| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Salvetti, P Mattei, I Sudan. Renal protection and antihypertensive drugs: current status. Drugs vol 57 issue 5 1999 10353294 |
secondly, intrarenal actions on mechanisms such as glomerular hypertension and hypertrophy, proteinuria, mesangial cell proliferation, mesangial matrix production and probably endothelial dysfunction, which can cause and/or worsen renal failure, are relevant for the renal protective action of some drug classes. |
1999-08-06 |
2023-01-24 |
Not clear |
| K M Hannan, P J Littl. Mechanisms regulating the vascular smooth muscle Na/H exchanger (NHE-1) in diabetes. Biochemistry and cell biology = Biochimie et biologie cellulaire vol 76 issue 5 1999 10353708 |
the pathology involves hypertrophy and proliferation of vascular smooth muscle cells and the production and modification of extracellular matrix. |
1999-08-05 |
2023-01-24 |
Not clear |
| Y Nakamura, H Makino, R Morishit. [Distribution and function of angiotensin receptor subtypes in cardiovascular system]. Nihon rinsho. Japanese journal of clinical medicine vol 57 issue 5 1999 10361430 |
in adult, at1 is a dominant subtype in cardiovascular system, and mediates virtually all the previously known actions of aii, including vasoconstriction, production of growth factors, hypertrophy of smooth muscle and cardiomyocyte, proliferation of smooth muscle and fibroblast, production of extracellular matrix and so on. |
1999-07-22 |
2023-01-24 |
Not clear |
| R Serra, A Karaplis, P Soh. Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation. The Journal of cell biology vol 145 issue 4 1999 10330406 |
mouse embryonic metatarsal bone rudiments grown in organ culture were used to demonstrate that tgf-beta inhibits several stages of endochondral bone formation, including chondrocyte proliferation, hypertrophic differentiation, and matrix mineralization. |
1999-07-21 |
2023-01-24 |
mouse |
| R Serra, A Karaplis, P Soh. Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation. The Journal of cell biology vol 145 issue 4 1999 10330406 |
pthrp added to cultures inhibited hypertrophic differentiation and matrix mineralization but did not affect cell proliferation. |
1999-07-21 |
2023-01-24 |
mouse |
| B D Boyan, V L Sylvia, D D Dean, H Pedrozo, F Del Toro, I Nemere, G H Posner, Z Schwart. 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2. Steroids vol 64 issue 1-2 1999 10323681 |
1,25 targets cells in the prehypertrophic and upper hypertrophic zones of the costochondral cartilage growth plate (gc cells), resulting in increased specific activity of alkaline phosphatase (alp), phospholipase a2 (pla2), and matrix metalloproteinases (mmps). |
1999-06-21 |
2023-01-24 |
Not clear |
| K Kuroda, O Okamoto, H Shinka. Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. The Journal of investigative dermatology vol 112 issue 5 1999 10233760 |
dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. |
1999-06-18 |
2023-01-24 |
Not clear |
| K Kuroda, O Okamoto, H Shinka. Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. The Journal of investigative dermatology vol 112 issue 5 1999 10233760 |
our results suggest that the decreased expression of dermatopontin is associated with the pathogenesis of fibrosis in hypertrophic scar and systemic sclerosis, and that the effect of the cytokines and matrix collagen on dermatopontin may have important implications for skin fibrosis. |
1999-06-18 |
2023-01-24 |
Not clear |
| Z H Liu, T J Guan, Z H Chen, L S L. Glucose transporter (GLUT1) allele (XbaI-) associated with nephropathy in non-insulin-dependent diabetes mellitus. Kidney international vol 55 issue 5 1999 10231446 |
several pieces of experimental evidence suggest that glucose transporter (glut1) activity is an important modulator for the cell hypertrophy and extracellular matrix formation of glomerular mesangial cells. |
1999-06-15 |
2023-01-24 |
Not clear |
| K Tamura, E Chiba, N Yokoyama, Y Sumida, M Yabana, N Tamura, I Takasaki, N Takagi, M Ishii, M Horiuchi, S Umemur. Renin-angiotensin system and fibronectin gene expression in Dahl Iwai salt-sensitive and salt-resistant rats. Journal of hypertension vol 17 issue 1 1999 10100098 |
the tissue renin-angiotensin system and extracellular matrix are involved in the cardiovascular hypertrophy and remodeling induced by hypertension. |
1999-05-26 |
2023-01-24 |
rat |
| G Li, A H Simpson, J T Triffit. The role of chondrocytes in intramembranous and endochondral ossification during distraction osteogenesis in the rabbit. Calcified tissue international vol 64 issue 4 1999 10089224 |
acid phosphatases were found within the cartilage matrix in some of the cartilage/bone transitional regions and type i collagen mrna and type ii collagen protein were found together in some of the marginal hypertrophic chondrocytes. |
1999-05-06 |
2023-01-24 |
rabbit |
| C M Ayanoglou, C Lest. Cyclosporin A-induced gingival overgrowth in the rat: a histological, ultrastructural and histomorphometric evaluation. Journal of periodontal research vol 34 issue 1 1999 10086881 |
these results indicate that (a) the csa induced modifications are not limited to enlarged gingiva (b) the overgrowth of the gct is the result of a vasodilatation and of an increase in the volume of the extracellular matrix and (c) the increase of the epithelial thickness is mainly the result of a cell hypertrophy in the keratinized epithelia and of a cell hyperplasia in the junctional epithelium. |
1999-05-03 |
2023-01-24 |
rat |
| V S Mujumdar, S C Tyag. Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure. Journal of hypertension vol 17 issue 2 1999 10067796 |
temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure. |
1999-04-28 |
2023-01-24 |
Not clear |
| H Fujioka, R Thakur, G J Wang, K Mizuno, G Balian, S R Hurwit. Comparison of surgically attached and non-attached repair of the rat Achilles tendon-bone interface. Cellular organization and type X collagen expression. Connective tissue research vol 37 issue 3-4 1999 9862222 |
in group i (tendon reattached), at 2 weeks postoperatively, many hypertrophic chondrocytes appeared at the reattachment site adjacent to bone and type x collagen was detected immunologically both in the cells and in the extracellular matrix. |
1999-03-23 |
2023-01-24 |
rat |
| D Vranes, M E Cooper, R J Dille. Cellular mechanisms of diabetic vascular hypertrophy. Microvascular research vol 57 issue 1 1999 9882558 |
furthermore, an increase in extracellular matrix within the media is an important feature of diabetes associated vascular hypertrophy. |
1999-03-22 |
2023-01-24 |
rat |
| G Palmer, J Zhao, J Bonjour, W Hofstetter, J Caverzasi. In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development. Bone vol 24 issue 1 1999 9916777 |
in conclusion, the glvr-1 phosphate transporter is selectively expressed in a subset of hypertrophic chondrocytes during endochondral bone formation, in a region where matrix mineralization proceeds. |
1999-03-22 |
2023-01-24 |
human |
| F Spencer, L Chi, M X Zh. Biochemical characterization of benomyl inhibition on endometrial growth during decidualization in rats. Advances in experimental medicine and biology vol 444 issue 1999 10026946 |
measured endometrial parameters were the wet weight, protein for hypertrophy, dna indicative of hyperplasia; enzymatic biomarkers- isocitrate dehydrogenase (icdh) and the matrix metalloproteinases (mmps); and serum progesterone which hormonally maintains decidual growth. |
1999-03-10 |
2023-01-24 |
rat |
| I Koffi, P Lacolley, M Kirchengaast, J P Pomi\\xc3\\xa8s, S Laurent, A Beneto. Prevention of arterial structural alterations with verapamil and trandolapril and consequences for mechanical properties in spontaneously hypertensive rats. European journal of pharmacology vol 361 issue 1 1999 9851541 |
we compared the chronic effects in spontaneously hypertensive rats (shr) of low doses of an angiotensin converting enzyme inhibitor, trandolapril, a ca2+ channel antagonist, verapamil, and their combination (trandolapril-verapamil), on arterial mechanical properties, arterial wall hypertrophy and extracellular matrix proteins. |
1999-03-04 |
2023-01-24 |
rat |
| R K Dubey, D G Gillespie, E K Jackso. Adenosine inhibits collagen and total protein synthesis in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979) vol 33 issue 1 Pt 2 1999 9931103 |
thus, exogenous a2b receptor agonists and drugs that modulate endogenous adenosine levels may protect against vasoocclusive disorders by attenuating extracellular matrix synthesis by and cellular hypertrophy of vascular smcs. |
1999-02-26 |
2023-01-24 |
Not clear |
| T Szuwart, H Kierdorf, U Kierdorf, G Cleme. Ultrastructural aspects of cartilage formation, mineralization, and degeneration during primary antler growth in fallow deer (Dama dama). Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft vol 180 issue 6 1999 9862029 |
concomitant with cell hypertrophy, formation of a lacunar and a perilacunar extracellular matrix was observed, the latter containing numerous collagenous fibers. |
1999-02-25 |
2023-01-24 |
Not clear |