| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew G Frank, Kathy H Nguyen, Jayson B Ball, Shelby Hopkins, Tel Kelley, Michael V Baratta, Monika Fleshner, Steven F Maie. SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: evidence of PAMP-like properties. Brain, behavior, and immunity. 2021-12-16. PMID:34915155. |
s1 increased and/or modulated neuroimmune gene expression (iba1, cd11b, mhciiα, cd200r1, gfap, tlr2, tlr4, nlrp3, il1b, hmgb1) and protein levels (ifnγ, il-1β, tnf, cxcl1, il-2, il-10), which varied across brain regions (hypothalamus, hippocampus, and frontal cortex) and time (24h and 7d) post-s1 treatment. |
2021-12-16 |
2023-08-13 |
human |
| Lu Wang, Min Zhang, Jing Wen, Yalan Xiang, Xiaoyu Duan, Changwei Yu, Miao Yan, Bikui Zhang, Pingfei Fan. Isoliquiritigenin Alleviates Semen Strychni-Induced Neurotoxicity by Restoring the Metabolic Pathway of Neurotransmitters in Rats. Frontiers in pharmacology. vol 12. 2021-12-07. PMID:34867385. |
the concentration of monoamines, amino acids, and choline neurotransmitters, the dopamine (da) and 5-hydroxytryptamine (5-ht) metabolic pathway in the hippocampus, cerebellum, striatum, prefrontal cortex, hypothalamus, serum, and plasma were detected by lc-ms/ms. |
2021-12-07 |
2023-08-13 |
rat |
| Tomasz Bielawski, Lucas Albrechet-Souza, Dorota Frydeck. Endocannabinoid system in trauma and psychosis: distant guardian of mental stability. Reviews in the neurosciences. vol 32. issue 7. 2021-12-06. PMID:33656307. |
endocannabinoid receptors are abundant among brain structures pivotal in different mental disorders development (for example, hippocampus, amygdala, medial-prefrontal cortex, hypothalamus). |
2021-12-06 |
2023-08-13 |
Not clear |
| Benoît Boulan, Charlotte Ravanello, Amandine Peyrel, Christophe Bosc, Christian Delphin, Florence Appaix, Eric Denarier, Alexandra Kraut, Muriel Jacquier-Sarlin, Alyson Fournier, Annie Andrieux, Sylvie Gory-Fauré, Jean-Christophe Deloulm. CRMP4-mediated fornix development involves semaphorin-3E signaling pathway. eLife. vol 10. 2021-12-06. PMID:34860155. |
semaphorin-3e (sema3e) is a guidance cue implicated in development of the fornix, a neuronal tract connecting the hippocampus to the hypothalamus. |
2021-12-06 |
2023-08-13 |
mouse |
| Yinxian Wen, Siyuan Cheng, Juan Lu, Xia He, Zhexiao Jiao, Dan Xu, Hui Wan. Dysfunction of the hypothalamic‑pituitary‑adrenal axis in male rat offspring with prenatal food restriction: Fetal programming of hypothalamic hyperexcitability and poor hippocampal feedback. Molecular medicine reports. vol 25. issue 1. 2021-12-03. PMID:34796908. |
although lower arginine vasopressin (avp), hippocampal vesicular glutamate transporter 2 (vglut2) and glutamic acid decarboxylase 65 (gad65) mrna expression levels were detected in the hippocampi of pfr fetuses, the ratio of the mrna expression levels of vglut2 and gad65 was higher compared with that of the controls, which was accompanied by histopathological and ultrastructural abnormalities of both the hypothalamus and hippocampus. |
2021-12-03 |
2023-08-13 |
rat |
| Aruna Sharma, Lianyuan Feng, Dafin F Muresanu, Seaab Sahib, Z Ryan Tian, José Vicente Lafuente, Anca D Buzoianu, Rudy J Castellani, Ala Nozari, Lars Wiklund, Hari Shanker Sharm. Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions. Progress in brain research. vol 265. 2021-11-24. PMID:34560926. |
at this time, bbb disruption, reduction in cerebral blood flow (cbf), brain edema formation and brain pathology were most marked in the sensory-motor cortex, hippocampus, caudate putamen, cerebellum and thalamus followed by hypothalamus, pons, medulla and spinal cord. |
2021-11-24 |
2023-08-13 |
rat |
| Judith Leyh, Karsten Winter, Madlen Reinicke, Uta Ceglarek, Ingo Bechmann, Julia Landman. Long-term diet-induced obesity does not lead to learning and memory impairment in adult mice. PloS one. vol 16. issue 9. 2021-11-22. PMID:34587222. |
neurons and microglia were histologically analyzed within the mediobasal hypothalamus, hippocampus and frontal motor cortex after long-term hfd and change of diet. |
2021-11-22 |
2023-08-13 |
mouse |
| Amin Haghani, Max Thorwald, Todd E Morgan, Caleb E Finc. The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 2. 2021-11-15. PMID:33215813. |
in humans, the ad vulnerable hippocampus and amygdala had stronger age decline in apoe cluster expression than the ad-resistant cerebellum and hypothalamus. |
2021-11-15 |
2023-08-13 |
mouse |
| Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Robson Luiz Oliveira Santos, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice. Behavioural brain research. vol 417. 2021-11-15. PMID:34656691. |
immunohistochemistry in the hippocampus (Δfosb, bdnf, and 8ohdg) and hypothalamus (Δfosb) was also performed. |
2021-11-15 |
2023-08-13 |
mouse |
| Silvia Giatti, Silvia Diviccaro, Lucia Cioffi, Eva Falvo, Donatella Caruso, Roberto C Melcang. Effects of paroxetine treatment and its withdrawal on neurosteroidogenesis. Psychoneuroendocrinology. vol 132. 2021-11-12. PMID:34325207. |
on this basis, we have here evaluated whether a subchronic treatment with paroxetine for two weeks and/or its withdrawal (i.e., a month) may affect the levels of neuroactive steroids in brain areas (i.e., hippocampus, hypothalamus, and cerebral cortex) and/or in plasma and cerebrospinal fluid of male rats. |
2021-11-12 |
2023-08-13 |
rat |
| Trevor J Buhr, Carter H Reed, Allyse Shoeman, Ella E Bauer, Rudy J Valentine, Peter J Clar. The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice. Frontiers in behavioral neuroscience. vol 15. 2021-11-11. PMID:33716684. |
moreover, daily running wheel access only mildly influenced alcohol-related norepinephrine concentrations in the hypothalamus and prefrontal cortex, as well as serotonin turnover in the hippocampus. |
2021-11-11 |
2023-08-13 |
mouse |
| Trevor J Buhr, Carter H Reed, Allyse Shoeman, Ella E Bauer, Rudy J Valentine, Peter J Clar. The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice. Frontiers in behavioral neuroscience. vol 15. 2021-11-11. PMID:33716684. |
however, access to alcohol during did eliminated wheel running-related decreases of norepinephrine, serotonin, and 5-hiaa content in the hypothalamus, but also to a lesser extent for norepinephrine in the hippocampus and caudal cortical areas. |
2021-11-11 |
2023-08-13 |
mouse |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
on this basis, gaba content in the drn and 5-ht contents in the pfc, hypothalamus, hippocampus and drn were detected using elisa. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
changes in 5-ht levels in the pfc, hypothalamus and hippocampus were detected afterward. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
the contents of 5-ht in the pfc, hypothalamus and hippocampus of rats with high and low aggressive behavior (no difference between the two groups) were significantly decreased, but the change in gaba content in the drn was the opposite. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
after microinjection of baclofen into the drn, the 5-ht contents in the pfc, hypothalamus and hippocampus of rats in each group decreased significantly. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
in contrast, the 5-ht contents in the pfc, hypothalamus and hippocampus of rats in each group increased significantly after injection with cgp35348. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
the significant increase in gaba in the drn combined with the significant increase in gb1 in the drn further mediated the synaptic inhibition effect, which reduced the 5-ht level of 5-ht neurons in the drn, resulting in a significant decrease in 5-ht levels in the pfc, hypothalamus and hippocampus. |
2021-11-11 |
2023-08-13 |
rat |
| Xiao-Ju Liu, Hai-Juan Wang, Xiao-Yu Wang, Yin-Xia Ning, Jie Ga. GABABR1 in DRN mediated GABA to regulate 5-HT expression in multiple brain regions in male rats with high and low aggressive behavior. Neurochemistry international. vol 150. 2021-11-11. PMID:34509561. |
therefore, gb1-mediated gaba regulation of 5-ht levels in the pfc, hypothalamus and hippocampus is one of the mechanisms of highly and less aggressive behavior originating in the drn. |
2021-11-11 |
2023-08-13 |
rat |
| Yosefa Avraham, David Mankuta, Leah Lipsker, Lia Vorobiev, Sigalit Patael, Golda Hassid, Elliot M Berry, Amnon Albec. Beta-Carotene derivatives as novel therapy for the prevention and treatment of autistic symptoms. Bioorganic chemistry. vol 115. 2021-11-09. PMID:34392174. |
the following biochemical and molecular biology parameters were also examined: serum oxt; gene expression in hippocampus and hypothalamus of cd 38, oxt, oxt receptor, bdnf, and retinoic acid receptor. |
2021-11-09 |
2023-08-13 |
mouse |