| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vera Regitz-Zagrosek, Sabine Oertelt-Prigione, Ute Seeland, Roland Hetze. Sex and gender differences in myocardial hypertrophy and heart failure. Circulation journal : official journal of the Japanese Circulation Society vol 74 issue 7 2010 20558892 |
women with aortic stenosis have more concentric hypertrophy with better systolic function, less upregulation of extracellular matrix genes and better reversibility after unloading. |
2010-10-19 |
2023-01-25 |
Not clear |
| Chikara Ushiku, Douglas J Adams, Xi Jiang, Liping Wang, David W Row. Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 28 issue 10 2010 20839319 |
second, the hypertrophic chondrocytes are dispersed and the cartilage matrix mineralized by the advancing col3.6+ osteoblasts. |
2010-10-07 |
2023-01-25 |
mouse |
| Kelly L Hudkins, Warangkana Pichaiwong, Tomasz Wietecha, Jolanta Kowalewska, Miriam C Banas, Min W Spencer, Anja M\\xc3\\xbchlfeld, Mariko Koelling, Jeffrey W Pippin, Stuart J Shankland, Bardia Askari, Mary E Rabaglia, Mark P Keller, Alan D Attie, Charles E Alper. BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. Journal of the American Society of Nephrology : JASN vol 21 issue 9 2010 20634301 |
glomerular hypertrophy and accumulation of mesangial matrix, characteristic of early dn, were present by 8 weeks, and glomerular lesions similar to those of advanced human dn were present by 20 weeks. |
2010-09-23 |
2023-01-25 |
mouse |
| B D Boyan, J Hurst-Kennedy, T A Denison, Z Schwart. 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells. The Journal of steroid biochemistry and molecular biology vol 121 issue 1-2 2010 20307662 |
24r,25(oh)2d3 increases rc cell proliferation and inhibits activity of matrix processing enzymes, suggesting it stabilizes cells in the reserve zone, possibly by inhibiting the matrix degradation characteristic of apoptotic hypertrophic gc cells. |
2010-09-20 |
2023-01-25 |
rat |
| P M van der Kraan, E N Blaney Davidson, W B van den Ber. Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's? Osteoarthritis and cartilage vol 18 issue 6 2010 20211748 |
although bmps are considered protective for articular cartilage these factors can also be involved in chondrocyte hypertrophy and matrix degradation. |
2010-09-16 |
2023-01-25 |
Not clear |
| Yu-Yu Lin, Nobuaki Tanaka, Satoru Ohkuma, Yasunori Iwabuchi, Yuki Tanne, Takashi Kamiya, Ryo Kunimatsu, Yu-Ching Huang, Motoko Yoshioka, Tomomi Mitsuyoshi, Kotaro Tanimoto, Eiji Tanaka, Kazuo Tann. Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system. European journal of oral sciences vol 118 issue 2 2010 20487004 |
chondrocytes co-cultured with unstressed osteoblasts showed a phenotypic shift to hypertrophic chondrocytes, characterized by decreased expression of type ii collagen, aggrecan, sry-related hmg box (sox-9), and cartilage oligomeric matrix protein (comp) genes and increased expression of type x collagen and bone sialoprotein (bsp) genes, suggesting that the co-culture may change the chondrocyte differentiation to some extent. |
2010-09-16 |
2023-01-25 |
Not clear |
| Hiroaki Kitaoka, Toru Kubo, Makoto Okawa, Kayo Hayato, Naohito Yamasaki, Yoshihisa Matsumura, Yoshinori L Do. Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy. Circulation journal : official journal of the Japanese Circulation Society vol 74 issue 6 2010 20453389 |
the impact of matrix metalloproteinase (mmp) on left ventricular (lv) remodeling and heart failure events is unresolved in patients with hypertrophic cardiomyopathy (hcm). |
2010-09-07 |
2023-01-25 |
Not clear |
| Pamela Lockyer, Jonathan C Schisler, Cam Patterson, Monte S Willi. Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart. Molecular endocrinology (Baltimore, Md.) vol 24 issue 6 2010 20016041 |
in this review, we describe what is known about these extrametabolic roles of ppars, including regulation of cardiac inflammation, extracellular matrix remodeling, oxidative stress, and regulation of cardiac hypertrophy. |
2010-09-02 |
2023-01-25 |
Not clear |
| A G Gasanov, T V Bershova, E N Basargina, M I Bakano. [Molecular mechanisms of genetic damages of the myocardium in cardiomyopathy]. Biomeditsinskaia khimiia vol 56 issue 3 2010 20695211 |
the role of the genetic factors coding contractile proteins, proteins of thin and thick filaments, and also extracellular matrix proteins in processes of formation and development of hypertrophic (hcm) and dilated (dcm) cardiomyopathy are analyzed. |
2010-08-31 |
2023-01-25 |
Not clear |
| Deepa Taneja, Joel Thompson, Patricia Wilson, Katie Brandewie, Liliana Schaefer, Bonnie Mitchell, Lisa R Tannoc. Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice. Journal of lipid research vol 51 issue 6 2010 20110440 |
consumption of the high-cholesterol diet exacerbated the development of diabetic nephropathy with elevations in urine albumin excretion, glomerular and renal hypertrophy, and mesangial matrix expansion. |
2010-08-17 |
2023-01-25 |
mouse |
| Kyoung-Hwan Choi, Byung Hyune Choi, So Ra Park, Byoung Ju Kim, Byoung-Hyun Mi. The chondrogenic differentiation of mesenchymal stem cells on an extracellular matrix scaffold derived from porcine chondrocytes. Biomaterials vol 31 issue 20 2010 20394983 |
the loss of chondrogenic phenotypes was accompanied by the calcification of matrix, and hypertrophic changes by immunohistochemistry for osteocalcin and collagen type i and x. |
2010-08-10 |
2023-01-25 |
mouse |
| Li Kong, Qingyun Tian, Fengjin Guo, Maria T Mucignat, Roberto Perris, Sandy Sercu, Joseph Merregaert, Paul E Di Cesare, Chuan-Ju Li. Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth. Matrix biology : journal of the International Society for Matrix Biology vol 29 issue 4 2010 20138147 |
ecm1 inhibits chondrocyte hypertrophy, matrix mineralization, and endochondral bone formation, and comp overcomes the inhibition by ecm1. |
2010-07-27 |
2023-01-25 |
Not clear |
| Christine Y Chuang, Megan S Lord, James Melrose, Martin D Rees, Sarah M Knox, Craig Freeman, Renato V Iozzo, John M Whiteloc. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry vol 49 issue 26 2010 20507176 |
in this study, perlecan was localized in the pericellular matrix of hypertrophic chondrocytes in developing human cartilage rudiments. |
2010-07-21 |
2023-01-25 |
human |
| Takayoshi Suganami, Yoshihiro Ogaw. Adipose tissue macrophages: their role in adipose tissue remodeling. Journal of leukocyte biology vol 88 issue 1 2010 20360405 |
indeed, obese adipose tissue is characterized by adipocyte hypertrophy, followed by increased angiogenesis, immune cell infiltration, extracellular matrix overproduction, and thus, increased production of proinflammatory adipocytokines during the progression of chronic inflammation. |
2010-07-12 |
2023-01-25 |
Not clear |
| Ashley S Hammond, Jie Ning, Carol V Ward, Matthew J Ravos. Mammalian limb loading and chondral modeling during ontogeny. Anatomical record (Hoboken, N.J. : 2007) vol 293 issue 4 2010 20235322 |
moreover, chondrocyte hypertrophy and proliferation were found to be responsive to locomotor loading and thus more important factors in chondral modeling than the extracellular matrix variables that were examined herein. |
2010-07-07 |
2023-01-25 |
Not clear |
| Yun Wang, Erika Bella, Christopher S D Lee, Claudio Migliaresi, Linda Pelcastre, Zvi Schwartz, Barbara D Boyan, Antonella Mott. The synergistic effects of 3-D porous silk fibroin matrix scaffold properties and hydrodynamic environment in cartilage tissue regeneration. Biomaterials vol 31 issue 17 2010 20303584 |
a hydrodynamic environment was beneficial to chondrocyte proliferation, differentiation, and integrin gene expression in a pore size dependent manner with superior cartilage matrix production but limited hypertrophic differentiation obtained using chondrocyte-seeded sl500 scaffolds. |
2010-06-28 |
2023-01-25 |
Not clear |
| Taku Saito, Atsushi Fukai, Akihiko Mabuchi, Toshiyuki Ikeda, Fumiko Yano, Shinsuke Ohba, Nao Nishida, Toru Akune, Noriko Yoshimura, Takumi Nakagawa, Kozo Nakamura, Katsushi Tokunaga, Ung-Il Chung, Hiroshi Kawaguch. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nature medicine vol 16 issue 6 2010 20495570 |
chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type x collagen (col10a1), matrix metalloproteinase-13 (mmp-13) and vascular endothelial growth factor (vegf), respectively, are central steps of endochondral ossification during normal skeletal growth and osteoarthritis development. |
2010-06-22 |
2023-01-25 |
mouse |
| Claire G Jeong, Scott J Holliste. A comparison of the influence of material on in vitro cartilage tissue engineering with PCL, PGS, and POC 3D scaffold architecture seeded with chondrocytes. Biomaterials vol 31 issue 15 2010 20219243 |
pgs was seen as the least favorable material for cartilage based on its relatively high de-differentiation (col1), hypertrophic mrna expression (col10) and high matrix degradation (mmp13, mmp3) results. |
2010-06-15 |
2023-01-25 |
Not clear |
| Y Sun, V Gandhi, M Prasad, W Yu, X Wang, Q Zhu, J Q Feng, R J Hinton, C Qi. Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible. International journal of oral and maxillofacial surgery vol 39 issue 3 2010 20097540 |
the nh(2)-terminal fragment of dmp1 is mainly detected in the matrix of the cartilage while the cooh-terminal fragment is primarily localized in the nuclei of cells in the chondroblastic and hypertrophic layers. |
2010-06-10 |
2023-01-25 |
rat |
| L J Mauro, S J Wenzel, G M Sindber. Regulation of chick bone growth by leptin and catecholamines. Poultry science vol 89 issue 4 2010 20308401 |
real-time pcr analysis showed that ne enhanced type x collagen mrna expression, a marker of mature hypertrophic chondrocytes, with no effect on type ii collagen mrna, the matrix protein secreted by proliferating chondrocytes. |
2010-06-03 |
2023-01-25 |
chicken |