| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andreas Jäger, Maria Setiawan, Eva Beins, Ingo Schmidt-Wolf, Anna Konerman. Analogous modulation of inflammatory responses by the endocannabinoid system in periodontal ligament cells and microglia. Head & face medicine. vol 16. issue 1. 2020-11-19. PMID:33190638. |
as these two cell types manifest similarities in their immunomodulatory behavior, this study investigated the thesis that the immunological features of pdl cells might be modulated by the endocannabinoid system, as seen for microglia. |
2020-11-19 |
2023-08-13 |
Not clear |
| Rachel Kelly, Valerie Joers, Malú G Tansey, Declan P McKernan, Eilís Dow. Microglial Phenotypes and Their Relationship to the Cannabinoid System: Therapeutic Implications for Parkinson's Disease. Molecules (Basel, Switzerland). vol 25. issue 3. 2020-11-05. PMID:31973235. |
microglia have a functional endocannabinoid signaling system, expressing the cannabinoid receptors in addition to being capable of synthesizing and degrading endocannabinoids. |
2020-11-05 |
2023-08-13 |
Not clear |
| Sarah J Spencer, Aniko Korosi, Sophie Layé, Barbara Shukitt-Hale, Ruth M Barriento. Food for thought: how nutrition impacts cognition and emotion. NPJ science of food. vol 1. 2020-10-01. PMID:31304249. |
low dietary intake of omega-3 polyunsaturated fatty acids can also contribute to depression through its effects on endocannabinoid and inflammatory pathways in specific brain regions leading to synaptic phagocytosis by microglia in the hippocampus, contributing to memory loss. |
2020-10-01 |
2023-08-13 |
Not clear |
| Urszula Hohmann, Markus Pelzer, Joshua Kleine, Tim Hohmann, Chalid Ghadban, Faramarz Dehghan. Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31787870. |
opposite effects of neuroprotective cannabinoids, palmitoylethanolamide, and 2-arachidonoylglycerol on function and morphology of microglia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Wei Bu, Huiling Ren, Yunping Deng, Nobel Del Mar, Natalie M Guley, Bob M Moore, Marcia G Honig, Anton Reine. Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist. Frontiers in neuroscience. vol 10. 2020-09-30. PMID:27766068. |
we have also shown that these functional deficits are reduced by targeting microglia through their cannabinoid type-2 (cb2) receptors using 2-week daily administration of the cb2 inverse agonist smm-189. |
2020-09-30 |
2023-08-13 |
mouse |
| Erica Zamberletti, Marina Gabaglio, Marie Woolley-Roberts, Sharon Bingham, Tiziana Rubino, Daniela Parolar. Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31447649. |
as dysregulations in the endocannabinoid system and neuroinflammatory markers contribute to the development of some asd phenotypes in the vpa model, neurochemical studies were performed after symptomatic treatment to investigate possible cbdv's effects on the endocannabinoid system, inflammatory markers and microglia activation in the hippocampus and prefrontal cortex. |
2020-09-29 |
2023-08-13 |
rat |
| Mikiei Tanaka, Scott Sackett, Yumin Zhan. Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology. Frontiers in neurology. vol 11. 2020-09-28. PMID:32117037. |
we hypothesize that cannabinoid 2 receptor (cb2r) signaling shifts the balance of expression between neuroinflammatory (m1-type) genes, neuroprotective (m2-type) genes, and homeostatic (m0-type) genes toward the latter two gene expressions, by which microglia acquire therapeutic functionality. |
2020-09-28 |
2023-08-13 |
Not clear |
| Miriam Mecha, Francisco J Carrillo-Salinas, Ana Feliú, Leyre Mestre, Carmen Guaz. Perspectives on Cannabis-Based Therapy of Multiple Sclerosis: A Mini-Review. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32140100. |
hence, the effects of cannabinoids on cells of the immune system, on the blood-brain barrier (bbb), microglia, astrocytes, oligodendrocytes and neurons, potentially open the way for a plethora of therapeutic actions on different targets that could aid the management of ms. as such, cannabinoids could have an important impact on the outcome of ms in terms of the resolution of inflammation or the potentiation of endogenous repair in the central nervous system (cns), as witnessed in the eae, tmev-idd and toxic demyelination models, and through other |
2020-09-28 |
2023-08-13 |
mouse |
| Rafael Franco, Irene Reyes-Resina, David Aguinaga, Alejandro Lillo, Jasmina Jiménez, Iu Raïch, Dasiel O Borroto-Escuela, Carlos Ferreiro-Vera, Enric I Canela, Verónica Sánchez de Medina, Anna Del Ser-Badia, Kjell Fuxe, Carlos A Saura, Gemma Navarr. Potentiation of cannabinoid signaling in microglia by adenosine A Glia. vol 67. issue 12. 2020-04-13. PMID:31429130. |
potentiation of cannabinoid signaling in microglia by adenosine a neuroprotective m2-skewed microglia appear as promising to alter the course of neurodegenerative diseases and g protein-coupled receptors (gpcrs) are potential targets to achieve such microglial polarization. |
2020-04-13 |
2023-08-13 |
Not clear |
| M Mecha, N Yanguas-Casás, A Feliú, L Mestre, F Carrillo-Salinas, I Azcoitia, V W Yong, C Guaz. The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia. Brain, behavior, and immunity. vol 77. 2020-02-25. PMID:30582962. |
the endocannabinoid 2-ag enhances spontaneous remyelination by targeting microglia. |
2020-02-25 |
2023-08-13 |
Not clear |
| M Mecha, N Yanguas-Casás, A Feliú, L Mestre, F Carrillo-Salinas, I Azcoitia, V W Yong, C Guaz. The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia. Brain, behavior, and immunity. vol 77. 2020-02-25. PMID:30582962. |
pharmacological treatment with the endocannabinoid 2-ag enhances the clearance of myelin debris by microglia and opc differentiation, resulting in complete remyelination and a thickening of the myelin sheath. |
2020-02-25 |
2023-08-13 |
Not clear |
| Marcia G Honig, Nobel A Del Mar, Desmond L Henderson, Tyler D Ragsdale, John B Doty, Jake H Driver, Chunyan Li, Andrew P Fortugno, William M Mitchell, Aaron M Perry, Bob M Moore, Anton Reine. Amelioration of visual deficits and visual system pathology after mild TBI via the cannabinoid Type-2 receptor inverse agonism of raloxifene. Experimental neurology. vol 322. 2020-02-24. PMID:31518568. |
we have found that treatment with the cannabinoid type-2 receptor (cb2) inverse agonist smm-189 for 2 weeks after closed-head blast tbi greatly attenuates the visual deficits and retinal pathology this otherwise produces in mice, by modulating the deleterious role of microglia in the injury process after trauma. |
2020-02-24 |
2023-08-13 |
mouse |
| Natalie M Guley, Nobel A Del Mar, Tyler Ragsdale, Chunyan Li, Aaron M Perry, Bob M Moore, Marcia G Honig, Anton Reine. Amelioration of visual deficits and visual system pathology after mild TBI with the cannabinoid type-2 receptor inverse agonist SMM-189. Experimental eye research. vol 182. 2020-02-17. PMID:30922891. |
using our focal cranial blast mouse model of closed-skull mild tbi, we evaluated the ability of the cannabinoid type-2 (cb2) receptor inverse agonist smm-189, which biases microglia from the harmful m1 state to the beneficial m2 state, to mitigate visual system dysfunction and injury after tbi. |
2020-02-17 |
2023-08-13 |
mouse |
| Mario Antonazzo, María Botta, Harkaitz Bengoetxea, José Ángel Ruiz-Ortega, Teresa Morera-Herrera. Therapeutic potential of cannabinoids as neuroprotective agents for damaged cells conducing to movement disorders. International review of neurobiology. vol 146. 2020-02-03. PMID:31349929. |
this potential therapeutic role of cannabinoids is based, among other qualities, on their capacity to reduce oxidative injury and excitotoxicity, control calcium influx and limit the toxicity of reactive microglia. |
2020-02-03 |
2023-08-13 |
Not clear |
| Rocio Saravia, Marc Ten-Blanco, María T Grande, Rafael Maldonado, Fernando Berrender. Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice. Brain, behavior, and immunity. vol 75. 2020-01-23. PMID:30391635. |
treatment with the non-psychoactive cannabinoid cannabidiol abolished memory impairment of nicotine withdrawal and microglia reactivity, reduced the expression of il1β and ifnγ in the hippocampus and the prefrontal cortex, respectively, and normalized ki67 levels. |
2020-01-23 |
2023-08-13 |
mouse |
| Jonathan W VanRyzin, Ashley E Marquardt, Kathryn J Argue, Haley A Vecchiarelli, Sydney E Ashton, Sheryl E Arambula, Matthew N Hill, Margaret M McCarth. Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play. Neuron. vol 102. issue 2. 2019-11-12. PMID:30827729. |
here, we report that androgen-induced increases in endocannabinoid tone promote microglia phagocytosis during a critical period of amygdala development. |
2019-11-12 |
2023-08-13 |
rat |
| Ana Juknat, Fuying Gao, Giovanni Coppola, Zvi Vogel, Ewa Kozel. miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia-Effect of cannabinoids. PloS one. vol 14. issue 2. 2019-11-08. PMID:30742662. |
in summary, we have identified a specific repertoire of mirnas that are regulated by cannabinoids, in resting (surveillant) and in lps-activated microglia. |
2019-11-08 |
2023-08-13 |
Not clear |
| Gemma Navarro, Dasiel Borroto-Escuela, Edgar Angelats, Íñigo Etayo, Irene Reyes-Resina, Marta Pulido-Salgado, Ana I Rodríguez-Pérez, Enric I Canela, Josep Saura, José Luis Lanciego, José Luis Labandeira-García, Carlos A Saura, Kjell Fuxe, Rafael Franc. Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28843453. |
receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. |
2018-07-11 |
2023-08-13 |
Not clear |
| Juan Niu, Dujuan Huang, Rui Zhou, MingXia Yue, Tao Xu, Junna Yang, Li He, Hong Tian, XiaoHong Liu, Junwei Zen. Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y Journal of neuroinflammation. vol 14. issue 1. 2018-05-29. PMID:28899427. |
activation of dorsal horn cannabinoid cb2 receptor suppresses the expression of p2y more evidence suggests that dorsal spinal cord microglia is an important site contributing to cb2 receptor-mediated analgesia. |
2018-05-29 |
2023-08-13 |
Not clear |
| Rosario Gajardo-Gómez, Valeria C Labra, Carola J Maturana, Kenji F Shoji, Cristian A Santibañez, Juan C Sáez, Christian Giaume, Juan A Orellan. Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism. Glia. vol 65. issue 1. 2018-02-01. PMID:27757991. |
we have demonstrated that synthetic and endogenous cannabinoids (cbs) reduce the opening of astrocyte cx43 hemichannels evoked by activated microglia or inflammatory mediators. |
2018-02-01 |
2023-08-13 |
Not clear |