| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mikiei Tanaka, Sean Moran, Jie Wen, Kwame Affram, Tinghua Chen, Aviva J Symes, Yumin Zhan. WWL70 attenuates PGE Journal of neuroinflammation. vol 14. issue 1. 2017-10-13. PMID:28086912. |
wwl70 attenuates pge α/β-hydrolase domain 6 (abhd6) is one of the major enzymes for endocannabinoid 2-arachidonoylglycerol (2-ag) hydrolysis in microglia cells. |
2017-10-13 |
2023-08-13 |
Not clear |
| M Mecha, F J Carrillo-Salinas, A Feliú, L Mestre, C Guaz. Microglia activation states and cannabinoid system: Therapeutic implications. Pharmacology & therapeutics. vol 166. 2017-07-31. PMID:27373505. |
microglia has a functional endocannabinoid (ecb) signaling system, composed of cannabinoid receptors and the complete machinery for the synthesis and degradation of ecbs. |
2017-07-31 |
2023-08-13 |
Not clear |
| M Mecha, F J Carrillo-Salinas, A Feliú, L Mestre, C Guaz. Microglia activation states and cannabinoid system: Therapeutic implications. Pharmacology & therapeutics. vol 166. 2017-07-31. PMID:27373505. |
the expression of cannabinoid receptors - mainly cb2 - and the production of ecbs have been related to the activation profile of these cells and therefore, the microglial phenotype, emerging as one of the mechanisms by which microglia becomes alternatively activated. |
2017-07-31 |
2023-08-13 |
Not clear |
| C Connolly, A Magnusson-Lind, G Lu, P K Wagner, A L Southwell, M R Hayden, M Björkqvist, B R Leavit. Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin. Neuroscience. vol 325. 2017-06-07. PMID:27033979. |
increased cytokine release in yac128 microglia can be blocked by cannabinoid activation or by mutant huntingtin knockdown with anti-sense oligonucleotide treatment. |
2017-06-07 |
2023-08-13 |
mouse |
| Andreu Viader, Daisuke Ogasawara, Christopher M Joslyn, Manuel Sanchez-Alavez, Simone Mori, William Nguyen, Bruno Conti, Benjamin F Cravat. A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation. eLife. vol 5. 2017-01-10. PMID:26779719. |
we uncover compelling evidence for the cellular compartmentalization of key chemical transmission pathways, including the functional segregation of endocannabinoid (ecb) biosynthetic enzymes diacylglycerol lipase-alpha (daglα) and -beta (daglβ) to neurons and microglia, respectively. |
2017-01-10 |
2023-08-13 |
mouse |
| Zoltán Benyó, Éva Ruisanchez, Miriam Leszl-Ishiguro, Péter Sándor, Pál Pache. Endocannabinoids in cerebrovascular regulation. American journal of physiology. Heart and circulatory physiology. vol 310. issue 7. 2016-08-19. PMID:26825517. |
all major cell types involved in cerebrovascular control pathways (i.e., smooth muscle, endothelium, neurons, astrocytes, pericytes, microglia, and leukocytes) are capable of synthesizing endocannabinoids and/or express some or several of their target proteins [i.e., the cannabinoid 1 and 2 (cb1 and cb2) receptors and the transient receptor potential vanilloid type 1 ion channel]. |
2016-08-19 |
2023-08-13 |
Not clear |
| Susan Fung, Allison E Cherry, Cong Xu, Nephi Stell. Alkylindole-sensitive receptors modulate microglial cell migration and proliferation. Glia. vol 63. issue 10. 2016-05-03. PMID:25914169. |
previous studies reported that win-2 activates an additional unknown gpcr that is not activated by plant-derived cannabinoids, and evidence indicates that microglia express these receptors. |
2016-05-03 |
2023-08-13 |
mouse |
| Jun Tang, Yihao Tao, Liang Tan, Liming Yang, Yin Niu, Qianwei Chen, Yunfeng Yang, Hua Feng, Zhi Chen, Gang Zh. Cannabinoid receptor 2 attenuates microglial accumulation and brain injury following germinal matrix hemorrhage via ERK dephosphorylation in vivo and in vitro. Neuropharmacology. vol 95. 2016-03-24. PMID:25963415. |
overall, these findings suggest that activation of the endocannabinoid system might attenuate inflammation-induced secondary brain injury after gmh in rats by reducing microglia accumulation through a mechanism involving erk dephosphorylation. |
2016-03-24 |
2023-08-13 |
rat |
| Sabrina F Lisboa, Felipe V Gomes, Francisco S Guimaraes, Alline C Campo. Microglial Cells as a Link between Cannabinoids and the Immune Hypothesis of Psychiatric Disorders. Frontiers in neurology. vol 7. 2016-02-09. PMID:26858686. |
cannabinoids regulate the brain-immune axis and inhibit microglial cell activation. |
2016-02-09 |
2023-08-13 |
Not clear |
| Anton Reiner, Scott A Heldt, Chaela S Presley, Natalie H Guley, Andrea J Elberger, Yunping Deng, Lauren D'Surney, Joshua T Rogers, Jessica Ferrell, Wei Bu, Nobel Del Mar, Marcia G Honig, Steven N Gurley, Bob M Moor. Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189. International journal of molecular sciences. vol 16. issue 1. 2015-09-14. PMID:25561230. |
because microglial activation can worsen brain damage after a concussive event and because microglia can be modulated by their cannabinoid type 2 receptors (cb2), we evaluated the effectiveness of the novel cb2 receptor inverse agonist smm-189 in altering microglial activation and mitigating deficits after mild tbi. |
2015-09-14 |
2023-08-13 |
mouse |
| Livia C M Rodrigues, Pedro H Gobira, Antonio Carlos de Oliveira, Renan Pelição, Antonio Lucio Teixeira, Fabricio A Moreira, Alline Cristina Campo. Neuroinflammation as a possible link between cannabinoids and addiction. Acta neuropsychiatrica. vol 26. issue 6. 2015-07-10. PMID:25455257. |
studies demonstrated that (endo)cannabinoids act as immunomodulators by inhibiting cytokines production and microglial cell activation. |
2015-07-10 |
2023-08-13 |
Not clear |
| Lei Ma, Ji Jia, Xiangyu Liu, Fuhai Bai, Qiang Wang, Lize Xion. Activation of murine microglial N9 cells is attenuated through cannabinoid receptor CB2 signaling. Biochemical and biophysical research communications. vol 458. issue 1. 2015-05-06. PMID:25637536. |
in this study, we used lipopolysaccharide (lps) plus interferon-γ (ifnγ) to activate n9 microglia and hypothesized the pretreatment with cannabinoid cb2 receptor agonist am1241 attenuates microglial activation by shifting microglial m1 to m2 state. |
2015-05-06 |
2023-08-13 |
Not clear |
| R Ribeiro, F Yu, J Wen, A Vana, Y Zhan. Therapeutic potential of a novel cannabinoid agent CB52 in the mouse model of experimental autoimmune encephalomyelitis. Neuroscience. vol 254. 2015-02-23. PMID:24036373. |
using primary cultures of mature oligodendrocytes, we tested the effect of a novel synthetic cannabinoid cb52 on oligodendrocyte toxicity induced by peroxynitrite, the primary toxic species released by microglia. |
2015-02-23 |
2023-08-12 |
mouse |
| Elizabeth J Rahn, Liting Deng, Ganesh A Thakur, Kiran Vemuri, Alexander M Zvonok, Yvonne Y Lai, Alexandros Makriyannis, Andrea G Hohman. Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery. Molecular pain. vol 10. 2014-10-17. PMID:24742127. |
the impact of chronic drug infusion on transcriptional regulation of mrna markers of astrocytes (gfap), microglia (cd11b) and cannabinoid receptors (cb1, cb2) was assessed in lumbar spinal cords of paclitaxel and vehicle-treated rats. |
2014-10-17 |
2023-08-13 |
rat |
| Shuxian Hu, Wen S Sheng, R Bryan Roc. CB2 receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120. PloS one. vol 8. issue 10. 2014-08-05. PMID:24147028. |
synthetic cannabinoids inhibit hiv-1 expression in human microglia, suppress production of inflammatory mediators in human astrocytes, and there is substantial literature demonstrating the neuroprotective properties of cannabinoids in other neuropathogenic processes. |
2014-08-05 |
2023-08-12 |
human |
| Shuxian Hu, Wen S Sheng, R Bryan Roc. CB2 receptor agonists protect human dopaminergic neurons against damage from HIV-1 gp120. PloS one. vol 8. issue 10. 2014-08-05. PMID:24147028. |
these data suggest that synthetic cannabinoids are capable of protecting human dopaminergic neurons from gp120 in a variety of ways, acting principally through the cb2 receptors and microglia. |
2014-08-05 |
2023-08-12 |
human |
| Marylou V Solbrig, Yijun Fan, Paul Hazelto. Prospects for cannabinoid therapies in viral encephalitis. Brain research. vol 1537. 2014-06-25. PMID:24021420. |
thus, hu-308 action on cb2 receptors, receptors known to be renewed during microglia proliferation and action, is a nontolerizing mechanism of controlling cns inflammation during viral encephalitis by reducing microglia activation, as well as partially limiting viral infection, and uses a nonpsychotropic cannabinoid agonist. |
2014-06-25 |
2023-08-12 |
rat |
| David Fernández-López, Ignacio Lizasoain, Maria Angeles Moro, José Martínez-Orgad. Cannabinoids: well-suited candidates for the treatment of perinatal brain injury. Brain sciences. vol 3. issue 3. 2014-06-25. PMID:24961520. |
an early responder to neuronal injury, the endocannabinoid system has been described as an endogenous neuroprotective system that once activated can prevent glutamate excitotoxicity, intracellular calcium accumulation, activation of cell death pathways, microglia activation, neurovascular reactivity and infiltration of circulating leukocytes across the blood-brain barrier. |
2014-06-25 |
2023-08-13 |
Not clear |
| Russell L Blayloc. Immunology primer for neurosurgeons and neurologists part 2: Innate brain immunity. Surgical neurology international. vol 4. 2014-06-24. PMID:24083053. |
a great number of biological systems alter microglia function, including neurohormones, cannabinoids, other neurotransmitters, adenosine triphosphate (atp), adenosine, and corticosteroids. |
2014-06-24 |
2023-08-12 |
Not clear |
| Weimin Kong, Hongbo Li, Ronald F Tuma, Doina Gane. Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS. Cellular immunology. vol 287. issue 1. 2014-03-10. PMID:24342422. |
cb2, the cannabinoid receptor expressed primarily on hematopoietic cells and activated microglia, mediates the immunoregulatory functions of cannabinoids. |
2014-03-10 |
2023-08-12 |
Not clear |