| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y L Du, B D Wilcox, M Teitler, J J Jeffre. Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter: constitutive and inducible activity in myometrial smooth muscle cells. Molecular pharmacology. vol 45. issue 6. 1994-08-01. PMID:8022406. |
previous studies from this laboratory have demonstrated that the 5-hydroxytryptamine (5-ht2) receptor subtype is transcriptionally regulated by 5-ht (serotonin) itself in rat myometrial smooth muscle cells. |
1994-08-01 |
2023-08-12 |
rat |
| Y L Du, B D Wilcox, M Teitler, J J Jeffre. Isolation and characterization of the rat 5-hydroxytryptamine type 2 receptor promoter: constitutive and inducible activity in myometrial smooth muscle cells. Molecular pharmacology. vol 45. issue 6. 1994-08-01. PMID:8022406. |
conversely, a selective 5-ht2 receptor agonist completely substituted for serotonin as an inducer. |
1994-08-01 |
2023-08-12 |
rat |
| A Panconesi, B Anselmi, C Curradi, F Perfetto, A Piluso, G Franch. Comparison between venoconstrictor effects of sumatriptan and ergotamine in migraine patients. Headache. vol 34. issue 4. 1994-07-27. PMID:8014033. |
ergotamine-induced hand vein contraction, almost completely inhibited by ketanserin, seems mediated at least in part by 5-ht2 receptors, like the one induced by 5-ht and sumatriptan, already observed in a previous study. |
1994-07-27 |
2023-08-12 |
human |
| L Cervo, C Bendotti, G Tarizzo, A Cagnotto, M Skorupska, T Mennini, R Samani. Potential antidepressant properties of SR 57746A, a novel compound with selectivity and high affinity for 5-HT1A receptors. European journal of pharmacology. vol 253. issue 1-2. 1994-07-26. PMID:8013540. |
the compound showed a high affinity for 5-ht1a specific binding sites in the rat hippocampus (ic50 3 nm), moderate affinity (10(-7)-10(-6) m) for dopamine d2 receptor, 5-ht uptake, 5-ht2 and alpha 1-adrenoceptor binding sites and practically no effect on binding sites of monoamine, gabaa, benzodiazepine and histamine receptors. |
1994-07-26 |
2023-08-12 |
rat |
| M V Waikar, A P Ford, D E Clark. Evidence for an inhibitory 5-HT4 receptor in urinary bladder of rhesus and Cynomolgus monkeys. British journal of pharmacology. vol 111. issue 1. 1994-07-25. PMID:8012699. |
the inhibitory action of 5-ht was resistant to antagonism by methysergide (1 microm) and ondansetron (5 microm), thereby eliminating a role for 5-ht1, 5-ht2 and 5-ht3 receptors. |
1994-07-25 |
2023-08-12 |
monkey |
| M Shinohara, T Kariy. [Etiology of affective disorders]. Nihon rinsho. Japanese journal of clinical medicine. vol 52. issue 5. 1994-07-20. PMID:7911850. |
neurochemically, decreased 5-ht uptake in the platelet, increased 5-ht2 receptor in the platelet and cortex of suicides, increased beta receptor in the brains of suicide, functional abnormality of alpha 2 receptor in clonidine, dmi test, gabab receptor up-regulation after chronic administration of antidepressants and mood stabilizers, participation of neuropeptide y, and abnormality of hpa axis were recognized. |
1994-07-20 |
2023-08-12 |
Not clear |
| C J Schmidt, J H Kehne, A A Carr, G M Fadayel, T M Humphreys, H J Kettler, T C McCloskey, R A Padich, V L Taylor, S M Sorense. Contribution of serotonin neurotoxins to understanding psychiatric disorders: the role of 5-HT2 receptors in schizophrenia and antipsychotic activity. International clinical psychopharmacology. vol 8 Suppl 2. 1994-07-07. PMID:7911139. |
contribution of serotonin neurotoxins to understanding psychiatric disorders: the role of 5-ht2 receptors in schizophrenia and antipsychotic activity. |
1994-07-07 |
2023-08-12 |
Not clear |
| P W Burnet, D Michelson, M A Smith, P W Gold, E M Sternber. The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199869. |
to further characterize these strains, we investigated the effect of chronic (8 wk) imipramine administration (5 mg/kg/day) on 5-ht1a and 5-ht2 receptor densities and mrna in the cortex and hippocampus and 5-ht transporter mrna in the dorsal raphe of lew/n, hsd, and f344/n rats, using quantitative autoradiography and in situ hybridization histochemistry. |
1994-07-07 |
2023-08-12 |
rat |
| N A Abdullah, M Hirata, K Matsumoto, H Aizawa, R Inoue, S Hamano, S Ikeda, Z Xie, N Hara, Y It. Contraction and depolarization induced by fetal bovine serum in airway smooth muscle. The American journal of physiology. vol 266. issue 5 Pt 1. 1994-07-07. PMID:8203546. |
methysergide (10(-6) m) or cyproheptadine (10(-6) m), nonspecific antagonists to serotonin receptors, 5-hydroxytryptamines (5-ht1 and 5-ht2), markedly reduced the fbs-induced increase in the muscle tone to approximately 20% of the original value but did not abolish the response. |
1994-07-07 |
2023-08-12 |
dog |
| K Minakam. [Brain monoamines and behavior in hyperammonemic sparse-fur mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 103. issue 5. 1994-06-22. PMID:8188118. |
the frequency of the head twitch response induced by 5-methoxy-n,n-dimethyltryptamine (5-meodmt) decreased in the hyperammonemic period, in which the concentration of brain tryptophan (trp) and 5-hydroxyindoleacetic acid (5-hiaa) increased, the ratio of 5-hiaa to serotonin (5-ht) in the brain increased and [3h]-ketanserin binding to 5-ht2 receptor significantly decreased in the frontal cortex and whole brain. |
1994-06-22 |
2023-08-12 |
mouse |
| K Minakam. [Brain monoamines and behavior in hyperammonemic sparse-fur mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 103. issue 5. 1994-06-22. PMID:8188118. |
the abnormal behavior of spf mice may derive from increased tryptophan in the brain due to hyperammonemia, increased 5-ht turnover rate and down regulation in the postsynaptic 5-ht2 receptor. |
1994-06-22 |
2023-08-12 |
mouse |
| O Yildiz, M Tunce. Characterization of 5-hydroxytryptamine receptors in rabbit isolated iliac artery. Archives internationales de pharmacodynamie et de therapie. vol 326. 1994-06-10. PMID:8185415. |
the 5-ht2 receptor antagonist ketanserin (0.1-1 microm) produced parallel displacements to the right of the 5-ht and phenylephrine concentration-effect curves, without significant reduction in the maximum responses. |
1994-06-10 |
2023-08-12 |
rabbit |
| S Benouali-Pellissier, T Roger, M Roch. A possible interaction between serotonin and cholecystokinin-8 in the ileo-colonic motor responses to feeding in rats. Scandinavian journal of gastroenterology. vol 29. issue 2. 1994-06-01. PMID:8171281. |
serotonin seems to play a role in cck-8 control through 5-ht2 receptors. |
1994-06-01 |
2023-08-12 |
rat |
| D H Bobke. A slow excitatory postsynaptic potential mediated by 5-HT2 receptors in nucleus prepositus hypoglossi. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 4. 1994-05-17. PMID:8158279. |
ketanserin and spiperone, 5-ht2 antagonists, blocked the depolarization due to both 5-ht and doi. |
1994-05-17 |
2023-08-12 |
Not clear |
| D H Bobke. A slow excitatory postsynaptic potential mediated by 5-HT2 receptors in nucleus prepositus hypoglossi. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 4. 1994-05-17. PMID:8158279. |
these data indicate that the s-epsp is mediated by 5-ht acting upon 5-ht2 receptors. |
1994-05-17 |
2023-08-12 |
Not clear |
| O A Nedergaar. Effect of dopexamine hydrochloride on contractions of rabbit isolated aorta evoked by various agonists. Pharmacology & toxicology. vol 74. issue 1. 1994-05-13. PMID:7909151. |
furthermore, dopexamine has no affinity to cholinoceptors, histamine and 5-hydroxytryptamine (5-ht2) receptors and is apparently not a calcium antagonist. |
1994-05-13 |
2023-08-12 |
rabbit |
| A Morán, C Velasco, M L Martín, L San Romá. Pharmacological characterization of 5-HT receptors in parasympathetic innervation of rat heart. European journal of pharmacology. vol 252. issue 2. 1994-05-13. PMID:8157057. |
when 5-ht1 and 5-ht2 receptors were blocked, 5-ht produced an increase in vagally induced bradycardia. |
1994-05-13 |
2023-08-12 |
rat |
| A Albinsson, E Palazidou, J Stephenson, G Andersso. Involvement of the 5-HT2 receptor in the 5-HT receptor-mediated stimulation of prolactin release. European journal of pharmacology. vol 251. issue 2-3. 1994-05-12. PMID:8149973. |
involvement of the 5-ht2 receptor in the 5-ht receptor-mediated stimulation of prolactin release. |
1994-05-12 |
2023-08-12 |
rat |
| b' K Andersen, T Liljefors, K Gundertofte, J Perregaard, K P B\\xc3\\xb8ges\\xc3\\xb. Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors. Journal of medicinal chemistry. vol 37. issue 7. 1994-05-12. PMID:8151622.' |
development of a receptor-interaction model for serotonin 5-ht2 receptor antagonists. |
1994-05-12 |
2023-08-12 |
Not clear |
| b' K Andersen, T Liljefors, K Gundertofte, J Perregaard, K P B\\xc3\\xb8ges\\xc3\\xb. Development of a receptor-interaction model for serotonin 5-HT2 receptor antagonists. Predicting selectivity with respect to dopamine D2 receptors. Journal of medicinal chemistry. vol 37. issue 7. 1994-05-12. PMID:8151622.' |
a receptor-interaction model for serotonin 5-ht2 receptor antagonists has been developed by conformational analysis with molecular mechanics (mm2(91)) and superimposition studies of serotonin 5-ht2 receptor antagonists. |
1994-05-12 |
2023-08-12 |
Not clear |