| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyung-Mun Yun, Hyewhon Rhi. The serotonin-6 receptor as a novel therapeutic target. Experimental neurobiology. vol 20. issue 4. 2013-03-14. PMID:22355260. |
5-ht mediates its diverse physiological responses through 7 different 5-ht receptor families: 5-ht(1), 5-ht(2), 5-ht(3), 5-ht(4), 5-ht(5), 5-ht(6), and 5-ht(7) receptors. |
2013-03-14 |
2023-08-12 |
Not clear |
| Hyung-Mun Yun, Hyewhon Rhi. The serotonin-6 receptor as a novel therapeutic target. Experimental neurobiology. vol 20. issue 4. 2013-03-14. PMID:22355260. |
among them, the 5-ht(6) receptor (5-ht(6)r) is the most recently cloned serotonin receptor and plays important roles in the central nervous system (cns) and in the etiology of neurological diseases. |
2013-03-14 |
2023-08-12 |
Not clear |
| Saida Haider, Saima Khaliq, Saiqa Tabassum, Darakhshan J Halee. Role of somatodendritic and postsynaptic 5-HT₁A receptors on learning and memory functions in rats. Neurochemical research. vol 37. issue 10. 2013-02-19. PMID:22814880. |
activation and blockade of various serotonin (5-ht) receptors has been reported to alter cognitive processes and 5-ht receptor antagonism could be beneficial in the treatment of cognitive diseases. |
2013-02-19 |
2023-08-12 |
rat |
| Yahan Liu, Xiao Yu Tian, Guangmei Mao, Xi Fang, Man Lung Fung, John Y-J Shyy, Yu Huang, Nanping Wan. Peroxisome proliferator-activated receptor-γ ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension (Dallas, Tex. : 1979). vol 60. issue 6. 2013-02-07. PMID:23108648. |
an elevated plasma level of 5-hydroxytryptamine (5-ht) or upregulation of 5-ht receptor signaling or both is implicated in vascular contraction and remodeling in pulmonary arterial hypertension (pah). |
2013-02-07 |
2023-08-12 |
rat |
| Jardel Gomes Villarinho, Roselei Fachinetto, Francielle de Vargas Pinheiro, Gabriela da Silva Sant'Anna, Pablo Machado, Patrícia Andréia Dombrowski, Cláudio da Cunha, Daniela de Almeida Cabrini, Marcos Antônio Pinto Martins, Helio Gauze Bonacorso, Nilo Zanatta, Maribel Antonello Rubin, Juliano Ferreir. Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22525823. |
the antidepressant-like effect of 2-dmpi was inhibited by the pretreatment of mice with methysergide (2 mg/kg, s.c., a non-selective serotonin receptor antagonist), way100635 (0.1 mg/kg, s.c., a selective 5-ht(1a) receptor antagonist) or haloperidol (0.05 mg/kg, i.p., a non-selective dopamine receptor antagonist). |
2013-01-21 |
2023-08-12 |
mouse |
| C M Olarte-Sánchez, L Valencia Torres, S Body, H J Cassaday, C M Bradshaw, E Szabadi, A J Goudi. A clozapine-like effect of cyproheptadine on progressive ratio schedule performance. Journal of psychopharmacology (Oxford, England). vol 26. issue 6. 2013-01-15. PMID:21890589. |
the atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-ht₂) and histamine (h₁) receptor antagonist effects, are shared by the non-selective 5-ht receptor antagonist cyproheptadine. |
2013-01-15 |
2023-08-12 |
rat |
| Joanne Ryan, Marie-Laure Anceli. Polymorphisms of estrogen receptors and risk of depression: therapeutic implications. Drugs. vol 72. issue 13. 2013-01-14. PMID:22901010. |
estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. |
2013-01-14 |
2023-08-12 |
Not clear |
| Katie Ann Jennings, Cecilie Löe Licht, Aynsley Bruce, Klaus-Peter Lesch, Gitte Moos Knudsen, Trevor Shar. Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT₄ receptor levels. The international journal of neuropsychopharmacology. vol 15. issue 8. 2012-12-28. PMID:21846421. |
genetic variation in 5-ht transporter (5-htt) expression is a key risk factor for psychiatric disorder and has been linked to changes in the expression of certain 5-ht receptor subtypes. |
2012-12-28 |
2023-08-12 |
mouse |
| Hannah K Delille, Judith M Becker, Sabrina Burkhardt, Barbara Bleher, Georg C Terstappen, Martin Schmidt, Axel H Meyer, Liliane Unger, Gerard J Marek, Mario Mezle. Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22300836. |
in the brain a functional crosstalk between the serotonin receptor 5-ht(2a) and the metabotropic glutamate receptor mglu(2) has been demonstrated. |
2012-12-20 |
2023-08-12 |
Not clear |
| Shinichi Kato, Narumi Matsuda, Kenjiro Matsumoto, Mai Wada, Naoki Onimaru, Masashi Yasuda, Kikuko Amagase, Syunji Horie, Koji Takeuch. Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Pharmacological research. vol 66. issue 3. 2012-12-11. PMID:22699012. |
serotonin (5-ht) exerts multiple physiological functions not only in the central and peripheral nervous systems but also in the gastrointestinal tract, and these multiple functions are accounted for by a variety of 5-ht receptor subtypes. |
2012-12-11 |
2023-08-12 |
mouse |
| Shinichi Kato, Narumi Matsuda, Kenjiro Matsumoto, Mai Wada, Naoki Onimaru, Masashi Yasuda, Kikuko Amagase, Syunji Horie, Koji Takeuch. Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Pharmacological research. vol 66. issue 3. 2012-12-11. PMID:22699012. |
we investigated the role of 5-ht in the pathogenesis of indomethacin-induced intestinal lesions in mice, in relation to 5-ht receptor subtypes. |
2012-12-11 |
2023-08-12 |
mouse |
| Stephanie Tung, Alexandre B Hardy, Michael B Wheeler, Denise D Belsha. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor. Endocrinology. vol 153. issue 10. 2012-12-11. PMID:22919062. |
serotonin (5-ht) activation of immortalized hypothalamic neuronal cells through the 5-ht1b serotonin receptor. |
2012-12-11 |
2023-08-12 |
mouse |
| Shamim Akhtar, Muhammad Arif, Nousheen Mushtaq, Zafar Saeed Saify, Ahsaan Ahmed, Darakhshan Jabeen Haleem, Arfa Akra. Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives. Pakistan journal of pharmaceutical sciences. vol 25. issue 4. 2012-12-11. PMID:23009984. |
moreover, these compounds have also shown the decreased level of 5-ht alone with increased level of dopamine as an indication of their antagonism towards 5-ht receptor. |
2012-12-11 |
2023-08-12 |
Not clear |
| Xueqing Hu, Yan Li, Zhiying Hu, John A Rudd, Shucai Ling, Fangzhen Jiang, Henry Davies, Marong Fan. The alteration of 5-HT(2A) and 5-HT(2C) receptors is involved in neuronal apoptosis of goldfish cerebellum following traumatic experience. Neurochemistry international. vol 61. issue 2. 2012-12-07. PMID:22561958. |
the effect of treatment with doxepin and fluoxetine, known to be selective serotonin reuptake inhibitor (ssri) antidepressants, on 5-ht receptor expression in goldfish with fin ablation was also investigated. |
2012-12-07 |
2023-08-12 |
Not clear |
| Paul R Alber. Transcriptional regulation of the 5-HT1A receptor: implications for mental illness. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826341. |
the serotonin-1a (5-ht(1a)) receptor is an abundant post-synaptic 5-ht receptor (heteroreceptor) implicated in regulation of mood, emotion and stress responses and is the major somatodendritic autoreceptor that negatively regulates 5-ht neuronal activity. |
2012-12-06 |
2023-08-12 |
Not clear |
| Adam Pigott, Stewart Frescas, John D McCorvy, Xi-Ping Huang, Bryan L Roth, David E Nichol. trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. Beilstein journal of organic chemistry. vol 8. 2012-12-05. PMID:23209503. |
screening for affinity at various serotonin receptor subtypes, however, revealed that the cyclopropane congeners also had increased affinity at several sites in addition to the 5-ht(2a) and 5-ht(2b) receptors. |
2012-12-05 |
2023-08-12 |
Not clear |
| Ercan Ozdemir, Sinan Gursoy, Ihsan Bagciva. The effects of serotonin/norepinephrine reuptake inhibitors and serotonin receptor agonist on morphine analgesia and tolerance in rats. The journal of physiological sciences : JPS. vol 62. issue 4. 2012-10-29. PMID:22544464. |
the aim of this study was to investigate the possible role of serotonin/norepinephrine reuptake inhibitors (amitriptyline, venlafaxine) and serotonin receptor (5-ht(1a) and 5-ht(1b/1d)) agonist (dihydroergotamine) in morphine analgesia and tolerance in rats. |
2012-10-29 |
2023-08-12 |
rat |
| Michael Maes, Karl Ringel, Marta Kubera, Michael Berk, Janusz Rybakowsk. Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression. Journal of affective disorders. vol 136. issue 3. 2012-10-09. PMID:22166399. |
lowering the 5-ht precursor tryptophan, and upregulating 5-ht receptor mrna. |
2012-10-09 |
2023-08-12 |
Not clear |
| Roland Heinig, Pavur Sundaresan, Anita Shah, Michael Boettche. Effect of gender and age on the pharmacokinetics of repinotan. Clinical drug investigation. vol 25. issue 2. 2012-10-02. PMID:17523762. |
repinotan hydrochloride (repinotan) is a selective, high-affinity, full serotonin receptor agonist at the 5-ht(1a) subtype that is undergoing clinical development in acute stroke. |
2012-10-02 |
2023-08-12 |
human |
| B Kacsóh, C E Grosveno. Regulation of Basal and nursing-induced secretion of growth hormone in the neonatal rat: the involvement of serotonergic, muscarinic cholinergic, alpha-adrenergic, somatostatin and growth hormone-releasing hormone systems. Journal of neuroendocrinology. vol 3. issue 5. 2012-10-02. PMID:19215503. |
the serotonin (5-ht) precursor 5-hydroxy-l-tryptophan (5-htp) and the 5-ht receptor agonist quipazine maleate stimulated serum gh levels in 2-day-old rat pups separated from their mothers for 6 h. the increase in serum gh during suckling was further elevated by 5-htp. |
2012-10-02 |
2023-08-12 |
rat |