| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N K Hollenberg, Q Ni. The effect of naftidrofuryl, a 5-HT2 antagonist, on collateral vascular responses to serotonin and to platelet activation. Journal of cardiovascular pharmacology. vol 16 Suppl 3. 1995-08-17. PMID:1369716. |
the observations strengthen the hypothesis that supersensitivity of collateral arterial vessels to serotonin reflects a 5-ht2 receptor mechanism. |
1995-08-17 |
2023-08-11 |
Not clear |
| N Oudar. Naftidrofuryl inhibits contractions to serotonin in intact and de-endothelialized cerebral arteries in vitro. Journal of cardiovascular pharmacology. vol 16 Suppl 3. 1995-08-17. PMID:1369718. |
at therapeutic concentrations, the 5-ht2 antagonist naftidrofuryl did not change perfusion pressure of normal vessels in the absence of 5-ht. |
1995-08-17 |
2023-08-11 |
rabbit |
| N Oudar. Naftidrofuryl inhibits contractions to serotonin in intact and de-endothelialized cerebral arteries in vitro. Journal of cardiovascular pharmacology. vol 16 Suppl 3. 1995-08-17. PMID:1369718. |
these data confirm the potentiating effect of 5-ht on vascular smooth muscle (even in intact vessels) and the anticonstricting effects of naftidrofuryl when 5-ht2 receptors on smooth muscle cells are activated by serotonin. |
1995-08-17 |
2023-08-11 |
rabbit |
| L Drouet, C Bal Dit Sollier, S Ruton, G Pignau. Role of serotonin in arteriolar thrombosis and secondary vasospasm. Journal of cardiovascular pharmacology. vol 16 Suppl 3. 1995-08-17. PMID:1369719. |
in this setting, we studied the reactivity of sprague-dawley rats treated with three 5-ht2 serotonergic antagonists (ketanserin, ritanserin, and naftidrofuryl) and that of fawn-hooded rats (a strain affected by a congenital reduction of platelet dense granules, with a resulting decrease in platelet content of serotonin, adp, and catecholamines). |
1995-08-17 |
2023-08-11 |
rat |
| R Tavakoli, N Frossar. 5-HT2-mediated bronchial responses after syngeneic lung transplantation in the rat. British journal of pharmacology. vol 114. issue 7. 1995-08-17. PMID:7606347. |
contraction to 5-ht was blocked by the selective 5-ht2 antagonist, ketanserin. |
1995-08-17 |
2023-08-12 |
rat |
| R Tavakoli, N Frossar. 5-HT2-mediated bronchial responses after syngeneic lung transplantation in the rat. British journal of pharmacology. vol 114. issue 7. 1995-08-17. PMID:7606347. |
responses to the selective 5-ht2 agonist, alpha-methyl-5-ht, were similar to those to 5-ht; pd2 values were similar in all groups (ranging from 5.41 to 5.74). |
1995-08-17 |
2023-08-12 |
rat |
| R Tavakoli, N Frossar. 5-HT2-mediated bronchial responses after syngeneic lung transplantation in the rat. British journal of pharmacology. vol 114. issue 7. 1995-08-17. PMID:7606347. |
these results show bronchial hyperresponsiveness to 5-ht in vitro one month after lung transplantation in the rat, mediated through 5-ht2 receptor activation. |
1995-08-17 |
2023-08-12 |
rat |
| C C Helfman, G F Anderson, R A Barrac. Presynaptic displacement of serotonin by alpha-methyl-5-hydroxytryptamine in the nucleus tractus solitarius of the rat. Neuroscience letters. vol 189. issue 2. 1995-08-17. PMID:7609920. |
alpha-methylserotonin (alpha-me-5-ht; 1.0 microm), a non-selective 5-ht1 and 5-ht2 receptor agonist, significantly reduced the s2/s1 ratio of [3h]5-ht without affecting the basal release ratios b2/b1 1.00 +/- 0.04. |
1995-08-17 |
2023-08-12 |
rat |
| L A Blackshaw, V Nisyrios, J Den. Responses of ferret lower esophageal sphincter to 5-hydroxytryptamine: pathways and receptor subtypes. The American journal of physiology. vol 268. issue 6 Pt 1. 1995-08-15. PMID:7611399. |
both 5-ht2 and 5-ht3 antagonists in combination abolished all effects of 5-ht on lesp. |
1995-08-15 |
2023-08-12 |
Not clear |
| T Takahashi, J K Ward, S Tadjkarimi, M H Yacoub, P J Barnes, M G Belvis. 5-Hydroxytryptamine facilitates cholinergic bronchoconstriction in human and guinea pig airways. American journal of respiratory and critical care medicine. vol 152. issue 1. 1995-08-10. PMID:7599849. |
the rank order of potency of 5-ht agonists was 5-ht > 2-methyl-5-ht (5-ht3 selective) > 5-methoxytryptamine (5-ht4 selective) > alpha-methyl-5-ht (5-ht2 selective). |
1995-08-10 |
2023-08-12 |
human |
| D N Krause, V E Barrios, S P Duckle. Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601206. |
this effect was inhibited by the melatonin receptor antagonist luzindole but not by the serotonin 5-ht2 receptor antagonist ketanserin. |
1995-08-10 |
2023-08-12 |
rat |
| K M Cross, R C Foreman, J E Cha. Enhancement by 5-hydroxytryptamine and analogues of desensitization of neuronal and muscle nicotinic receptors expressed in Xenopus oocytes. British journal of pharmacology. vol 114. issue 8. 1995-08-08. PMID:7599934. |
ketanserin, a 5-ht2 receptor antagonist, was more potent than 5-ht, the ic50 being 49.0 +/- 1.4 microm. |
1995-08-08 |
2023-08-12 |
xenopus_laevis |
| Y Ogawa, T Takenaka, S Onodera, K Tobise, A Takeda, T Hirayama, K Morita, K Kikuch. Comparison of 5-hydroxytryptamine-induced contraction of rat pulmonary artery to that of aorta in vitro. Japanese circulation journal. vol 59. issue 2. 1995-08-01. PMID:7596027. |
these results suggest that 5-ht produces contraction via not only 5-ht2 receptor, but also non-5-ht2 receptor (probably alpha 1-adrenoceptor) in the rat pulmonary artery. |
1995-08-01 |
2023-08-12 |
rat |
| S C Pandey, J M Davis, G N Pande. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates. Journal of psychiatry & neuroscience : JPN. vol 20. issue 3. 1995-07-27. PMID:7786883. |
serotonin (5-ht) receptors have been classified into several categories, and they are termed as 5-ht1, 5-ht2, 5-ht3, 5-ht4, 5-ht5, 5-ht6 and 5-ht7 type receptors. |
1995-07-27 |
2023-08-12 |
Not clear |
| A Walcourt-Ambakederemo, W Winlo. 5-HT receptors on identified Lymnaea neurones in culture: pharmacological characterization of 5-HT3 receptors. General pharmacology. vol 26. issue 3. 1995-07-27. PMID:7789728. |
the 5-ht2 antagonist ketanserin failed to block the m-cpbg-evoked responses, whilst partially blocking the 5-ht responses. |
1995-07-27 |
2023-08-12 |
Not clear |
| R C McIntyre, A Banerjee, J Agrafojo, D A Fullerto. Pulmonary hypertension in acute lung injury is due to impaired vasodilation with intact vascular contractility. The Journal of surgical research. vol 58. issue 6. 1995-07-24. PMID:7791358. |
our purpose was to determine the effect of endotoxemia (etx) on the contractile response of pulmonary vsm to (1) tubular depolarization (kcl), (2) alpha 1-adrenoreceptor stimulation (phenylephrine, pe), (3) 5ht2 receptor stimulation (serotonin, 5ht), and (4) prostaglandin f2 alpha receptor stimulation. |
1995-07-24 |
2023-08-12 |
rat |
| F Okada, H Saito, N Matsuk. Blockade of motion- and cisplatin-induced emesis by a 5-HT2 receptor agonist in Suncus murinus. British journal of pharmacology. vol 114. issue 5. 1995-07-14. PMID:7780647. |
the present results suggest an inhibitory role for central 5-ht2 receptors in the emetic reflex mechanism and that a 5-ht2 receptor agonist may be a useful tool to investigate the involvement of 5-ht receptors in the emetic reflex. |
1995-07-14 |
2023-08-12 |
Not clear |
| D Cambridge, M V Whiting, L J Butterfield, C Marsto. Vascular 5-HT1-like receptors mediating vasoconstriction and vasodilatation: their characterization and distribution in the intact canine cardiovascular system. British journal of pharmacology. vol 114. issue 5. 1995-07-14. PMID:7780651. |
in anaesthetized dogs, intra-left atrial administration of 5-hydroxytryptamine (5-ht) and selected tryptamine analogues (5-carboxamidotryptamine, 5-ct; 5-methyl tryptamine, 5-mt; alpha-methyl 5-hydroxytryptamine, alpha-ht; sumatriptan, sum) in the presence of ketanserin and mdl72222 (5-ht2 and 5-ht3 receptor antagonists, respectively), produced dose-related changes in carotid, coronary and renal vascular conductance mediated by vascular 5-ht1-like receptors. |
1995-07-14 |
2023-08-12 |
Not clear |
| K Ikeguchi, A Kurod. Mianserin treatment of patients with psychosis induced by antiparkinsonian drugs. European archives of psychiatry and clinical neuroscience. vol 244. issue 6. 1995-07-07. PMID:7772616. |
these results suggest that serotonin antagonism at 5-ht2 receptors may not only play an important role in the treatment of drug-induced psychosis in pd, but may also ameliorate the symptoms of parkinsonism. |
1995-07-07 |
2023-08-12 |
Not clear |
| A Mota, A Bento, A Peñalva, M Pombo, C Diegue. Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion. The Journal of clinical endocrinology and metabolism. vol 80. issue 6. 1995-07-07. PMID:7775648. |
at present, four main types of serotonin (5-ht) receptors have been identified in the brain (5-ht1, 5-ht2, 5-ht3, and 5-ht4). |
1995-07-07 |
2023-08-12 |
human |