| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akanksha Mishra, Sairam Krishnamurth. Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 3. 2021-01-25. PMID:31654086. |
ambroxol restored th and dat levels on d-71 as the markers of dopaminergic cell and extracellular da concentration respectively, indicating the recovery of dopaminergic system. |
2021-01-25 |
2023-08-13 |
rat |
| Hirotaka Sekiguchi, Geoff Pavey, Brian Dea. Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia. NPJ schizophrenia. vol 5. issue 1. 2021-01-10. PMID:31792225. |
we postulated that the dopamine transporter (dat), which regulates intra-synaptic dopamine concentrations by transporting dopamine from the synaptic cleft into the pre-synaptic neuron, could be involved in dopaminergic dysfunction in schizophrenia. |
2021-01-10 |
2023-08-13 |
human |
| Rafieh Alizadeh, Farnaz Ramezanpour, Amirhossein Mohammadi, Mina Eftekharzadeh, Sara Simorgh, Milad Kazemiha, Fatemeh Morad. Differentiation of human olfactory system-derived stem cells into dopaminergic neuron-like cells: A comparison between olfactory bulb and mucosa as two sources of stem cells. Journal of cellular biochemistry. vol 120. issue 12. 2020-11-05. PMID:31297865. |
quantitative real-time polymerase chain reaction analysis 3 weeks after induction demonstrated that the mrna expression of the dopaminergic activity markers tyrosine hydroxylase (th), dopamine transporter (dat), paired box gene 2 (pax2), and pax5 in the neuron-like cells derived from ob-nscs was significantly higher than those derived from oe-mscs. |
2020-11-05 |
2023-08-13 |
human |
| Francesco Napolitano, Arianna De Rosa, Rosita Russo, Anna Di Maio, Martina Garofalo, Mauro Federici, Sara Migliarini, Ada Ledonne, Francesca Romana Rizzo, Luigi Avallone, Tommaso Nuzzo, Tommaso Biagini, Massimo Pasqualetti, Nicola Biagio Mercuri, Tommaso Mazza, Angela Chambery, Alessandro Usiell. The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31653935. |
despite dramatic striatal alterations associated to cocaine exposure, our data did not reveal any significant changes in midbrain dopaminergic neurons as a lack of rhes did not affect: (i) dat activity; (ii) d2r-dependent regulation of girk; and (iii) d2r-dependent regulation of dopamine release. |
2020-11-05 |
2023-08-13 |
mouse |
| Alfonso Rubino, Claudio D'Addario, Martina Di Bartolomeo, Enrico Michele Salamone, Nicoletta Locuratolo, Francesco Fattapposta, Nicola Vanacore, Esterina Pascal. DNA methylation of the 5'-UTR DAT 1 gene in Parkinson's disease patients. Acta neurologica Scandinavica. vol 142. issue 3. 2020-11-05. PMID:32415851. |
among others, we, here, focused the attention on the dopamine transporter (dat) gene playing a critical role in maintaining the integrity of dopaminergic neurons. |
2020-11-05 |
2023-08-13 |
Not clear |
| Vinícia Garzella Metz, Hecson Jesser Segat, Verônica Tironi Dias, Raquel Cristine Silva Barcelos, Luana Haselein Maurer, Jéssica Stiebe, Tatiana Emanuelli, Marilise Escobar Burger, Camila Simonetti Pas. Omega-3 decreases D1 and D2 receptors expression in the prefrontal cortex and prevents amphetamine-induced conditioned place preference in rats. The Journal of nutritional biochemistry. vol 67. 2020-11-04. PMID:30951972. |
while fo prevented amph-induced oxidative damages in the prefrontal cortex, molecular assays allowed us to observe that it was also able to modulate dopaminergic cascade markers (dat, th, vmat-2, d1r and d2r) in the same brain area, thus preventing amph-induced molecular changes. |
2020-11-04 |
2023-08-13 |
rat |
| Jeong-Yoon Lee, Soo Bin Park, Mina Lee, Hyunjin Ju, Kayeong Im, Kyum-Yil Kwo. Detailed visual assessment of striatal dopaminergic depletion in patients with idiopathic normal pressure hydrocephalus: unremarkable or not? BMC neurology. vol 20. issue 1. 2020-10-19. PMID:32652959. |
however, a specific pattern of dopaminergic loss in dat imaging of inph patients remains to be further elucidated. |
2020-10-19 |
2023-08-13 |
Not clear |
| Anupam Raina, Sameehan Mahajani, Mathias Bähr, Sebastian Kügle. Neuronal Trans-differentiation by Transcription Factors Ascl1 and Nurr1: Induction of a Dopaminergic Neurotransmitter Phenotype in Cortical GABAergic Neurons. Molecular neurobiology. vol 57. issue 1. 2020-10-07. PMID:31317490. |
combining nurr1 with the generic neuronal differentiator and re-programming factor ascl1, however, resulted in generation of neurons which express dopaminergic markers th, aadc, vmat2 and dat. |
2020-10-07 |
2023-08-13 |
rat |
| Wolfgang G Bywalez, Tiffany Ona-Jodar, Michael Lukas, Jovica Ninkovic, Veronica Egge. Dendritic Arborization Patterns of Small Juxtaglomerular Cell Subtypes within the Rodent Olfactory Bulb. Frontiers in neuroanatomy. vol 10. 2020-10-01. PMID:28163674. |
dopaminergic neurons were identified in a transgenic mouse line where the expression of dopamine transporter (dat) was labeled with gfp. |
2020-10-01 |
2023-08-13 |
mouse |
| Ambra Lanzo, Bryan D Safratowich, Sirisha R Kudumala, Ivan Gallotta, Giuseppina Zampi, Elia Di Schiavi, Lucia Carvell. Silencing of Frontiers in physiology. vol 9. 2020-10-01. PMID:29872404. |
silencing of the dopamine transporter (dat) is a cell membrane protein whose main function is to reuptake the dopamine (da) released in the synaptic cleft back into the dopaminergic neurons. |
2020-10-01 |
2023-08-13 |
Not clear |
| Susanna Jakobson Mo, Jan Linder, Lars Forsgren, Katrine Riklun. Accuracy of Visual Assessment of Dopamine Transporter Imaging in Early Parkinsonism. Movement disorders clinical practice. vol 2. issue 1. 2020-10-01. PMID:30363855. |
dopamine transporter (dat) imaging may be supportive in the initial clinical diagnostic workup in patients with suspected parkinsonian diseases, given that the method has the potential to detect dopaminergic degeneration. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ashley L Green, Aseel Eid, Le Zhan, Helmut Zarbl, Grace L Guo, Jason R Richardso. Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter. Frontiers in genetics. vol 10. 2020-10-01. PMID:31749842. |
the dopamine transporter (dat) is a plasma membrane transport protein responsible for regulating the duration and intensity of dopaminergic signaling. |
2020-10-01 |
2023-08-13 |
rat |
| Rahul Patel, Joshua M Bradner, Kristen A Stout, William Michael Caudl. Alteration to Dopaminergic Synapses Following Exposure to Perfluorooctane Sulfonate (PFOS), in Vitro and in Vivo. Medical sciences (Basel, Switzerland). vol 4. issue 3. 2020-09-30. PMID:29083377. |
however, subsequent exposure to the selective dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly reduced the expression of dopamine transporter (dat) and tyrosine hydroxylase (th), and resulted in an even greater reduction in dat expression in animals previously exposed to pfos. |
2020-09-30 |
2023-08-13 |
mouse |
| Diptaman Chatterjee, Mansi Bhatt, David Butler, Erwin De Genst, Christopher M Dobson, Anne Messer, Jeffrey H Kordowe. Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model. NPJ Parkinson's disease. vol 4. 2020-09-29. PMID:30155513. |
vh14*pest showed considerable maintenance of striatal dopaminergic tone in comparison to saline-treated and nbsyn87*pest-treated animals as measured by tyrosine hydroxylase immunoreactivity (optical density), dat immunoreactivity (optical density), and dopamine concentration (high-performance liquid chromatography). |
2020-09-29 |
2023-08-13 |
rat |
| József Attila Szász, Viorelia Adelina Constantin, Károly Orbán-Kis, Attila Rácz, Ligia Ariana Bancu, Dan Georgescu, János Szederjesi, István Mihály, Ana-Mária Fárr, Krisztina Kelemen, Tamás Vajda, Szabolcs Szatmár. Profile Of Patients With Advanced Parkinson's disease Suitable For Device-Aided Therapies: Restrospective Data Of A Large Cohort Of Romanian Patients. Neuropsychiatric disease and treatment. vol 15. 2020-09-28. PMID:32009788. |
we are not sure what is the upper limit of dopaminergic medication, especially the levodopa (ld) dosage, and how it is influenced by access and suitability to the various add-on and device-aided therapies (dat). |
2020-09-28 |
2023-08-13 |
Not clear |
| Fabrizio Sanna, Jessica Bratzu, Maria Pina Serra, Damiana Leo, Marina Quartu, Marianna Boi, Stefano Espinoza, Raul R Gainetdinov, Maria Rosaria Melis, Antonio Argiola. Altered Sexual Behavior in Dopamine Transporter (DAT) Knockout Male Rats: A Behavioral, Neurochemical and Intracerebral Microdialysis Study. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32372926. |
together these findings confirm a key role of dopamine in sexual behavior and provide evidence that the permanently high levels of dopamine triggered by dat gene silencing cause alterations in both the frontocortical glutamatergic neurons projecting to the acb and vta and in the mesolimbic dopaminergic neurons, leading to specific brain regional changes in trophic support and neuroplastic processes, which may have a role in the sexual behavior differences found among the three rat genotypes. |
2020-09-28 |
2023-08-13 |
rat |
| Vera S Kerstens, Patrik Fazio, Mathias Sundgren, Granville J Matheson, Erika Franzén, Christer Halldin, Simon Cervenka, Per Svenningsson, Andrea Varron. Reliability of dopamine transporter PET measurements with [ EJNMMI research. vol 10. issue 1. 2020-09-28. PMID:32797307. |
due to degeneration of dopaminergic neurons and thus lower expected radioligand binding to dat, higher measurement variability in pd patients might be expected than earlier reproducibility results in healthy controls. |
2020-09-28 |
2023-08-13 |
Not clear |
| Wei-Lun Sun, Pamela M Quizon, Yaxia Yuan, Matthew J Strauss, Richard McCain, Chang-Guo Zhan, Jun Zh. Mutational effects of human dopamine transporter at tyrosine88, lysine92, and histidine547 on basal and HIV-1 Tat-inhibited dopamine transport. Scientific reports. vol 9. issue 1. 2020-09-24. PMID:30846720. |
dysregulation of dopaminergic system induced by hiv-1 tat protein-mediated direct inhibition of the dopamine transporter (dat) has been implicated as a mediating factor of hiv-1 associated neurocognitive disorders. |
2020-09-24 |
2023-08-13 |
human |
| Zongbo Sun, Ye Ma, Lei Xie, Jinzhuang Huang, Shouxing Duan, Ruiwei Guo, Yao Xie, Junyao Lv, Zhirong Lin, Shuhua M. Behavioral Changes and Neuronal Damage in Rhesus Monkeys after 10 Weeks of Ketamine Administration Involve Prefrontal Cortex Dopamine D2 Receptor and Dopamine Transporter. Neuroscience. vol 415. 2020-09-23. PMID:31330230. |
the dopamine d2 receptor (drd2) and dopamine transporter (dat) play a regulatory role in dopaminergic neurotransmission and thus play an important role in drug addiction. |
2020-09-23 |
2023-08-13 |
monkey |
| Giulia Castellani, Gabriella Contarini, Maddalena Mereu, Ennio Albanesi, Céline Devroye, Claudio D'Amore, Valentina Ferretti, Sara De Martin, Francesco Papale. Dopamine-mediated immunomodulation affects choroid plexus function. Brain, behavior, and immunity. vol 81. 2020-08-04. PMID:31175999. |
we performed a peripheral and cerebral immunophenotyping in mice bearing dopaminergic alteration produced by genetic liability (hypofunction of the dopamine transporter dat) and psychostimulant (amphetamine) administration. |
2020-08-04 |
2023-08-13 |
mouse |