| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ezio Carboni, Anna R Cart. BDNF Alterations in Brain Areas and the Neurocircuitry Involved in the Antidepressant Effects of Ketamine in Animal Models, Suggest the Existence of a Primary Circuit of Depression. Journal of integrative neuroscience. vol 21. issue 5. 2022-09-22. PMID:36137960. |
in this review we have examined the role of several brain areas: namely, the hippocampus, the medial prefrontal cortex (mpfc), the nucleus accumbens (nac), the lateral habenula (lhb), the amygdala and the bed nucleus of stria terminalis (bnst). |
2022-09-22 |
2023-08-14 |
Not clear |
| Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salu. The Antioxidant N-Acetyl-L-Cysteine Restores the Behavioral Deficits in a Neurodevelopmental Model of Schizophrenia Through a Mechanism That Involves Nitric Oxide. Frontiers in pharmacology. vol 13. 2022-07-29. PMID:35903343. |
analyses of markers involved in the inflammatory response, such as astrocytes (glial fibrillary acid protein, gfap) and microglia (binding adapter molecule 1, iba1), and parvalbumin (pv) positive gabaergic, were conducted in the prefrontal cortex [pfc, medial orbital cortex (mo) and prelimbic cortex (prl)] and dorsal and ventral hippocampus [ca1, ca2, ca3, and dentate gyrus (dg)] in rats under chronic treatment with nac. |
2022-07-29 |
2023-08-14 |
rat |
| Ana Lopes-Rocha, Thiago Ohno Bezerra, Roberta Zanotto, Inda Lages Nascimento, Angela Rodrigues, Cristiane Salu. The Antioxidant N-Acetyl-L-Cysteine Restores the Behavioral Deficits in a Neurodevelopmental Model of Schizophrenia Through a Mechanism That Involves Nitric Oxide. Frontiers in pharmacology. vol 13. 2022-07-29. PMID:35903343. |
nac increased the density of iba1 cells at pfc and of pv cells at mo and ca1 of the ventral hippocampus. |
2022-07-29 |
2023-08-14 |
rat |
| L Stan Leung, Jingyi M. Medial Septum Modulates Consciousness and Psychosis-Related Behaviors Through Hippocampal Gamma Activity. Frontiers in neural circuits. vol 16. 2022-07-25. PMID:35874429. |
glutamatergic projection of the hippocampus to the nucleus accumbens (nac) and dopaminergic transmission in nac is necessary for abnormal behaviors. |
2022-07-25 |
2023-08-14 |
rat |
| L Stan Leung, Jingyi M. Medial Septum Modulates Consciousness and Psychosis-Related Behaviors Through Hippocampal Gamma Activity. Frontiers in neural circuits. vol 16. 2022-07-25. PMID:35874429. |
local inactivation or lesion of the medial septum, nac, and brain areas connected to the septohippocampal-nac system attenuates the increase in hippocampal gamma and associated behavioral disruptions induced by hippocampal seizure or pcp/ketamine. |
2022-07-25 |
2023-08-14 |
rat |
| Aaron E Miller, Atul P Daiwile, Jean Lud Cade. Sex-Dependent Alterations in the mRNA Expression of Enzymes Involved in Dopamine Synthesis and Breakdown After Methamphetamine Self-Administration. Neurotoxicity research. 2022-07-14. PMID:35834057. |
to better understand the molecular bases for the differences in da metabolism, we measured the levels of mrnas of enzymes that catalyze da synthesis and breakdown in the prefrontal cortex (pfc), nucleus accumbens (nac), dorsal striatum (dstr), and hippocampus (hip) of rats that had self-administered meth. |
2022-07-14 |
2023-08-14 |
human |
| Corey Baimel, Emily Jang, Samantha L Scudder, Kasra Manoocheri, Adam G Carte. Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens. Cell reports. vol 40. issue 1. 2022-07-06. PMID:35793623. |
here, we find that the ventral hippocampus (vhpc) and the paraventricular nucleus of the thalamus (pvt) are the main excitatory inputs to chis in the nac medial shell. |
2022-07-06 |
2023-08-14 |
Not clear |
| Marco Pagliusi, Daniela Franco, Shannon Cole, Gessynger Morais-Silva, Ramesh Chandra, Megan E Fox, Sergio D Iñiguez, Cesar R Sartori, Mary Kay Lob. The BDNF-TrkB Pathway Acts Through Nucleus Accumbens D2 Expressing Neurons to Mediate Stress Susceptible Outcomes. Frontiers in psychiatry. vol 13. 2022-06-20. PMID:35722560. |
in stress outcomes, bdnf acting in the hippocampus has a stress resilience effect, and, inversely, in the nucleus accumbens (nac), bdnf acts as a stress susceptible molecule. |
2022-06-20 |
2023-08-14 |
mouse |
| Cai-N Cheng, Shaw-Jye Wu, Andrew Chih Wei Huan. Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683439. |
the c-fos expression analysis showed that the medial prefrontal cortex (i.e., cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), nucleus accumbens (nac), basolateral amygdala (bla), ventral tegmental area (vta), caudate-putamen (cpu), and hippocampus (i.e., ca1, ca3, and dentate gyrus (dg)) contributed to mamph-induced behavioral sensitization. |
2022-06-10 |
2023-08-14 |
mouse |
| Twinkle Dhillon, Amit Kumar, Vijay Kuma. Neuroprotective Effect of N-acetylcysteine Against Monocrotophos-Induced Oxidative Stress in Different Brain Regions of Rats. Applied biochemistry and biotechnology. 2022-05-19. PMID:35587328. |
in the present study, we have shown the protective role of n-acetylcysteine (nac) against mcp-induced oxidative stress in frontal cortex, corpus striatum and hippocampus brain regions of rats. |
2022-05-19 |
2023-08-13 |
rat |
| Ming Lin, Jiamin Xu, Xi Liu, Zhenfeng Dai, Zhimin Liu, Xin Zhao, Yi Sun, Xiaoping P. Metabolomics profiling of methamphetamine addicted human serum and three rat brain areas. RSC advances. vol 9. issue 70. 2022-05-11. PMID:35540062. |
by using maldi-msi, the relative quantification and distribution of 14 metabolites were investigated in the nucleus accumbens (nac), dorsal hippocampus (dhpc) and ventral hippocampus (vhpc) of cpp rat brain. |
2022-05-11 |
2023-08-13 |
human |
| Atul P Daiwile, Patricia Sullivan, Subramaniam Jayanthi, David S Goldstein, Jean Lud Cade. Sex-Specific Alterations in Dopamine Metabolism in the Brain after Methamphetamine Self-Administration. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35457170. |
dopamine and its metabolites were measured in the prefrontal cortex (pfc), nucleus accumbens (nac), dorsal striatum (dstr), and hippocampus (hip). |
2022-04-23 |
2023-08-13 |
rat |
| Mariusz Papp, Piotr Gruca, Magdalena Lason, Ewa Litwa, Wojciech Solecki, Paul Willne. Optogenetic stimulation of medial prefrontal cortex excites GABAergic cells in the nucleus accumbens and hippocampus of Wistar-Kyoto rats exposed to chronic mild stress. Psychopharmacology. 2022-03-16. PMID:35292832. |
here we have examined the effect of ogs on activity in the plc and in two other regions implicated in depression, the nucleus accumbens (nac) and hippocampus (hpc). |
2022-03-16 |
2023-08-13 |
rat |
| Sara Schiavi, Piergiorgio La Rosa, Sara Petrillo, Emilia Carbone, Jessica D'Amico, Fiorella Piemonte, Viviana Trezz. N-Acetylcysteine Mitigates Social Dysfunction in a Rat Model of Autism Normalizing Glutathione Imbalance and the Altered Expression of Genes Related to Synaptic Function in Specific Brain Areas. Frontiers in psychiatry. vol 13. 2022-03-14. PMID:35280167. |
furthermore, nac normalized the altered gsh levels displayed by these animals in the hippocampus and nucleus accumbens, and it partially rescued the altered expression of post-synaptic terminal network genes found in vpa-exposed rats, such as |
2022-03-14 |
2023-08-13 |
human |
| Rodolpho Pereira de Oliveira, José Simões de Andrade, Marianna Spina, João Vítor Chamon, Paulo Henrique Dias Silva, Ana Keyla Werder, Daniela Ortolani, Lucas de Santana Cardoso Thomaz, Simone Romariz, Daniel Araki Ribeiro, Beatriz Monteiro Longo, Regina Célia Spadari, Milena de Barros Viana, Liana Melo-Thomas, Isabel Cristina Céspedes, Regina Cláudia Barbosa da Silv. Clozapine prevented social interaction deficits and reduced c-Fos immunoreactivity expression in several brain areas of rats exposed to acute restraint stress. PloS one. vol 17. issue 3. 2022-03-03. PMID:35239670. |
in the present study, we evaluate the effect of acute restraint stress (15 min) of male wistar rats on social interaction measurements and c-fos immunoreactivity (c-fos-ir) expression, a marker of neuronal activity, in areas involved with the modulation of acute physical restraint in rats, i.e., the paraventricular nucleus of the hypothalamus (pvn), median raphe nucleus (mnr), medial prefrontal cortex (mpfc), cingulate prefrontal cortex (cpfc), nucleus accumbens (nac), hippocampus (ca3), lateral septum (ls) and medial amygdala (mea). |
2022-03-03 |
2023-08-13 |
rat |
| Zofia Rogóż, Kinga Kamińska, Marta Anna Lech, Elżbieta Lorenc-Koc. N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216241. |
the aim of our study was to compare the efficacy of chronic administration of the atypical antipsychotic drug aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butoxy}-3,4-dihydro-2(1h)-quinolinone; ari) and the well-known antioxidant n-acetylcysteine (nac) both in alleviating schizophrenia-like social and cognitive deficits and in reducing the decreases in the levels of the brain-derived neurotrophic factor (bdnf) in the prefrontal cortex (pfc) and hippocampus (hip) of adult sprague-dawley rats, that have been induced by chronic administration of the model compound l-buthionine-(s, r)-sulfoximine (bso) during the early postnatal development (p5-p16). |
2022-02-26 |
2023-08-13 |
rat |
| Ying Hao Yu, Yeou San Lim, Chen Yin Ou, Kai Chieh Chang, Arthur C Tsai, Fang Chih Chang, Andrew Chih Wei Huan. The Medial Prefrontal Cortex, Nucleus Accumbens, Basolateral Amygdala, and Hippocampus Regulate the Amelioration of Environmental Enrichment and Cue in Fear Behavior in the Animal Model of PTSD. Behavioural neurology. vol 2022. 2022-02-18. PMID:35178125. |
the present study addressed this issue and examined whether the medial prefrontal cortex (mpfc, including the cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), the nucleus accumbens (nac), the basolateral amygdala (bla), and the hippocampus (e.g., ca1, ca3, and dentate gyrus (dg)) regulated the amelioration of the ee, cue, or the combination of ee and cue. |
2022-02-18 |
2023-08-13 |
Not clear |
| Bryan W Jenkins, Shoshana Buckhalter, Melissa L Perreault, Jibran Y Khokha. Cannabis Vapor Exposure Alters Neural Circuit Oscillatory Activity in a Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents. Schizophrenia bulletin open. vol 3. issue 1. 2022-01-17. PMID:35036917. |
in adulthood, electrodes were implanted targeting the cingulate cortex (cg), the prelimbic cortex (prlc), the hippocampus (hip), and the nucleus accumbens (nac). |
2022-01-17 |
2023-08-13 |
rat |
| Daifeng Dong, Maria Ironside, Emily L Belleau, Xiaoqiang Sun, Chang Cheng, Ge Xiong, Lisa D Nickerson, Xiang Wang, Shuqiao Yao, Diego A Pizzagall. Sex-specific neural responses to acute psychosocial stress in depression. Translational psychiatry. vol 12. issue 1. 2022-01-11. PMID:35013110. |
based on prior studies, amygdala, hippocampus, medial orbitofrontal cortex (mofc), nucleus accumbens (nac) and dorsolateral prefrontal cortex (dlpfc) were selected as a priori regions of interest. |
2022-01-11 |
2023-08-13 |
Not clear |
| Daifeng Dong, Maria Ironside, Emily L Belleau, Xiaoqiang Sun, Chang Cheng, Ge Xiong, Lisa D Nickerson, Xiang Wang, Shuqiao Yao, Diego A Pizzagall. Sex-specific neural responses to acute psychosocial stress in depression. Translational psychiatry. vol 12. issue 1. 2022-01-11. PMID:35013110. |
relative to female hcs, the female mdd group had less deactivation in limbic/striatal regions (amygdala, nac, hippocampus, amygdala-nac-acc network). |
2022-01-11 |
2023-08-13 |
Not clear |