992-12-04. PMID:1330157. |
under such conditions, the following efficacies (5-ht = 100) were found: lisuride 106, (+)-lysergic-acid diethylamide 100, 5-methoxy-n,n-dimethyltryptamine 98, ru 24949 98, 5-carboxamidotryptamine 97, (+/-)-8-oh-dpat 90, (+)-8-oh-dpat 87, 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)-piperazine 86, flesinoxan 79/88, (-)-8-oh-dpat 62, buspirone 43/50, ipsapirone 46. |
1992-12-04 |
2023-08-11 |
rat |
| J Yamazaki, H Fukuda, T Nagao, H On. 5-HT2/5-HT1C receptor-mediated facilitatory action on unit activity of ventral horn cells in rat spinal cord slices. European journal of pharmacology. vol 220. issue 2-3. 1992-12-01. PMID:1358651. |
5-meodmt, doi, 5-hydroxytryptamine (5-ht), 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and tandospirone facilitated the probability of firing in the motor nuclei, with 5-meodmt and doi being the most potent. |
1992-12-01 |
2023-08-11 |
rat |
| G Curzon, G A Kennett, G S Sarna, P S Whitto. The effects of tianeptine and other antidepressants on a rat model of depression. The British journal of psychiatry. Supplement. issue 15. 1992-11-23. PMID:1356358. |
single high doses, post-restraint, of 8-oh-dpat, gepirone (5-ht agonists), and tianeptine normalised open field activity, whereas desipramine, chlordiazepoxide, and diazepam did not. |
1992-11-23 |
2023-08-11 |
rat |
| P Van den Hooff, M Galva. Actions of 5-hydroxytryptamine and 5-HT1A receptor ligands on rat dorso-lateral septal neurones in vitro. British journal of pharmacology. vol 106. issue 4. 1992-11-20. PMID:1393288. |
5-ht, 8-oh-dpat and dp-5-ct appeared to act as full agonists whereas buspirone behaved as a partial agonist. |
1992-11-20 |
2023-08-11 |
rat |