| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Lozoya, J B Flore. A novel rat osteoarthrosis model to assess apoptosis and matrix degradation. Pathology, research and practice. vol 196. issue 11. 2001-02-08. PMID:11186168. |
oa cartilage displayed a rough and eroded surface, fibrosis and even complete loss; we also found hypertrophy, chondrocyte clusters and a disrupted extracellular matrix. |
2001-02-08 |
2023-08-12 |
rat |
| D A Stevens, R P Hasserjian, H Robson, T Siebler, S M Shalet, G R William. Thyroid hormones regulate hypertrophic chondrocyte differentiation and expression of parathyroid hormone-related peptide and its receptor during endochondral bone formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 15. issue 12. 2001-02-01. PMID:11127207. |
hypothyroid growth plates were grossly disorganized, contained an abnormal matrix rich in heparan sulfate, and hypertrophic chondrocyte differentiation failed to progress. |
2001-02-01 |
2023-08-12 |
rat |
| T Sasaki, N Amizuka, K Irie, S Ejiri, H Ozaw. Localization of alkaline phosphatase and osteopontin during matrix mineralization in the developing cartilage of coccygeal vertebrae. Archives of histology and cytology. vol 63. issue 3. 2001-01-25. PMID:10989939. |
in the cartilage matrix of coccygeal vertebrae, we observed the localization of alpase activity in the boundary of the proliferative and the hypertrophic zones. |
2001-01-25 |
2023-08-12 |
Not clear |
| M Varedi, E E Tredget, A Ghahary, P G Scot. Stress-relaxation and contraction of a collagen matrix induces expression of TGF-beta and triggers apoptosis in dermal fibroblasts. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 78. issue 4. 2001-01-18. PMID:11012081. |
they further suggest that inability to reorganize this matrix could be responsible for the maintenance of the fibroproliferative phenotype associated with fibroblasts in hypertrophic scarring. |
2001-01-18 |
2023-08-12 |
human |
| M Laser, C D Willey, W Jiang, G Cooper, D R Menick, M R Zile, D Kuppuswam. Integrin activation and focal complex formation in cardiac hypertrophy. The Journal of biological chemistry. vol 275. issue 45. 2001-01-04. PMID:10958798. |
cardiac hypertrophy is characterized by both remodeling of the extracellular matrix (ecm) and hypertrophic growth of the cardiocytes. |
2001-01-04 |
2023-08-12 |
Not clear |
| C G Pham, A E Harpf, R S Keller, H T Vu, S Y Shai, J C Loftus, R S Ros. Striated muscle-specific beta(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. American journal of physiology. Heart and circulatory physiology. vol 279. issue 6. 2000-12-28. PMID:11087248. |
alterations in the extracellular matrix occur during the cardiac hypertrophic process. |
2000-12-28 |
2023-08-12 |
Not clear |
| b' M T Engsig, Q J Chen, T H Vu, A C Pedersen, B Therkidsen, L R Lund, K Henriksen, T Lenhard, N T Foged, Z Werb, J M Delaiss\\xc3\\xa. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. The Journal of cell biology. vol 151. issue 4. 2000-12-22. PMID:11076971.' |
hypertrophic cartilage also expresses vascular endothelial growth factor (vegf), which binds to extracellular matrix and is made bioavailable by mmp-9 (bergers, g., r. brekken, g. mcmahon, t.h. |
2000-12-22 |
2023-08-12 |
mouse |
| L Legeai-Mallet, A Rossi, C Benoist-Lasselin, R Piazza, J F Mallet, A L Delezoide, A Munnich, J Bonaventure, L Zylberber. EXT 1 gene mutation induces chondrocyte cytoskeletal abnormalities and defective collagen expression in the exostoses. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 15. issue 8. 2000-12-11. PMID:10934647. |
the unexpected presence of collagen type i unevenly distributed in the cartilage matrix further suggested that some of the hypertrophic chondrocytes detected in the cartilaginous caps of the exostoses underwent accelerated differentiation. |
2000-12-11 |
2023-08-12 |
Not clear |
| S Moskalewski, A Hyc, A Osiecka-Iwan, P Strzelczy. [Molecular basis of achondroplasia, hypochondroplasia, and thanatophoric dysplasia]. Chirurgia narzadow ruchu i ortopedia polska. vol 65. issue 3. 2000-12-08. PMID:11057021. |
fibroblast growth factor 2 (fgf2) inhibits proliferation and hypertrophy of chondrocytes in the growth plate, synthesis of cartilage matrix, terminal differentiation of hypertrophic chondrocytes and matrix calcification. |
2000-12-08 |
2023-08-12 |
Not clear |
| J Ling, S A Kincaid, G R McDaniel, W Waegel. Immunolocalization analysis of transforming growth factor-beta1 in the growth plates of broiler chickens with high and low incidences of tibial dyschondroplasia. Poultry science. vol 79. issue 8. 2000-11-30. PMID:10947187. |
however, immunolocalization in extracellular matrix was restricted to the hypertrophic zones of both lines. |
2000-11-30 |
2023-08-12 |
Not clear |
| J Ling, S A Kincaid, G R McDaniel, W Waegel. Immunolocalization analysis of transforming growth factor-beta1 in the growth plates of broiler chickens with high and low incidences of tibial dyschondroplasia. Poultry science. vol 79. issue 8. 2000-11-30. PMID:10947187. |
in the hypertrophic zone of low td incidence line, immunolocalization of tgf-beta1 in the extracellular matrix adjacent to collapsed cartilage canals (matrix streaks) was significantly greater than immunolocalization between patent cartilage canals. |
2000-11-30 |
2023-08-12 |
Not clear |
| J Ling, S A Kincaid, G R McDaniel, W Waegel. Immunolocalization analysis of transforming growth factor-beta1 in the growth plates of broiler chickens with high and low incidences of tibial dyschondroplasia. Poultry science. vol 79. issue 8. 2000-11-30. PMID:10947187. |
results indicate that chondrocytes of all zones of the growth plate contain tgf-beta1 but do not release it into extracellular matrix until hypertrophy has occurred. |
2000-11-30 |
2023-08-12 |
Not clear |
| G M Hargrove, J Dufresne, C Whiteside, D A Muruve, N C Won. Diabetes mellitus increases endothelin-1 gene transcription in rat kidney. Kidney international. vol 58. issue 4. 2000-11-13. PMID:11012888. |
mesangial cell hypertrophy and increased extracellular matrix (ecm) contribute to mesangial expansion in early progressive diabetic nephropathy. |
2000-11-13 |
2023-08-12 |
rat |
| C Farquharson, D Jefferie. Chondrocytes and longitudinal bone growth: the development of tibial dyschondroplasia. Poultry science. vol 79. issue 7. 2000-11-09. PMID:10901201. |
immunolocalization studies of matrix components suggest an abnormal distribution within the td growth plate that is consistent with a failure of the chondrocytes to fully hypertrophy. |
2000-11-09 |
2023-08-12 |
chicken |
| N Guarino, H Shima, P Pur. Structural immaturity of the pylorus muscle in infantile hypertrophic pyloric stenosis. Pediatric surgery international. vol 16. issue 4. 2000-11-07. PMID:10898230. |
recent reports indicate that extracellular matrix and cytoskeleton plasmalemmal elements are altered in infantile hypertrophic pyloric stenosis (ihps). |
2000-11-07 |
2023-08-12 |
Not clear |
| G Costache, D Popov, A Georgescu, M Cenuse, V V Jinga, M Simionesc. The effects of simultaneous hyperlipemia-hyperglycemia on the resistance arteries, myocardium and kidney glomeruli. Journal of submicroscopic cytology and pathology. vol 32. issue 1. 2000-10-13. PMID:10877102. |
the hd hamsters displayed also modifications that may be dependent on or may lead to an increase in blood pressure, such as: a) approximately 2 fold increase in the activity of serum angiotensin converting enzyme; b) approximately 4.8 fold enhancement of erythrocytes fragility (as a measure of the oxidative stress); c) left ventricular hypertrophy associated with a progressive disarray of cardiomyocyte contractile fibers, interruptions of the z bands, and accumulation of collagen-rich extracellular matrix indicative of interstitial fibrosis; d) the kidney glomerular capillaries appeared partially or totally collapsed, with a thickened basement membrane which appeared polymorphic, and in some locations made up of successive layers connected by fine bridges and intercalated nodules; in addition, an increase (approximately 1.50 fold) of the mesangial volume was indicative of glomerulosclerosis. |
2000-10-13 |
2023-08-12 |
Not clear |
| D Duprez, M De Buyzere, E R Rietzschel, D L Clemen. Aldosterone and vascular damage. Current hypertension reports. vol 2. issue 3. 2000-10-13. PMID:10981167. |
moreover, aldosterone is involved in vascular smooth muscle cell hypertrophy and hyperplasia, as well as in vascular matrix impairment and endothelial dysfunction. |
2000-10-13 |
2023-08-12 |
Not clear |
| A J Ingram, L James, H Ly, K Thai, L Cai, J W Schole. Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells. Kidney international. vol 58. issue 3. 2000-10-12. PMID:10972671. |
in vivo, intraglomerular hypertension results in resident cell hypertrophy, proliferation and matrix protein production, leading to glomerulosclerosis. |
2000-10-12 |
2023-08-12 |
Not clear |
| S Kagami, S Kondo, M Urushihara, K Löster, W Reutter, T Saijo, A Kitamura, S Kobayashi, Y Kurod. Overexpression of alpha1beta1 integrin directly affects rat mesangial cell behavior. Kidney international. vol 58. issue 3. 2000-10-12. PMID:10972673. |
glomerular mesangial cell (mc) proliferation, hypertrophy, and abnormal matrix remodeling characterized by increased expression of fibronectin, laminin and collagen type iv, and neoexpression of collagen i and iii are the main biological features of progressive glomerulonephritis (gn). |
2000-10-12 |
2023-08-12 |
rat |
| V J Matukas, B J Panner, J L Orbiso. Studies on ultrastructural identification and distribution of protein-polysaccharide in cartilage matrix. The Journal of cell biology. vol 32. issue 2. 2000-09-14. PMID:10976228. |
when the matrix of epiphyseal cartilage is compared to that of the zone of hypertrophic cells, fibers are similar but the granules in the latter zone are larger and more numerous. |
2000-09-14 |
2023-08-12 |
chicken |