| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Waeber, J M Palacio. Binding sites for 5-hydroxytryptamine-2 receptor agonists are predominantly located in striosomes in the human basal ganglia. Brain research. Molecular brain research. vol 24. issue 1-4. 1994-12-07. PMID:7968358. |
previous autoradiographic studies have shown that serotonin 5-ht2 receptors are homogeneously distributed in the human striatum. |
1994-12-07 |
2023-08-12 |
human |
| R Monteau, E Di Pasquale, G Hilair. Further evidence that various 5-HT receptor subtypes modulate central respiratory activity: in vitro studies with SR 46349B. European journal of pharmacology. vol 259. issue 1. 1994-12-01. PMID:7957597. |
the ability of sr 46349b [trans,4-([3z)3-(2-dimethylaminoethyl)oxyimino- 3(2-flurophenyl)propen-1-yl]phenol hemifumarate], a 5-ht2 receptor antagonist, to block the changes in respiratory activity induced by serotonin was analysed by using brain stem-spinal cord preparations from newborn rats. |
1994-12-01 |
2023-08-12 |
rat |
| R Monteau, E Di Pasquale, G Hilair. Further evidence that various 5-HT receptor subtypes modulate central respiratory activity: in vitro studies with SR 46349B. European journal of pharmacology. vol 259. issue 1. 1994-12-01. PMID:7957597. |
the tonic discharge of cervical motoneurons and the depression of inspiratory hypoglossal activity elicited by serotonin (and 5-ht2 receptor agonist) were reduced in a dose-dependent manner by sr 46349b. |
1994-12-01 |
2023-08-12 |
rat |
| S Stah. 5HT1A receptors and pharmacotherapy. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs? Psychopharmacology bulletin. vol 30. issue 1. 1994-12-01. PMID:7972628. |
a general hypothesis of 5-ht receptor dysregulation in depression suggests that 5-ht1a receptors may be down-regulated, whereas 5-ht2 receptors may be up-regulated and display an inadequate ability to convert receptor occupancy by 5-ht into an adequate physiological response. |
1994-12-01 |
2023-08-12 |
Not clear |
| K Rickels, E Schweizer, C Clary, I Fox, C Weis. Nefazodone and imipramine in major depression: a placebo-controlled trial. The British journal of psychiatry : the journal of mental science. vol 164. issue 6. 1994-11-29. PMID:7952987. |
nefazodone is a phenylpiperazine antidepressant with 5-ht2 antagonism and 5-ht reuptake inhibition. |
1994-11-29 |
2023-08-12 |
Not clear |
| M Yamada, T Nishigami, K Nakasho, Y Nishimoto, H Miyaj. Relationship between sigma-like site and progesterone-binding site of adult male rat liver microsomes. Hepatology (Baltimore, Md.). vol 20. issue 5. 1994-11-23. PMID:7927262. |
as a result, we demonstrated that adult male rat liver microsomes, especially smooth endoplasmic reticulum, possessed a saturable haloperidol-binding site closely resembling the sigma site, with a high affinity (kd 1.0 +/- 0.3 nmol/l) and high capacity (bmax 9.3 +/- 1.5 pmol/mg protein) and with the rank order of affinity of the ligands: haloperidol > reduced haloperidol > clorgyline > ifenprodil > 1,3-di(2-tolyl)guanidine, (-)-butaclamol > gbr-12909 > skf-525a > progesterone > 5 alpha-dihydrotestosterone > r(+)-3- (hydroxyphenyl)-n-propylpiperidine > testosterone >> corticosteroids, estradiol-17 beta, cholesterol and neuroactive compounds displaying high affinities for other neurotransmitter receptors such as dopamine d2, serotonin (5-ht1a and 5-ht2) and alpha 1-adrenergic and gabaa receptors. |
1994-11-23 |
2023-08-12 |
rat |
| L J Cohe. Risperidone. Pharmacotherapy. vol 14. issue 3. 1994-11-21. PMID:7524043. |
risperidone, a benzisoxazole derivative, is a novel antipsychotic agent that has an extremely strong binding affinity for serotonin 5-ht2 receptors, a strong binding affinity for dopamine d2 receptors, and a high affinity for alpha 1- and alpha 2-adrenergic receptors and histamine h1 receptors. |
1994-11-21 |
2023-08-12 |
Not clear |
| M B Hansen, J E Thørboll, E Beubler, E Skadhaug. Effect of indomethacin, renzapride, methysergide, ketanserin, granisetron and citalopram on serotonin-induced fluid accumulation in pig jejunum. Physiological research. vol 43. issue 2. 1994-11-16. PMID:7918343. |
the antagonistic effects of indomethacin, ketanserin and granisetron, suggest the involvement of prostaglandins, as well as the 5-ht2 and the 5-ht3 receptor subtypes in the fluid accumulating response of 5-ht. |
1994-11-16 |
2023-08-12 |
Not clear |
| A Siniscalchi, I Badini, C Bianchi, L Bean. Monoamines modulate the electrically-evoked efflux of 3H-choline from slices of guinea pig nucleus basalis magnocellularis. Naunyn-Schmiedeberg's archives of pharmacology. vol 350. issue 1. 1994-11-16. PMID:7935846. |
5-hydroxytryptamine (5-ht) 0.3-30 microm, and alpha-methyl-5-ht, 10 microm, significantly increased 3h-ch efflux from nbm slices; the 5-ht2 antagonist ritanserin, 1 microm, prevented this response. |
1994-11-16 |
2023-08-12 |
Not clear |
| T Obi, A Kabeyama, A Nishi. Equine coronary artery responds to 5-hydroxytryptamine with relaxation in vitro. Journal of veterinary pharmacology and therapeutics. vol 17. issue 3. 1994-11-15. PMID:7933060. |
both 5-ht and alpha-methyl-5-ht (alpha-me-5-ht; 5-ht2 agonist) produced concentration-dependent relaxations in equine coronary arteries precontracted with a thromboxane a2 derivative (ono11113). |
1994-11-15 |
2023-08-12 |
Not clear |
| T Obi, A Kabeyama, A Nishi. Equine coronary artery responds to 5-hydroxytryptamine with relaxation in vitro. Journal of veterinary pharmacology and therapeutics. vol 17. issue 3. 1994-11-15. PMID:7933060. |
in the coronary arteries without endothelium, alpha-me-5-ht produced no relaxation, but 5-ht caused relaxation, which was inhibited by a 5-ht1 antagonist (methysergide, mianserin and methiothepin), but was inhibited neither by ketanserin (5-ht2 antagonist) nor by mdl72222 (5-ht3 antagonist). |
1994-11-15 |
2023-08-12 |
Not clear |
| T Obi, A Kabeyama, A Nishi. Equine coronary artery responds to 5-hydroxytryptamine with relaxation in vitro. Journal of veterinary pharmacology and therapeutics. vol 17. issue 3. 1994-11-15. PMID:7933060. |
these results suggest that the relaxation induced by 5-ht in equine coronary arteries depends mainly on the stimulation of both 5-ht1 receptor subtype on smooth muscle cells directly, and 5-ht2 receptor subtype on endothelial cells indirectly by liberating endothelium-derived no. |
1994-11-15 |
2023-08-12 |
Not clear |
| I A Khan, P Thoma. Seasonal and daily variations in the plasma gonadotropin II response to a LHRH analog and serotonin in Atlantic croaker (Micropogonias undulatus): evidence for mediation by 5-HT2 receptors. The Journal of experimental zoology. vol 269. issue 6. 1994-11-10. PMID:7931125. |
seasonal and daily variations in the plasma gonadotropin ii response to a lhrh analog and serotonin in atlantic croaker (micropogonias undulatus): evidence for mediation by 5-ht2 receptors. |
1994-11-10 |
2023-08-12 |
Not clear |
| I A Khan, P Thoma. Seasonal and daily variations in the plasma gonadotropin II response to a LHRH analog and serotonin in Atlantic croaker (Micropogonias undulatus): evidence for mediation by 5-HT2 receptors. The Journal of experimental zoology. vol 269. issue 6. 1994-11-10. PMID:7931125. |
pretreatment of the fish with a 5-ht2 antagonist, ly 53,857 maleate, almost completely abolished the stimulatory effect of 5-ht on lhrha-induced gth ii secretion, whereas a 5-ht1 antagonist, methiothepin mesylate, failed to influence the stimulatory effect of 5-ht on gth ii secretion. |
1994-11-10 |
2023-08-12 |
Not clear |
| I A Khan, P Thoma. Seasonal and daily variations in the plasma gonadotropin II response to a LHRH analog and serotonin in Atlantic croaker (Micropogonias undulatus): evidence for mediation by 5-HT2 receptors. The Journal of experimental zoology. vol 269. issue 6. 1994-11-10. PMID:7931125. |
in addition, a 5-ht2 agonist, (+/-) doi hydrochloride, potentiated the effect of 5-ht on basal and lhrha-induced gth ii secretion, while a 5-ht1 agonist, m-chlorophenylpiperazine dihydrochloride, did not. |
1994-11-10 |
2023-08-12 |
Not clear |
| I A Khan, P Thoma. Seasonal and daily variations in the plasma gonadotropin II response to a LHRH analog and serotonin in Atlantic croaker (Micropogonias undulatus): evidence for mediation by 5-HT2 receptors. The Journal of experimental zoology. vol 269. issue 6. 1994-11-10. PMID:7931125. |
moreover, the stimulatory effect of 5-ht appears to be mediated by 5-ht2 receptors in this species. |
1994-11-10 |
2023-08-12 |
Not clear |
| D S Choi, G Birraux, J M Launay, L Maroteau. The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors. FEBS letters. vol 352. issue 3. 1994-11-07. PMID:7926008. |
the human serotonin 5-ht2b receptor: pharmacological link between 5-ht2 and 5-ht1d receptors. |
1994-11-07 |
2023-08-12 |
human |
| Y Kuroda, Y Watanabe, D S Albeck, N B Hastings, B S McEwe. Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on 5-HT1A and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain. Brain research. vol 648. issue 1. 1994-10-31. PMID:7922518. |
effects of adrenalectomy and type i or type ii glucocorticoid receptor activation on 5-ht1a and 5-ht2 receptor binding and 5-ht transporter mrna expression in rat brain. |
1994-10-31 |
2023-08-12 |
rat |
| Y Kuroda, Y Watanabe, D S Albeck, N B Hastings, B S McEwe. Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on 5-HT1A and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain. Brain research. vol 648. issue 1. 1994-10-31. PMID:7922518. |
we evaluated the effects of adrenalectomy (adx) and replacement with glucocorticoid receptor agonists on serotonin (5-ht) 5-ht1a and 5-ht2 receptor binding in rat brain. |
1994-10-31 |
2023-08-12 |
rat |
| T Hohlfeld, M Braun, H Strobach, K Schrö. Protection of reperfused ischemic pig myocardium by nexopamil, a new combined Ca2+ and serotonin antagonist. Journal of cardiovascular pharmacology. vol 23. issue 6. 1994-10-25. PMID:7523784. |
we investigated the ability of a newly developed calcium and serotonin (5-ht2) antagonist, nexopamil, to protect the heart from ischemia- and reperfusion-induced myocardial injury. |
1994-10-25 |
2023-08-12 |
Not clear |