| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Del Sole, V Chiesa, G Lucignani, A Vignoli, L Giordano, M Lecchi, M P Canevin. Exploring dopaminergic activity in ring chromosome 20 syndrome: a SPECT study. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 2019-11-20. PMID:20585311. |
conclusion: striatal neurons are involved in r(20) epilepsy; the relationship found between r(20) mosaicism and dat expression suggests that drugs acting on the dopaminergic system could have a place in the treatment of this rare form of epilepsy. |
2019-11-20 |
2023-08-12 |
Not clear |
| Artor Niccoli Asabella, Angelo Fabio Gigante, Cristina Ferrari, Alessandra Di Palo, Domenico Rubini, Emilio Paolo Mossa, Sabino Dagostino, Roberta Pellicciari, Giovanni Defazio, Giuseppe Rubin. Role of dopaminergic neurotransmission in pathophysiology of action tremor in Parkinson's disease. Hellenic journal of nuclear medicine. vol 18 Suppl 1. 2019-11-20. PMID:26665206. |
by contrast, neither rigidity nor rest tremor seems to be closely related to the degree of dopaminergic denervation as measured by dat imaging. |
2019-11-20 |
2023-08-13 |
Not clear |
| Zade R Holloway, Timothy G Freels, Josiah F Comstock, Hunter G Nolen, Helen J Sable, Deranda B Leste. Comparing phasic dopamine dynamics in the striatum, nucleus accumbens, amygdala, and medial prefrontal cortex. Synapse (New York, N.Y.). 2019-11-20. PMID:30317673. |
to summarize results, the present study found that the striatum and nac had increased stimulation-evoked phasic dopamine release, faster dopamine uptake (leading to restricted dopamine diffusion), weaker autoreceptor functioning, greater supply levels of available dopamine, and increased dopaminergic responses to dat blockade compared to the amygdala and mpfc. |
2019-11-20 |
2023-08-13 |
mouse |
| Dorothee Kübler, Henning Schroll, Ralph Buchert, Andrea A Küh. Cognitive performance correlates with the degree of dopaminergic degeneration in the associative part of the striatum in non-demented Parkinson's patients. Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 9. 2019-07-29. PMID:28643101. |
we hypothesized that cognitive performance during the dopaminergic off state correlates with dat availability in the associative striatum. |
2019-07-29 |
2023-08-13 |
Not clear |
| Verônica Tironi Dias, Higor Zuquetto Rosa, Lívia Ferraz D'avila, Luciana Taschetto Vey, Raquel Cristine Silva Barcelos, Marilise Escobar Burge. Modafinil reduces amphetamine preference and prevents anxiety-like symptoms during drug withdrawal in young rats: Involvement of dopaminergic targets in VTA and striatum. Progress in neuro-psychopharmacology & biological psychiatry. vol 92. 2019-06-27. PMID:30664970. |
at molecular level, md exerted an interesting modulatory activity on the vta and induced an up-regulation in striatal dopaminergic targets (th, dat, d1r and d2r). |
2019-06-27 |
2023-08-13 |
rat |
| Tayyabah Yousaf, Gennaro Pagano, Flavia Niccolini, Marios Politi. Excessive daytime sleepiness may be associated with caudate denervation in Parkinson disease. Journal of the neurological sciences. vol 387. 2019-05-28. PMID:29571867. |
using the parkinson's progression markers initiative database, we performed a case-control study to investigate whether dopaminergic deficit is associated with the development of eds using dopaminergic specific single photon emission computed tomography (spect) molecular imaging of dopamine transporters (dat). |
2019-05-28 |
2023-08-13 |
Not clear |
| Phillip Mackie, Joe Lebowitz, Leila Saadatpour, Emily Nickoloff, Peter Gaskill, Habibeh Khoshboue. The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease. Brain, behavior, and immunity. vol 70. 2019-05-21. PMID:29551693. |
the dopamine transporter (dat), the main regulator of dopaminergic tone in the cns, is known to exist in lymphocytes and monocytes/macrophages, but little is known about peripheral dat biology or how dat regulates the dopaminergic tone, much less how peripheral dat alters immune function. |
2019-05-21 |
2023-08-13 |
Not clear |
| Phuong-Tram Nguyen, Duy-Khanh Dang, Hai-Quyen Tran, Eun-Joo Shin, Ji Hoon Jeong, Seung-Yeol Nah, Min Chang Cho, Yong Sup Lee, Choon-Gon Jang, Hyoung-Chun Ki. Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors. Chemico-biological interactions. vol 305. 2019-05-10. PMID:30922767. |
moreover, treatment with mpa resulted in significant impairments in dopaminergic parameters [i.e., changes in dopamine level, dopamine turnover rate, tyrosine hydroxylase (th) levels, dopamine transporter (dat) expression, and vesicular monoamine transporter-2 (vmat-2) expression], and in behavioral deficits. |
2019-05-10 |
2023-08-13 |
mouse |
| Andrea Varrone, Maria Teresa Pellecchi. SPECT Molecular Imaging in Familial Parkinson's Disease. International review of neurobiology. vol 142. 2019-05-08. PMID:30409254. |
dopamine transporter (dat) imaging with single-photon emission computed tomography (spect) is a diagnostic tool to study the integrity of the dopaminergic system in patients with parkinsonism and uncertain diagnosis. |
2019-05-08 |
2023-08-13 |
human |
| Andrea Varrone, Maria Teresa Pellecchi. SPECT Molecular Imaging in Familial Parkinson's Disease. International review of neurobiology. vol 142. 2019-05-08. PMID:30409254. |
for these reasons, dat spect has been also used as a tool to study genetic conditions that are associated with parkinsonism in order to examine the degree and patterns of dopaminergic deficits that are present in at risk subjects and in affected patients carrying the mutations. |
2019-05-08 |
2023-08-13 |
human |
| Phuong-Tram Nguyen, Eun-Joo Shin, Duy-Khanh Dang, Hai-Quyen Tran, Choon-Gon Jang, Ji Hoon Jeong, Yu Jeung Lee, Hyo Jong Lee, Yong Sup Lee, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Ki. Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochemistry international. vol 113. 2019-04-10. PMID:29197543. |
moreover, 3-fma significantly produced dopaminergic impairments [i.e., increase in dopamine (da) turnover rate and decreases in da level, and in the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat-2)] with behavioral impairments. |
2019-04-10 |
2023-08-13 |
mouse |
| Yongchul Jang, Insu Kwon, Wankeun Song, Ludmila M Cosio-Lima, Youngil Le. Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy. Neuroscience. vol 379. 2019-03-18. PMID:29559387. |
our biochemical data showed that ee-induced neuroprotection occurs in combination with multiple synergic neuroprotective pathways: (1) increased neurogenesis shown by an increase in brdu-positive neurons; (2) diminished loss of dopaminergic neurons evidenced by upregulated tyrosine hydroxylase (th) and dopamine transporter (dat) levels; (3) increased antioxidant capacity (e.g., cuznsod, catalase, gpx1/2, ho-1, dj1 and prxiii); and (4) enhanced autophagy (lc3 ii, p62, beclin1, bnip3, lamp2, cathepsin l and tfeb). |
2019-03-18 |
2023-08-13 |
mouse |
| Hwei-Hsien Chen, Pei-Chi Chang, Shiaw-Pyng Wey, Pei-Mei Chen, Chinpiao Chen, Ming-Huan Cha. Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30223096. |
recovery of motor function was correlated with reversal of nigrostriatal dopaminergic neuronal loss, accompanied by higher tyrosine hydroxylase (th) density, dopamine transporter (dat) expression and vesicular monoamine transporter-2 (vmat2) levels. |
2019-03-14 |
2023-08-13 |
mouse |
| Amaia M Erdozain, Stéphanie De Gois, Véronique Bernard, Victor Gorgievski, Nicolas Pietrancosta, Sylvie Dumas, Carlos E Macedo, Peter Vanhoutte, Jorge E Ortega, J Javier Meana, Eleni T Tzavara, Vincent Vialou, Bruno Giro. Structural and Functional Characterization of the Interaction of Snapin with the Dopamine Transporter: Differential Modulation of Psychostimulant Actions. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 5. 2019-02-06. PMID:28905875. |
using different approaches, we demonstrated that (i) snapin is expressed in vivo in dopaminergic neurons along with dat; (ii) both proteins colocalize in cultured cells and brain and, (iii) dat and snapin are present in the same protein complex. |
2019-02-06 |
2023-08-13 |
mouse |
| G Pagano, T Yousaf, H Wilson, F Niccolini, S Polychronis, K R Chaudhuri, M Politi. Constipation is not associated with dopamine transporter pathology in early drug-naïve patients with Parkinson's disease. European journal of neurology. vol 25. issue 2. 2019-02-04. PMID:29078029. |
the aim of the study was to investigate whether constipation is associated with dopaminergic pathology on dopamine transporter (dat) single-photon emission computed tomography in early drug-naïve patients with pd. |
2019-02-04 |
2023-08-13 |
Not clear |
| Jun Zhu, Subramaniam Ananthan, Chang-Guo Zha. The role of human dopamine transporter in NeuroAIDS. Pharmacology & therapeutics. vol 183. 2018-12-11. PMID:28987321. |
the presynaptic dopamine (da) transporter (dat) is essential for da homeostasis and dopaminergic modulation of the brain function including cognition. |
2018-12-11 |
2023-08-13 |
human |
| Katherine Coulombe, Olivier Kerdiles, Cyntia Tremblay, Vincent Emond, Manon Lebel, Anne-Sophie Boulianne, Mélanie Plourde, Francesca Cicchetti, Frédéric Calo. Impact of DHA intake in a mouse model of synucleinopathy. Experimental neurology. vol 301. issue Pt A. 2018-10-24. PMID:29229294. |
thy1-αsyn mice displayed impaired motor skills, lower dopaminergic neuronal counts within the substantia nigra (-13%) in parallel to decreased levels of the striatal dopamine transporter (dat) (-24%), as well as reduced neun (-41%) and synaptic proteins psd-95 (-51%), synaptophysin (-80%) and vesicular acetylcholine transporter (vchat) (-40%) in the cerebral cortex compared to c57/bl6 mice. |
2018-10-24 |
2023-08-13 |
mouse |
| Adelaide Greco, Antonella Zannetti, Sabina Pappatà, Sandra Albanese, Anna R Coda, Monica Ragucci, Anna Nardelli, Arturo Brunetti, Alberto Cuocolo, Marco Salvator. Measurement of [123I]FP-CIT binding to the dopamine transporter (DAT) in healthy mouse striatum using dedicated small animal SPECT imaging: feasibility, optimization and validation. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 62. issue 1. 2018-08-17. PMID:26329495. |
in-vivo imaging of dopamine transporter (dat), a reliable marker of degeneration of nigrostriatal dopaminergic innervation, has gained increasing interest in preclinical neurodegenerative research for studying disease mechanisms and testing new therapeutic strategies. |
2018-08-17 |
2023-08-13 |
mouse |
| Giulia Costa, Micaela Morelli, Nicola Simol. Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage. Neurotoxicity research. vol 32. issue 4. 2018-08-07. PMID:28597409. |
in order to characterize how the number of administrations influenced the severity of mdma-induced dopaminergic damage and to describe the localization and persistence of this damage, we evaluated the changes in tyrosine hydroxylase (th) and dopamine transporter (dat) in different regions of the mouse brain. |
2018-08-07 |
2023-08-13 |
mouse |
| J Garcia-Olivares, T Baust, S Harris, P Hamilton, A Galli, S G Amara, G E Torre. Gβγ subunit activation promotes dopamine efflux through the dopamine transporter. Molecular psychiatry. vol 22. issue 12. 2018-07-10. PMID:28894302. |
specifically, a gβγ-binding/activating peptide, msirk, increases da efflux through dat in heterologous cells and primary dopaminergic neurons in culture. |
2018-07-10 |
2023-08-13 |
Not clear |