| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashley L Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L Guo, Jason R Richardso. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. vol 125. 2018-06-12. PMID:28743636. |
the dopamine transporter (dat) is the key regulator of dopaminergic transmission and is a target of several xenobiotics, including pesticides and pharmacological agents. |
2018-06-12 |
2023-08-13 |
rat |
| Ashley L Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L Guo, Jason R Richardso. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. vol 125. 2018-06-12. PMID:28743636. |
here, we utilized a rat dopaminergic cell line (n27) to probe the responsiveness of dat mrna expression to inhibitors of histone acetylation. |
2018-06-12 |
2023-08-13 |
rat |
| David Bäckström, Magdalena Eriksson Domellöf, Gabriel Granåsen, Jan Linder, Sofia Mayans, Eva Elgh, Susanna Jakobson Mo, Lars Forsgre. PITX3 genotype and risk of dementia in Parkinson's disease: A population-based study. Journal of the neurological sciences. vol 381. 2018-06-11. PMID:28991698. |
this study investigates whether a common polymorphism in the pitx3 gene (rs2281983), which is of importance for the function of dopaminergic neurons, affects the risk of developing dementia in pd and whether it affects dopamine transporter (dat) uptake. |
2018-06-11 |
2023-08-13 |
Not clear |
| Gwynne L Davis, Adele Stewart, Gregg D Stanwood, Raajaram Gowrishankar, Maureen K Hahn, Randy D Blakel. Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. Behavioural brain research. vol 337. 2018-06-08. PMID:28964912. |
in keeping with studies suggesting dopaminergic contributions to attention-deficit hyperactivity disorder (adhd), bipolar disorder (bpd) and autism spectrum disorder (asd), subjects with these diagnoses have been found to express a rare, functional coding substitution in the dopamine (da) transporter (dat), ala559val. |
2018-06-08 |
2023-08-13 |
mouse |
| Gwynne L Davis, Adele Stewart, Gregg D Stanwood, Raajaram Gowrishankar, Maureen K Hahn, Randy D Blakel. Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice. Behavioural brain research. vol 337. 2018-06-08. PMID:28964912. |
we developed dat val559 knock-in mice as a construct valid model of dopaminergic alterations that drive multiple clinical phenotypes, and here evaluate the impact of lifelong expression of the variant on impulsivity and motivation utilizing the 5- choice serial reaction time task (5-csrtt) and go/nogo as well as tests of time estimation (peak interval analysis), reward salience (sucrose preference), and motivation (progressive ratio test). |
2018-06-08 |
2023-08-13 |
mouse |
| E Jaakkola, J Joutsa, E Mäkinen, J Johansson, V Kaasine. Ventral striatal dopaminergic defect is associated with hallucinations in Parkinson's disease. European journal of neurology. vol 24. issue 11. 2018-05-21. PMID:28834102. |
the aim of this study was to investigate the dopaminergic mechanisms of vhs and specifically whether the degree of striatal dopamine transporter (dat) function or extrastriatal serotonin transporter (sert) function can predict the appearance of vhs in patients with pd. |
2018-05-21 |
2023-08-13 |
Not clear |
| Danielle E Rastedt, Roxanne A Vaughan, James D Foste. Palmitoylation mechanisms in dopamine transporter regulation. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28115272. |
dat is also a target of psychostimulant and therapeutic drugs that inhibit da reuptake and lead to elevated dopaminergic neurotransmission. |
2018-05-11 |
2023-08-13 |
Not clear |
| Danielle E Rastedt, Roxanne A Vaughan, James D Foste. Palmitoylation mechanisms in dopamine transporter regulation. Journal of chemical neuroanatomy. vol 83-84. 2018-05-11. PMID:28115272. |
better understanding of the role of palmitoylation in regulation of dat function may lead to identification of therapeutic targets for modulation of da homeostasis in the treatment of dopaminergic disorders. |
2018-05-11 |
2023-08-13 |
Not clear |
| Cody A Siciliano, Sara R Jone. Cocaine Potency at the Dopamine Transporter Tracks Discrete Motivational States During Cocaine Self-Administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 9. 2018-05-09. PMID:28139678. |
although the dopamine transporter (dat) is the primary site of action for cocaine, and the dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic variations underlying individual differences in cocaine self-administration behaviors are not fully understood. |
2018-05-09 |
2023-08-13 |
rat |
| Kathrin LaFaver, Alberto J Espa. Diagnosis and Treatment of Functional (Psychogenic) Parkinsonism. Seminars in neurology. vol 37. issue 2. 2018-04-30. PMID:28511263. |
in selected cases where examination features remain insufficient to render a clinically definite fp diagnosis, normal dopaminergic transporter imaging (dat scan) confirms "laboratory supported" fp. |
2018-04-30 |
2023-08-13 |
Not clear |
| b' Vjekoslav Peitl, Mario \\xc5\\xa0tefanovi\\xc4\\x87, Dalibor Karlovi\\xc4\\x8. Depressive symptoms in schizophrenia and dopamine and serotonin gene polymorphisms. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28416295.' |
as impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (sert 5-httlpr, mao-a vntr, comt val158met and dat vntr) and schizophrenia. |
2018-03-05 |
2023-08-13 |
human |
| Troels Rahbek-Clemmensen, Matthew D Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N Jørgensen, Freja H Hansen, Ulrik Gethe. Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains. Nature communications. vol 8. issue 1. 2018-01-26. PMID:28963530. |
the molecular organization of the dopamine transporter in nanodomains is reversibly reduced by short-term activation of nmda-type ionotropic glutamate receptors, implicating dopamine transporter nanodomain distribution as a potential mechanism to modulate dopaminergic neurotransmission in response to excitatory input.the dopamine transporter (dat) has a crucial role in the regulation of neurotransmission. |
2018-01-26 |
2023-08-13 |
Not clear |
| Jun Zhu, Yaxia Yuan, Narasimha M Midde, Adrian M Gomez, Wei-Lun Sun, Pamela M Quizon, Chang-Guo Zha. HIV-1 transgenic rats display an increase in [(3)H]dopamine uptake in the prefrontal cortex and striatum. Journal of neurovirology. vol 22. issue 3. 2018-01-24. PMID:26501780. |
together, these findings suggest that neuroadaptive changes in dat function are evidenced in the hiv-1tg rats, perhaps compensating for viral-protein-induced abnormal dopaminergic transmission. |
2018-01-24 |
2023-08-13 |
rat |
| Victoria Kacprzak, Neil A Patel, Elizabeth Riley, Lili Yu, Jing-Ruey J Yeh, Irina V Zhdanov. Dopaminergic control of anxiety in young and aged zebrafish. Pharmacology, biochemistry, and behavior. vol 157. 2018-01-12. PMID:28408289. |
in this study, we explored the role of the dopaminergic system in the anxiogenic effects of aging and acute cocaine exposure by comparing the behavioral phenotypes of wild type (wt) and dat knockout zebrafish (dat-ko) of different ages. |
2018-01-12 |
2023-08-13 |
zebrafish |
| V Cunha, P Rodrigues, M M Santos, P Moradas-Ferreira, M Ferreir. Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos. Chemosphere. vol 191. 2018-01-10. PMID:29145140. |
the transcription levels of serotonergic and dopaminergic transporters (sert and dat) and vmat were down-regulated at environmentally relevant concentration (0.0015 μm). |
2018-01-10 |
2023-08-13 |
zebrafish |
| Chung-Yin Lin, Han-Yi Hsieh, Chiung-Mei Chen, Shang-Rung Wu, Chih-Hung Tsai, Chiung-Yin Huang, Mu-Yi Hua, Kuo-Chen Wei, Chih-Kuang Yeh, Hao-Li Li. Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model. Journal of controlled release : official journal of the Controlled Release Society. vol 235. 2017-12-25. PMID:27235980. |
dopamine (da) and its metabolites as well as dopamine active transporter (dat) were quantitatively analyzed to show dopaminergic neuronal dopamine secretion/activity/metabolism. |
2017-12-25 |
2023-08-13 |
mouse |
| Evgeniya V Efimova, Raul R Gainetdinov, Evgeny A Budygin, Tatyana D Sotnikov. Dopamine transporter mutant animals: a translational perspective. Journal of neurogenetics. vol 30. issue 1. 2017-12-20. PMID:27276191. |
the dopamine transporter (dat) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. |
2017-12-20 |
2023-08-13 |
mouse |
| Arthur S C França, Larissa Muratori, George Carlos Nascimento, Catia Mendes Pereira, Sidarta Ribeiro, Bruno Lobão-Soare. Object recognition impairment and rescue by a dopamine D2 antagonist in hyperdopaminergic mice. Behavioural brain research. vol 308. 2017-11-21. PMID:27059337. |
here we investigated the capacity for object recognition in mildly hyperdopaminergic mice heterozygous for dat (dat +/-), with synaptic dopaminergic levels situated between those shown by dat -/- homozygous and wild-type (wt) mice. |
2017-11-21 |
2023-08-13 |
mouse |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model. PloS one. vol 12. issue 10. 2017-10-27. PMID:29028815. |
finally, proteins normally found in neurons (th, dat and α-synuclein) were observed within astrocytes 2-5 days after the dopaminergic degeneration, suggesting that the intracellular contents of degenerated cells had been transferred to astrocytes. |
2017-10-27 |
2023-08-13 |
rat |
| Franziska Richter, Lauryn Gabby, Kimberly A McDowell, Caitlyn K Mulligan, Krystal De La Rosa, Pedrom C Sioshansi, Farzad Mortazavi, Ingrid Cely, Larry C Ackerson, Linda Tsan, Niall P Murphy, Nigel T Maidment, Marie-Françoise Chessele. Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice. Neurobiology of aging. vol 51. 2017-09-28. PMID:28038352. |
using unbiased stereology in dat knock-down mice (dat-kd) and wild-type (wt) littermates, we found that decreased dat caused a loss of tyrosine hydroxylase-positive (dopaminergic) neurons in subregions of the substantia nigra pars compacta at 3-4 days, 5 weeks, and 18 months of age. |
2017-09-28 |
2023-08-13 |
mouse |