| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Plaznik, R Stefanski, W Palejko, A Bidzinski, W Kostowski, M Jessa, M Naza. Antidepressant treatment and limbic serotonergic mechanisms regulating rat locomotor activity. Pharmacology, biochemistry, and behavior. vol 48. issue 2. 1994-10-20. PMID:8090797. |
it is concluded that the present data indicate diminished activity of 5-ht systems related to the 5-ht1a and 5-ht2 receptors in the limbic nucleus, after chronic antidepressant treatment. |
1994-10-20 |
2023-08-12 |
rat |
| A J Kaumann, M Frenken, H Posival, A M Brow. Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors. Circulation. vol 90. issue 3. 1994-10-18. PMID:8087924. |
serotonin may contract human large coronary arteries through two 5-hydroxytryptamine (5-ht) receptors, 5-ht1-like and 5-ht2. |
1994-10-18 |
2023-08-12 |
human |
| E Garcia de Yebenes, S Li, G Pelletie. Role of serotonin in the regulation of prolactin gene expression in the male rat as evaluated by in situ hybridization. Brain research bulletin. vol 34. issue 5. 1994-10-13. PMID:8082037. |
to evaluate the role of 5-ht on prl gene expression, we have investigated the effects of repeated administration (during 2 days) of 5-ht, the 5-ht1 + 2 receptor antagonist methysergide, the 5-ht2 receptor antagonist ketanserin, and a combination of 5-ht and methysergide on prl mrna levels as measured by in situ hybridization in the adult male rat. |
1994-10-13 |
2023-08-12 |
rat |
| M Stroebel, M Goppelt-Strueb. Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells. The Journal of biological chemistry. vol 269. issue 37. 1994-10-11. PMID:8083194. |
as shown by specific inhibitors, 5-ht signal transduction was mediated by 5-ht2 receptors, which couple to phospholipase c via pertussis toxin-sensitive g-proteins. |
1994-10-11 |
2023-08-12 |
rat |
| S M Dyer, S Bexis, M T Mano, I S de la Lande, D B Frewin, R J Hea. Interactions between 5-hydroxytryptamine, noradrenaline and the thromboxane-A2 mimetic U44069 in the marmoset isolated aorta. Clinical and experimental pharmacology & physiology. vol 21. issue 3. 1994-10-06. PMID:8076422. |
the 5-ht2 receptor antagonist ly53857 (0.1 mumol/l) unmasked a contractile response to low concentrations of 5-ht (0.01-1.0 mumol/l) and reduced relaxation to high concentrations of 5-ht (1.0-10 mumol/l) in vessels precontracted with na. |
1994-10-06 |
2023-08-12 |
marmoset |
| C el Rawadi, M Davy, M Midol-Monnet, Y Cohe. Biochemical characterization of the mechanisms involved in the 5-hydroxytryptamine-induced increase in rat atrial rate. Biochemical pharmacology. vol 48. issue 4. 1994-09-30. PMID:7915903. |
several possible mechanisms for 5-hydroxytryptamine (5-ht)-induced tachycardia in rat have been suggested: an activation of 5-ht1c or 5-ht2 receptors, an indirect sympathomimetic effect or a mechanism independent of 5-ht2 receptor stimulation. |
1994-09-30 |
2023-08-12 |
rat |
| C el Rawadi, M Davy, M Midol-Monnet, Y Cohe. Biochemical characterization of the mechanisms involved in the 5-hydroxytryptamine-induced increase in rat atrial rate. Biochemical pharmacology. vol 48. issue 4. 1994-09-30. PMID:7915903. |
indeed, the 5-ht1c and 5-ht2 receptors are linked to phosphoinositide hydrolysis and the noradrenaline (na) released by 5-ht can stimulate the beta 1-adrenergic receptors linked to adenylate cyclase stimulation. |
1994-09-30 |
2023-08-12 |
rat |
| C el Rawadi, M Davy, M Midol-Monnet, Y Cohe. Biochemical characterization of the mechanisms involved in the 5-hydroxytryptamine-induced increase in rat atrial rate. Biochemical pharmacology. vol 48. issue 4. 1994-09-30. PMID:7915903. |
the 5-ht2 antagonist ketanserin (1 microm) abolished ip accumulation induced by 5-ht microm), which indicates that this accumulation is 5-ht2 and not 5-ht1c receptor-mediated. |
1994-09-30 |
2023-08-12 |
rat |
| C el Rawadi, M Davy, M Midol-Monnet, Y Cohe. Biochemical characterization of the mechanisms involved in the 5-hydroxytryptamine-induced increase in rat atrial rate. Biochemical pharmacology. vol 48. issue 4. 1994-09-30. PMID:7915903. |
it is concluded that 5-ht stimulates both phosphoinositide turnover and adenylate cyclase activity in the rat isolated atria by activation of 5-ht2 receptors and by an indirect sympathomimetic effect. |
1994-09-30 |
2023-08-12 |
rat |
| D Baines, R G Downe. Octopamine enhances phagocytosis in cockroach hemocytes: involvement of inositol trisphosphate. Archives of insect biochemistry and physiology. vol 26. issue 4. 1994-09-29. PMID:8068962. |
phentolamine, a general octopamine antagonist, blocked the effects of octopamine and 5-ht, while a mammalian 5-ht2 antagonist that blocks 5-ht-sensitive receptors in insect peripheral tissue, ketanserin, did not. |
1994-09-29 |
2023-08-12 |
Not clear |
| A Choppin, S E O'Conno. 5-Hydroxytryptamine1D-like receptors mediate contraction of partially depolarized rabbit renal arteries. The Journal of pharmacology and experimental therapeutics. vol 270. issue 2. 1994-09-28. PMID:8071857. |
in the presence of ketanserin (10(-6) m) to block 5-ht2 receptors, 5-ht, 5-carboxamido-tryptamine (5-ct) and other 5-ht receptor agonists caused contraction of partially depolarized (22 mm kcl) rabbit renal arteries whereas they were without effect in quiescent tissues (4.7 mm kcl). |
1994-09-28 |
2023-08-12 |
rabbit |
| b' G J Christ, M Valcic, M C Gondr\\xc3\\xa. Augmentation in the kinetic characteristics of phenylephrine- and 5-hydroxytryptamine-induced contractions in the isolated rat aorta following eight weeks of STZ-diabetes. Life sciences. vol 55. issue 10. 1994-09-23. PMID:8072377.' |
kinetic studies were conducted on the contractile response elicited by phenylephrine (pe) and 5-hydroxytryptamine (5-ht) activation of the alpha 1-adrenergic- and 5-ht2 receptor subtypes, respectively, in aortic rings isolated from streptozotocin (stz)-diabetic and age-matched control rats. |
1994-09-23 |
2023-08-12 |
rat |
| S I Garssadi, K Régely, Y Mándi, I Bélád. Inhibition of cytotoxicity of chicken granulocytes by serotonin and ketanserin. Veterinary immunology and immunopathology. vol 41. issue 1-2. 1994-09-22. PMID:7520645. |
ketanserin, a 5-ht2 receptor antagonist, did not reverse the inhibitory effect of 5-ht on chicken granulocyte cytotoxicity. |
1994-09-22 |
2023-08-12 |
human |
| B A McMillen, S Walter, H L Williams, R D Myer. Comparison of the action of the 5-HT2 antagonists amperozide and trazodone on preference for alcohol in rats. Alcohol (Fayetteville, N.Y.). vol 11. issue 3. 1994-09-22. PMID:8060520. |
in this study, trazodone was compared to amperozide for its effect on the volitional consumption of alcohol because, like amperozide, trazodone is a potent 5-ht2 receptor antagonist but a weak inhibitor of 5-ht reuptake. |
1994-09-22 |
2023-08-12 |
rat |
| D J Woollard, J C Bornstein, J B Furnes. Characterization of 5-HT receptors mediating contraction and relaxation of the longitudinal muscle of guinea-pig distal colon in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 349. issue 5. 1994-09-19. PMID:8065459. |
the 5-ht2 antagonist, ketanserin, in concentrations up to 10(-5) mol/l, had no effect on the contractions evoked by 5-ht. |
1994-09-19 |
2023-08-12 |
Not clear |
| M H Norman, G C Rigdon, F Navas, B R Coope. Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents. Journal of medicinal chemistry. vol 37. issue 16. 1994-09-13. PMID:7914539. |
the target compounds were examined in vitro for their binding affinities to the dopamine d2, serotonin 5-ht2, and serotonin 5-ht1a receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. |
1994-09-13 |
2023-08-12 |
mouse |
| b' S Kosti\\xc4\\x87, V Soski\\xc4\\x87, J Joksimovi\\xc4\\x8. Design, synthesis and properties of several heterocyclic dopaminergic ligands. Arzneimittel-Forschung. vol 44. issue 6. 1994-09-08. PMID:7914413.' |
none of the 19 compounds examined expressed significant affinity for d-1 receptors, while compounds 15, 17 and 19, in this order of potency, strongly competed with [3h]spiperone binding to d-2 receptors under conditions that prevented radioligand binding to serotonin 5ht2 receptors. |
1994-09-08 |
2023-08-12 |
cattle |
| J M Vanelle, J P Olié, P Lévy-Soussa. New antipsychotics in schizophrenia: the French experience. Acta psychiatrica Scandinavica. Supplementum. vol 380. 1994-09-01. PMID:7914051. |
its pharmacological profile is close to that of clozapine: it has dopamine (d2), histamine (h1), serotonin (5-ht2) and adrenergic (alpha 1)-blocking activities. |
1994-09-01 |
2023-08-12 |
Not clear |
| R C Dow, B C Williams, J Bennie, S Carroll, G Fin. A central 5-HT2 receptor mechanism plays a key role in the proestrous surge of luteinizing hormone in the rat. Psychoneuroendocrinology. vol 19. issue 4. 1994-08-30. PMID:8047643. |
the role of serotonin (5-ht) in generating the spontaneous preovulatory surge of luteinizing hormone (lh) has been investigated by studying the effect of ketanserin (a mixed 5-ht2/alpha 1 adrenoreceptor antagonist); the selective 5-ht2 receptor antagonist, ritanserin; and the selective alpha 1 adrenoreceptor antagonist, prazosin, on the plasma concentrations of lh during the afternoon of proestrus in conscious wistar rats. |
1994-08-30 |
2023-08-12 |
rat |
| W H Weintraub, P Cleveland-Wolfe, C Fewtrel. Paracrine Ca2+ signaling in vitro: serotonin-mediated cell-cell communication in mast cell/smooth muscle cocultures. Journal of cellular physiology. vol 160. issue 2. 1994-08-25. PMID:8040194. |
a7r5 cells elevate intracellular ca2+ via 5ht2 receptors in response to bath-applied serotonin with an ed50 for serotonin of 550nm. |
1994-08-25 |
2023-08-12 |
Not clear |