| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher A Ayoub, Khadijah I Moore, Jeff Kure. Quantification of Methylation and Phosphorylation Stoichiometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512670. |
tauopathies including alzheimer's disease (ad) are neurodegenerative disorders accompanied by the conversion of functional forms of the microtubule associated protein tau into non-functional aggregates. |
2024-03-21 |
2024-03-24 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Kristen E Fun. Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512680. |
microtubule-associated protein tau is an intracellular protein that self-aggregates into neurofibrillary tangles in alzheimer's disease and many other neurodegenerative diseases. |
2024-03-21 |
2024-03-24 |
Not clear |
| Katharina Schindowsk. Differential Regulation of Neurotrophic Factors During Pathogenic Tau-Aggregation in a Tau Transgenic Mouse Model for Alzheimer's Disease: A Protocol for Double-Labeling mRNA by In Situ Hybridization and Protein Epitopes by Immunohistochemistry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512677. |
differential regulation of neurotrophic factors during pathogenic tau-aggregation in a tau transgenic mouse model for alzheimer's disease: a protocol for double-labeling mrna by in situ hybridization and protein epitopes by immunohistochemistry. |
2024-03-21 |
2024-03-24 |
mouse |
| Qixu Cai, Hwan-Ching Ta. Super-Resolution Imaging of Tau Proteins in Isolated and Immobilized Brain Synaptosomes. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512681. |
pathological tau species are also associated with synaptic dysfunctions in several neurodegenerative disorders, especially alzheimer's disease. |
2024-03-21 |
2024-03-24 |
Not clear |
| Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512682. |
in alzheimer's disease, microglia get over activated upon the accumulation of tau and amyloid-β species in the extracellular space, ultimately leading to neurodegeneration. |
2024-03-21 |
2024-03-24 |
Not clear |
| Sarah Buchholz, Michael Bell-Simons, Cagla Cakmak, Jennifer Klimek, Li Gan, Hans Zempe. Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512688. |
in most of these disorders, such as alzheimer's disease, the neuronal axonal microtubule-binding tau protein becomes mislocalized to the somatodendritic compartment. |
2024-03-21 |
2024-03-24 |
human |
| Nadine Allroggen, Helen Breuer, Sarah Bachmann, Michael Bell, Hans Zempe. Studying Microtubule Dynamics in Human Neurons: Two-Dimensional Microtubule Tracing and Kymographs in iPSC- and SH-SY5Y-Derived Neurons for Tau Research. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512690. |
these accumulations of hyperphosphorylated tau in the neurons disrupt the physiological mt-based transport machinery within the cell and can potentially lead to the development of neurodegenerative disorders, such as alzheimer's disease (ad) and related tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Dror Shir, Nick Corriveau-Lecavalier, Camilo Bermudez Noguera, Leland Barnard, Nha Trang Thu Pham, Hugo Botha, Joseph R Duffy, Heather M Clark, Rene L Utianski, David S Knopman, Ronald C Petersen, Bradley F Boeve, Melissa E Murray, Aivi T Nguyen, R Ross Reichard, Dennis W Dickson, Gregory S Day, Walter K Kremers, Neill R Graff-Radford, David T Jones, Mary M Machulda, Julie A Fields, Jennifer L Whitwell, Keith A Josephs, Jonathan Graff-Radfor. Clinicoradiological and neuropathological evaluation of primary progressive aphasia. Journal of neurology, neurosurgery, and psychiatry. 2024-03-21. PMID:38514176. |
three ppa variants correlate with distinct underlying pathologies: semantic variant ppa (svppa) with transactive response dna-binding protein of 43 kd (tdp-43) proteinopathy, agrammatic variant ppa (agppa) with tau deposition and logopenic variant ppa (lvppa) with alzheimer's disease (ad). |
2024-03-21 |
2024-03-24 |
Not clear |
| Fangjia Yang, Paula Beltran-Lobo, Katherine Sung, Caoimhe Goldrick, Cara L Croft, Agnes Nishimura, Erin Hedges, Farah Mahiddine, Claire Troakes, Todd E Golde, Beatriz G Perez-Nievas, Diane P Hanger, Wendy Noble, Maria Jimenez-Sanche. Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Science advances. vol 10. issue 12. 2024-03-20. PMID:38507480. |
molecular chaperones are protective in neurodegenerative diseases by preventing protein misfolding and aggregation, such as extracellular amyloid plaques and intracellular tau neurofibrillary tangles in alzheimer's disease (ad). |
2024-03-20 |
2024-03-23 |
human |
| Karin L Meeker, Patrick H Luckett, Nicolas R Barthélemy, Diana A Hobbs, Charles Chen, James Bollinger, Vitaliy Ovod, Shaney Flores, Sarah Keefe, Rachel L Henson, Elizabeth M Herries, Eric McDade, Jason J Hassenstab, Chengjie Xiong, Carlos Cruchaga, Tammie L S Benzinger, David M Holtzman, Suzanne E Schindler, Randall J Bateman, John C Morris, Brian A Gordon, Beau M Ance. Comparison of cerebrospinal fluid, plasma and neuroimaging biomarker utility in Alzheimer's disease. Brain communications. vol 6. issue 2. 2024-03-20. PMID:38505230. |
four clusters emerged reflecting: core alzheimer's disease pathology (amyloid and tau), neurodegeneration, at8 antibody-associated phosphorylated tau sites and neuronal dysfunction. |
2024-03-20 |
2024-03-23 |
human |
| Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackre. HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species. Nature communications. vol 15. issue 1. 2024-03-19. PMID:38499535. |
the pdz serine protease htra1 degrades fibrillar tau, which is associated with alzheimer's disease, and inactivating mutations to mitochondrial htra2 are implicated in pd. |
2024-03-19 |
2024-03-21 |
Not clear |
| Pratima Srivastava, Dhananjay Yadav, Santosh Kumar Singh, Sung Hae Kim, Shivendra Singh, Shweta Katiyar, Minseok Son. Investigating Bacopa monnieri L. Therapeutic Potential for the Treatment of Neurological Diseases. Current pharmaceutical design. 2024-03-19. PMID:38500283. |
alzheimer's disease is a neurological condition caused by the production of reactive oxygen species, which also causes amyloid-beta (a) and tau protein aggregation and increases neuro-inflammation and neurotoxicity. |
2024-03-19 |
2024-03-21 |
Not clear |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Haichao Wei, Joseph Withrow, Jyotirmoy Rakshit, Faiz Ul Amin, Joshua Nahm, Francesca E Mowry, Zhengmei Mao, Meenakshi B Bhattacharjee, Jay-Jiguang Zhu, Yongjie Yang, Jia Qian W. The identification of a Distinct Astrocyte Subtype that Diminishes in Alzheimer's Disease. Aging and disease. 2024-03-19. PMID:38502590. |
alzheimer's disease (ad) is characterized by the presence of two hallmark pathologies: the accumulation of amyloid beta (aβ) and tau proteins in the brain. |
2024-03-19 |
2024-03-23 |
mouse |
| Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kaye. Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation. ACS chemical neuroscience. 2024-03-19. PMID:38503425. |
the pathological misfolding and aggregation of the microtubule associated protein tau (mapt), a full length tau2n4r with 441aa, is considered the principal disease relevant constituent in tauopathies including alzheimer's disease (ad) with an imbalanced ratio in 3r/4r isoforms. |
2024-03-19 |
2024-03-23 |
Not clear |
| Qi Guo, Lingyan Ping, Eric B Dammer, Luming Yin, Kaiming Xu, Anantharaman Shantaraman, Edward J Fox, Todd E Golde, Erik C B Johnson, Blaine R Roberts, James J Lah, Allan I Levey, Nicholas T Seyfrie. Heparin-enriched plasma proteome is significantly altered in Alzheimer's Disease. Research square. 2024-03-18. PMID:38464223. |
heparin binding proteins (hbps) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (aβ) and tau pathology in alzheimer's disease (ad) brain and cerebrospinal fluid (csf). |
2024-03-18 |
2024-03-20 |
Not clear |
| Hunsica J Jayaprakash, Akiko Mizuno, Beth E Snitz, Ann D Cohen, Willian E Klunk, Howard J Aizenstein, Helmet T Kari. Voxel-wise hemispheric Amyloid Asymmetry and its association with cerebral metabolism and grey matter density in cognitively normal older adults. medRxiv : the preprint server for health sciences. 2024-03-18. PMID:38496561. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by changes in beta amyloid (aß) and tau as well as changes in cerebral glucose metabolism and gray matter volume. |
2024-03-18 |
2024-03-20 |
Not clear |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
brain regions in alzheimer's (ad) exhibit distinct vulnerability to the disease's hallmark pathology, with the entorhinal cortex and hippocampus succumbing early to tau tangles while others like primary sensory cortices remain resilient. |
2024-03-18 |
2024-03-20 |
Not clear |
| Chaitali Anand, Justin Torok, Farras Abdelnour, Pedro D Maia, Ashish Ra. Selective vulnerability and resilience to Alzheimer's disease tauopathy as a function of genes and the connectome. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496606. |
we therefore employed an extended network diffusion model (endm) and tested it on tau pathology pet data from 196 ad patients from the alzheimer's disease neuroimaging initiative (adni). |
2024-03-18 |
2024-03-20 |
Not clear |