| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A D Widgerow, L A Chait, R Stals, P J Stal. New innovations in scar management. Aesthetic plastic surgery. vol 24. issue 3. 2000-08-17. PMID:10890953. |
tension on a scar from many directions or intermittently will result in a hypertrophic scar, possibly initiated by lymphocytes but definitely related to a prolongation of the inflammatory process, with increased fibroblast activity and overabundant extracellular matrix secretion [24,26]. |
2000-08-17 |
2023-08-12 |
Not clear |
| J M Taylor, J D Rovin, J T Parson. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes. The Journal of biological chemistry. vol 275. issue 25. 2000-08-16. PMID:10749882. |
here we report that signals provided by extracellular matrix proteins (ecm) augment the pe-induced hypertrophic response of cardiomyocytes and provide evidence that ecm-dependent signaling is mediated in part by the protein tyrosine kinase, focal adhesion kinase (fak). |
2000-08-16 |
2023-08-12 |
rat |
| M D'Angelo, Z Yan, M Nooreyazdan, M Pacifici, D S Sarment, P C Billings, P S Lebo. MMP-13 is induced during chondrocyte hypertrophy. Journal of cellular biochemistry. vol 77. issue 4. 2000-08-15. PMID:10771523. |
during development, mrna for matrix metalloproteinase-13 (mmp-13) is found associated with cartilage undergoing hypertrophy, suggesting that this collagenase plays a role in cell enlargement and/or cartilage calcification. |
2000-08-15 |
2023-08-12 |
chicken |
| E Ogawa, Y Saito, M Harada, S Kamitani, K Kuwahara, Y Miyamoto, M Ishikawa, I Hamanaka, N Kajiyama, N Takahashi, O Nakagawa, I Masuda, I Kishimoto, K Naka. Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes. Journal of molecular and cellular cardiology. vol 32. issue 5. 2000-08-11. PMID:10775482. |
cardiac hypertrophy involves the accumulation of extracellular matrix proteins, such as fibronectin, leading to increasing myocardial stiffness, ventricular dysfunction and heart failure. |
2000-08-11 |
2023-08-12 |
human |
| E Ogawa, Y Saito, M Harada, S Kamitani, K Kuwahara, Y Miyamoto, M Ishikawa, I Hamanaka, N Kajiyama, N Takahashi, O Nakagawa, I Masuda, I Kishimoto, K Naka. Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes. Journal of molecular and cellular cardiology. vol 32. issue 5. 2000-08-11. PMID:10775482. |
these findings demonstrate that the interaction of fibronectin and rgd-dependent integrins is involved in the hypertrophic responses of myocyte in vitro, and suggest that extracellular matrix proteins such as fibronectin are not merely passive adhesive molecules but are active participants in processes leading to myocyte hypertrophy. |
2000-08-11 |
2023-08-12 |
human |
| F N Ziyadeh, B B Hoffman, D C Han, M C Iglesias-De La Cruz, S W Hong, M Isono, S Chen, T A McGowan, K Sharm. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 14. 2000-08-10. PMID:10859350. |
we showed previously that short-term treatment with a neutralizing monoclonal anti-tgf-beta antibody (alphat) in streptozotocin-diabetic mice prevents early changes of renal hypertrophy and increased matrix mrna. |
2000-08-10 |
2023-08-12 |
mouse |
| Z R Yousef, M S Marbe. The open artery hypothesis: potential mechanisms of action. Progress in cardiovascular diseases. vol 42. issue 6. 2000-07-12. PMID:10871164. |
almost immediately, neurohormones are activated that alter hemodynamic load, and, later, stimulate myocyte hypertrophy, while locally, inflammatory processes clear necrotic debris, reorganize the extracellular matrix, and orchestrate scar formation. |
2000-07-12 |
2023-08-12 |
Not clear |
| N Joki, S Kaname, M Hirakata, Y Hori, T Yamaguchi, T Fujita, T Katoh, K Kurokaw. Tyrosine-kinase dependent TGF-beta and extracellular matrix expression by mechanical stretch in vascular smooth muscle cells. Hypertension research : official journal of the Japanese Society of Hypertension. vol 23. issue 2. 2000-06-21. PMID:10770255. |
vascular hypertrophy, which is characterized by proliferation of vascular smooth muscle cells (vsmc) and accumulation of extracellular matrix (ecm), is a major pathological change in blood vessels after chronic exposure to hypertension. |
2000-06-21 |
2023-08-12 |
rat |
| M O Boluyt, O H Bin. Matrix gene expression and decompensated heart failure: the aged SHR model. Cardiovascular research. vol 46. issue 2. 2000-06-12. PMID:10773227. |
impaired functional performance despite hypertrophic enlargement, and an excessive accumulation of extracellular matrix, are hallmarks of the decompensated failing heart. |
2000-06-12 |
2023-08-12 |
rat |
| B Nedelec, A Ghahary, P G Scott, E E Tredge. Control of wound contraction. Basic and clinical features. Hand clinics. vol 16. issue 2. 2000-06-08. PMID:10791174. |
because the prolonged presence of myofibroblasts, producing an imbalance in extracellular matrix proteins and proteases, probably exacerbates hypertrophic scars and wound contraction, accelerating the rate of apoptotic cell death to reduce the cell number to that seen in normal scar may be a useful strategy for providing effective and efficient treatment of scar contracture. |
2000-06-08 |
2023-08-12 |
Not clear |
| Q Q Wu, Q Che. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Experimental cell research. vol 256. issue 2. 2000-05-18. PMID:10772811. |
mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. |
2000-05-18 |
2023-08-12 |
Not clear |
| Q Q Wu, Q Che. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Experimental cell research. vol 256. issue 2. 2000-05-18. PMID:10772811. |
cyclic matrix deformation greatly stimulated proliferation of immature chondrocytes, but not that of hypertrophic chondrocytes. |
2000-05-18 |
2023-08-12 |
Not clear |
| Q Q Wu, Q Che. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: ion-channel dependent transduction of matrix deformation signals. Experimental cell research. vol 256. issue 2. 2000-05-18. PMID:10772811. |
synthesis of cartilage matrix protein (cmp/matrilin-1), a mature chondrocyte marker, and type x collagen, a hypertrophic chondrocyte marker, was up-regulated by stretch-induced matrix deformation. |
2000-05-18 |
2023-08-12 |
Not clear |
| C H Lohmann, Z Schwartz, G G Niederauer, B D Boya. [Degree of differentiation of chondrocytes and their pretreatment with platelet-derived-growth factor. Regulating induction of cartilage formation in resorbable tissue carriers in vivo]. Der Orthopade. vol 29. issue 2. 2000-05-03. PMID:10743633. |
prior in vitro studies showed that platelet derived growth factor-bb (pdgf-bb), but not transforming growth factor beta-1 (tgf-beta 1), basic fibroblast growth factor, or bone morphogenetic protein-2 promoted proliferation and extracellular matrix sulfation of resting zone chondrocytes without causing the cells to exhibit a hypertrophic chondrocyte phenotype. |
2000-05-03 |
2023-08-12 |
mouse |
| D C Han, B B Hoffman, S W Hong, J Guo, F N Ziyade. Therapy with antisense TGF-beta1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice. American journal of physiology. Renal physiology. vol 278. issue 4. 2000-05-02. PMID:10751224. |
in conclusion, therapy with antisense tgf-beta1 odn decreases tgf-beta1 production and attenuates high-glucose-induced proximal tubular cell hypertrophy in vitro and partially prevents the increase in kidney weight and extracellular matrix expression in diabetic mice. |
2000-05-02 |
2023-08-12 |
mouse |
| V Mericq, J A Uyeda, K M Barnes, F De Luca, J Baro. Regulation of fetal rat bone growth by C-type natriuretic peptide and cGMP. Pediatric research. vol 47. issue 2. 2000-03-30. PMID:10674345. |
we conclude that cnp stimulates longitudinal bone growth by increasing chondrocyte proliferation, chondrocyte hypertrophy, and cartilage matrix production. |
2000-03-30 |
2023-08-12 |
rat |
| Y T Chiu, S K Liu, M Liu, S P Chen, Y H Lin, S J Mao, R Ch. Characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 3. 2000-03-29. PMID:10722240. |
characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. |
2000-03-29 |
2023-08-12 |
human |
| Y T Chiu, S K Liu, M Liu, S P Chen, Y H Lin, S J Mao, R Ch. Characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 3. 2000-03-29. PMID:10722240. |
the purpose of this study was to elucidate the morphological changes in the collagen of the extracellular matrix (ecm) in the hearts of pigs with hypertrophic cardiomyopathy. |
2000-03-29 |
2023-08-12 |
human |
| Y T Chiu, S K Liu, M Liu, S P Chen, Y H Lin, S J Mao, R Ch. Characterization and quantitation of extracellular collagen matrix in myocardium of pigs with spontaneously occurring hypertrophic cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 8. issue 3. 2000-03-29. PMID:10722240. |
our findings of an overall increase of collagen content suggested that the accumulation of collagen matrix might be another factor responsible for the diastolic dysfunction of hypertrophic cardiomyopathy. |
2000-03-29 |
2023-08-12 |
human |
| A R Klatt, D P Nitsche, B Kobbe, M Mörgelin, M Paulsson, R Wagene. Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development. The Journal of biological chemistry. vol 275. issue 6. 2000-03-16. PMID:10660556. |
it is found both inside the lacunae and in the interterritorial matrix of the resting, proliferating, hypertrophic, and calcified cartilage zones, whereas the expression is lower in the superficial articular cartilage. |
2000-03-16 |
2023-08-12 |
mouse |