| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohle. Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress. Brain, behavior, and immunity. 2023-01-21. PMID:36681359. |
adding to this, our work showed that 14 days of chronic unpredictable stress (cus) reduced bdnf transcript in pfc microglia, evincing its relevance in the effects of stress. |
2023-01-21 |
2023-08-14 |
mouse |
| Yuki Nishikawa, Mohammed E Choudhury, Kanta Mikami, Matsuura Taisei, Madoka Kubo, Masahiro Nagai, Satoru Yamagishi, Tomomi Doi, Manami Hisai, Haruto Yamamoto, Chisato Yajima, Tasuku Nishihara, Naoki Abe, Hajime Yano, Toshihiro Yorozuya, Junya Tanak. Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model. Neurochemistry international. 2023-01-07. PMID:36608872. |
microglia in the normal mature rat prefrontal cortex (pfc) were sorted and significant expression of d1r, d2r, and d4r was observed. |
2023-01-07 |
2023-08-14 |
rat |
| Yuki Nishikawa, Mohammed E Choudhury, Kanta Mikami, Matsuura Taisei, Madoka Kubo, Masahiro Nagai, Satoru Yamagishi, Tomomi Doi, Manami Hisai, Haruto Yamamoto, Chisato Yajima, Tasuku Nishihara, Naoki Abe, Hajime Yano, Toshihiro Yorozuya, Junya Tanak. Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model. Neurochemistry international. 2023-01-07. PMID:36608872. |
increased cytokine expression was observed in sorted microglia from the pfc of the delirium model; however, tnfα, but not il-1β expression, was abruptly decreased 21 h after lps administration in the delirium model, whereas da levels were increased. |
2023-01-07 |
2023-08-14 |
rat |
| N A Uranova, O V Vikhreva, V I Rakhmanov. [Specific interactions between microglia and oligodendrocytes in white matter in continuous schizophrenia]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 122. issue 12. 2022-12-20. PMID:36537643. |
to study the ultrastructure of microglia adjacent to oligodendrocytes in white matter of the prefrontal cortex in continuous schizophrenia (csch) as compared to controls and attack-like schizophrenia (asch) and to perform correlation analysis between the parameters of microglia and adjacent oligodendrocytes previously detected in both clinical types of schizophrenia. |
2022-12-20 |
2023-08-14 |
Not clear |
| Justin L Bollinger, David T Dadosky, James K Flurer, Ivanka L Rainer, Samuel C Woodburn, Eric S Wohle. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-12-14. PMID:36517583. |
stress alters excitatory neurotransmission in the pfc, thus we aimed to determine if p2y12 signaling promotes functional changes in microglia in chronic stress. |
2022-12-14 |
2023-08-14 |
mouse |
| Justin L Bollinger, David T Dadosky, James K Flurer, Ivanka L Rainer, Samuel C Woodburn, Eric S Wohle. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-12-14. PMID:36517583. |
in line with this, pharmacological blockade of p2y12 prevented cus-induced increases in the proportion of microglia with neuronal inclusions, limited dendritic spine loss in the pfc, and attenuated alterations in stress coping behavior and working memory function. |
2022-12-14 |
2023-08-14 |
mouse |
| Liang Shen, Dan-Yang Chen, Qian-Qian Lou, Peng Cao, Rui Hu, Yan Jin, Di Wang, Shan-Shan H. Angiotensin Type 2 Receptor Pharmacological Agonist Relieves Neurocognitive Deficits via Reducing Neuroinflammation and Microglial Engulfment of Dendritic Spines. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2022-12-04. PMID:36464726. |
brain hippocampus and prefrontal cortex tissues were collected for immunofluorescence staining and western blotting to evaluate the resulting impacts on microglia, including morphological traits, functional markers, synaptic engulfment, superoxide production, and signaling molecules. |
2022-12-04 |
2023-08-14 |
mouse |
| Xingying Wu, Bowen Chen, Zhong Di, Shuo Jiang, Haipeng Xu, Mengting Shi, Rong Hu, Shaopeng Sun, Zhujin Song, Jiapeng Liu, Ruijie Ma, Qin Gu. Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model. BMC neuroscience. vol 23. issue 1. 2022-11-11. PMID:36357867. |
kyn is a precursor for qa in microglia, which could activate the n-methyl-d-aspartate receptor (nmdar), increasing the glu release, mirrored by increased ido activity, quinolinic acid and glu levels in the hippocampus, prefrontal cortex and serum. |
2022-11-11 |
2023-08-14 |
mouse |
| Tianze Yu, Yi Chen, Jiani Lu, Luyun Gong, Yuechen Mao, Xinya Liu, Yiying Zhou, Lei Guo, Xiang Wu, Junfang Zhang, Chuang Wang, Haowei Shen, Wenhua Zhou, Disen Mei, Wei Cu. Chronic multiple mild stress induces sustained adverse psychological states in rats. Neuroreport. vol 33. issue 15. 2022-09-20. PMID:36126265. |
furthermore, these antidepressants prevented the cmms-induced inhibition of brain-derived neurotrophic factor/camp-response element binding protein pathway, reduction of synaptic protein expression, and the activation of microglia and astrocytes in the hippocampus and the prefrontal cortex of rats. |
2022-09-20 |
2023-08-14 |
human |
| Chenlu Xu, Jia Zhang, Qinfeng Zhou, Juling Wang, Chenyang Liu, Yu Tian, Danni Huang, Huaizhuang Ye, Yongtang Ji. Exposure to a real traffic environment impairs brain cognition in aged mice. Environmental research. 2022-09-16. PMID:36113572. |
trap exposure increased the number of activated microglia in the hippocampal dg, ca1, ca3 regions and dorsolateral prefrontal cortex (dpfc). |
2022-09-16 |
2023-08-14 |
mouse |
| Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry. vol 13. 2022-09-12. PMID:36090351. |
transcripts more highly expressed in pfc isolated microglia were enriched for synapse-related pathways while microglia isolated from the striatum were enriched for pathways related to microtubule polymerization. |
2022-09-12 |
2023-08-14 |
mouse |
| Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C Tseng, Ryan W Logan, Marianne L Sene. Brain region- and sex-specific transcriptional profiles of microglia. Frontiers in psychiatry. vol 13. 2022-09-12. PMID:36090351. |
we also found evidence for a gradient of expression of microglia-specific transcripts across the rostral-to-caudal axes of the brain, with microglia extracted from the striatum exhibiting a transcriptional profile intermediate between that of the pfc and midbrain. |
2022-09-12 |
2023-08-14 |
mouse |
| Jelena Martinovic, Marina Zaric Kontic, Milorad Dragic, Ana Todorovic, Ivana Gusevac Stojanovic, Natasa Mitrovic, Ivana Grkovic, Dunja Drakuli. Chronic oral d-galactose intake provokes age-related changes in the rat prefrontal cortex. Behavioural brain research. 2022-08-28. PMID:36030906. |
in the pfc, analysis of microglia revealed reduction of branching pattern following d-gal intake, in parallel with increased oxidative damage of proteins, lipids and disturbed pro-oxidant antioxidant balance. |
2022-08-28 |
2023-08-14 |
rat |
| Leonardo C Souza, Marcos K Andrade, Evellyn M Azevedo, Daniele C Ramos, Ellen L Bail, Maria A B F Vita. Andrographolide Attenuates Short-Term Spatial and Recognition Memory Impairment and Neuroinflammation Induced by a Streptozotocin Rat Model of Alzheimer's Disease. Neurotoxicity research. 2022-08-27. PMID:36029454. |
in the present study, we investigated the effects of andro in the icv-stz model relative to short-term spatial memory (object location test (olt) and y maze test), short-term recognition memory (object recognition test (ort)), locomotor activity (open field test (oft)), expression of amyloid precursor protein (app), and activation of astrocytes (glial fibrillary acidic protein (gfap) expression) and microglia (ionized calcium-binding adapter molecule-1 (iba-1) immunohistochemistry) in the prefrontal cortex (pfc) and hippocampus (hip). |
2022-08-27 |
2023-08-14 |
rat |
| Sara V Blagburn-Blanco, Megan S Chappell, Lindsay M De Biase, Laura A DeNard. Synapse-specific roles for microglia in development: New horizons in the prefrontal cortex. Frontiers in molecular neuroscience. vol 15. 2022-08-25. PMID:36003220. |
synapse-specific roles for microglia in development: new horizons in the prefrontal cortex. |
2022-08-25 |
2023-08-14 |
Not clear |
| Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salu. The Antioxidant N-Acetyl-L-Cysteine Restores the Behavioral Deficits in a Neurodevelopmental Model of Schizophrenia Through a Mechanism That Involves Nitric Oxide. Frontiers in pharmacology. vol 13. 2022-07-29. PMID:35903343. |
analyses of markers involved in the inflammatory response, such as astrocytes (glial fibrillary acid protein, gfap) and microglia (binding adapter molecule 1, iba1), and parvalbumin (pv) positive gabaergic, were conducted in the prefrontal cortex [pfc, medial orbital cortex (mo) and prelimbic cortex (prl)] and dorsal and ventral hippocampus [ca1, ca2, ca3, and dentate gyrus (dg)] in rats under chronic treatment with nac. |
2022-07-29 |
2023-08-14 |
rat |
| Yunting Zhu, Maree J Webster, Caitlin E Murphy, Frank A Middleton, Paul T Massa, Chunyu Liu, Rujia Dai, Cyndi Shannon Weicker. Distinct Phenotypes of Inflammation Associated Macrophages and Microglia in the Prefrontal Cortex Schizophrenia Compared to Controls. Frontiers in neuroscience. vol 16. 2022-07-18. PMID:35844224. |
distinct phenotypes of inflammation associated macrophages and microglia in the prefrontal cortex schizophrenia compared to controls. |
2022-07-18 |
2023-08-14 |
Not clear |
| Yunting Zhu, Maree J Webster, Caitlin E Murphy, Frank A Middleton, Paul T Massa, Chunyu Liu, Rujia Dai, Cyndi Shannon Weicker. Distinct Phenotypes of Inflammation Associated Macrophages and Microglia in the Prefrontal Cortex Schizophrenia Compared to Controls. Frontiers in neuroscience. vol 16. 2022-07-18. PMID:35844224. |
to test whether microglia and/or macrophages are associated with increased inflammatory signaling in schizophrenia, we measured microglia- and macrophage-associated transcripts in the postmortem dorsolateral prefrontal cortex of 69 controls and 72 people with schizophrenia. |
2022-07-18 |
2023-08-14 |
Not clear |
| Man-Man Zhang, Guo-Ming Huo, Jie Cheng, Qiu-Ping Zhang, Na-Zhi Li, Min-Xia Guo, Qing Liu, Guang-Hui Xu, Ji-Xiao Zhu, Cheng-Fu Li, Feng Zhou, Li-Tao Y. Gypenoside XVII, an Active Ingredient from Gynostemma Pentaphyllum, Inhibits C3aR-Associated Synaptic Pruning in Stressed Mice. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745148. |
moreover, cums induced excessive synaptic pruning by activating microglia, while gypenoside xvii restored it in the prefrontal cortex. |
2022-06-24 |
2023-08-14 |
mouse |
| Daniel C Shippy, Tyler K Ullan. Exploring the zinc-related transcriptional landscape in Alzheimer's disease. IBRO neuroscience reports. vol 13. 2022-06-17. PMID:35711243. |
we identified 582 zinc-related differentially expressed genes (deg) in human dorsolateral prefrontal cortex samples of late-onset ad (load) versus non-ad controls, 146 zinc-related deg in 5xfad versus wild-type mice, and 95 zinc-related deg in lipopolysaccharide (lps)-stimulated n9 microglia versus unstimulated control cells, with 19 zinc-related deg common to all three datasets. |
2022-06-17 |
2023-08-14 |
mouse |