| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liu Yang, Zhen Li, Zujin Xu, Bin Zhang, Anpeng Liu, Feng Zheng, Jia Zha. Protective effects of cannabinoid type 2 receptor against microglia overactivation and neuronal pyroptosis in sepsis-associated encephalopathy. Neuroscience. 2022-04-23. PMID:35460837. |
protective effects of cannabinoid type 2 receptor against microglia overactivation and neuronal pyroptosis in sepsis-associated encephalopathy. |
2022-04-23 |
2023-08-13 |
Not clear |
| Alexander P Young, Eileen M Denovan-Wrigh. The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation. Frontiers in pharmacology. vol 12. 2022-02-21. PMID:35185547. |
the dynamic role of microglia and the endocannabinoid system in neuroinflammation. |
2022-02-21 |
2023-08-13 |
Not clear |
| Alexander P Young, Eileen M Denovan-Wrigh. The Dynamic Role of Microglia and the Endocannabinoid System in Neuroinflammation. Frontiers in pharmacology. vol 12. 2022-02-21. PMID:35185547. |
the endocannabinoid system has been identified as a promising therapeutic target for chronic neuroinflammation as there is evidence that synthetic and endogenously produced cannabinoids temper the pro-inflammatory response of microglia and may encourage a switch to an anti-inflammatory phenotype. |
2022-02-21 |
2023-08-13 |
Not clear |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, Meghna Yammanur, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. Experimental eye research. 2022-02-10. PMID:35143834. |
raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. |
2022-02-10 |
2023-08-13 |
mouse |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, Meghna Yammanur, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene, a cannabinoid type-2 receptor inverse agonist, mitigates visual deficits and pathology and modulates microglia after ocular blast. Experimental eye research. 2022-02-10. PMID:35143834. |
cannabinoid type-2 receptor (cb2) inverse agonists specifically target activated microglia, biasing them away from the harmful pro-inflammatory m1 state toward the helpful reparative m2 state. |
2022-02-10 |
2023-08-13 |
mouse |
| Liana V Basova, Savannah Eve Lukkes, Richard Milner, Ronald J Ellis, Mariana Cherner, Jennifer Iudicello, Maria Cecilia Garibaldi Marconde. Polygenic networks in peripheral leukocytes indicate patterns associated with HIV infection and context-dependent effects of cannabis use. Brain, behavior, & immunity - health. vol 20. 2022-02-07. PMID:35128491. |
importantly, the hiv brain target cells, macrophages and microglia, express receptors to neurotransmitters elevated by such drugs, and express receptors to cannabinoids, particularly cb2r. |
2022-02-07 |
2023-08-13 |
human |
| Valerie L Joers, Hannah Staley, Maclean Bassett, Brenda D Moore, Malu Gamez Tanse. The role of cannabinoid receptor 2 in microglial clearance of human tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109165. |
cannabinoid type 2 receptors (cb2) are highly expressed in immune cells and upregulated in activated microglia under conditions of neurologic disease, such as ad. |
2022-02-03 |
2023-08-13 |
human |
| Nynke J van den Hoogen, Erika K Harding, Chloé E D Davidson, Tuan Tran. Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation. Frontiers in neural circuits. vol 15. 2022-01-24. PMID:35069129. |
cannabinoids in chronic pain: therapeutic potential through microglia modulation. |
2022-01-24 |
2023-08-13 |
Not clear |
| Alba García-Baos, Laia Alegre-Zurano, Lídia Cantacorps, Ana Martín-Sánchez, Olga Valverd. Role of cannabinoids in alcohol-induced neuroinflammation. Progress in neuro-psychopharmacology & biological psychiatry. vol 104. 2021-11-22. PMID:32758518. |
furthermore, a number of cannabinoids are able to activate complementary anti-inflammatory pathways, which are necessary for the transition from chronically overactivated microglia to a regenerative microglial phenotype. |
2021-11-22 |
2023-08-13 |
Not clear |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Dylan O'Neal, John B Doty, Rachel Cox, Chunyan Li, Aaron M Perry, Bob M Moore, Anton Reine. Raloxifene Modulates Microglia and Rescues Visual Deficits and Pathology After Impact Traumatic Brain Injury. Frontiers in neuroscience. vol 15. 2021-11-17. PMID:34776838. |
the upregulation of cannabinoid type-2 receptors (cb2) when microglia become activated allows cb2-binding drugs to selectively target microglia. |
2021-11-17 |
2023-08-13 |
mouse |
| Fatma Nihan Cankara, Zülfinaz Betül Çelik, Caner Günaydı. Cannabinoid receptors modulate LPS-induced increase of class-II transactivator expression levels in a microglial cell line. Journal of receptor and signal transduction research. vol 41. issue 3. 2021-11-12. PMID:33401964. |
cannabinoid receptors modulate lps-induced increase of class-ii transactivator expression levels in a microglial cell line. |
2021-11-12 |
2023-08-13 |
human |
| Álvaro Moreno-García, Ana Bernal-Chico, Teresa Colomer, Alfredo Rodríguez-Antigüedad, Carlos Matute, Susana Mat. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination. Biomolecules. vol 10. issue 9. 2021-09-07. PMID:32846891. |
gene expression analysis of astrocyte and microglia endocannabinoid signaling during autoimmune demyelination. |
2021-09-07 |
2023-08-13 |
mouse |
| Álvaro Moreno-García, Ana Bernal-Chico, Teresa Colomer, Alfredo Rodríguez-Antigüedad, Carlos Matute, Susana Mat. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination. Biomolecules. vol 10. issue 9. 2021-09-07. PMID:32846891. |
here we used a microfluidic rt-qpcr screen to assess changes in the expression of the main endocannabinoid signaling genes in astrocytes and microglia purified from female mice during the time-course of experimental autoimmune encephalomyelitis (eae). |
2021-09-07 |
2023-08-13 |
mouse |
| Álvaro Moreno-García, Ana Bernal-Chico, Teresa Colomer, Alfredo Rodríguez-Antigüedad, Carlos Matute, Susana Mat. Gene Expression Analysis of Astrocyte and Microglia Endocannabinoid Signaling during Autoimmune Demyelination. Biomolecules. vol 10. issue 9. 2021-09-07. PMID:32846891. |
our results demonstrate that astrocytes and microglia responses to autoimmune demyelination involve alterations in the expression of multiple endocannabinoid signaling-associated genes and suggest that this system may regulate the induction of neurotoxic and pro-inflammatory transcriptional programs in both cell types during ms. |
2021-09-07 |
2023-08-13 |
mouse |
| Samuel S Duffy, Jessica P Hayes, Nathan T Fiore, Gila Moalem-Taylo. The cannabinoid system and microglia in health and disease. Neuropharmacology. vol 190. 2021-06-09. PMID:33845074. |
homeostatic microglia synthesise the endogenous cannabinoids 2-arachidonoylglycerol and anandamide and express the cannabinoid receptors cb1 and cb2 at constitutively low levels. |
2021-06-09 |
2023-08-13 |
Not clear |
| Qing-Rong Liu, Ana Canseco-Alba, Ying Liang, Hiroki Ishiguro, Emmanuel S Onaiv. Low Basal CB2R in Dopamine Neurons and Microglia Influences Cannabinoid Tetrad Effects. International journal of molecular sciences. vol 21. issue 24. 2021-04-02. PMID:33371336. |
low basal cb2r in dopamine neurons and microglia influences cannabinoid tetrad effects. |
2021-04-02 |
2023-08-13 |
mouse |
| Jorge Carrera, Jensen Tomberlin, John Kurtz, Eda Karakaya, Mehmet Bostanciklioglu, Onder Albayra. Endocannabinoid Signaling for GABAergic-Microglia (Mis)Communication in the Brain Aging. Frontiers in neuroscience. vol 14. 2021-02-23. PMID:33613174. |
the endocannabinoid system (ecs) is emerging as a regulator of microglia and the neuronal-microglia communication system. |
2021-02-23 |
2023-08-13 |
Not clear |
| Jorge Carrera, Jensen Tomberlin, John Kurtz, Eda Karakaya, Mehmet Bostanciklioglu, Onder Albayra. Endocannabinoid Signaling for GABAergic-Microglia (Mis)Communication in the Brain Aging. Frontiers in neuroscience. vol 14. 2021-02-23. PMID:33613174. |
interestingly, if endocannabinoid signaling on gabaergic neurons are disturbed, the phenotypes mimic central nervous system insult models by activating microglia and leading to accelerated brain aging. |
2021-02-23 |
2023-08-13 |
Not clear |
| Huan Liu, Rehana K Leak, Xiaoming H. Neurotransmitter receptors on microglia. Stroke and vascular neurology. vol 1. issue 2. 2021-01-18. PMID:28959464. |
here we review data supporting the importance of neurotransmitter receptors on microglia, with a special emphasis on glutamate, γ-aminobutyric acid (gaba), norepinephrine, cannabinoid and acetylcholine receptors. |
2021-01-18 |
2023-08-13 |
Not clear |
| Andreas Jäger, Maria Setiawan, Eva Beins, Ingo Schmidt-Wolf, Anna Konerman. Analogous modulation of inflammatory responses by the endocannabinoid system in periodontal ligament cells and microglia. Head & face medicine. vol 16. issue 1. 2020-11-19. PMID:33190638. |
analogous modulation of inflammatory responses by the endocannabinoid system in periodontal ligament cells and microglia. |
2020-11-19 |
2023-08-13 |
Not clear |