| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Yamasaki, Y Maeshima, T Nasu, D Saito, K Tanabe, K Hirokoshi-Kawahara, H Sugiyama, Y Sakai, H Makin. Intermittent administration of a sustained-release prostacyclin analog ONO-1301 ameliorates renal alterations in a rat type 1 diabetes model. Prostaglandins, leukotrienes, and essential fatty acids vol 84 issue 3-4 2011 21177088 |
sr-ono significantly suppressed albuminuria, glomerular hypertrophy, mesangial matrix accumulation, glomerular accumulation of monocyte/macrophage, increase in glomerular levels of pro-fibrotic factor transforming growth factor (tgf)-beta1 and the number of glomerular alpha-smooth muscle actin (sma)(+) cells in diabetic animals. |
2011-06-28 |
2023-01-25 |
rat |
| Sara Hinds, Weining Bian, Robert G Dennis, Nenad Bursa. The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. Biomaterials vol 32 issue 14 2011 21324402 |
optimized matrix composition yielded significant cellular hypertrophy (protein/dna ratio\xc2\xa0=\xc2\xa011.4\xc2\xa0\xc2\xb1\xc2\xa04.1 vs. 6.5\xc2\xa0\xc2\xb1\xc2\xa01.9\xc2\xa0\xce\xbcg/\xce\xbcg in control) and a prolonged ca(2+) transient half-width (ca(50)\xc2\xa0=\xc2\xa0232.8\xc2\xa0\xc2\xb1\xc2\xa033.3 vs. 101.7\xc2\xa0\xc2\xb1\xc2\xa019.8\xc2\xa0ms). |
2011-06-22 |
2023-01-25 |
rat |
| Anne Marie Rauten, Petra Surlin, B Oprea, Izabela Silo\\xc5\\x9fi, Mihaela Moisa, D Caramizaru, Mihaela V\\xc4\\x83t. Matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie vol 52 issue 1 Suppl 2011 21424088 |
matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. |
2011-06-09 |
2023-01-25 |
Not clear |
| Mahipal Singh, Cerrone R Foster, Suman Dalal, Krishna Sing. Role of osteopontin in heart failure associated with aging. Heart failure reviews vol 15 issue 5 2011 20127409 |
the post-mi infarct healing process involves temporarily overlapping phases that include the following--(1) inflammation with migration and adhesion of neutrophils and macrophages, phagocytosis and inflammatory gene expression; (2) tissue repair with fibroblast adhesion and proliferation, myofibroblast differentiation, extracellular matrix deposition and scar formation; and (3) structural and functional remodeling of infarcted and non-infarcted myocardium through cardiac myocyte apoptosis, hypertrophy and myocardial angiogenesis. |
2011-06-02 |
2023-01-25 |
Not clear |
| Sunila Mahavadi, Robert S Flynn, John R Grider, Li-Ya Qiao, Karnam S Murthy, Krystina B Hazelgrove, John F Kuemmerl. Amelioration of excess collagen I\\xce\\xb1I, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice. Inflammatory bowel diseases vol 17 issue 3 2011 20722057 |
strictures occur in \xe2\x89\x88 30% of patients with crohn's disease (cd) and are characterized by intestinal smooth muscle hyperplasia, hypertrophy, and fibrosis due to excess extracellular matrix production including collagen. |
2011-05-31 |
2023-01-25 |
mouse |
| Chetan P Hans, Yumei Feng, Amarjit S Naura, Dana Troxclair, Mourad Zerfaoui, Danish Siddiqui, Ju Jihang, Hogyoung Kim, Alan D Kaye, Khalid Matrougui, Eric Lazartigues, A Hamid Boulare. Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology vol 20 issue 2 2011 20434371 |
given that characteristics of dilated cardiomyopathy closely associate with atherosclerosis and are mediated by an imbalance between matrix metalloproteinases (mmps) and timps, we hypothesized that parp-1 gene deletion may protect against hf-induced cardiac hypertrophy and dilatations by altering timp-2/mmps balance in favor of a maintenance of tissue homeostasis. |
2011-05-26 |
2023-01-25 |
Not clear |
| Motofumi Sasaki, Kenichi Shikata, Shinichi Okada, Satoshi Miyamoto, Shingo Nishishita, Hitomi Usui Kataoka, Chikage Sato, Jun Wada, Daisuke Ogawa, Hirofumi Makin. The macrophage is a key factor in renal injuries caused by glomerular hyperfiltration. Acta medica Okayama vol 65 issue 2 2011 21519365 |
the 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. |
2011-05-19 |
2023-01-25 |
mouse |
| Robert S Flynn, Sunila Mahavadi, Karnam S Murthy, John R Grider, John M Kellum, Homayoon Akbari, John F Kuemmerl. Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures. Inflammatory bowel diseases vol 17 issue 1 2011 20848532 |
strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, including collagen. |
2011-05-12 |
2023-01-25 |
human |
| Sandeep Kumar, Rachid Seqqat, Sravanthi Chigurupati, Rajesh Kumar, Kenneth M Baker, David Young, Subha Sen, Sudhiranjan Gupt. Inhibition of nuclear factor \\xce\\xbaB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free radical biology & medicine vol 50 issue 1 2011 21047552 |
inhibition of nuclear factor \xce\xbab regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. |
2011-05-09 |
2023-01-25 |
mouse |
| Sandeep Kumar, Rachid Seqqat, Sravanthi Chigurupati, Rajesh Kumar, Kenneth M Baker, David Young, Subha Sen, Sudhiranjan Gupt. Inhibition of nuclear factor \\xce\\xbaB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free radical biology & medicine vol 50 issue 1 2011 21047552 |
increased production of ros and nuclear factor \xce\xbab (nf-\xce\xbab) activation provide a strong link between oxidative stress and extracellular matrix (ecm) remodeling in cardiac hypertrophy. |
2011-05-09 |
2023-01-25 |
mouse |
| Francis I Achike, Nim-Hin Peter To, Huidi Wang, Chiu-Yin Kwa. Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint. Clinical and experimental pharmacology & physiology vol 38 issue 1 2011 21083697 |
excess fat deposition requires space, created by adipocyte (hypertrophy and hyperplasia) and extracellular matrix (ecm) remodelling. |
2011-05-04 |
2023-01-25 |
Not clear |
| Takashi Nishida, Kenji Emura, Satoshi Kubota, Karen M Lyons, Masaharu Takigaw. CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 26 issue 2 2011 20721934 |
the phenotype of ccn2 null mice, having an expanded hypertrophic zone, indicates that the resorption of the cartilage extracellular matrix is impaired therein. |
2011-04-28 |
2023-01-25 |
mouse |
| Emmanuelle David, Pierre Guihard, B\\xc3\\xa9n\\xc3\\xa9dicte Brounais, Anne Riet, C\\xc3\\xa9line Charrier, S\\xc3\\xa9verine Battaglia, Fran\\xc3\\xa7ois Gouin, St\\xc3\\xa9phanie Ponsolle, Ronan Le Bot, Carl D Richards, Dominique Heymann, Fran\\xc3\\xa7oise R\\xc3\\xa9dini, Fr\\xc3\\xa9d\\xc3\\xa9ric Blanchar. Direct anti-cancer effect of oncostatin M on chondrosarcoma. International journal of cancer vol 128 issue 8 2011 21344373 |
in two tested cell lines, osm induced a hypertrophic chondrocyte differentiation, with an induced cbfa1/sox9 ratio and induced coll10, matrix metalloproteinase 13 (mmp13) and rankl expression. |
2011-04-18 |
2023-01-25 |
rat |
| Kim Sergerie, Stefan Parent, Pierre-Francois Beauchemin, Irene Londo\\xc3\\xb1o, Florina Moldovan, Isabelle Villemur. Growth plate explants respond differently to in vitro static and dynamic loadings. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 29 issue 4 2011 21337387 |
however, dynamic compressive loads preserved the proliferative and hypertrophic zones ratio and contributed to the synthesis of aggrecan and type ii collagen in the extracellular matrix. |
2011-04-12 |
2023-01-25 |
Not clear |
| Norifumi Fujita, Takehiko Matsushita, Kazunari Ishida, Seiji Kubo, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, Ryosuke Kurod. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 29 issue 4 2011 21337390 |
our observations suggest that sirt1 expression decreases with development of oa and the reduction of sirt1 in chondrocytes may cause chondrocyte hypertrophy and cartilage matrix loss. |
2011-04-12 |
2023-01-25 |
Not clear |
| Christoffer K Abrahamsson, Fan Yang, Hyoungshin Park, Jonathan M Brunger, Piia K Valonen, Robert Langer, Jean F Welter, Arnold I Caplan, Farshid Guilak, Lisa E Free. Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds. Tissue engineering. Part A vol 16 issue 12 2011 20673022 |
in chondrogenic medium, cartilaginous tissue formed by day 21, and hypertrophic mineralization was observed in the newly formed extracellular matrix at the interface with underlying scaffold by day 45. |
2011-04-07 |
2023-01-25 |
human |
| Debby Gawlitta, Eric Farrell, Jos Malda, Laura B Creemers, Jacqueline Alblas, Wouter J A Dher. Modulating endochondral ossification of multipotent stromal cells for bone regeneration. Tissue engineering. Part B, Reviews vol 16 issue 4 2011 20131956 |
subsequent terminal differentiation (hypertrophy) of the chondrocytes initiates the formation of a mineralized matrix that will then be converted into bone. |
2011-04-06 |
2023-01-25 |
Not clear |
| Arash Haghikia, Britta Stapel, Melanie Hoch, Denise Hilfiker-Kleine. STAT3 and cardiac remodeling. Heart failure reviews vol 16 issue 1 2011 20407820 |
multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (stat3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. |
2011-04-05 |
2023-01-25 |
Not clear |
| Julian C Lui, Jeffrey Baro. Effects of glucocorticoids on the growth plate. Endocrine development vol 20 issue 2011 21164272 |
glucocorticoids slow longitudinal bone growth by inhibiting chondrocyte proliferation, hypertrophy, and cartilage matrix synthesis. |
2011-03-31 |
2023-01-25 |
Not clear |
| Hiu-Wa Cheng, Keith D K Luk, Kenneth M C Cheung, Barbara P Cha. In vitro generation of an osteochondral interface from mesenchymal stem cell-collagen microspheres. Biomaterials vol 32 issue 6 2011 21093047 |
cells at the interface region are hypertrophic chondrocytes while the extracellular matrix in this region contains collagen type ii and x, calcium deposits and vertically running fibers. |
2011-03-29 |
2023-01-25 |
Not clear |