| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M L Cohen, A D Susemichel, W Bloomquist, D W Robertso. 5-HT4 receptors in rat but not guinea pig, rabbit or dog esophageal smooth muscle. General pharmacology. vol 25. issue 6. 1995-04-06. PMID:7875537. |
serotonin contracted the guinea pig and rabbit esophagus; an effect blocked by ly53857 (10(-7 m) and ketanserin (10(-7) m), consistent with 5-ht2 receptor activation mediating this contraction. |
1995-04-06 |
2023-08-12 |
dog |
| M L Cohen, A D Susemichel, W Bloomquist, D W Robertso. 5-HT4 receptors in rat but not guinea pig, rabbit or dog esophageal smooth muscle. General pharmacology. vol 25. issue 6. 1995-04-06. PMID:7875537. |
thus, in guinea pig and rabbit esophagus, serotonin induced a contraction mediated by 5-ht2 receptors; and serotonin neither contracted nor relaxed the canine esophagus. |
1995-04-06 |
2023-08-12 |
dog |
| V Vouret-Craviari, P Auberger, J Pouysségur, E Van Obberghen-Schillin. Distinct mechanisms regulate 5-HT2 and thrombin receptor desensitization. The Journal of biological chemistry. vol 270. issue 9. 1995-04-05. PMID:7533166. |
we have compared the desensitization of two receptors, the thrombin receptor which displays dual coupling to both pertussis toxin-sensitive (gi) and -insensitive (gq) proteins and the serotonin type 2 (5-ht2) receptor which selectively couples to gq. |
1995-04-05 |
2023-08-12 |
Not clear |
| A Kłodzińska, E Chojnacka-Wójci. Hyperthermia induced by m-trifluoromethylphenylpiperazine (TFMPP) or m-chlorophenylpiperazine (m-CPP) in heat-adapted rats. Psychopharmacology. vol 109. issue 4. 1995-04-04. PMID:1365864. |
the hyperthermic effect of tfmpp (10 mg/kg) or m-cpp (10 mg/kg) was dose-dependently antagonized by the 5-ht1c and 5-ht2 receptor antagonists mesulergine (0.5-4 mg/kg), ketanserin (0.6-2.5 mg/kg) and ritanserin (0.5-2 mg/kg) and by the non-selective 5-ht antagonist metergoline (0.5-1 mg/kg), or was attenuated by the 5-ht1a, 5-ht2 and dopamine receptor antagonist spiperone (3 mg/kg, but not 0.3 or 1 mg/kg). |
1995-04-04 |
2023-08-11 |
rat |
| J D Ramamoorthy, S Ramamoorthy, V B Mahesh, F H Leibach, V Ganapath. Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells. Endocrinology. vol 136. issue 3. 1995-03-29. PMID:7867601. |
these binding sites were not related to dopamine (d2) and serotonin (5-ht2) receptors nor to serotonin and norepinephrine transporters. |
1995-03-29 |
2023-08-12 |
human |
| G Grignaschi, R Samani. Role of serotonin receptors in the effect of sertraline on feeding behaviour. Psychopharmacology. vol 110. issue 1-2. 1995-03-29. PMID:7870886. |
the effect of sertraline, a serotonin (5-ht) uptake inhibitor, on 1 h food intake of food-deprived rats was studied in male rats treated intraperitoneally with 1 and 2.5 mg/kg metergoline, a 5-ht1 and 5-ht2 receptor antagonist, 0.5 mg/kg gr 38032f, a 5-ht3 receptor antagonist, or intracerebroventricularly with 6-hydroxy-dopamine to destroy catecholamine-containing neurons. |
1995-03-29 |
2023-08-12 |
rat |
| S Caccia, S Confalonieri, G Guiso, P Bernasconi, A Cagnotto, M Skorupska, T Mennin. Brain uptake and distribution of the potential memory enhancer CL 275,838 and its main metabolites in rats: relationship between brain concentrations and in vitro potencies on neurotransmitter mechanisms. Psychopharmacology. vol 115. issue 4. 1995-03-28. PMID:7871095. |
at micromolar concentrations the parent compound had affinity for serotonin (5-ht) uptake sites, 5-ht2 and dopamine (da2) receptors. |
1995-03-28 |
2023-08-12 |
rat |
| P D Hrdina, D Bakish, J Chudzik, A Ravindran, Y D Lapierr. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of psychiatry & neuroscience : JPN. vol 20. issue 1. 1995-03-27. PMID:7865496. |
the uptake of [3h]5-ht and the density (bmax) as well as affinity (kd) of 5-ht uptake sites labelled with [3h]paroxetine and of 5-ht2 receptors labelled by [3h]lsd were determined in platelets from 25 medication-free patients with major depression and 20 normal controls. |
1995-03-27 |
2023-08-12 |
human |
| P D Hrdina, D Bakish, J Chudzik, A Ravindran, Y D Lapierr. Serotonergic markers in platelets of patients with major depression: upregulation of 5-HT2 receptors. Journal of psychiatry & neuroscience : JPN. vol 20. issue 1. 1995-03-27. PMID:7865496. |
no changes were found in the affinity (kd) of 5-ht2 receptors and in 5-ht uptake or [3h]paroxetine binding parameters. |
1995-03-27 |
2023-08-12 |
human |
| T A Bruning, P C Chang, G J Blauw, P Vermeij, P A Van Zwiete. Interactions between serotonin and endogenous and exogenous noradrenaline in the human forearm. Blood pressure. vol 3. issue 5. 1995-03-27. PMID:7866595. |
na or 5-ht (1 ng/kg/min) were also infused with the selective 5-ht2 receptor antagonist ritanserin (500 ng/kg/min). |
1995-03-27 |
2023-08-12 |
human |
| I Kusumi, T Koyama, I Yamashit. Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacology. vol 113. issue 3-4. 1995-03-20. PMID:7862840. |
serotonin(5-ht)-stimulated intracellular calcium(ca) mobilization was measured in the platelets of depressed patients to assess 5-ht2 receptor function. |
1995-03-20 |
2023-08-12 |
Not clear |
| I Kusumi, T Koyama, I Yamashit. Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacology. vol 113. issue 3-4. 1995-03-20. PMID:7862840. |
these results suggest that 5-ht2 receptor function is increased in some types of depression, and raise the possibility that the enhanced ca response to 5-ht may be trait dependent rather than state dependent. |
1995-03-20 |
2023-08-12 |
Not clear |
| G G Nomikos, M Iurlo, J L Andersson, K Kimura, T H Svensso. Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862887. |
the putative atypical antipsychotic drug amperozide (apz) shows high affinity for serotonin 5-ht2 receptors but only low affinity for dopamine (da) d2 receptors. |
1995-03-20 |
2023-08-12 |
rat |
| M Ansseau, P Darimont, A Lecoq, A De Nayer, J L Evrard, P Krémer, J M Devoitille, M Dierick, C Mertens, F Mesotte. Controlled comparison of nefazodone and amitriptyline in major depressive inpatients. Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862904. |
nefazodone, a phenylpiperazine antidepressant, exhibits novel dual activity on serotonin (5-ht) neurons; it binds to 5-ht2 receptors and inhibits 5-ht reuptake. |
1995-03-20 |
2023-08-12 |
Not clear |
| B Cusack, A Nelson, E Richelso. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology. vol 114. issue 4. 1995-03-16. PMID:7855217. |
using radioligand binding assays and post-mortem normal human brain tissue, we obtained equilibrium dissociation constants (kds) for 17 antidepressants and two of their metabolites at histamine h1, muscarinic, alpha 1-adrenergic, alpha 2-adrenergic, dopamine d2, serotonin 5-ht1a, and serotonin 5-ht2 receptors. |
1995-03-16 |
2023-08-12 |
human |
| H Y Meltzer, M Mae. Effect of pindolol on the L-5-HTP-induced increase in plasma prolactin and cortisol concentrations in man. Psychopharmacology. vol 114. issue 4. 1995-03-16. PMID:7855226. |
previous studies with direct-acting serotonin (5-ht) agonists and antagonists have demonstrated that stimulation of 5-ht1a, 5-ht1c and 5-ht2 receptors may promote cortisol and prolactin (prl) secretion in man. |
1995-03-16 |
2023-08-12 |
human |
| A E Pickering, D Spanswick, S D Loga. 5-Hydoxytryptamine evokes depolarizations and membrane potential oscillations in rat sympathetic preganglionic neurones. The Journal of physiology. vol 480 ( Pt 1). 1995-03-10. PMID:7853215. |
the 5-ht2 receptor agonist alpha-methyl-5-ht mimicked the 5-ht response on all neurones, as did the 5-ht1 receptor agonist 5-carboxamidotryptamine (5-ct) on 71% of spn. |
1995-03-10 |
2023-08-12 |
rat |
| A E Pickering, D Spanswick, S D Loga. 5-Hydoxytryptamine evokes depolarizations and membrane potential oscillations in rat sympathetic preganglionic neurones. The Journal of physiology. vol 480 ( Pt 1). 1995-03-10. PMID:7853215. |
the responses to 5-ht, alpha-methyl-5-ht and 5-ct were inhibited by the 5-ht2 antagonists ketanserin and ritanserin. |
1995-03-10 |
2023-08-12 |
rat |
| A E Pickering, D Spanswick, S D Loga. 5-Hydoxytryptamine evokes depolarizations and membrane potential oscillations in rat sympathetic preganglionic neurones. The Journal of physiology. vol 480 ( Pt 1). 1995-03-10. PMID:7853215. |
spn are powerfully depolarized by 5-ht acting at 5-ht2 receptors, via the closure of an outwardly rectifying potassium conductance. |
1995-03-10 |
2023-08-12 |
rat |
| A A Megens, F H Awouters, A Schotte, T F Meert, C Dugovic, C J Niemegeers, J E Leyse. Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7531353. |
the primary action of risperidone is serotonin 5-ht2 receptor blockade as shown by displacement of radioligand binding (ki: 0.16 nm), activity on isolated tissues (ec50: 0.5 nm), and antagonism of peripherally (ed50: 0.0011 mg/kg) and centrally (ed50: 0.014 mg/kg) acting 5-ht2 receptor agonists in rats. |
1995-03-08 |
2023-08-12 |
rat |