| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G D Tollefson, J Montague-Clouse, S L Tollefso. Treatment of comorbid generalized anxiety in a recently detoxified alcoholic population with a selective serotonergic drug (buspirone). Journal of clinical psychopharmacology. vol 12. issue 1. 1992-04-30. PMID:1552035. |
we investigated 51 dually diagnosed patients (generalized anxiety/alcohol abuse:dependence) in a randomized, double-blind, placebo-controlled trial of the serotonin partial agonist buspirone. |
1992-04-30 |
2023-08-11 |
Not clear |
| M J Millan, H Canton, J M Rivet, F Lejeune, M Laubie, G Laviell. S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency. European journal of pharmacology. vol 203. issue 2. 1992-04-21. PMID:1839284. |
the novel, naphthylpiperazine 5-ht1a agonist, s 14671 (4-[(thenoyl-2)aminoethyl]-1-(7-methoxynaphtylpiperazine], displayed very high affinity for 5-ht1a binding sites (pki = 9.3) as compared to the serotonin (5-ht)1a agonists, 8-oh-dpat (9.2) and (+)-flesinoxan (8.7) and the 5-ht1a partial agonists, buspirone (7.9) and bmy 7378 (8.8). |
1992-04-21 |
2023-08-11 |
Not clear |
| I V Komissarov, A V Mamonov, I T Filippo. [Effects of buspirone and buspirone-like 1-A-agonists of serotonin on the level of systemic blood pressure]. Biulleten' eksperimental'noi biologii i meditsiny. vol 112. issue 7. 1992-04-09. PMID:1686564. |
[effects of buspirone and buspirone-like 1-a-agonists of serotonin on the level of systemic blood pressure]. |
1992-04-09 |
2023-08-11 |
rat |
| G Tunniclif. Molecular basis of buspirone's anxiolytic action. Pharmacology & toxicology. vol 69. issue 3. 1992-04-06. PMID:1796057. |
behavioural, electrophysiological and receptor binding experiments gradually led to the idea that buspirone owes much of its anxiolytic activity to its ability to attenuate central 5-hydroxytryptamine neurotransmission. |
1992-04-06 |
2023-08-11 |
Not clear |
| F Lafaille, S A Welner, B E Suranyi-Cadott. Regulation of serotonin type 2 (5-HT2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment. Journal of psychiatry & neuroscience : JPN. vol 16. issue 4. 1992-03-24. PMID:1664741. |
the effect of a classical antidepressant drug, desmethylimipramine, was compared with two compounds which have more recently been used to treat depression, ie., adinazolam, a tirazolobenzodiazepine, and buspirone, a serotonin type 1a partial agonist, both of which possesses combined anxiolytic and antidepressant effects. |
1992-03-24 |
2023-08-11 |
rat |
| F Lafaille, S A Welner, B E Suranyi-Cadott. Regulation of serotonin type 2 (5-HT2) and beta-adrenergic receptors in rat cerebral cortex following novel and classical antidepressant treatment. Journal of psychiatry & neuroscience : JPN. vol 16. issue 4. 1992-03-24. PMID:1664741. |
on the other hand, adinazolam and buspirone, as well as desmethylimipramine, decreased the maximal binding of [125i]7-amino-8-iodo-ketanserin binding to serotonin type 2 receptors. |
1992-03-24 |
2023-08-11 |
rat |
| I I Abramets, I V Komissarov, I M Samoĭlovic. [Effects of serotonin-IA receptors on amino acid and dopaminergic responses of neurons]. Biulleten' eksperimental'noi biologii i meditsiny. vol 112. issue 12. 1992-03-12. PMID:1777625. |
it is shown that buspirone, campirone and serotonin increase the gaba effects but inhibit the effects of aspartate via the gaba- and nmda-receptors modulation. |
1992-03-12 |
2023-08-11 |
rat |
| M E Newman, B Shapira, B Lere. Regulation of 5-hydroxytryptamine1A receptor function in rat hippocampus by short- and long-term administration of 5-hydroxytryptamine1A agonist and antidepressants. The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1530973. |
single s.c. injections of the 5-hydroxytryptamine (5-ht)1a receptor agonists buspirone at 4 mg/kg, 8-hydroxy-2-(di-n-propylamino)tetralin at 1 or 4 mg/kg or ipsapirone at 10 mg/kg did not affect 5-ht inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes. |
1992-02-18 |
2023-08-11 |
rat |
| M E Newman, B Shapira, B Lere. Regulation of 5-hydroxytryptamine1A receptor function in rat hippocampus by short- and long-term administration of 5-hydroxytryptamine1A agonist and antidepressants. The Journal of pharmacology and experimental therapeutics. vol 260. issue 1. 1992-02-18. PMID:1530973. |
however, a single injection of buspirone at 8 mg/kg, and daily injections of each of the agonists for 8 days, resulted in a reduction in the degree of enzyme inhibition by 5-ht. |
1992-02-18 |
2023-08-11 |
rat |
| K P Lesc. [Psychobiology of compulsive disease]. Fortschritte der Neurologie-Psychiatrie. vol 59. issue 10. 1992-02-07. PMID:1761269. |
in addition, growing evidence suggests that potent inhibitors of 5-ht reuptake and other 5-ht subsystem-selective agents, such as the azapirones with partial agonist properties at the 5-ht1a receptor, are effective in ocd not only has improved the therapeutic perspective but may also reveal clues to the aetiopathogenesis of ocd. |
1992-02-07 |
2023-08-11 |
Not clear |
| P A Broderick, M F Pierce. 5-HT1A agonists uncouple noradrenergic somatodendritic impulse flow and terminal release. Brain research bulletin. vol 27. issue 5. 1992-02-06. PMID:1684526. |
both buspirone and ipsapirone significantly depressed 5-ht neuronal firing rates in dorsal raphe (dr), but significantly increased ne neuronal firing rates in locus coeruleus (lc). |
1992-02-06 |
2023-08-11 |
Not clear |
| P A Broderick, M F Pierce. 5-HT1A agonists uncouple noradrenergic somatodendritic impulse flow and terminal release. Brain research bulletin. vol 27. issue 5. 1992-02-06. PMID:1684526. |
in ca1 region of hippocampus, both buspirone and ipsapirone significantly depressed ne release with potencies greater than those required for the significant depression of 5-ht release. |
1992-02-06 |
2023-08-11 |
Not clear |
| H S Lee, H Y Meltze. Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man. Journal of neural transmission. General section. vol 86. issue 1. 1992-01-24. PMID:1751030. |
buspirone, a putative serotonin (5-ht)1a partial agonist, did not produce hypothermia in 17 normal volunteers in a placebo controlled, single blind study. |
1992-01-24 |
2023-08-11 |
human |
| D P Sachs, S J Leischo. Pharmacologic approaches to smoking cessation. Clinics in chest medicine. vol 12. issue 4. 1992-01-23. PMID:1747993. |
other agents in various phases of preclinical and clinical evaluation include 5-ht1a partial agonists such as buspirone; alpha 2-noradrenergic agonists such as clonidine; tricyclics such as doxepin; serotonin re-uptake antagonists such as fluoxetine; acth; 5-ht2 antagonists such as ritanserin; central excitatory amino acid inhibitors such as kynurenate; and calcium channel blockers. |
1992-01-23 |
2023-08-11 |
Not clear |
| G S Spencer, P Dobbie, J J Bas. Neuroendocrine regulation of growth hormone secretion in sheep. III. Serotoninergic systems. Domestic animal endocrinology. vol 8. issue 3. 1992-01-17. PMID:1684145. |
intravenous administration of the serotonin agonist, buspirone, at 1.2 mg/kg/h lowered plasma gh levels (p less than 0.001) but at 0.21 mg/kg/h there was no significant decrease. |
1992-01-17 |
2023-08-11 |
Not clear |
| F D Yocca, A S Eison, D K Hyslop, E Ryan, D P Taylor, G Gianutso. Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment. Life sciences. vol 49. issue 24. 1991-12-26. PMID:1682780. |
continuous administration of gepirone in non-lesioned rats for 3, 7, or 14 days enhanced the head shake response to the 5-ht agonist quipazine. |
1991-12-26 |
2023-08-11 |
rat |
| F D Yocca, A S Eison, D K Hyslop, E Ryan, D P Taylor, G Gianutso. Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment. Life sciences. vol 49. issue 24. 1991-12-26. PMID:1682780. |
these results suggest that the curious dissociation of behavioral and biochemical indices of 5-ht2 receptor function produced by continuous gepirone treatment may be the result of a dual yet separate action of the drug on central presynaptic noradrenergic and serotonergic mechanisms and postsynaptic 5-ht receptors. |
1991-12-26 |
2023-08-11 |
rat |
| M L Brandão, J A Lopez-Garcia, F G Graeff, M H Robert. Electrophysiological evidence for excitatory 5-HT2 and depressant 5-HT1A receptors on neurones of the rat midbrain tectum. Brain research. vol 556. issue 2. 1991-12-17. PMID:1682008. |
the 5-ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), buspirone and gepirone caused consistent reduction in the firing rate of cells depressed by 5-ht while they did not change the firing activity of cells excited by 5-ht. |
1991-12-17 |
2023-08-11 |
rat |
| M L Brandão, J A Lopez-Garcia, F G Graeff, M H Robert. Electrophysiological evidence for excitatory 5-HT2 and depressant 5-HT1A receptors on neurones of the rat midbrain tectum. Brain research. vol 556. issue 2. 1991-12-17. PMID:1682008. |
previous administration of zimelidine, a selective 5-ht uptake inhibitor, caused a significant enhancement of the excitatory effects of 5-ht while similar application of gepirone did not affect the size of the excitatory responses to 5-ht. |
1991-12-17 |
2023-08-11 |
rat |
| P J Fletcher, M H Zack, D V Coscin. Influence of taste and food texture on the feeding responses induced by 8-OH-DPAT and gepirone. Psychopharmacology. vol 104. issue 3. 1991-11-18. PMID:1681556. |
previously it has been shown that 5-hydroxy-tryptamine (5-ht)1a agonists such as 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and gepirone increase food intake in free-feeding rats. |
1991-11-18 |
2023-08-11 |
rat |