| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B J Everitt, K Fux. Serotonin and sexual behaviour in female rats. Effects of hallucinogenic indolealkylamines and phenylethylamines. Neuroscience letters. vol 4. issue 3-4. 2012-10-02. PMID:19604947. |
preliminary experiments on extensor reflexes (which are highly dependent on serotonin (5-ht) receptor activity) indicated that the drugs possess marked 5-ht receptor agonist properties. |
2012-10-02 |
2023-08-12 |
rat |
| S B Ross, O Frödé. On the mechanism of the acute decrease of rat brain tryptophan hydroxylase activity by 4-chloroamphetamine. Neuroscience letters. vol 5. issue 3-4. 2012-10-02. PMID:19604997. |
it is suggested that the decrease of the tryptophan hydroxylase activity is secondary to the release of 5-ht and mediated by 5-ht receptor stimulation. |
2012-10-02 |
2023-08-12 |
rat |
| B E Sumner, R Rosie, G Fin. Relative density of 5-hydroxytryptamine receptor subtype mRNAs in female rat neuroendocrine brain determined by in situ hybridization histochemistry. Molecular and cellular neurosciences. vol 3. issue 3. 2012-10-02. PMID:19912863. |
this distribution of 5-ht receptor mrna is consistent with a role of 5-ht(2) receptors in the control of ovulation (high density in dbb, ms, and mpoa) and mating (high density in vmh) and 5-ht(1a) receptors in the 5-ht control of circadian rhythms (scn) and in some functions of the son and pvn. |
2012-10-02 |
2023-08-12 |
rat |
| C Chanez, M A Flexor, M Hamo. Long lasting effects of intrauterine growth retardation on basal and 5-HT-stimulated Na(+)/K(+)-ATPase in the brain of developing rats. Neurochemistry international. vol 7. issue 2. 2012-10-02. PMID:20492930. |
since potent 5-ht antagonists such as cinanserin, methiothepin and methysergide, prevented the 5-ht induced-activation of na(+)/k(+)-atpase in brain homogenates, these results are discussed in relation with the possible existence of a specific 5-ht receptor controlling na(+)/k(+)-atpase activity in the rat brain. |
2012-10-02 |
2023-08-12 |
rat |
| P R Hartig, M J Evans, A M Krohn, S A Leder, P C Sze, D A Stoffer. [(125)I]LSD binding to serotonin and dopamine receptors in bovine caudate membranes. Neurochemistry international. vol 7. issue 4. 2012-10-02. PMID:20492977. |
[(125)i]lsd is a sensitive and selective label for 5-ht(2) (s2) serotonin receptor sites in both rat frontal cortex and bovine caudate membranes. |
2012-10-02 |
2023-08-12 |
rat |
| M B Assie, M Charveron, M Brile. In vivo [(3)H]ketanserin binding: effect of modifying synaptic serotonin levels. Neurochemistry international. vol 12. issue 1. 2012-10-02. PMID:20501207. |
since [(3)hjketanserin is an antagonist at the 5ht(2) serotonin receptor, one would expect its in vivo binding to be inhibited by increased levels of synaptic serotonin. |
2012-10-02 |
2023-08-12 |
mouse |
| T S King, I S Kan. Progesterone stimulation of in vitro GnRH release from the hypothalamus of the estrogen-primed, ovariectomized rat: serotoninergic role. Neurochemistry international. vol 13. issue 4. 2012-10-02. PMID:20501305. |
results of this study show that (1) progesterone can stimulate in vitro gnrh and 5-ht release from hypothalamic tissue slices of ovariectomized rats primed with estrogen and (2) the 5-ht receptor antagonist mianserin blocks the ability of progesterone to augment in vitro gnrh release from these tissue slices. |
2012-10-02 |
2023-08-12 |
rat |
| F P Zemlan, E F Schwab, R Maureen Murphy, M M Behbehan. Identification of a novel 5-HT(1) binding site in rat spinal cord. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504589. |
high affinity, specific [(3)h]5-hydroxytryptamine (5-ht) binding to spinal cord synaptosomes was examined to identify the 5-ht receptor subtypes present. |
2012-10-02 |
2023-08-12 |
rat |
| H E Connor, P P Humphrey, W Feniu. Serotonin receptors Therapeutic prospects in cardiovascular disease. Trends in cardiovascular medicine. vol 1. issue 5. 2012-10-02. PMID:21239312. |
recent advances in the classification of serotonin receptors, along with the identification of selective drug tools for some of these receptor types, enables the putative role of different serotonin receptor subtypes in both the etiology and treatment of disease states to be explored. |
2012-10-02 |
2023-08-12 |
Not clear |
| Kartik Balachandran, Samiya Hussain, Choon-Hwai Yap, Muralidhar Padala, Adrian H Chester, Ajit P Yoganatha. Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT(2A) receptor-dependent pathway. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 21. issue 3. 2012-10-02. PMID:21865058. |
in this study, we sought to understand the effects of elevated 5-ht levels and stretch overload on aortic valve remodeling and the dominant 5-ht receptor subtype that regulates these processes. |
2012-10-02 |
2023-08-12 |
Not clear |
| Yiyi Wang, Sun Young Park, Kyung Hoon Oh, Youngsil Min, Yun-Jeong Lee, Seok-Yong Lee, Uy Dong Soh. Characteristics of 5-hydroxytryptamine receptors involved in contraction of feline ileal longitudinal smooth muscle. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 15. issue 5. 2012-10-02. PMID:22128258. |
a number of studies have demonstrated that 5-hydroxytryptamine (5-ht) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-ht receptor subtypes. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Ongini, M Trampu. Modulation of sleep and waking states by D-1 receptors. Journal of psychopharmacology (Oxford, England). vol 6. issue 1. 2012-10-02. PMID:22291243. |
the effect appears to be specifically mediated by d-1 receptors, whereas the interaction of sch 23390 or its derivatives with the serotonin receptor subtype 5-ht(2) may contribute to an increase of total sleep, but does not seem to influence rem changes. |
2012-10-02 |
2023-08-12 |
Not clear |
| M Skingle, G A Higgins, W Feniu. Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig. Journal of psychopharmacology (Oxford, England). vol 8. issue 1. 2012-10-02. PMID:22298475. |
in contrast, the poorly selective 5-ht receptor antagonist, metergoline (1-10 mg/kg s.c.), and the potent 5-ht(1d) receptor antagonist, gr127935 (0.1-1 mg/kg p.o. |
2012-10-02 |
2023-08-12 |
Not clear |
| Katsunori Nonogak. Serotonin conflict in sleep-feeding. Vitamins and hormones. vol 89. 2012-10-01. PMID:22640616. |
although 5-ht predominately promotes waking and satiety, the effects of 5-ht depend on 5-ht receptor function. |
2012-10-01 |
2023-08-12 |
mouse |
| Zhiyong Yang, Xijin Liu, Yaping Yin, Shenggang Sun, Xuejun Den. Involvement of 5-HT₇ receptors in the pathogenesis of temporal lobe epilepsy. European journal of pharmacology. vol 685. issue 1-3. 2012-09-28. PMID:22543085. |
the 5-hydroxytryptamine 7 (5-ht(7)) receptor is the most recently classified member of the serotonin receptor family. |
2012-09-28 |
2023-08-12 |
human |
| T Watanabe, H Aonum. Identification and expression analyses of a novel serotonin receptor gene, 5-HT2β, in the field cricket, Gryllus bimaculatus. Acta biologica Hungarica. vol 63 Suppl 2. 2012-09-17. PMID:22776473. |
in our previous report, in order to elucidate the molecular basis of the cricket 5-ht system, we identified three genes involved in 5-ht biosynthesis, as well as four 5-ht receptor genes (5-ht1a, 5-ht1b, 5-ht2α, and 5-ht7) expressed in the brain of the field cricket gryllus bimaculatus degeer [7]. |
2012-09-17 |
2023-08-12 |
cricket |
| Katharina Heimes, Florian Hauk, Eugen J Verspoh. Mode of action of peppermint oil and (-)-menthol with respect to 5-HT3 receptor subtypes: binding studies, cation uptake by receptor channels and contraction of isolated rat ileum. Phytotherapy research : PTR. vol 25. issue 5. 2012-09-12. PMID:21077259. |
three different in vitro models were used to investigate the effects on 5-ht(3) receptors (serotonin receptor subtype): [(14)c]guanidinium influx into n1e-115 cells which express 5-ht(3) receptors, isotonic contractions of the isolated rat ileum and equilibrium competition binding studies using a radioactively labelled 5-ht(3) receptor antagonist ([(3)h]gr65630) (3-(5-methyl-1h-imidazol-4-yl)-1-(1-methyl-1h-indol-3-yl)-1-propanone). |
2012-09-12 |
2023-08-12 |
rat |
| Takashi Yoshimasu, Takaharu Ikeda, Koji Uede, Nobuo Kanazawa, Fukumi Furukaw. Effects of sarpogrelate hydrochloride on skin ulcers and quality of life in patients with systemic sclerosis. The Journal of dermatology. vol 39. issue 6. 2012-09-06. PMID:22077618. |
5-hydroxytryptamine 2a serotonin receptor (5-ht(2a) ) is associated with the contraction of vascular smooth muscle, platelet aggregation and thrombus formation and coronary artery spasms. |
2012-09-06 |
2023-08-12 |
Not clear |
| Jérôme Maheux, Laura Vuillier, Mylène Mahfouz, Claude Rouillard, Daniel Lévesqu. Modulation of haloperidol-induced patterns of the transcription factor Nur77 and Nor-1 expression by serotonergic and adrenergic drugs in the mouse brain. The international journal of neuropsychopharmacology. vol 15. issue 4. 2012-09-05. PMID:21524335. |
taken together, these results show the ability of a 5-ht(1a) agonist or a 5-ht(2a) antagonist to reduce haloperidol-induced nur77 and nor-1 striatal expression, suggesting that these serotonin receptor subtypes participate in the differential pattern of gene expression induced by typical and atypical antipsychotic drugs. |
2012-09-05 |
2023-08-12 |
mouse |
| Celso Almeida, Stefan Kehraus, Miguel Prudêncio, Gabriele M Köni. Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp. Beilstein journal of organic chemistry. vol 7. 2012-08-23. PMID:22238541. |
marilone b (2) showed selective antagonistic activity towards the serotonin receptor 5-ht(2b) with a k(i) value of 7.7 µm. |
2012-08-23 |
2023-08-12 |
Not clear |