| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Suzuki, Y Ohuchi, H Asanuma, T Kaneko, S Yokomori, C Ito, Y Isobe, M Muramats. Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as potent and selective serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 49. issue 1. 2001-03-29. PMID:11201221. |
of the compounds synthesized, n-(endo-8-(3-hydroxypropyl)-8-azabicyclo[3.2.1]oct-3-yl)-1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxamide (15a, ts-951) exhibited the most potent serotonin 5-ht4 receptor agonistic activity. |
2001-03-29 |
2023-08-12 |
Not clear |
| M Suzuki, Y Ohuchi, H Asanuma, T Kaneko, S Yokomori, C Ito, Y Isobe, M Muramats. Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as potent and selective serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 49. issue 1. 2001-03-29. PMID:11201221. |
this compound had a high affinity for the serotonin 5-ht4 receptor although it had no affinities for other broad spectrum receptors. |
2001-03-29 |
2023-08-12 |
Not clear |
| M Suzuki, Y Ohuchi, H Asanuma, T Kaneko, S Yokomori, C Ito, Y Isobe, M Muramats. Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as potent and selective serotonin 5-HT4 receptor agonists. Chemical & pharmaceutical bulletin. vol 49. issue 1. 2001-03-29. PMID:11201221. |
furthermore, it remarkably enhanced gastrointestinal motility in conscious fed dogs without unfavorable effects that non-selective serotonin 5-ht4 receptor agonist has. |
2001-03-29 |
2023-08-12 |
Not clear |
| H Lefebvre, D Cartier, C Duparc, V Contesse, I Lihrmann, C Delarue, H Vaudry, R Fischmeister, J M Kuh. Effect of serotonin4 (5-HT4) receptor agonists on aldosterone secretion in idiopathic hyperaldosteronism. Endocrine research. vol 26. issue 4. 2001-03-22. PMID:11196433. |
serotonin (5-ht) stimulates aldosterone secretion in man through 5-ht4 receptors positively coupled to adenylyl cyclase. |
2001-03-22 |
2023-08-12 |
human |
| V Contesse, H Lefebvre, S Lenglet, J M Kuhn, C Delarue, H Vaudr. Role of 5-HT in the regulation of the brain-pituitary-adrenal axis: effects of 5-HT on adrenocortical cells. Canadian journal of physiology and pharmacology. vol 78. issue 12. 2001-03-01. PMID:11149386. |
in frogs and humans, the stimulatory effect of 5-ht on adrenocortical cells is mediated through a 5-ht4 receptor subtype positively coupled to adenylyl cyclase and calcium influx. |
2001-03-01 |
2023-08-12 |
mouse |
| S Kojima, M Ikeda, Y Kamikaw. Investigation into the 5-hydroxytryptophan-evoked luminal 5-hydroxytryptamine release from the guinea pig colon. Japanese journal of pharmacology. vol 84. issue 2. 2001-02-15. PMID:11128040. |
furthermore, non-neuronal 5-ht3 and 5-ht4 receptors appear to contribute to the regulation of the luminal 5-ht release evoked by 5-htp. |
2001-02-15 |
2023-08-12 |
Not clear |
| E Edwards, J F Pato. Glutamate stimulation of raphe pallidus attenuates the cardiopulmonary reflex in anaesthetised rats. Autonomic neuroscience : basic & clinical. vol 82. issue 3. 2001-01-25. PMID:11023614. |
we propose that neurones in raphe pallidus that project to the nts can release serotonin which acts via 5-ht4 receptors to attenuate the reflex phrenic nerve activity and heart rate components of the cardiopulmonary reflex. |
2001-01-25 |
2023-08-12 |
rat |
| A Lucchelli, M G Santagostino-Barbone, G D'Agostino, E Masoero, M Tonin. The interaction of antidepressant drugs with enteric 5-HT7 receptors. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 3. 2001-01-05. PMID:10997731. |
this evidence extends our previous findings demonstrating the interaction of antidepressants with other 5-ht receptors, namely 5-ht3 and 5-ht4 receptors. |
2001-01-05 |
2023-08-12 |
Not clear |
| R Ranganathan, S C Cannon, H R Horvit. MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans. Nature. vol 408. issue 6811. 2000-12-28. PMID:11100728. |
the neurotransmitter and neuromodulator serotonin (5-ht) functions by binding either to metabotropic g-protein-coupled receptors (for example, 5-ht1, 5-ht2, 5-ht4 to 5-ht7), which mediate 'slow' modulatory responses through numerous second messenger pathways, or to the ionotropic 5-ht3 receptor, a non-selective cation channel that mediates 'fast' membrane depolarizations. |
2000-12-28 |
2023-08-12 |
caenorhabditis_elegans |
| K Taniyama, N Makimoto, A Furuichi, Y Sakurai-Yamashita, Y Nagase, M Kaibara, T Kanemats. Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine4 receptor, in gastrointestinal motility. Journal of gastroenterology. vol 35. issue 8. 2000-12-07. PMID:10955595. |
in this article, we described mainly the 5-ht4 receptor of four subtypes of functional 5-ht receptors, 5-ht1, 5-ht2, 5-ht3, and 5-ht4, recognized in the gastrointestinal tract. |
2000-12-07 |
2023-08-12 |
human |
| H Mircescu, J Jilwan, N N'Diaye, I Bourdeau, J Tremblay, P Hamet, A Lacroi. Are ectopic or abnormal membrane hormone receptors frequently present in adrenal Cushing's syndrome? The Journal of clinical endocrinology and metabolism. vol 85. issue 10. 2000-11-15. PMID:11061496. |
all six patients with bilateral acth-independent macronodular adrenal hyperplasia were found to have one or two abnormal adrenal receptors, including those for gastric inhibitory polypeptide, vasopressin (v1-vasopressin), beta-adrenergic agonists, lh/human cg, or serotonin 5-ht4. |
2000-11-15 |
2023-08-12 |
Not clear |
| A Zahorodna, K Tokarski, M Bija. [Electrophysiologic tests for testing the effects of antidepressant drugs and corticosterone on reactivity of serotonin receptors in the hippocampus]. Postepy higieny i medycyny doswiadczalnej. vol 54. issue 3. 2000-11-13. PMID:10941273. |
activity of hippocampal cells can be modulated by 5-ht via inhibitory 5-ht1a and excitatory 5-ht4 receptors. |
2000-11-13 |
2023-08-12 |
Not clear |
| Y Nagakura, T Kiso, H Ito, K Miyata, T Yamaguch. The role of 5-hydroxytryptamine3 and 5-hydroxytryptamine4 receptors in the regulation of gut motility in the ferret. Life sciences. vol 66. issue 24. 2000-07-13. PMID:10864103. |
the role of 5-hydroxytryptamine (5-ht)3 and 5-ht4 receptors in the regulation of gut motility in the ferret was investigated. |
2000-07-13 |
2023-08-12 |
Not clear |
| U Ladabaum, W L Hasle. Novel approaches to the treatment of nausea and vomiting. Digestive diseases (Basel, Switzerland). vol 17. issue 3. 2000-03-09. PMID:10697661. |
agents which act on gastric serotonin (5-ht4), dopamine, and motilin receptors accelerate gastric emptying and relieve symptoms in gastroparesis. |
2000-03-09 |
2023-08-12 |
Not clear |
| A N Rizk, P J Hesket. Antiemetics for cancer chemotherapy-induced nausea and vomiting. A review of agents in development. Drugs in R&D. vol 2. issue 4. 2000-02-28. PMID:10659396. |
several other serotonin receptors have been targeted including the 5-ht4, 5-ht1a and 5-ht2a receptors. |
2000-02-28 |
2023-08-12 |
Not clear |
| M L López-Rodríguez, B Benhamú, A Viso, M J Morcillo, M Murcia, L Orensanz, M J Alfaro, M I Martí. Benzimidazole derivatives. Part 1: Synthesis and structure-activity relationships of new benzimidazole-4-carboxamides and carboxylates as potent and selective 5-HT4 receptor antagonists. Bioorganic & medicinal chemistry. vol 7. issue 11. 2000-02-14. PMID:10632037. |
amides 12-15 and esters 24 and 25 bound at central 5-ht4 sites with very high affinity (ki = 0.11-2.9 nm) and excellent selectivity over serotonin 5-ht3, 5-ht2a, and 5-ht1a receptors (ki > 1000-10,000 nm). |
2000-02-14 |
2023-08-12 |
Not clear |
| A Menese. 5-HT system and cognition. Neuroscience and biobehavioral reviews. vol 23. issue 8. 2000-02-11. PMID:10643820. |
likewise, the stimulation or blockade of presynaptic 5-ht1a, 5-ht1b, 5-ht(2a/2c) and 5-ht3 receptors, postsynaptic 5-ht(2b/2c) and 5-ht4 receptors and 5-ht uptake/transporter sites modulate these processes. |
2000-02-11 |
2023-08-12 |
Not clear |
| A Menese. 5-HT system and cognition. Neuroscience and biobehavioral reviews. vol 23. issue 8. 2000-02-11. PMID:10643820. |
in this regard, it is probable that selective drugs with agonists, neutral antagonist, agonists or inverse agonist properties for 5-ht1a, 5-ht(1b/1d), 5-ht(2a/2b/2c), 5-ht4 and 5-ht7 receptors could constitute a new therapeutic opportunity for learning and memory alterations. |
2000-02-11 |
2023-08-12 |
Not clear |
| E Bender, A Pindon, I van Oers, Y B Zhang, W Gommeren, P Verhasselt, M Jurzak, J Leysen, W Luyte. Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. Journal of neurochemistry. vol 74. issue 2. 2000-02-10. PMID:10646498. |
structure of the human serotonin 5-ht4 receptor gene and cloning of a novel 5-ht4 splice variant. |
2000-02-10 |
2023-08-12 |
human |
| E Bender, A Pindon, I van Oers, Y B Zhang, W Gommeren, P Verhasselt, M Jurzak, J Leysen, W Luyte. Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant. Journal of neurochemistry. vol 74. issue 2. 2000-02-10. PMID:10646498. |
several variants of the serotonin 5-ht4 receptor are known to be produced by alternative splicing. |
2000-02-10 |
2023-08-12 |
human |