| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zhou, Jiayu Wang, Xiaofeng Li, Ke Li, Lei Chen, Zongze Zhang, Mian Pen. Neuroprotectin D1 Protects Against Postoperative Delirium-Like Behavior in Aged Mice. Frontiers in aging neuroscience. vol 12. 2020-12-01. PMID:33250764. |
npd1 also abolished the activation of microglia and astrocytes in the hippocampus and prefrontal cortex, which is associated with improved general and memory function after surgery. |
2020-12-01 |
2023-08-13 |
mouse |
| Yue Wu, Minhui Gao, Jingjing Wu, Peili Hu, Xing Xu, Yaru Zhang, Dan Wang, Zhuo Chen, Chao Huan. Sulforaphane triggers a functional elongation of microglial process via the Akt signal. The Journal of nutritional biochemistry. vol 67. 2020-11-04. PMID:30856464. |
this pro-elongation effect of sfn was also observed in the prefrontal cortex in vivo and accompanied with an attenuation of pro-inflammatory response as well as an enhancement of anti-inflammatory response in primary cultured microglia. |
2020-11-04 |
2023-08-13 |
mouse |
| B R Loman, K R Jordan, B Haynes, M T Bailey, L M Pyte. Chemotherapy-induced neuroinflammation is associated with disrupted colonic and bacterial homeostasis in female mice. Scientific reports. vol 9. issue 1. 2020-11-04. PMID:31712703. |
although microbial community composition was not directly related to available brain or behavioral measures, structural differences in colonic tissue were strongly related to microglia activation in the dentate gyrus and the prefrontal cortex. |
2020-11-04 |
2023-08-13 |
mouse |
| Chikara Abe, Yang Yi, Masaya Hane, Ken Kitajima, Chihiro Sat. Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain. Scientific reports. vol 9. issue 1. 2020-11-03. PMID:31289315. |
the use of inhibitors for sialidase, microglia and astrocytes revealed that these declines were due to a transient action of sialidase from microglia and astrocytes in the olfactory bulb and prefrontal cortex, respectively. |
2020-11-03 |
2023-08-13 |
mouse |
| Emma K Erickson, Yuri A Blednov, R Adron Harris, R Dayne Mayfiel. Glial gene networks associated with alcohol dependence. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31358844. |
genes related to innate immune signaling, specifically interferon pathways, were consistently up-regulated across cie-exposed astrocytes, microglia, and total homogenate pfc tissue. |
2020-10-27 |
2023-08-13 |
mouse |
| Ning Xu, Xiao-Hui Tang, Wei Pan, Ze-Min Xie, Guang-Fen Zhang, Mu-Huo Ji, Jian-Jun Yang, Mai-Tao Zhou, Zhi-Qiang Zho. Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28458629. |
spared nerve injury increases the expression of microglia m1 markers in the prefrontal cortex of rats and provokes depression-like behaviors. |
2020-10-01 |
2023-08-13 |
rat |
| Ning Xu, Xiao-Hui Tang, Wei Pan, Ze-Min Xie, Guang-Fen Zhang, Mu-Huo Ji, Jian-Jun Yang, Mai-Tao Zhou, Zhi-Qiang Zho. Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28458629. |
the levels of microglia markers including ionized calcium-binding adaptor molecule 1 (iba1), cluster of differentiation 11b (cd11b), m1 markers including cd68, inducible nitric oxide synthase (inos), interleukin-1β (il-1β), il-6, tumor necrosis factor-a (tnf-α), 8-hydroxy-2-deoxyguanosine (8-oh-dg), and m2 markers including cd206, arginase 1 (arg1), il-4 in the prefrontal cortex were determined on day 14 after sni. |
2020-10-01 |
2023-08-13 |
rat |
| Ning Xu, Xiao-Hui Tang, Wei Pan, Ze-Min Xie, Guang-Fen Zhang, Mu-Huo Ji, Jian-Jun Yang, Mai-Tao Zhou, Zhi-Qiang Zho. Spared Nerve Injury Increases the Expression of Microglia M1 Markers in the Prefrontal Cortex of Rats and Provokes Depression-Like Behaviors. Frontiers in neuroscience. vol 11. 2020-10-01. PMID:28458629. |
the results showed that sni produced mechanical allodynia and depressive-like behaviors, and also increased the expressions of microglia markers (iba1, cd11b) and m1 markers (cd68, inos, il-1β, tnf-α, and 8-oh-dg) in the prefrontal cortex. |
2020-10-01 |
2023-08-13 |
rat |
| Wei Wang, Rui Wang, Jingjing Xu, Xiaqing Qin, Hong Jiang, Arslan Khalid, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30459654. |
the effects of minocycline on pro-inflammatory cytokines, activation of microglia, and nf-κb in the pfc and hippocampus were also examined. |
2020-10-01 |
2023-08-13 |
rat |
| Wei Wang, Rui Wang, Jingjing Xu, Xiaqing Qin, Hong Jiang, Arslan Khalid, Dexiang Liu, Fang Pan, Cyrus S H Ho, Roger C M H. Minocycline Attenuates Stress-Induced Behavioral Changes via Its Anti-inflammatory Effects in an Animal Model of Post-traumatic Stress Disorder. Frontiers in psychiatry. vol 9. 2020-10-01. PMID:30459654. |
taken together, our results suggest that the anxiolytic effect of minocycline is related to its ability to decrease the levels of pro-inflammatory cytokines and inhibit activation of microglia and nf-κb in the pfc and hippocampus. |
2020-10-01 |
2023-08-13 |
rat |
| Yihe Wang, Tianrui Zhu, Min Wang, Feng Zhang, Guitao Zhang, Jing Zhao, Yuanyuan Zhang, Erxi Wu, Xiaohong L. Icariin Attenuates M1 Activation of Microglia and Aβ Plaque Accumulation in the Hippocampus and Prefrontal Cortex by Up-Regulating PPARγ in Restraint/Isolation-Stressed APP/PS1 Mice. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31001073. |
icariin attenuates m1 activation of microglia and aβ plaque accumulation in the hippocampus and prefrontal cortex by up-regulating pparγ in restraint/isolation-stressed app/ps1 mice. |
2020-09-29 |
2023-08-13 |
mouse |
| Erica Zamberletti, Marina Gabaglio, Marie Woolley-Roberts, Sharon Bingham, Tiziana Rubino, Daniela Parolar. Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31447649. |
as dysregulations in the endocannabinoid system and neuroinflammatory markers contribute to the development of some asd phenotypes in the vpa model, neurochemical studies were performed after symptomatic treatment to investigate possible cbdv's effects on the endocannabinoid system, inflammatory markers and microglia activation in the hippocampus and prefrontal cortex. |
2020-09-29 |
2023-08-13 |
rat |
| Lulu Xie, Zhimin Gu, Haizhao Liu, Beitian Jia, Yiyang Wang, Min Cao, Ruiwen Song, Zhaiyi Zhang, Yuhong Bia. The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32922291. |
pcr and western blot were used to monitor the differences of nlrp3, caspase-1, asc activation in the levels of genes and proteins in the pfc of rats and microglia. |
2020-09-28 |
2023-08-13 |
rat |
| Lulu Xie, Zhimin Gu, Haizhao Liu, Beitian Jia, Yiyang Wang, Min Cao, Ruiwen Song, Zhaiyi Zhang, Yuhong Bia. The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32922291. |
in addition, hesperidin decreased the expression levels of il-1β, il-6, tnf-α, nlrp3, caspase-1, and asc in the pfc and microglia. |
2020-09-28 |
2023-08-13 |
rat |
| Matthew J Horchar, Eric S Wohle. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31255679. |
other reports indicate that elevated corticosterone causes pyramidal neuron atrophy and microglia activation in the medial pfc, implicating glucocorticoid signaling in microglia-mediated neuronal remodeling following chronic stress. |
2020-08-14 |
2023-08-13 |
mouse |
| Matthew J Horchar, Eric S Wohle. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31255679. |
moreover, ru486 administration diminished cus-induced csf1 signaling in the pfc and reduced markers of phagocytosis on purified microglia. |
2020-08-14 |
2023-08-13 |
mouse |
| Matthew J Horchar, Eric S Wohle. Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31255679. |
this study presents primary evidence that neuroendocrine responses engage neuron-microglia interactions in the pfc; further implicating microglia in stress-induced neuronal remodeling, pfc dysfunction, and associated behavioral consequences. |
2020-08-14 |
2023-08-13 |
mouse |
| Mohammed E Choudhury, Kazuya Miyanishi, Haruna Takeda, Afsana Islam, Nayu Matsuoka, Madoka Kubo, Shirabe Matsumoto, Takeharu Kunieda, Masahiro Nomoto, Hajime Yano, Junya Tanak. Phagocytic elimination of synapses by microglia during sleep. Glia. vol 68. issue 1. 2020-06-04. PMID:31429116. |
systemic administration of the brain monoamine-depleting agent reserpine decreased na content and synapsin i expression in pfc, and increased expression of microglia markers, c3 and mfg-e8, while increasing the sleeping period. |
2020-06-04 |
2023-08-13 |
rat |
| David J Clarke, Tariq W Chohan, Mustafa S Kassem, Kristie L Smith, Rose Chesworth, Tim Karl, Michael P Kuligowski, Sandra Y Fok, Maxwell R Bennett, Jonathon C Arnol. Neuregulin 1 Deficiency Modulates Adolescent Stress-Induced Dendritic Spine Loss in a Brain Region-Specific Manner and Increases Complement 4 Expression in the Hippocampus. Schizophrenia bulletin. vol 45. issue 2. 2020-04-06. PMID:29566220. |
stress in wt mice promoted dendritic spine loss and microglial cell activation in the prefrontal cortex and the hippocampus. |
2020-04-06 |
2023-08-13 |
mouse |
| Sami Alzarea, Shafiqur Rahma. Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice. Behavioural brain research. vol 366. 2020-03-26. PMID:30877025. |
following lps treatment, pnu120596 hindered activation markers of the microglia and astrocytes (cluster of differentiation molecule 11b and glial fibrillary acidic protein) and upregulation of proinflammatory cytokines such as interleukin 1 beta and tumor necrosis factor-alpha in the hippocampus and prefrontal cortex. |
2020-03-26 |
2023-08-13 |
mouse |