| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Mi, Gui-Rong Zeng, Jie-Qing Liu, Zhou-Song Luo, Ling Zhang, Xiao-Man Dai, Wen-Ting Fang, Jing Zhang, Xiao-Chun Che. Ganoderma Lucidum Triterpenoids Improve Maternal Separation-Induced Anxiety- and Depression-like Behaviors in Mice by Mitigating Inflammation in the Periphery and Brain. Nutrients. vol 14. issue 11. 2022-06-10. PMID:35684068. |
maternal separation up-regulated the pro-inflammatory markers in the periphery and brain, and activated microglia in the prefrontal cortex and hippocampus. |
2022-06-10 |
2023-08-14 |
mouse |
| Sami I Alzarea, Muhammad Afzal, Metab Alharbi, Abdulrahman Alshammari, Ameeduzzafar Zafa. Renin inhibitor attenuates lipopolysaccharide-induced anhedonia and upregulation of neuroinflammatory markers in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35556749. |
proinflammatory cytokines (tnf-α, il-1β, and il-6) and glial cells markers (cd11b for microglia and gfap for astrocytes) in the prefrontal cortex were determined via rt-pcr. |
2022-05-13 |
2023-08-13 |
mouse |
| O V Vikhreva, N A Uranov. [Microglial reactivity in the prefrontal cortex in different types of schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 121. issue 12. 2022-01-18. PMID:35041316. |
to estimate microglial density and the ultrastructural parameters of microglia in the prefrontal cortex in chronic attack-like and continuous schizophrenia as compared to healthy controls. |
2022-01-18 |
2023-08-13 |
Not clear |
| Jiayu Wang, Ying Zhou, Ke Li, Xiaofeng Li, Meimei Guo, Mian Pen. A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation. Frontiers in molecular neuroscience. vol 14. 2021-12-17. PMID:34916906. |
in addition, dsp-4 treatment attenuated hippocampal-dependent learning and memory impairment in rats with pocd, with a downregulation of the activation of microglia and astrocytes in the prefrontal cortex and hippocampus. |
2021-12-17 |
2023-08-13 |
rat |
| Chenhui Ji, Yalin Tang, Yanyan Zhang, Congcong Li, Huazheng Liang, Lu Ding, Xiaohuan Xia, Lize Xiong, Xin-Rui Qi, Jialin C Zhen. Microglial glutaminase 1 deficiency mitigates neuroinflammation associated depression. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34678461. |
lps-induced anxiety/depression-like behavior was attenuated in gls1 cko mice, paralleled by a significant reduction in pro-inflammatory cytokines and an abnormal microglia morphological phenotype in the prefrontal cortex. |
2021-12-11 |
2023-08-13 |
mouse |
| Janace J Gifford, Pooja Deshpande, Priyanka Mehta, George C Wagner, Alexander W Kusneco. The Effect of Valproic Acid Exposure throughout Development on Microglia Number in the Prefrontal Cortex, Hippocampus and Cerebellum. Neuroscience. 2021-12-11. PMID:34780921. |
the effect of valproic acid exposure throughout development on microglia number in the prefrontal cortex, hippocampus and cerebellum. |
2021-12-11 |
2023-08-13 |
Not clear |
| Anuradha Tennakoon, Viythia Katharesan, Ian Francis Musgrave, Simon Andrea Koblar, Richard Lewis Maxwell Faull, Maurice Anthony Curtis, Ian Paul Johnso. Normal aging, motor neurone disease, and Alzheimer's disease are characterized by cortical changes in inflammatory cytokines. Journal of neuroscience research. 2021-12-09. PMID:34882833. |
immunocytochemistry showed that fgf-2 is expressed in neurons, astrocytes, and microglia in normal aging prefrontal cortex, ad prefrontal cortex, and mnd motor cortex. |
2021-12-09 |
2023-08-13 |
human |
| Amy C Reichelt, Claire A Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J Bussey, Lisa M Saksid. Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33692414. |
age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. |
2021-11-22 |
2023-08-13 |
mouse |
| Amy C Reichelt, Claire A Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J Bussey, Lisa M Saksid. Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33692414. |
hfhs diet increased microgliosis in the adult cohort, and morphological changes to microglia were observed in the pfc and hippocampus of the adolescent cohort, with a shift to activated microglia phenotypes. |
2021-11-22 |
2023-08-13 |
mouse |
| Noriyoshi Usui, Yuta Ono, Ryoko Aramaki, Stefano Berto, Genevieve Konopka, Hideo Matsuzaki, Shoichi Shimad. Early Life Stress Alters Gene Expression and Cytoarchitecture in the Prefrontal Cortex Leading to Social Impairment and Increased Anxiety. Frontiers in genetics. vol 12. 2021-11-20. PMID:34795694. |
in histological analysis, we found a reduced number of neurons and an increased number of microglia in the pfc of els mice. |
2021-11-20 |
2023-08-13 |
mouse |
| Vasiliy Reshetnikov, Yulia Ryabushkina, Anna Kovner, Arina Lepeshko, Natalia Bonda. Repeated and single maternal separation specifically alter microglial morphology in the prefrontal cortex and neurogenesis in the hippocampus of 15-day-old male mice. Neuroreport. vol 31. issue 18. 2021-11-15. PMID:33165192. |
immunohistochemical analysis was performed on slices of the hippocampus and prefrontal cortex (pfc) with antibodies against a marker of mature neurons (neun), of microglia (iba1), proliferating cells (ki67), and immature neurons (dcx). |
2021-11-15 |
2023-08-13 |
mouse |
| Vasiliy Reshetnikov, Yulia Ryabushkina, Anna Kovner, Arina Lepeshko, Natalia Bonda. Repeated and single maternal separation specifically alter microglial morphology in the prefrontal cortex and neurogenesis in the hippocampus of 15-day-old male mice. Neuroreport. vol 31. issue 18. 2021-11-15. PMID:33165192. |
we found higher density of ameboid microglia and intermediate microglia in the pfc in groups ms and md, respectively, than in a control group. |
2021-11-15 |
2023-08-13 |
mouse |
| Miloš Vratarić, Vladimir Šenk, Biljana Bursać, Ljupka Gligorovska, Djurdjica Ignjatović, Sanja Kovačević, Nataša Veličković, Ana Djordjevi. Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice. BioFactors (Oxford, England). 2021-11-12. PMID:34767656. |
the results showed concomitant increase of tnf-α, tlr-4, myd88 and m2 microglia markers (arg-1, mrc-1, lif) in the pfc of mif-ko, paralleled with unchanged glucocorticoid and insulin signaling. |
2021-11-12 |
2023-08-13 |
mouse |
| Wei Wang, Rui Wang, Zhijun Jiang, Haonan Li, Zemeng Zhu, Arslan Khalid, Dexiang Liu, Fang Pa. Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats. Journal of neurochemistry. vol 158. issue 4. 2021-11-11. PMID:34050937. |
the results found that ifs induced ptsd-like behaviors and indicated obvious brd4 expression in microglia of the prefrontal cortex (pfc), hippocampus, and amygdala, pro-inflammatory cytokines over-expression, microglial activation, and nuclear factor-kappa b over-expression in pfc and hippocampus but not in amygdala. |
2021-11-11 |
2023-08-13 |
rat |
| Juciano Gasparotto, Mario Roberto Senger, Emilio Telles de Sá Moreira, Pedro Ozorio Brum, Flávio Gabriel Carazza Kessler, Daniel Oppermann Peixoto, Alana Castro Panzenhagen, Lin Kooi Ong, Marlene Campos Soares, Patricia Alves Reis, Giuliana Viegas Schirato, Walter César Góes Valente, Bogar Omar Araújo Montoya, Floriano P Silva, José Claudio Fonseca Moreira, Felipe Dal-Pizzol, Hugo C Castro-Faria-Neto, Daniel Pens Gelai. Neurological impairment caused by Schistosoma mansoni systemic infection exhibits early features of idiopathic neurodegenerative disease. The Journal of biological chemistry. vol 297. issue 2. 2021-10-29. PMID:34303703. |
we observed that systemic infection with s. mansoni led to astrocyte and microglia activation, expression of oxidative stress-induced transcription factor nrf2, oxidative damage, tau phosphorylation, and amyloid-β peptide accumulation in the prefrontal cortex of infected animals. |
2021-10-29 |
2023-08-13 |
Not clear |
| Pamela Reyes-Ortega, Durairaj Ragu Varman, Verónica M Rodríguez, Daniel Reyes-Har. Anorexia induces a microglial associated pro-inflammatory environment and correlates with neurodegeneration in the prefrontal cortex of young female rats. Behavioural brain research. vol 392. 2021-10-13. PMID:32387351. |
in this study we tested if anorexia induces a pro-inflammatory environment associated with microglia in the medial prefrontal cortex (mpfc) and orbitofrontal cortex (ofc), specific subregions of the pfc involved in appetite. |
2021-10-13 |
2023-08-13 |
rat |
| Yishun Hong, Wenyao Wu, Shuo Wang, Quanshui Hao, Hua Zheng, Shiyong Li, Xianwei Zhang, Rao Su. Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord. Neuropharmacology. vol 196. 2021-10-01. PMID:34252405. |
our results showed that sps exposure increased the levels of angiotensin ii in the hippocampus, prefrontal cortex (pfc) and spinal cord; intraperitoneal injection of losartan attenuated sps-induced mechanical allodynia, and suppressed sps-induced glial activation (both microglia and astrocytes) and proinflammatory cytokine expression in the pfc and spinal cord, but not in the hippocampus. |
2021-10-01 |
2023-08-13 |
rat |
| Morgana D da Silva, Giselle Guginski, Karina L Sato, Luciana Sayuri Sanada, Kathleen A Sluka, Adair R S Santo. Persistent pain induces mood problems and memory loss by the involvement of cytokines, growth factors, and supraspinal glial cells. Brain, behavior, & immunity - health. vol 7. 2021-10-01. PMID:34589875. |
further, in our data was a decrease in the density of microglia and astrocytes in the hippocampus and increased microglial density in the prefrontal cortex, areas associated with neuropathic pain conditions. |
2021-10-01 |
2023-08-13 |
mouse |
| Ronak Mousaviyan, Nahid Davoodian, Faezeh Alizadeh, Maryam Ghasemi-Kasman, Seyed Abdollah Mousavi, Fatemeh Shaerzadeh, Haniyeh Kazem. Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation. Biological trace element research. vol 199. issue 11. 2021-09-27. PMID:33400154. |
at postnatal day 60, the density of both microglia and astrocyte cells and the expression levels of il-6, il-1β, inos, tnf-α, nf-κb, and gfap were evaluated in the pfc of male pups. |
2021-09-27 |
2023-08-13 |
rat |
| Ronak Mousaviyan, Nahid Davoodian, Faezeh Alizadeh, Maryam Ghasemi-Kasman, Seyed Abdollah Mousavi, Fatemeh Shaerzadeh, Haniyeh Kazem. Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation. Biological trace element research. vol 199. issue 11. 2021-09-27. PMID:33400154. |
although maternal lps treatment increased microglia and astrocyte density, number of neurons in the pfc of adult offspring remained unchanged. |
2021-09-27 |
2023-08-13 |
rat |