| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R J Katz, P S Landau, M Lott, A Bystritsky, B Diamond, R Hoehn-Saric, M Rosenthal, C Weis. Serotonergic (5-HT2) mediation of anxiety-therapeutic effects of serazepine in generalized anxiety disorder. Biological psychiatry. vol 34. issue 1-2. 1993-10-15. PMID:8104044. |
in chemical assays it was a highly specific inhibitor of serotonin (5-ht2) binding, and it was active in preliminary preclinical assays of anxiolytic potential. |
1993-10-15 |
2023-08-12 |
Not clear |
| M H Pietraszek, N A Choudhury, S Baba, S Sakaguchi, T Hachiya, T Urano, Y Takada, A Takad. Serotonin as a factor involved in pathophysiology of thromboangiitis obliterans. International angiology : a journal of the International Union of Angiology. vol 12. issue 1. 1993-10-15. PMID:8376917. |
we conclude that impaired platelet serotonin uptake and increased local concentration of serotonin in the vicinity of platelets in buerger's disease may lead to platelet activation via 5-ht2 receptors, and it could be involved in the pathogenesis of thromboembolic complications. |
1993-10-15 |
2023-08-12 |
human |
| D Kaminski, N Weiner, G Sturm, W Weseman. Modulation of serotonin binding sites in the brain of the Djungarian hamster, Phodopus sungorus, during adaptation to a short photoperiod. Journal of neural transmission. General section. vol 92. issue 2-3. 1993-10-12. PMID:8369107. |
the radioligands [3h]5-ht and [3h]ketanserin were used to characterize total 5-ht1 and 5-ht2 binding sites, respectively. |
1993-10-12 |
2023-08-12 |
Not clear |
| Y Watanabe, R R Sakai, B S McEwen, S Mendelso. Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin. Brain research. vol 615. issue 1. 1993-10-05. PMID:8364729. |
stress and antidepressant effects on hippocampal and cortical 5-ht1a and 5-ht2 receptors and transport sites for serotonin. |
1993-10-05 |
2023-08-12 |
rat |
| Y Watanabe, R R Sakai, B S McEwen, S Mendelso. Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin. Brain research. vol 615. issue 1. 1993-10-05. PMID:8364729. |
the interactions between 14 days of repeated restraint stress and daily administration of imipramine or tianeptine (2 h before the beginning of stress) were investigated in rats to assess responses of 5-ht2 and 5-ht1a receptors and serotonin transporter sites labelled by [3h]paroxetine in the cerebral cortex and hippocampus, two brain regions in which adrenal steroid effects on serotonin receptor-binding have been reported. |
1993-10-05 |
2023-08-12 |
rat |
| Y Watanabe, R R Sakai, B S McEwen, S Mendelso. Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin. Brain research. vol 615. issue 1. 1993-10-05. PMID:8364729. |
whereas the actions of imipramine and tianeptine on 5-ht2 and 5-ht1a receptors are specific to each drug, the surprising finding of a similar effect of both drugs to reduce serotonin transporter sites labelled by [3h]paroxetine suggest the possibility of a common action for these two drugs in spite of their opposite effects on serotonin re-uptake. |
1993-10-05 |
2023-08-12 |
rat |
| K A Hubel, L Rus. Mechanisms of the secretory response to luminal propionate in rat descending colon in vitro. Journal of the autonomic nervous system. vol 43. issue 3. 1993-10-01. PMID:8366252. |
it was not reduced by inhibitors of 5-ht2 or 5ht3 receptors or by partial tachyphylaxis to 5-ht. |
1993-10-01 |
2023-08-12 |
rat |
| A K Siriwardena, E H Smith, E H Borum, J M Kellu. Identification of a 5-hydroxytryptamine (5-HT2) receptor on guinea pig small intestinal crypt cells. The American journal of physiology. vol 265. issue 2 Pt 1. 1993-10-01. PMID:8368315. |
identification of a 5-hydroxytryptamine (5-ht2) receptor on guinea pig small intestinal crypt cells. |
1993-10-01 |
2023-08-12 |
Not clear |
| A Abi-Dargham, M Laruelle, B Lipska, G E Jaskiw, D T Wong, D W Robertson, D R Weinberger, J E Kleinma. Serotonin 5-HT3 receptors in schizophrenia: a postmortem study of the amygdala. Brain research. vol 616. issue 1-2. 1993-09-30. PMID:8358629. |
alterations in density of some serotonin receptor sites (5-ht1a receptors, 5-ht2 receptors and 5-ht uptake sites) have been reported in postmortem studies of brain obtained from subjects with schizophrenia, suggesting a disturbance in serotonergic transmission in schizophrenia. |
1993-09-30 |
2023-08-12 |
human |
| D I Wallis, J W. The pharmacology of descending responses evoked by thoracic stimulation in the neonatal rat spinal cord in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 6. 1993-09-28. PMID:8103194. |
potentiation of certain responses by the 5-ht2 antagonists, ketanserin, ritanserin and lilly 53837, indicated that endogenous 5-ht was exerting a modulatory depression of these responses. |
1993-09-28 |
2023-08-12 |
rat |
| S J McAuliffe, H M Snow, B Cox, C C Smith, M I Nobl. Interaction between the effects of 5-hydroxytryptamine and adrenaline on the growth of platelet thrombi in the coronary artery of the anaesthetized dog. British journal of pharmacology. vol 109. issue 2. 1993-09-27. PMID:8358542. |
changes in the plasma concentration of adrenaline were produced by varying the rate of an intravenous infusion of adrenaline and in the effects of 5-ht, by intravenous injections of the selective 5-ht2 receptor antagonist, ici 170809. |
1993-09-27 |
2023-08-12 |
dog |
| A Kagaya, M Mikuni, S Muraoka, K Saitoh, T Ogawa, H Shinno, S Yamawaki, K Takahash. Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8360672. |
homologous desensitization of serotonin 5-ht2 receptor-stimulated intracellular calcium mobilization in c6bu-1 glioma cells via a mechanism involving a calmodulin pathway. |
1993-09-27 |
2023-08-12 |
rat |
| A Kagaya, M Mikuni, S Muraoka, K Saitoh, T Ogawa, H Shinno, S Yamawaki, K Takahash. Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8360672. |
serotonin 5-ht2 receptor-mediated intracellular ca2+ mobilization was investigated in rat glioma c6bu-1 cells. |
1993-09-27 |
2023-08-12 |
rat |
| A Kagaya, M Mikuni, S Muraoka, K Saitoh, T Ogawa, H Shinno, S Yamawaki, K Takahash. Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8360672. |
the desensitization of 5-ht2 receptor-mediated intracellular signaling appeared to be homologous because previous exposure to 5-ht did not alter the response to other transmitters such as thrombin or isoproterenol and because previous exposure to thrombin or isoproterenol did not diminish the response to 5-ht. |
1993-09-27 |
2023-08-12 |
rat |
| A Kagaya, M Mikuni, S Muraoka, K Saitoh, T Ogawa, H Shinno, S Yamawaki, K Takahash. Homologous desensitization of serotonin 5-HT2 receptor-stimulated intracellular calcium mobilization in C6BU-1 glioma cells via a mechanism involving a calmodulin pathway. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8360672. |
these results suggest that 5-ht2 receptor-mediated ca2+ mobilization can be desensitized homologously after prolonged exposure to 5-ht in a calmodulin-dependent manner in rat glioma c6bu-1 cells. |
1993-09-27 |
2023-08-12 |
rat |
| F Licata, G Li Volsi, G Maugeri, F Santangel. Excitatory and inhibitory effects of 5-hydroxytryptamine on the firing rate of medial vestibular nucleus neurons in the rat. Neuroscience letters. vol 154. issue 1-2. 1993-09-27. PMID:8361640. |
it is concluded that 5-ht can variously influence the background activity of mvn neurons and that 5-ht2 and probably 5-ht1a receptors are involved in the responses. |
1993-09-27 |
2023-08-12 |
rat |
| A M Ismaiel, J De Los Angeles, M Teitler, S Ingher, R A Glenno. Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. Journal of medicinal chemistry. vol 36. issue 17. 1993-09-23. PMID:8355253. |
although the neuroleptic agent spiperone binds at d2 dopamine receptors and 5-ht1a serotonin receptors, (a) it displays about a 1000-fold selectivity for 5-ht2 versus 5-ht1c sites and (b) it has been used as a "5-ht2-selective" antagonist. |
1993-09-23 |
2023-08-12 |
rat |
| S Le Corre, P Cheminea. Serotonergic 5HT2 receptors mediate the inhibitory action of serotonin on luteinizing hormone secretion in ovariectomized, estradiol-treated ewes that are refractory to short days. Biology of reproduction. vol 49. issue 1. 1993-09-22. PMID:8353180. |
serotonergic 5ht2 receptors mediate the inhibitory action of serotonin on luteinizing hormone secretion in ovariectomized, estradiol-treated ewes that are refractory to short days. |
1993-09-22 |
2023-08-12 |
Not clear |
| S I Garssadi, Y Mándi, K Régely, B Taródi, I Bélád. The inhibitory effect of interferon-alpha on the serotonin-induced impairment of human NK cell activity in whole blood. Brain, behavior, and immunity. vol 7. issue 2. 1993-09-15. PMID:8347897. |
it is very likely that the 5-ht2 receptor is involved in the inhibition of cytotoxicity because ketanserin, an inhibitor of the 5-ht2 receptor, partially prevented the effect of 5-ht. |
1993-09-15 |
2023-08-12 |
human |
| P D Hrdina, E Demeter, T B Vu, P Sótónyi, M Palkovit. 5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala. Brain research. vol 614. issue 1-2. 1993-09-14. PMID:8348328. |
5-ht uptake sites and 5-ht2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-ht2 sites in cortex and amygdala. |
1993-09-14 |
2023-08-12 |
Not clear |