| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanne K Meles, Wolfgang H Oertel, Klaus L Leender. Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-09-23. PMID:34530732. |
studies have focused on radiotracer imaging of the dopaminergic nigrostriatal system, which can be assessed with dopamine transporter (dat) single photon emission computed tomography (spect). |
2021-09-23 |
2023-08-13 |
human |
| Sven R Suwijn, Hamdia Samim, Carsten Eggers, Alberto J Espay, Susan Fox, Anthony E Lang, Mike Samuel, Monty Silverdale, Constant V M Verschuur, Joke M Dijk, Hein J Verberne, Jan Booij, Rob M A de Bi. Value of Clinical Signs in Identifying Patients with Scans without Evidence of Dopaminergic Deficit (SWEDD). Journal of Parkinson's disease. vol 10. issue 4. 2021-09-17. PMID:32597819. |
in clinical trials that recruited patients with early parkinson's disease (pd), 4-15% of the participants with a clinical diagnosis of pd had normal dopamine transporter single photon emission computed tomography (dat spect) scans, also called "scans without evidence of dopaminergic deficit" (swedd). |
2021-09-17 |
2023-08-13 |
human |
| Kristina Xiao Liang, Guro Helén Vatne, Cecilie Katrin Kristiansen, Oleksandr Ievglevskyi, Elena Kondratskaya, Joel C Glover, Anbin Chen, Gareth John Sullivan, Laurence A Bindof. N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation. Experimental neurology. vol 337. 2021-09-13. PMID:33264635. |
using human induced pluripotent stem cells (hipscs), we generated functional dopaminergic (da) neurons showing positive expression of dopaminergic markers th and dat, mature neuronal marker map2 and functional synaptic markers synaptophysin and psd-95. |
2021-09-13 |
2023-08-13 |
human |
| Emma A Honkanen, Tommi Noponen, Risto Hirvilammi, Kari Lindholm, Riitta Parkkola, Juho Joutsa, Andrea Varrone, Valtteri Kaasine. Sex correction improves the accuracy of clinical dopamine transporter imaging. EJNMMI research. vol 11. issue 1. 2021-09-10. PMID:34424408. |
since there are sex differences in presynaptic dopaminergic function, we investigated the effect of dat sex correction in a sample of healthy volunteers who underwent brain [ |
2021-09-10 |
2023-08-13 |
human |
| Vinícia Garzella Metz, Jéssica Leandra Oliveira da Rosa, Domenika Rubert Rossato, Laura Hautrive Milanesi, Marilise Escobar Burger, Camila Simonetti Pas. Cannabidiol prevents amphetamine relapse and modulates D1- and D2-receptor levels in mesocorticolimbic brain areas of rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 50. 2021-08-30. PMID:33951588. |
regarding molecular levels, cbd modulated at basal levels the dopaminergic targets (d1r, d2r, dat, and th) in the assessed brain areas, preventing amph relapse and decreasing anxiety-like behavior per se and in amph-cpp animals. |
2021-08-30 |
2023-08-13 |
rat |
| Arunkumar Singh Koijam, Aruna Chanu Hijam, Asem Surindro Singh, Preeti Jaiswal, Kanchan Mukhopadhyay, Usha Rajamma, Reena Haoba. Association of Dopamine Transporter Gene with Heroin Dependence in an Indian Subpopulation from Manipur. Journal of molecular neuroscience : MN. vol 71. issue 1. 2021-08-27. PMID:32557146. |
dopamine transporter (dat) or solute carrier family 6 member 3 (slc6a3) is a transmembrane protein regulating dopaminergic neurotransmission. |
2021-08-27 |
2023-08-13 |
Not clear |
| Caline S Karam, Brenna L Williams, Sandra K Jones, Jonathan A Javitc. The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila. Neurochemical research. 2021-08-26. PMID:33630236. |
the dopamine transporter (dat) mediates the inactivation of released dopamine (da) through its reuptake, and thereby plays an important homeostatic role in dopaminergic neurotransmission. |
2021-08-26 |
2023-08-13 |
drosophila_melanogaster |
| Lauren Jackson, Pierpaolo Turcano, Derek Stitt, Elizabeth Coon, Rodolfo Savic. Autonomic Testing Profiles in Scans without Evidence of Dopaminergic Deficit (SWEDD). Journal of Parkinson's disease. vol 10. issue 3. 2021-08-19. PMID:32538867. |
scans without evidence of dopaminergic deficit (swedds) on 123i-fp-cit spect (dat) can occur in patients with clinical evidence of parkinsonism. |
2021-08-19 |
2023-08-13 |
Not clear |
| Diego Luis-Ravelo, Felipe Fumagallo-Reading, Javier Castro-Hernandez, Pedro Barroso-Chinea, Domingo Afonso-Oramas, Alejandro Febles-Casquero, Ignacio Cruz-Muros, Josmar Salas-Hernandez, Virginia Mesa-Infante, Julia Rodriguez-Nuñez, Tomas Gonzalez-Hernande. Prolonged dopamine D Pharmacological research. vol 165. 2021-07-16. PMID:33484816. |
prolonged dopamine d the dopamine transporter (dat) is a membrane glycoprotein in dopaminergic neurons, which modulates extracellular and intracellular dopamine levels. |
2021-07-16 |
2023-08-13 |
Not clear |
| Liga Zvejniece, Baiba Zvejniece, Melita Videja, Gundega Stelfa, Edijs Vavers, Solveiga Grinberga, Baiba Svalbe, Maija Dambrov. Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. Inflammopharmacology. vol 28. issue 5. 2021-07-01. PMID:32279140. |
since growing evidence suggests that dysfunction of the dopaminergic system is associated with persistent neuroinflammation, the aim of this study was to determine whether r-php, an inhibitor of dat, has neuroprotective and anti-inflammatory effects in male mice. |
2021-07-01 |
2023-08-13 |
mouse |
| Kyoungjune Pak, Ju Won Seok, Hyun-Yeol Nam, Seongho Seo, Myung Jun Lee, Keunyoung Kim, In Joo Ki. The association of DAT gene methylation with striatal DAT availability in healthy subjects. EJNMMI research. vol 11. issue 1. 2021-06-29. PMID:34120227. |
functioning of nigrostriatal dopaminergic neurons is influenced by the expression of the dopamine transporter (dat), and genetic variations in the gene encoding dat contribute to differences in reward processing. |
2021-06-29 |
2023-08-13 |
human |
| Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil A Harrison, Mitul A Mehta, Mara Cercignan. Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 9. 2021-06-23. PMID:32473593. |
here, we focus on methylphenidate (mph), which binds to the dopamine transporter (dat) and the norepinephrine transporter (net), to unravel its effects on dopaminergic and noradrenergic functional circuits in the healthy brain at rest. |
2021-06-23 |
2023-08-13 |
Not clear |
| Mary K Estes, Jasric J Bland, Kenya K Ector, Melissa J Puppa, Douglas W Powell, Deranda B Leste. A high fat western diet attenuates phasic dopamine release. Neuroscience letters. vol 756. 2021-06-22. PMID:33979702. |
mice that consumed the wd demonstrated a hypodopaminergic profile, specifically reduced baseline dopamine release and an attenuated dopaminergic response to dat inhibition compared to the control diet group. |
2021-06-22 |
2023-08-13 |
mouse |
| Daryl A Guthrie, Carmen Klein Herenbrink, Matthew Domenic Lycas, Therese Ku, Alessandro Bonifazi, Brian T DeVree, Signe Mathiasen, Jonathan A Javitch, Jonathan B Grimm, Luke Lavis, Ulrik Gether, Amy Hauck Newma. Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter. ACS chemical neuroscience. vol 11. issue 20. 2021-06-18. PMID:32926777. |
the dopamine transporter (dat) is critical for spatiotemporal control of dopaminergic neurotransmission and is the target for therapeutic agents, including adhd medications, and abused substances, such as cocaine. |
2021-06-18 |
2023-08-13 |
Not clear |
| Lorena Oliveira de Matos, Ana Luiza de Araujo Lima Reis, Lorena Terene Lopes Guerra, Leonardo de Oliveira Guarnieri, Muiara Aparecida Moraes, Laila Blanc Arabe, Renan Pedra de Souza, Grace Schenatto Pereira, Bruno Rezende Souz. Early postnatal l-Dopa treatment causes behavioral alterations in female vs. male young adult Swiss mice. Neuropharmacology. vol 170. 2021-06-03. PMID:32325324. |
knockout mice for dopamine transporters (dat) as well as site-specific knockout mice lacking dopaminergic d2 autoreceptors in dopaminergic neurons (da-d2rko) display behavioral alterations such as hyperlocomotion and abnormal prepulse inhibition. |
2021-06-03 |
2023-08-13 |
mouse |
| Mike Jeon, Guanyou Lin, Zachary R Stephen, Josey E Vechey, Manjot Singh, Richard Revia, Amy Hauck Newman, Diana Martinez, Miqin Zhan. Cocaine analogue conjugated magnetic nanoparticles for labeling and imaging dopaminergic neurons. Biomaterials science. vol 8. issue 15. 2021-05-14. PMID:32515443. |
here we present a magnetic nanoparticle (np) that specifically targets dopaminergic neurons and allows dat imaging with magnetic resonance imaging (mri). |
2021-05-14 |
2023-08-13 |
Not clear |
| Mike Jeon, Guanyou Lin, Zachary R Stephen, Josey E Vechey, Manjot Singh, Richard Revia, Amy Hauck Newman, Diana Martinez, Miqin Zhan. Cocaine analogue conjugated magnetic nanoparticles for labeling and imaging dopaminergic neurons. Biomaterials science. vol 8. issue 15. 2021-05-14. PMID:32515443. |
the nanoparticle (namely, np-dn) is composed of an iron oxide core and a polyethylene glycol (peg) coating to which a dat specific dopaminergic neurolabeler (dn) is conjugated. |
2021-05-14 |
2023-08-13 |
Not clear |
| Giulia Gaggi, Andrea Di Credico, Pascal Izzicupo, Francesco Alviano, Michele Di Mauro, Angela Di Baldassarre, Barbara Ghinass. Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage. International journal of molecular sciences. vol 21. issue 18. 2021-03-05. PMID:32916865. |
moreover, hfm-mscs that underwent a dopaminergic differentiation protocol gradually increased the transcription of dopaminergic markers lmx1b, nurr1, pitx3, and dat. |
2021-03-05 |
2023-08-13 |
human |
| Giulia Gaggi, Andrea Di Credico, Pascal Izzicupo, Francesco Alviano, Michele Di Mauro, Angela Di Baldassarre, Barbara Ghinass. Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage. International journal of molecular sciences. vol 21. issue 18. 2021-03-05. PMID:32916865. |
we finally obtained a homogeneous population of cells resembling the morphology of primary midbrain dopaminergic neurons that expressed the functional dopaminergic markers th, dat, and nurr1. |
2021-03-05 |
2023-08-13 |
human |
| Akanksha Mishra, Sairam Krishnamurth. Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 3. 2021-01-25. PMID:31654086. |
ambroxol restored th and dat levels on d-71 as the markers of dopaminergic cell and extracellular da concentration respectively, indicating the recovery of dopaminergic system. |
2021-01-25 |
2023-08-13 |
rat |