| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Franziska Richter, Lauryn Gabby, Kimberly A McDowell, Caitlyn K Mulligan, Krystal De La Rosa, Pedrom C Sioshansi, Farzad Mortazavi, Ingrid Cely, Larry C Ackerson, Linda Tsan, Niall P Murphy, Nigel T Maidment, Marie-Françoise Chessele. Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice. Neurobiology of aging. vol 51. 2017-09-28. PMID:28038352. |
in particular, we show that a potentially protective effect of low dat against toxin exposure is not sufficient to reduce death of all nigrostriatal dopaminergic neurons. |
2017-09-28 |
2023-08-13 |
mouse |
| Kirsten R Müller-Vahl, Gesa Loeber, Alexandra Kotsiari, Linda Müller-Engling, Helge Frielin. Gilles de la Tourette syndrome is associated with hypermethylation of the dopamine D2 receptor gene. Journal of psychiatric research. vol 86. 2017-09-12. PMID:27883923. |
while drd2 hypermethylation seems to be directly related to the neurobiology of ts that may lead to dopaminergic dysfunction resulting in enhanced thalamo-cortical movement-stimulating activity, dat hypomethylation might reflect a secondary mechanism in order to compensate for increased dopaminergic signal transduction due to drd2 hypermethylation. |
2017-09-12 |
2023-08-13 |
Not clear |
| Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R Free. Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. PloS one. vol 11. issue 8. 2017-08-07. PMID:27512998. |
in the current study, we have performed multiple rounds of clonal cultures and have identified a dopaminergic cell clone expressing high levels of th and the dopamine transporter (dat). |
2017-08-07 |
2023-08-13 |
rat |
| Sarah R Mikelman, Bipasha Guptaroy, Margaret E Gneg. Tamoxifen and its active metabolites inhibit dopamine transporter function independently of the estrogen receptors. Journal of neurochemistry. vol 141. issue 1. 2017-07-13. PMID:28075498. |
as one of the primary mechanisms by which dopamine signaling is regulated, the dopamine transporter (dat) is an attractive pharmacological target for the treatment of diseases based in dopaminergic dysfunction. |
2017-07-13 |
2023-08-13 |
Not clear |
| A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howe. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Molecular psychiatry. vol 22. issue 5. 2017-06-29. PMID:28289283. |
tentatively, this evidence suggests a model where an elevation in striatal d2/3 receptor availability would lead to increased dopaminergic neurotransmission and mania, whilst increased striatal dopamine transporter (dat) levels would lead to reduced dopaminergic function and depression. |
2017-06-29 |
2023-08-13 |
Not clear |
| Pier Francesca Porceddu, Ismail Ogunbayode Ishola, Liliana Contu, Micaela Morell. Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:27251371. |
the neuroprotective effect of metformin on mdma-induced dopaminergic damage was evaluated by dopamine transporter (dat) and tyrosine hydroxylase (th) immunohistochemistry in snc and cpu. |
2017-06-26 |
2023-08-13 |
mouse |
| Matan Soll, Orit Bar Am, Atif Mahammed, Irena Saltsman, Silvia Mandel, Moussa B H Youdim, Zeev Gros. Neurorescue by a ROS Decomposition Catalyst. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27442690. |
important findings that accompanied the ability to rescue dopaminergic neurons were increased expression of phenotypic dopaminergic proteins, such as tyrosine hydroxylase (th) and dopamine transporter (dat), which were significantly depleted upon 6-ohda-mediated damage. |
2017-06-21 |
2023-08-13 |
Not clear |
| Wei Hung Chang, Kao Chin Chen, I Hui Lee, Mei Hung Chi, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yan. Unaltered Dopamine Transporter Availability in Drug-Naive Patients With Schizophrenia After 6 Months of Antipsychotics Treatment: A Naturalistic Study. Journal of clinical psychopharmacology. vol 37. issue 1. 2017-05-10. PMID:28027110. |
dopaminergic dysfunction, namely, dopamine transporter (dat) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. |
2017-05-10 |
2023-08-13 |
Not clear |
| Maria João Valente, Maria de Lourdes Bastos, Eduarda Fernandes, Félix Carvalho, Paula Guedes de Pinho, Márcia Carvalh. Neurotoxicity of β-Keto Amphetamines: Deathly Mechanisms Elicited by Methylone and MDPV in Human Dopaminergic SH-SY5Y Cells. ACS chemical neuroscience. vol 8. issue 4. 2017-05-02. PMID:28067045. |
dopaminergic differentiated cells evidenced higher sensitivity to the neurotoxic effects of both cathinones and mdma than the undifferentiated ones, but this effect was not inhibited by the dat inhibitor gbr 12909. |
2017-05-02 |
2023-08-13 |
human |
| Tao Xie, Daniel Appelbaum, Jacqueline Bernard, Mahesh Padmanaban, Yonglin Pu, Christopher Gome. Evaluation of parkinsonism and striatal dopamine transporter loss in patients with spinocerebellar ataxia type 6. Journal of neurology. vol 263. issue 11. 2017-04-07. PMID:27544504. |
we conclude that there is no convincing parkinsonism or dat loss in sca6 patients in this unique study with a larger than previously reported number of patients compared to both age- and gender-matched hcs, suggesting that dopaminergic dysfunction is not usually involved in sca6. |
2017-04-07 |
2023-08-13 |
Not clear |
| Camille Pham-Lake, Elizabeth B Aronoff, Chad R Camp, Aimee Vester, Sam J Peters, W Michael Caudl. Impairment in the mesohippocampal dopamine circuit following exposure to the brominated flame retardant, HBCDD. Environmental toxicology and pharmacology. vol 50. 2017-03-13. PMID:28214749. |
these exposures elicited significant reductions in presynaptic dopaminergic proteins, including th, comt, mao-b, dat, vmat2, and alpha-synuclein. |
2017-03-13 |
2023-08-13 |
mouse |
| Xiaojian Jia, Feng Wang, Ying Han, Xuewen Geng, Minghua Li, Yu Shi, Lin Lu, Yun Che. miR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells. Neuroscience bulletin. vol 32. issue 6. 2017-02-27. PMID:27628529. |
a 40-bp variable-number tandem repeat (vntr) polymorphism in the 3'-untranslated region (3'utr) of the dat has been reported to be associated with various phenotypes that are involved in the aberrant regulation of dopaminergic neurotransmission. |
2017-02-27 |
2023-08-13 |
Not clear |
| Elina Jaakkola, Juho Joutsa, Valtteri Kaasine. Predictors of normal and abnormal outcome in clinical brain dopamine transporter imaging. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 3. 2016-12-13. PMID:26676600. |
brain dopamine transporter (dat) imaging with [(123)i]fp-cit spect can be used to evaluate the integrity of the mesostriatal dopaminergic system in patients with clinically uncertain parkinsonism. |
2016-12-13 |
2023-08-13 |
Not clear |
| Pedro Barroso-Chinea, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Javier Castro-Hernández, Josmar Salas-Hernández, Abdelwahed Chtarto, Diego Luis-Ravelo, Marie Humbert-Claude, Liliane Tenenbaum, Tomás González-Hernánde. Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system. Neurobiology of disease. vol 88. 2016-12-13. PMID:26777664. |
the dopamine (da) transporter (dat) is a plasma membrane glycoprotein expressed in dopaminergic (da-) cells that takes back da into presynaptic neurons after its release. |
2016-12-13 |
2023-08-13 |
human |
| K Berghauzen-Maciejewska, J Wardas, B Kosmowska, H Domin, M Śmiałowska, U Głowacka, K Ossowsk. Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine-induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment. Neuroscience. vol 314. 2016-10-13. PMID:26628402. |
intrastriatal 6-ohda injections decreased the number of dopaminergic, but not serotonergic neurons in the dr. 6-ohda reduced the dat binding in the cp, and sert binding in the nigrostriatal system (cp, substantia nigra (sn)), limbic system (ventral tegmental area (vta), nucleus accumbens (nac), amygdala, prefrontal cortex (pfcx), habenula, hippocampus) and dr. a significant positive correlation was found between dat and sert binding in the cp. |
2016-10-13 |
2023-08-13 |
rat |
| Shining Deng, Lingli Zhang, Tailin Zhu, Yan-Mei Liu, Hailong Zhang, Yiping Shen, Wei-Guang Li, Fei L. A behavioral defect of temporal association memory in mice that partly lack dopamine reuptake transporter. Scientific reports. vol 5. 2016-10-13. PMID:26658842. |
the shared phenotypes resulting from either the genetic reduction of dat or the pharmacological inhibition of the d2 receptor collectively indicate that temporal association memory necessitates precise regulation of dopaminergic signaling. |
2016-10-13 |
2023-08-13 |
mouse |
| Miriam Kannebley Frank, Marco Tulio de Mello, Kil Sun Lee, Paulo Daubian-Nosé, Sergio Tufik, Andrea Maculano Esteve. Sleep-related movement disorder symptoms in SHR are attenuated by physical exercise and an angiotensin-converting enzyme inhibitor. Physiology & behavior. vol 154. 2016-09-30. PMID:26650246. |
in addition, these treatments led to changes in dopaminergic signaling in the striatal region (i.e., d2 receptor, th and dat). |
2016-09-30 |
2023-08-13 |
rat |
| Julieta E Arena, A Jon Stoess. Optimizing diagnosis in Parkinson's disease: Radionuclide imaging. Parkinsonism & related disorders. vol 22 Suppl 1. 2016-09-12. PMID:26439947. |
presynaptic dopaminergic dysfunction in pd can be revealed through the imaging of different steps in the process of dopamine synthesis and storage: l-aromatic amino acid decarboxylase (aadc) activity, vesicular monoamine transporter type 2 (vmat2) binding or its reuptake via the dopamine transporter (dat). |
2016-09-12 |
2023-08-13 |
Not clear |
| Shu-Ying Liu, Jian-Jun Wu, Jue Zhao, Si-Fei Huang, Yi-Xuan Wang, Jing-Jie Ge, Ping Wu, Chuan-Tao Zuo, Zheng-Tong Ding, Jian Wan. Onset-related subtypes of Parkinson's disease differ in the patterns of striatal dopaminergic dysfunction: A positron emission tomography study. Parkinsonism & related disorders. vol 21. issue 12. 2016-09-12. PMID:26559130. |
this study investigated whether the two subtypes differ in the pattern of dysfunction in striatal (caudate and putamen) dopaminergic system and if the dopamine transporter (dat) imaging patterns are associated with the clinical features of corresponding pd subtype. |
2016-09-12 |
2023-08-13 |
Not clear |
| Ioannis U Isaias, Paula Trujillo, Paul Summers, Giorgio Marotta, Luca Mainardi, Gianni Pezzoli, Luigi Zecca, Antonella Cost. Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease. Frontiers in aging neuroscience. vol 8. 2016-09-06. PMID:27597825. |
striatal dopaminergic innervation was measured as density of dopamine transporter (dat) by means of single-photon emission computed tomography and [(123)i] n-ω-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) tropane. |
2016-09-06 |
2023-08-13 |
human |