| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fabricia Petronilho, Leonardo Tenfen, Amanda Della Giustina, Larissa Joaquim, Michele Novochadlo, Aloir Neri de Oliveira Junior, Erick Bagio, Mariana Pereira de Souza Goldim, Raquel Jaconi de Carli, Sandra Regina Santana de Aguiar Bonfante, Kiuanne Lino Lobo Metzker, Samara Muttini, Thayná Marinho Dos Santos, Mariana Pacheco de Oliveira, Nicole Alessandra Engel, Gislaine Tezza Rezin, Luiz Alberto Kanis, Tatiana Barichell. Gold nanoparticles potentiates N-acetylcysteine effects on neurochemicals alterations in rats after polymicrobial sepsis. Journal of drug targeting. vol 28. issue 4. 2021-08-18. PMID:31594390. |
complex i activity was increased with aunp + nac association and nac isolated in the hippocampus. |
2021-08-18 |
2023-08-13 |
rat |
| H Z Rosa, R C S Barcelos, H J Segat, Kr Roversi, V T Dias, L H Milanesi, M E Burge. Physical exercise modifies behavioral and molecular parameters related to opioid addiction regardless of training time. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31899030. |
on the last exercising week, one-half of the animals from sed and all animals from s-, m- and l-exe were concomitantly exposed to morphine-conditioned place preference (cpp) paradigm and y-maze task for behavioral assessments followed by molecular assays in both nucleus accumbens (nac) and hippocampus. |
2021-08-10 |
2023-08-13 |
rat |
| H Z Rosa, R C S Barcelos, H J Segat, Kr Roversi, V T Dias, L H Milanesi, M E Burge. Physical exercise modifies behavioral and molecular parameters related to opioid addiction regardless of training time. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 32. 2021-08-10. PMID:31899030. |
besides the small morphine-cpp in relation to sed group, all periods decreased dat, d1r, and gr immunoreactivity in nac, dat and d1r in hippocampus, while d2r in both brain areas and gr in hippocampus were primarily decreased by l-exe. |
2021-08-10 |
2023-08-13 |
rat |
| Rajas P Kale, Thanh Thanh L Nguyen, J Blair Price, Nathanael J Yates, Ken Walder, Michael Berk, Roy V Sillitoe, Abbas Z Kouzani, Susannah J Ty. Mood Regulatory Actions of Active and Sham Nucleus Accumbens Deep Brain Stimulation in Antidepressant Resistant Rats. Frontiers in human neuroscience. vol 15. 2021-08-06. PMID:34349629. |
we investigated the antidepressant-like effects of chronic nucleus accumbens (nac) dbs and its association with change in glycogen synthase kinase 3 (gsk3) and mammalian target of rapamycin (mtor) expression in the infralimbic cortex (il), and the dorsal (dhip) and ventral (vhip) subregions of the hippocampus of antidepressant resistant rats. |
2021-08-06 |
2023-08-13 |
rat |
| Yasaman Razavi, Sara Karimi, Saeideh Karimi-Haghighi, Soghra Hesam, Abbas Haghparas. Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala. Canadian journal of physiology and pharmacology. vol 98. issue 11. 2021-08-02. PMID:32574519. |
neural circuitry comprising the nucleus accumbens (nac), prefrontal cortex (pfc), amygdala (amy), and hippocampus (hip) are the main components of the reward circuit. |
2021-08-02 |
2023-08-13 |
rat |
| Mi Yang, Chang-Hao Luo, Ying-Qi Zhu, Yuan-Chu Liu, Ye-Juan An, Javed Iqbal, Zhe-Zhi Wang, Xin-Ming M. 7, 8-Dihydroxy-4-methylcoumarin reverses depression model-induced depression-like behaviors and alteration of dendritic spines in the mood circuits. Psychoneuroendocrinology. vol 119. 2021-07-21. PMID:32563935. |
the aim of this study was to investigate whether dhmc alleviates chronic unpredictable mild stress (cums)-induced depression-like behaviors and reverses cums-induced alterations in dendritic spines of principal neurons in brain areas of the emotional circuits including the hippocampus, medial prefrontal cortex (mpfc), nucleus accumbens (nac) and basolateral amygdala (bla) in male rats. |
2021-07-21 |
2023-08-13 |
rat |
| Mi Yang, Chang-Hao Luo, Ying-Qi Zhu, Yuan-Chu Liu, Ye-Juan An, Javed Iqbal, Zhe-Zhi Wang, Xin-Ming M. 7, 8-Dihydroxy-4-methylcoumarin reverses depression model-induced depression-like behaviors and alteration of dendritic spines in the mood circuits. Psychoneuroendocrinology. vol 119. 2021-07-21. PMID:32563935. |
our results showed that cums-induced depression-like behaviors were accompanied by a decrease in spine density in pyramidal neurons of both the hippocampal ca3 area and the mpfc, and an increase in spine density in both the neurons of bla and the medium spiny neurons (msns) of the nac, as well as a decrease in the levels of the ampa receptor subunit glua1 and kalirin-7 in the hippocampus compared with the control group. |
2021-07-21 |
2023-08-13 |
rat |
| Andre U Deutschmann, Julia M Kirkland, Lisa A Brian. Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling. Addiction biology. 2021-07-19. PMID:34278652. |
optogenetically activating the glutamatergic input from the ventral hippocampus to the nac is sufficient to recapitulate the decreases in paired-pulse ratio and readily releasable pool size seen following electrical stimulation of all nac afferents. |
2021-07-19 |
2023-08-13 |
mouse |
| Andrew Chih Wei Huang, Ying Hao Yu, Alan Bo Han He, Chen Yin O. Interactions between prelimbic cortex and basolateral amygdala contribute to morphine-induced conditioned taste aversion in conditioning and extinction. Neurobiology of learning and memory. vol 172. 2021-07-14. PMID:32407964. |
the consequences of exciting or destroying the prelimbic cortex (prl) or the basolateral amygdala (bla) remain unclear, including the effects on morphine-induced conditioned taste aversion (cta) in the conditioning and extinction phases, plasma corticosterone (cort) levels, and c-fos/p-erk expressions in the subareas of the medial prefrontal cortex (i.e., prl, infralimbic cortex [il], cingulate cortex 1 [cg1]), basolateral amygdala (bla), central amygdala (cea), hippocampus (i.e., ca1, ca2, ca3, and dentate gyrus [dg]), nucleus accumbens (nac), lateral hypothalamus (lh), and piriform cortex (pc). |
2021-07-14 |
2023-08-13 |
Not clear |
| Caroline E Strong, Mohamed Kabba. Neural Mechanisms Underlying the Rewarding and Therapeutic Effects of Ketamine as a Treatment for Alcohol Use Disorder. Frontiers in behavioral neuroscience. vol 14. 2021-07-08. PMID:33362485. |
to do this, the focus will be on reward-related brain regions such as the nucleus accumbens (nac), dorsal striatum, prefrontal cortex (pfc), hippocampus, and ventral tegmental area (vta) to understand how acute vs. chronic exposure will alter reward signaling over time. |
2021-07-08 |
2023-08-13 |
human |
| Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-Ih, Ekkasit Kumarnsi. Adaptive changes in local field potential oscillation associated with morphine conditioned place preference in mice. Physiology & behavior. vol 235. 2021-06-25. PMID:33757777. |
male swiss albino mice implanted with intracranial electrodes into the nucleus accumbens (nac), striatum (str) and hippocampus (hc) were used for recording of local field potentials (lfps). |
2021-06-25 |
2023-08-13 |
mouse |
| Kaili Du, Zhuoyi Wang, Huimin Zhang, Yaofang Zhang, Hongliang Su, Zhiwen Wei, Chao Zhang, Keming Yun, Bin Con. Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice. Neuroscience letters. vol 756. 2021-06-22. PMID:34029649. |
western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (erk) and camp response element binding protein (creb) in related brain regions, including the hippocampus (hip), caudate putamen (cpu), prefrontal cortex (pfc), and nucleus accumbens (nac), which may mediate the effects of l-thp on fentanyl-induced cpp. |
2021-06-22 |
2023-08-13 |
mouse |
| Miguel Skirzewski, Marie E Cronin, Ricardo Murphy, Wambura Fobbs, Alexxai V Kravitz, Andres Buonann. ErbB4 Null Mice Display Altered Mesocorticolimbic and Nigrostriatal Dopamine Levels as well as Deficits in Cognitive and Motivational Behaviors. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32354758. |
here, we report that extracellular steady-state levels of da are reduced in the medial prefrontal cortex (mpfc; -65%), hippocampus (-53%) and nucleus accumbens (nac; -35%), but are elevated in the dorsal striatum (+25%) of erbb4 knock-out mice (erbb4 kos) relative to wild-type controls. |
2021-06-18 |
2023-08-13 |
mouse |
| Luis A Trujillo-Villarreal, Viktor J Romero-Díaz, Iván Alberto Marino-Martínez, Lizeth Fuentes-Mera, Marco Antonio Ponce-Camacho, Gabriel A Devenyi, M Mallar Chakravarty, Alberto Camacho-Morales, Eduardo E Garza-Villarrea. Maternal cafeteria diet exposure primes depression-like behavior in the offspring evoking lower brain volume related to changes in synaptic terminals and gliosis. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446642. |
macrostructural dbm analysis showed reduction in the frontomesocorticolimbic circuit volume including the nucleus accumbens (nac), hippocampus, and prefrontal cortex. |
2021-06-18 |
2023-08-13 |
rat |
| Luis A Trujillo-Villarreal, Viktor J Romero-Díaz, Iván Alberto Marino-Martínez, Lizeth Fuentes-Mera, Marco Antonio Ponce-Camacho, Gabriel A Devenyi, M Mallar Chakravarty, Alberto Camacho-Morales, Eduardo E Garza-Villarrea. Maternal cafeteria diet exposure primes depression-like behavior in the offspring evoking lower brain volume related to changes in synaptic terminals and gliosis. Translational psychiatry. vol 11. issue 1. 2021-06-18. PMID:33446642. |
microstructural analysis revealed reduced synaptic terminals in hippocampus and nac, whereas increased glial fibrillary acidic protein in hippocampus and lateral hypothalamus, as well as a decrease in the hippocampal cell number and myelin reduction in the dentate gyrus and hilus, respectively. |
2021-06-18 |
2023-08-13 |
rat |
| Tracy L Fetterly, Max F Oginsky, Allison M Nieto, Yanaira Alonso-Caraballo, Zuleirys Santana-Rodriguez, Carrie R Ferrari. Insulin Bidirectionally Alters NAc Glutamatergic Transmission: Interactions between Insulin Receptor Activation, Endogenous Opioids, and Glutamate Release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 11. 2021-06-11. PMID:33514676. |
insulin receptors are expressed by nac medium spiny neurons (msns), and studies of cultured cortical and hippocampal neurons suggest that insulin influences excitatory transmission via presynaptic and postsynaptic mechanisms. |
2021-06-11 |
2023-08-13 |
human |
| Keith A Misquitta, Amy Miles, Thomas D Prevot, Jaime K Knoch, Corey Fee, Dwight F Newton, Jacob Ellegood, Jason P Lerch, Etienne Sibille, Yuliya S Nikolova, Mounira Banas. Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density. Neuropharmacology. vol 190. 2021-06-09. PMID:33864799. |
clinical and preclinical studies report that chronic stress induces behavioral deficits as well as volumetric and synaptic alterations in corticolimbic brain regions including the anterior cingulate cortex (acc), amygdala (amy), nucleus accumbens (nac) and hippocampus (hpc). |
2021-06-09 |
2023-08-13 |
Not clear |
| Yoon-Hyung Lee, Seong-Ryong Le. Neuroprotective effects of N-acetylcysteine via inhibition of matrix metalloproteinase in a mouse model of transient global cerebral ischemia. Brain research bulletin. vol 154. 2021-06-07. PMID:31722253. |
the effect of nac on neuronal damage and matrix metalloproteinase (mmp)-9 activity were assessed and immunofluorescence, and hippocampal terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling (tunel) assay experiments were conducted and results compared between nac- and vehicle-treated groups. |
2021-06-07 |
2023-08-13 |
mouse |
| Yoon-Hyung Lee, Seong-Ryong Le. Neuroprotective effects of N-acetylcysteine via inhibition of matrix metalloproteinase in a mouse model of transient global cerebral ischemia. Brain research bulletin. vol 154. 2021-06-07. PMID:31722253. |
nac increased laminin and neun expression and inhibited increases in tunel-positive cells, all in the hippocampus. |
2021-06-07 |
2023-08-13 |
mouse |
| Yoon-Hyung Lee, Seong-Ryong Le. Neuroprotective effects of N-acetylcysteine via inhibition of matrix metalloproteinase in a mouse model of transient global cerebral ischemia. Brain research bulletin. vol 154. 2021-06-07. PMID:31722253. |
these results suggest that nac reduces hippocampal neuronal damage following transient global ischemia, potentially via reductions in mmp-9 activity. |
2021-06-07 |
2023-08-13 |
mouse |