| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. |
profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin d3 treatment in the mice model of vascular dementia. |
2023-05-23 |
2023-08-14 |
mouse |
| Jafar Sadeghzadeh, Jaber Jafarzadeh, Pezhman Hadinezhad, Ahmad Nazari, Saeedeh Sohrabi, Vali Musazadeh, Ali Barzegar, Parviz Shahab. Profiling inflammatory mechanisms, hyperphosphorylated tau of hippocampal tissue and spatial memory following vitamin D3 treatment in the mice model of vascular dementia. International immunopharmacology. vol 120. 2023-05-23. PMID:37220695. |
the aim of this study was to investigate the effect of vitamin d3 (vitd3) on inflammatory mechanisms, hyperphosphorylated tau (p-tau) in the hippocampus, and cognitive impairment of the mouse model of vascular dementia (vad). |
2023-05-23 |
2023-08-14 |
mouse |
| Antonio Terracciano, Keenan Walker, Yang An, Martina Luchetti, Yannick Stephan, Abhay R Moghekar, Angelina R Sutin, Luigi Ferrucci, Susan M Resnic. The association between personality and plasma biomarkers of astrogliosis and neuronal injury. Neurobiology of aging. vol 128. 2023-05-21. PMID:37210782. |
personality traits have been associated with the risk of dementia and alzheimer's disease neuropathology, including amyloid and tau. |
2023-05-21 |
2023-08-14 |
human |
| Luisa Diomede, Elisa R Zanier, Federico Moro, Gloria Vegliante, Laura Colombo, Luca Russo, Alfredo Cagnotto, Carmina Natale, Federica Marta Xodo, Ada De Luigi, Michele Mosconi, Marten Beeg, Marcella Catania, Giacomina Rossi, Fabrizio Tagliavini, Giuseppe Di Fede, Mario Salmon. Aβ1-6 Molecular psychiatry. 2023-05-17. PMID:37198260. |
aβ1-6 alzheimer's disease (ad), the leading cause of dementia in older adults, is a double proteinopathy characterized by amyloid-β (aβ) and tau pathology. |
2023-05-17 |
2023-08-14 |
Not clear |
| Laia Montoliu-Gaya, Andréa L Benedet, Cécile Tissot, Agathe Vrillon, Nicholas J Ashton, Wagner S Brum, Juan Lantero-Rodriguez, Jenna Stevenson, Johanna Nilsson, Mathias Sauer, Nesrine Rahmouni, Gunnar Brinkmalm, Firoza Z Lussier, Tharick A Pascoal, Ingmar Skoog, Silke Kern, Henrik Zetterberg, Claire Paquet, Johan Gobom, Pedro Rosa-Neto, Kaj Blenno. Mass spectrometric simultaneous quantification of tau species in plasma shows differential associations with amyloid and tau pathologies. Nature aging. 2023-05-17. PMID:37198279. |
in this study, we employed an immunoprecipitation mass spectrometry method to simultaneously quantify six phosphorylated (p-tau181, p-tau199, p-tau202, p-tau205, p-tau217 and p-tau231) and two non-phosphorylated plasma tau peptides in a total of 214 participants from the paris lariboisière and translational biomarkers of aging and dementia cohorts. |
2023-05-17 |
2023-08-14 |
human |
| Ylenia Pastorello, Roxana O Carare, Claudia Banescu, Lawrence Potempa, Mario Di Napoli, Mark Slevi. Monomeric C-reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction. Brain pathology (Zurich, Switzerland). 2023-05-09. PMID:37158450. |
in vitro, in vivo, and human tissue co-localization analyses have linked mcrp to neurovascular dysfunction, vascular activation resulting in increased permeability, and leakage, compromise of blood brain barrier function, buildup of toxic proteins including tau and beta amyloid (aβ), association with and capacity to "manufacture" aβ-mcrp-hybrid plaques, and, greater susceptibility to neurodegeneration and dementia. |
2023-05-09 |
2023-08-14 |
human |
| Saira Jahangir, Manoj Allala, Armughan S Khan, Veronica E Muyolema Arce, Anandkumar Patel, Karsh Soni, Alireza Sharafsha. A Review of Biomarkers in Delirium Superimposed on Dementia (DSD) and Their Clinical Application to Personalized Treatment and Management. Cureus. vol 15. issue 5. 2023-05-09. PMID:37159618. |
we identify 17 genes commonly associated with both dementia and delirium including apolipoprotein e (apoe), brain-derived neurotrophic factor (bdnf), catechol-o-methyltransferase (comt), butyrylcholinesterase (bche), acetylcholinesterase (ache), dna methyltransferase 1 (dnmt1), prion protein (prp), tumor necrosis factor (tnf), serine palmitoyltransferase long chain base subunit 1 (sptlc1), microtubule-associated protein tau (mapt), alpha-synuclein (αs), superoxide dismutase 1 (sod1), amyloid beta precursor protein (app), neurofilament light (nfl), neurofilament heavy, 5-hydroxytryptamine receptor 2a (htr2a), and serpin family a member 3 (erap3). |
2023-05-09 |
2023-08-14 |
Not clear |
| Kumarappan Chidambara. Identification of BACE-1 Inhibitors against Alzheimer's Disease through E-Pharmacophore-Based Virtual Screening and Molecular Dynamics Simulation Studies: An Insilco Approach. Life (Basel, Switzerland). vol 13. issue 4. 2023-04-28. PMID:37109481. |
alzheimer is a severe memory and cognitive impairment neurodegenerative disease that is the most common cause of dementia worldwide and characterized by the pathological accumulation of tau protein and amyloid-beta peptides. |
2023-04-28 |
2023-08-14 |
Not clear |
| Nicolas R Barthélemy, Benjamin Saef, Yan Li, Brian A Gordon, Yingxin He, Kanta Horie, Erik Stomrud, Gemma Salvadó, Shorena Janelidze, Chihiro Sato, Vitaliy Ovod, Rachel L Henson, Anne M Fagan, Tammie L S Benzinger, Chengjie Xiong, John C Morris, Oskar Hansson, Randall J Bateman, Suzanne E Schindle. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer's disease. Nature aging. vol 3. issue 4. 2023-04-28. PMID:37117788. |
in two independent cohorts of participants with symptoms of ad dementia (n = 55 and n = 90), csf pt217/t217 and pt205/t205 were better correlated with tau pet measures than csf p-tau181 concentration. |
2023-04-28 |
2023-08-14 |
human |
| Nader Morshed, Meelim J Lee, Felicia H Rodriguez, Douglas A Lauffenburger, Diego Mastroeni, Forest M Whit. Quantitative phosphoproteomics uncovers dysregulated kinase networks in Alzheimer's disease. Nature aging. vol 1. issue 6. 2023-04-28. PMID:37117831. |
alzheimer's disease (ad) is a form of dementia characterized by amyloid-β plaques and tau neurofibrillary tangles that progressively disrupt neural circuits in the brain. |
2023-04-28 |
2023-08-14 |
Not clear |
| Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. |
then, we evaluated the associations between these measurements and ndis in 29 candidate wm tracts using pearson correlation and multiple regression models results: based on 223 participants who were amyloid positive (mean age of 78 y/o and 57.0% male, 119 cognitively unimpaired, 56 mci, 48 dementia), the results showed that wm tracts ndi decreased with increasing regional braak tau suvrs. |
2023-04-17 |
2023-08-14 |
human |
| Monica van den Berg, Daniëlle Toen, Marleen Verhoye, Georgios A Keliri. Alterations in theta-gamma coupling and sharp wave-ripple, signs of prodromal hippocampal network impairment in the TgF344-AD rat model. Frontiers in aging neuroscience. vol 15. 2023-04-10. PMID:37032829. |
alzheimer's disease (ad) is a severe neurodegenerative disorder caused by the accumulation of toxic proteins, amyloid-beta (aβ) and tau, which eventually leads to dementia. |
2023-04-10 |
2023-08-14 |
rat |
| Feng Han, Xufu Liu, Yifan Yang, Xiao Li. Sex-specific age-related changes in glymphatic function assessed by resting-state functional magnetic resonance imaging. bioRxiv : the preprint server for biology. 2023-04-10. PMID:37034667. |
the glymphatic system that clears out brain wastes, such as amyloid-β (aβ) and tau, through cerebrospinal fluid (csf) flow may play an important role in aging and dementias. |
2023-04-10 |
2023-08-14 |
human |
| Shreya Gupta, Sanjay K A Jinka, Saugat Khanal, Neha Bhavnani, Fayez Almashhori, Jason Lallo, Amy Mathias, Yasmine Al-Rhayyel, Danielle Herman, John G Holden, Sheila M Fleming, Priya Rama. Cognitive dysfunction and increased phosphorylated tau are associated with reduced O-GlcNAc signaling in an aging mouse model of metabolic syndrome. Journal of neuroscience research. 2023-04-09. PMID:37031439. |
recent studies in patients and mouse models suggest a putative link between hyperphosphorylated tau, a component of alzheimer's disease-related dementia (adrd) pathology, and cerebral glucose hypometabolism. |
2023-04-09 |
2023-08-14 |
mouse |
| Ajay Elangovan, Harysh Winster Suresh Babu, Mahalaxmi Iyer, Abilash Valsala Gopalakrishnan, Balachandar Vellingir. Untangle the mystery behind DS-associated AD - Is APP the main protagonist? Ageing research reviews. 2023-04-09. PMID:37031726. |
with the recent development in patient care, the life expectancy of ds patients has gradually increased, leading to the high prospect of ad development, consequently leading to the development of plaques of amyloid proteins and neurofibrillary tangles made of tau by the fourth decade of the patient leading to dementia. |
2023-04-09 |
2023-08-14 |
Not clear |
| R López-Cuevas, M Baquero-Toledo, A Cuevas-Jiménez, N Martín-Ibáñez, R Pascual-Costa, M J Moreno-Monedero, A Cañada-Martínez, C Peña-Bautista, I Ferrer-Cairols, L Álvarez-Sánchez, C Cháfer-Pericá. Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease. Neurologia. 2023-04-09. PMID:37031800. |
baseline levels of total and phosphorylated tau were higher in the group of patients that progressed to dementia than in those remaining with mild cognitive impairment. |
2023-04-09 |
2023-08-14 |
Not clear |
| R López-Cuevas, M Baquero-Toledo, A Cuevas-Jiménez, N Martín-Ibáñez, R Pascual-Costa, M J Moreno-Monedero, A Cañada-Martínez, C Peña-Bautista, I Ferrer-Cairols, L Álvarez-Sánchez, C Cháfer-Pericá. Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease. Neurologia. 2023-04-09. PMID:37031800. |
after adjusting for age, sex, history of hypertension, diabetes, and educational level, a 10% increase in total tau protein values was associated with a 7.60% increase in the risk of progression to dementia (hazard ratio: 2.22; 95% confidence interval, 1.28-3.84]; p = .004). |
2023-04-09 |
2023-08-14 |
Not clear |
| R López-Cuevas, M Baquero-Toledo, A Cuevas-Jiménez, N Martín-Ibáñez, R Pascual-Costa, M J Moreno-Monedero, A Cañada-Martínez, C Peña-Bautista, I Ferrer-Cairols, L Álvarez-Sánchez, C Cháfer-Pericá. Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease. Neurologia. 2023-04-09. PMID:37031800. |
among patients with mild cognitive impairment due to ad and abnormal cerebrospinal fluid biomarker profiles, progressively higher concentrations of total or phosphorylated tau were associated with increased risk of progression to dementia. |
2023-04-09 |
2023-08-14 |
Not clear |
| Sylvain Lehmann, Susanna Schraen-Maschke, Jean-Sébastien Vidal, Constance Delaby, Frédéric Blanc, Claire Paquet, Bernadette Allinquant, Stéphanie Bombois, Audrey Gabelle, Olivier Hano. Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function. Journal of neurology, neurosurgery, and psychiatry. 2023-04-03. PMID:37012068. |
plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function. |
2023-04-03 |
2023-08-14 |
Not clear |
| Md Rejaul Hoq, Sakshibeedu R Bharath, Grace I Hallinan, Anllely Fernandez, Frank S Vago, Kadir A Ozcan, Daoyi Li, Holly J Garringer, Ruben Vidal, Bernardino Ghetti, Wen Jian. Cross-β helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia. Acta neuropathologica. 2023-03-23. PMID:36952000. |
cross-β helical filaments of tau and tmem106b in gray and white matter of multiple system tauopathy with presenile dementia. |
2023-03-23 |
2023-08-14 |
Not clear |