| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mauro Pettorruso, Daniela Di Giuda, Giovanni Martinotti, Fabrizio Cocciolillo, Luisa De Risio, Chiara Montemitro, Giovanni Camardese, Marco Di Nicola, Luigi Janiri, Massimo di Giannantoni. Dopaminergic and clinical correlates of high-frequency repetitive transcranial magnetic stimulation in gambling addiction: a SPECT case study. Addictive behaviors. vol 93. 2020-08-03. PMID:30798016. |
after two weeks of left dlpfc-rtms treatment, we found a decrease in dat availability in striatal regions, that represents a putative neurobiological substrate of dopaminergic pathways modulation. |
2020-08-03 |
2023-08-13 |
Not clear |
| Mary Hongying Cheng, Luca Ponzoni, Tatiana Sorkina, Ji Young Lee, She Zhang, Alexander Sorkin, Ivet Baha. Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations. Neuropharmacology. vol 161. 2020-07-14. PMID:31228486. |
aim-100 binding promotes dat endocytosis and thereby moderates dopaminergic transmission. |
2020-07-14 |
2023-08-13 |
Not clear |
| Mary Hongying Cheng, Luca Ponzoni, Tatiana Sorkina, Ji Young Lee, She Zhang, Alexander Sorkin, Ivet Baha. Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations. Neuropharmacology. vol 161. 2020-07-14. PMID:31228486. |
the study suggests the possibility of controlling the effective transport of dopamine by altering the oligomerization state of dat upon small molecule binding, as a possible intervention strategy to modulate dopaminergic signaling. |
2020-07-14 |
2023-08-13 |
Not clear |
| Danielle E Bolland, Amy E Moritz, Daniel J Stanislowski, Roxanne A Vaughan, James D Foste. Palmitoylation by Multiple DHHC Enzymes Enhances Dopamine Transporter Function and Stability. ACS chemical neuroscience. vol 10. issue 6. 2020-07-07. PMID:30965003. |
the dopamine transporter (dat) is a plasma membrane protein that mediates the reuptake of extracellular dopamine (da) and controls the spatiotemporal dynamics of dopaminergic neurotransmission. |
2020-07-07 |
2023-08-13 |
human |
| Rafieh Alizadeh, Zohreh Bagher, Seyed Kamran Kamrava, Masoumeh Falah, Hatef Ghasemi Hamidabadi, Mahdi Eskandarian Boroujeni, Fatemeh Mohammadi, Sepideh Khodaverdi, Arash Zare-Sadeghi, Arta Olya, Ali Komeil. Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton's Jelly and olfactory mucosa as sources of MSCs. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30639339. |
however, it was demonstrated that having the same neuroectodermal origin as the nervous system, the olfactory ectomesenchymal stem cells (oe-mscs) expressed the neural marker map2 as well as dopaminergic markers such as tyrosine hydroxylase (th), dopamine transporter (dat) and pitx3 to a greater extent than the wj-mscs both at the level of mrna and protein. |
2020-06-15 |
2023-08-13 |
human |
| Diane Stephenson, Derek Hill, Jesse M Cedarbaum, Maria Tome, Spiros Vamvakas, Klaus Romero, Daniela J Conrado, David T Dexter, John Seibyl, Danna Jennings, Timothy Nicholas, Dawn Matthews, Zhiyong Xie, Syed Imam, Paul Maguire, David Russell, Mark Forrest Gordon, Glenn T Stebbins, Ed Somer, Jill Gallagher, Arthur Roach, Peter Basseches, Donald Grosset, Kenneth Mare. The Qualification of an Enrichment Biomarker for Clinical Trials Targeting Early Stages of Parkinson's Disease. Journal of Parkinson's disease. vol 9. issue 3. 2020-06-02. PMID:31306141. |
the presence of reduced striatal dat binding based on visual reads of single photon emission tomography (spect) scans in early motor pd subjects was an independent predictor of faster decline in updrs parts ii and iii as compared to subjects with scans without evidence of dopaminergic deficit (swedd) over 24 months. |
2020-06-02 |
2023-08-13 |
human |
| Junpei Kobayashi, Takafumi Hasegawa, Naoto Sugeno, Shun Yoshida, Tetsuya Akiyama, Koki Fujimori, Hiroyasu Hatakeyama, Yasuo Miki, Arata Tomiyama, Yasushi Kawata, Mitsunori Fukuda, Ichiro Kawahata, Tohru Yamakuni, Michinori Ezura, Akio Kikuchi, Toru Baba, Atsushi Takeda, Makoto Kanzaki, Koichi Wakabayashi, Hideyuki Okano, Masashi Aok. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 9. 2020-05-27. PMID:31211923. |
moreover, we demonstrated that α-syn itself exploited the dat endocytic process to enter dopaminergic neuron-like cells, and both flot1 and dat were found to be the components of lbs. |
2020-05-27 |
2023-08-13 |
Not clear |
| Junpei Kobayashi, Takafumi Hasegawa, Naoto Sugeno, Shun Yoshida, Tetsuya Akiyama, Koki Fujimori, Hiroyasu Hatakeyama, Yasuo Miki, Arata Tomiyama, Yasushi Kawata, Mitsunori Fukuda, Ichiro Kawahata, Tohru Yamakuni, Michinori Ezura, Akio Kikuchi, Toru Baba, Atsushi Takeda, Makoto Kanzaki, Koichi Wakabayashi, Hideyuki Okano, Masashi Aok. Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 9. 2020-05-27. PMID:31211923. |
altogether, these findings revealed a novel role of extracellular α-syn on cellular trafficking of dat and may provide a rationale for the cell type-specific, functional, and pathologic alterations in pd.-kobayashi, j., hasegawa, t., sugeno, n., yoshida, s., akiyama, t., fujimori, k., hatakeyama, h., miki, y., tomiyama, a., kawata, y., fukuda, m., kawahata, i., yamakuni, t., ezura, m., kikuchi, a., baba, t., takeda, a., kanzaki, m., wakabayashi, k., okano, h., aoki, m. extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis. |
2020-05-27 |
2023-08-13 |
Not clear |
| Giovanni Palermo, Roberto Ceravol. Molecular Imaging of the Dopamine Transporter. Cells. vol 8. issue 8. 2020-05-11. PMID:31405186. |
dopamine transporter (dat) single-photon emission tomography (spect) with (123)ioflupane is a widely used diagnostic tool for patients with suspected parkinsonian syndromes, as it assists with differentiating between parkinson's disease (pd) or atypical parkinsonisms and conditions without a presynaptic dopaminergic deficit such as essential tremor, vascular and drug-induced parkinsonisms. |
2020-05-11 |
2023-08-13 |
Not clear |
| Giovanni Palermo, Roberto Ceravol. Molecular Imaging of the Dopamine Transporter. Cells. vol 8. issue 8. 2020-05-11. PMID:31405186. |
recent evidence supports its utility as in vivo proof of degenerative parkinsonisms, and dat imaging has been proposed as a potential surrogate marker for dopaminergic nigrostriatal neurons. |
2020-05-11 |
2023-08-13 |
Not clear |
| Maria Cecilia Manenti Alexandre, Niuany Viel Mendes, Carolina Antunes Torres, Samira Leila Baldin, Henrique Teza Bernardo, Rahisa Scussel, Suelen Baggio, Ben Hur Marins Mussulini, Kamila Cagliari Zenki, Maria Inês da Rosa, Eduardo Pacheco Ric. Weekly ethanol exposure alters dopaminergic parameters in zebrafish brain. Neurotoxicology and teratology. vol 75. 2020-05-01. PMID:31421226. |
brain dopaminergic function was assessed by the activity of the dopamine transporters (dat); monoamine oxidase (mao) activity; dopamine and noradrenaline levels by chromatography. |
2020-05-01 |
2023-08-13 |
zebrafish |
| Naoko Kuzumaki, Yukari Suda, Chizuru Iwasawa, Michiko Narita, Takefumi Sone, Moe Watanabe, Aya Maekawa, Takuya Matsumoto, Wado Akamatsu, Katsuhide Igarashi, Hideki Tamura, Hideyuki Takeshima, Vivianne L Tawfik, Toshikazu Ushijima, Nobutaka Hattori, Hideyuki Okano, Minoru Narit. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain : a journal of neurology. vol 142. issue 6. 2020-03-12. PMID:31135049. |
in dopamine transporter (dat)-cre mice, overexpression of comt, specifically in dopaminergic neurons of the substantia nigra, produced cataleptic behaviours associated with impaired motor coordination. |
2020-03-12 |
2023-08-13 |
mouse |
| Merve Çapkın Yurtsever, Arlin Kiremitci, Menemşe Gümüşderelioğl. Dopaminergic induction of human dental pulp stem cells by photobiomodulation: comparison of 660nm laser light and polychromatic light in the nir. Journal of photochemistry and photobiology. B, Biology. vol 204. 2020-03-11. PMID:31982670. |
real time rt-qpcr analysis indicated that expressions of brain derived neurotrophic factor (bdnf), glial cell line derived neurotropic factor (gndf), matrix associated protein 2 (map2), nuclear receptor related 1 protein (nurr1) and dopamine transporter (dat) were increased, especially in the first 7 days of dopaminergic induction when 660 nm laser light was applied with a total energy density of 1.6 j/cm |
2020-03-11 |
2023-08-13 |
human |
| Jordan M Buck, Kelsey N Sanders, Charles R Wageman, Valerie S Knopik, Jerry A Stitzel, Heidi C O'Neil. Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice. Neuropharmacology. vol 149. 2020-01-27. PMID:30742847. |
pharmacological characterization of nicotinic and dopaminergic systems in striatum and frontal cortex reveals altered expression and dysfunction of nicotinic acetylcholine receptors (nachrs), hypersensitivity to nicotine-induced nachr-mediated dopamine release, and impaired dopamine transporter (dat) function in dne mice. |
2020-01-27 |
2023-08-13 |
mouse |
| Merijn Joling, Chris Vriend, Pieter G H M Raijmakers, Jessica J van der Zande, Afina W Lemstra, Henk W Berendse, Jan Booij, Odile A van den Heuve. Striatal DAT and extrastriatal SERT binding in early-stage Parkinson's disease and dementia with Lewy bodies, compared with healthy controls: An NeuroImage. Clinical. vol 22. 2020-01-17. PMID:30884365. |
striatal dat and extrastriatal sert binding in early-stage parkinson's disease and dementia with lewy bodies, compared with healthy controls: an parkinson's disease (pd) and dementia with lewy bodies (dlb) are thought to be part of a spectrum: both have a clinical profile including symptoms associated with dopaminergic and serotonergic loss, yet few imaging studies have focused on serotonergic neurodegeneration in both disorders. |
2020-01-17 |
2023-08-13 |
Not clear |
| Joseph J Lebowitz, Jose A Pino, Phillip M Mackie, Min Lin, Cheyenne Hurst, Keeley Divita, Anthony T Collins, Dimitri N Koutzoumis, Gonzalo E Torres, Habibeh Khoshboue. Clustered Kv2.1 decreases dopamine transporter activity and internalization. The Journal of biological chemistry. vol 294. issue 17. 2020-01-07. PMID:30824538. |
interactions with partner proteins alter dat function and thereby dynamically shape dopaminergic tone important for normal brain function. |
2020-01-07 |
2023-08-13 |
Not clear |
| Mei Zhou, Xiaokang Gong, Qin Ru, Qi Xiong, Lin Chen, Yuanren Si, Huaqiao Xiao, Chaoying L. The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice. Neurotoxicity research. vol 36. issue 2. 2020-01-02. PMID:31201732. |
meanwhile, the protein expression of dopaminergic d2 receptors in hippocampus area was significantly increased by repeated meth exposure, while the protein expression of dopamine transporter (dat) was significantly reduced. |
2020-01-02 |
2023-08-13 |
mouse |
| Achut P Silwal, H Peter L. Mode-Selective Raman Imaging of Dopamine-Human Dopamine Transporter Interaction in Live Cells. ACS chemical neuroscience. vol 9. issue 12. 2019-12-23. PMID:30024721. |
interactions of da, its analogue with dars, or dat have been studied extensively to understand the mechanism of the dopaminergic signaling process and several neurodegenerative diseases, including schizophrenia, parkinson's diseases, addiction, attention deficit hyperactivity disorder, and bipolar disorder. |
2019-12-23 |
2023-08-13 |
human |
| Miao He, Hainan Zhang, Yuju Li, Changhai Tian, Beisha Tang, Yunlong Huang, Jialin Zhen. Direct and selective lineage conversion of human fibroblasts to dopaminergic precursors. Neuroscience letters. vol 699. 2019-12-17. PMID:30664902. |
furthermore, the hidps could be differentiated into dopaminergic neurons with ˜80% efficiency, which significantly increased major functionally relevant proteins such as th, dat, aadc, lmx1b, and vmat2 compared to hidps. |
2019-12-17 |
2023-08-13 |
mouse |
| Cynthia Anckaerts, Jaana van Gastel, Valerie Leysen, Rukun Hinz, Abdelkrim Azmi, Pascal Simoens, Disha Shah, Firat Kara, An Langbeen, Peter Bols, Charlotte Laloux, Vincent Prevot, Marleen Verhoye, Stuart Maudsley, Annemie Van der Linde. Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality. Neurobiology of aging. vol 74. 2019-11-26. PMID:30439596. |
furthermore, this quantitative mass spectrometry proteomics-based analysis of molecular signaling patterns further identified a strong involvement of altered dopaminergic functionality (e.g., dat and predicted upstream regulators drd3, nr4a2), reproductive signaling (e.g., srd5a2), rotatin expression (rttn), cellular aging (e.g., rxfp3, git2), myelination, and axogenesis (e.g., nefl, mag). |
2019-11-26 |
2023-08-13 |
mouse |