| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ronak Mousaviyan, Nahid Davoodian, Faezeh Alizadeh, Maryam Ghasemi-Kasman, Seyed Abdollah Mousavi, Fatemeh Shaerzadeh, Haniyeh Kazem. Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation. Biological trace element research. vol 199. issue 11. 2021-09-27. PMID:33400154. |
although maternal lps treatment increased microglia and astrocyte density, number of neurons in the pfc of adult offspring remained unchanged. |
2021-09-27 |
2023-08-13 |
rat |
| Ronak Mousaviyan, Nahid Davoodian, Faezeh Alizadeh, Maryam Ghasemi-Kasman, Seyed Abdollah Mousavi, Fatemeh Shaerzadeh, Haniyeh Kazem. Zinc Supplementation During Pregnancy Alleviates Lipopolysaccharide-Induced Glial Activation and Inflammatory Markers Expression in a Rat Model of Maternal Immune Activation. Biological trace element research. vol 199. issue 11. 2021-09-27. PMID:33400154. |
maternal zinc supplementation alleviated increased expression levels of inflammatory mediators and microglia and astrocyte density induced by lps in the pfc of treated offspring. |
2021-09-27 |
2023-08-13 |
rat |
| Livia J De Picker, Gerardo Mendez Victoriano, Rhys Richards, Alexander J Gorvett, Simeon Lyons, George R Buckland, Tommaso Tofani, Jeanette L Norman, David S Chatelet, James A R Nicoll, Delphine Boch. Immune environment of the brain in schizophrenia and during the psychotic episode: A human post-mortem study. Brain, behavior, and immunity. vol 97. 2021-09-22. PMID:34339805. |
dorsal prefrontal cortex of 40 controls (22f:18m) and 37 (10f:27m) schizophrenia cases, of whom 16 had active psychotic symptoms at the time of death, was immunostained for seven markers of microglia (cd16, cd32a, cd64, cd68, hla-dr, iba1 and p2ry12), two markers for perivascular macrophages (cd163 and cd206) and t-lymphocytes (cd3). |
2021-09-22 |
2023-08-13 |
human |
| Marina Gabaglio, Erica Zamberletti, Cristina Manenti, Daniela Parolaro, Tiziana Rubin. Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats. International journal of molecular sciences. vol 22. issue 16. 2021-09-20. PMID:34445602. |
cbd content is able to mitigate some of the long-term behavioral alterations induced by adolescent thc exposure as well as long-term changes in cb1 receptor and microglia activation in the prefrontal cortex (pfc). |
2021-09-20 |
2023-08-13 |
rat |
| Yong Yang, Tamaki Ishima, Xiayun Wan, Yan Wei, Lijia Chang, Jiancheng Zhang, Youge Qu, Kenji Hashimot. Microglial depletion and abnormalities in gut microbiota composition and short-chain fatty acids in mice after repeated administration of colony stimulating factor 1 receptor inhibitor PLX5622. European archives of psychiatry and clinical neuroscience. 2021-09-04. PMID:34480631. |
repeated administration of plx5622 caused significant reductions of the expression of genes and proteins for microglial markers in the prefrontal cortex (pfc) and hippocampus compared to control mice although the elimination of brain's microglia was partial. |
2021-09-04 |
2023-08-13 |
mouse |
| Yangping Shentu, Qiuyun Tian, Jinge Yang, Xiaoyuan Liu, Yujiao Han, Dichen Yang, Nan Zhang, Xiaofang Fan, Ping Wang, Jianshe Ma, Ran Chen, Dantong Li, Shouting Liu, Yongyu Wang, Sunzhong Mao, Yongsheng Gong, Congkuo Du, Junming Fa. Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice. Behavioural brain research. vol 408. 2021-09-02. PMID:33865886. |
we found that kdm6b, vgll4, interleukin-1β (il-1β), and ionized calcium-binding adaptor molecule-1 (iba-1, microglia marker) protein levels were increased in lps-dose dependent manner in the hippocampus but not in prefrontal cortex. |
2021-09-02 |
2023-08-13 |
mouse |
| Marianela Evelyn Traetta, Nonthué Alejandra Uccelli, Sandra Cristina Zárate, Dante Gómez Cuautle, Alberto Javier Ramos, Analía Reiné. Long-Lasting Changes in Glial Cells Isolated From Rats Subjected to the Valproic Acid Model of Autism Spectrum Disorder. Frontiers in pharmacology. vol 12. 2021-08-24. PMID:34421599. |
or saline (control) at embryonic day 10.5 were used to study synapses, microglia, and astroglia in the prefrontal cortex (pfc) at postnatal days 3 and 35 (pnd3 and pnd35). |
2021-08-24 |
2023-08-13 |
rat |
| Marianela Evelyn Traetta, Nonthué Alejandra Uccelli, Sandra Cristina Zárate, Dante Gómez Cuautle, Alberto Javier Ramos, Analía Reiné. Long-Lasting Changes in Glial Cells Isolated From Rats Subjected to the Valproic Acid Model of Autism Spectrum Disorder. Frontiers in pharmacology. vol 12. 2021-08-24. PMID:34421599. |
at pnd3, microglia and astroglia from vpa animals were morphologically similar to those of age-matched controls, whereas at pnd35, reactive microgliosis and astrogliosis were observed in the pfc of vpa animals. |
2021-08-24 |
2023-08-13 |
rat |
| N A Uranova, O V Vikhreva, V I Rakhmanov. Abnormal microglial reactivity in gray matter of the prefrontal cortex in schizophrenia. Asian journal of psychiatry. vol 63. 2021-08-17. PMID:34274629. |
the study provides evidence for microgliosis associated with age, duration of disease and age at onset of disease, progressive dystrophy and accelerated aging of microglia in gray matter of the prefrontal cortex in schizophrenia. |
2021-08-17 |
2023-08-13 |
Not clear |
| Wadzanai Manjeese, Nontobeko E Mvubu, Adrie J C Steyn, Thabisile Mpofan. Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-05. PMID:33932039. |
neuroinflammation was measured by assessing microglia and astrocyte population in the prefrontal cortex (pfc) and cerebellum (cer) of pups. |
2021-08-05 |
2023-08-13 |
mouse |
| Wadzanai Manjeese, Nontobeko E Mvubu, Adrie J C Steyn, Thabisile Mpofan. Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-05. PMID:33932039. |
mtb infection increased the microglia population and caused morphological changes to a reactive phenotype in the pfc. |
2021-08-05 |
2023-08-13 |
mouse |
| Liang He, Yury Loika, Yongjin Park, David A Bennett, Manolis Kellis, Alexander M Kulminsk. Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33637690. |
our cell-type-specific eqtl analysis using ~80,000 single nuclei in the prefrontal cortex revealed that the protective minor allele of rs12373123 significantly increased the expression of grn in microglia, and was associated with mapt expression in astrocytes. |
2021-06-28 |
2023-08-13 |
human |
| Noriyoshi Usui, Stefano Berto, Ami Konishi, Makoto Kondo, Genevieve Konopka, Hideo Matsuzaki, Shoichi Shimad. Zbtb16 regulates social cognitive behaviors and neocortical development. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33895774. |
furthermore, we found increased dendritic spines and microglia, as well as developmental defects in oligodendrocytes and neocortical myelination in the prefrontal cortex (pfc) of zbtb16 ko mice. |
2021-06-28 |
2023-08-13 |
mouse |
| Justin L Bollinger, Matthew J Horchar, Eric S Wohle. Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 10. 2021-06-23. PMID:32454511. |
our recent findings indicate that microglia contribute to structural remodeling of neurons via increased colony-stimulating factor (csf)-1 in the medial pfc. |
2021-06-23 |
2023-08-13 |
mouse |
| Justin L Bollinger, Matthew J Horchar, Eric S Wohle. Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 10. 2021-06-23. PMID:32454511. |
other work shows that chronic stress induces aberrant neuronal activity in the medial pfc, and that neuronal hyperactivity increases csf1 signaling and alters microglia function. |
2021-06-23 |
2023-08-13 |
mouse |
| Justin L Bollinger, Matthew J Horchar, Eric S Wohle. Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 10. 2021-06-23. PMID:32454511. |
further studies showed that diazepam normalized csf1 and c3 mrna in the pfc, and prevented increases in csf1r and cd11b in frontal cortex microglia following cus. |
2021-06-23 |
2023-08-13 |
mouse |
| Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihar. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology. vol 456. 2021-06-22. PMID:33872730. |
the effects of acrylamide were examined by landing foot spread test, immunohistochemistry for noradrenaline (na) and serotonin (5-ht)-containing axons and iba1-positive microglia in the prefrontal cortex as well as quantitative real-time polymerase chain reaction (qrt-pcr) on antioxidant, proinflammatory and anti-inflammatory genes in the prefrontal cortex. |
2021-06-22 |
2023-08-13 |
mouse |
| Jie Chen, Haochen Wang, Chengliang Luo, Cheng Gao, Yalai Zhang, Guang Chen, Wei Chen, Xiping Chen, Luyang Ta. Chd8 Rescued TBI-Induced Neurological Deficits by Suppressing Apoptosis and Autophagy Via Wnt Signaling Pathway. Cellular and molecular neurobiology. vol 40. issue 7. 2021-06-11. PMID:32034634. |
in vivo, we found that chd8 co-localized in neurons, astrocytes, and microglia, but predominantly presented in neurons in the prefrontal cortex, hippocampus, and cortex. |
2021-06-11 |
2023-08-13 |
Not clear |
| Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye, Wei-Jye Li. Repetitive transcranial magnetic stimulation increases the brain's drainage efficiency in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 9. issue 1. 2021-06-07. PMID:34078467. |
significant reduction of aβ deposits, suppression of microglia and astrocyte activation, and prevention of decline of neuronal activity as indicated by the elevated c-fos expression, were observed in the prefrontal cortex and hippocampus of the rtms-treated 5xfad mice. |
2021-06-07 |
2023-08-13 |
mouse |
| Ahmed M Mohamed, Mohamed Z Habib, Mai A Ebeid, Sahar M Abdelraouf, Yasser El Faramawy, Sawsan Aboul-Fotouh, Yosra Magd. Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway. European journal of pharmacology. vol 885. 2021-05-18. PMID:32800810. |
amisulpride alleviates chronic mild stress-induced cognitive deficits: role of prefrontal cortex microglia and wnt/β-catenin pathway. |
2021-05-18 |
2023-08-13 |
rat |