| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Markstein, M Matsumoto, C Kohler, H Togashi, M Yoshioka, D Hoye. Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 6. 1999-10-04. PMID:10431755. |
cyclic amp accumulation induced by 1 microm 5-ht was partly inhibited by the selective 5-ht1a receptor antagonist way 100,635 (1 microm), the selective 5-ht4 receptor antagonist sb 203,186 (1 microm), and the 5-ht2a/c/ 5-ht7 receptor antagonist mesulergine (25 microm). |
1999-10-04 |
2023-08-12 |
rat |
| R Markstein, M Matsumoto, C Kohler, H Togashi, M Yoshioka, D Hoye. Pharmacological characterisation of 5-HT receptors positively coupled to adenylyl cyclase in the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 6. 1999-10-04. PMID:10431755. |
5-carboxamidotryptamine (5-ct; 0.008-125 microm), a 5-ht1/5-ht7 receptor agonist, and sdz 216-454 (0.008-125 microm), a selective 5-ht4 receptor agonist, concentration-dependently stimulated cyclic amp formation, but the maximal effect of each agonist was smaller than that of 5-ht alone. |
1999-10-04 |
2023-08-12 |
rat |
| M D Gersho. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Alimentary pharmacology & therapeutics. vol 13 Suppl 2. 1999-08-10. PMID:10429737. |
the major enteric depot of 5-ht is found in mucosal enterochromaffin cells, which are sensory transducers that utilize 5-ht to activate both intrinsic (via 5-ht1p and 5-ht4 receptors) and extrinsic (via 5-ht3 receptors) primary afferent nerves. |
1999-08-10 |
2023-08-12 |
Not clear |
| S Gidener, M Gümüştekin, Z Kirkal. Pharmacological analysis of 5-hydroxytryptamine effects on human isolated ureter. Pharmacological research. vol 39. issue 6. 1999-08-05. PMID:10373245. |
in the present study the receptor mediating the contractile response to 5-ht in the human upper ureter could not be clearly designated 5-ht1-like, 5-ht2, 5-ht3or 5-ht4. |
1999-08-05 |
2023-08-12 |
human |
| Y Nagakura, S Akuzawa, K Miyata, T Kamato, T Suzuki, H Ito, T Yamaguch. Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacological research. vol 39. issue 5. 1999-08-03. PMID:10328995. |
binding properties of gastrointestinal prokinetic benzamides for both cloned human 5-hydroxytryptamine (5-ht)3 receptors and cloned human 5-ht4 receptors were examined and pharmacological properties of ym-53389{(+)-(s)-2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2, 4-oxadiazol-3-yl]aniline monohydrochloride} were characterised in animals. |
1999-08-03 |
2023-08-12 |
mouse |
| R P Ward, D M Dors. Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199625. |
molecular and behavioral effects mediated by gs-coupled adenosine a2a, but not serotonin 5-ht4 or 5-ht6 receptors following antipsychotic administration. |
1999-07-07 |
2023-08-12 |
rat |
| R P Ward, D M Dors. Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration. Neuroscience. vol 89. issue 3. 1999-07-07. PMID:10199625. |
we examined three striatal gs-coupled receptor systems (serotonin 5-ht4, serotonin 5-ht6 and adenosine a2a) to assess their potential involvement in the mechanism of action of the typical antipsychotic haloperidol. |
1999-07-07 |
2023-08-12 |
rat |
| M Takeda, K Tsukamoto, Y Mizutani, T Suzuki, K Taniyam. Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. Japanese journal of pharmacology. vol 79. issue 2. 1999-06-29. PMID:10202856. |
the pharmacological profile of sk-951 ((-)4-amino-n-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo[b]furan-7-carboxamide hemifumarate) was identified in relation to serotonin 5-ht3 and 5-ht4 receptors by the receptor binding assay and functional studies. |
1999-06-29 |
2023-08-12 |
rat |
| M Takeda, K Tsukamoto, Y Mizutani, T Suzuki, K Taniyam. Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. Japanese journal of pharmacology. vol 79. issue 2. 1999-06-29. PMID:10202856. |
the receptor binding assay showed that sk-951 bound to the 5-ht3 receptor with a high affinity, to the 5-ht4 receptor with relatively higher affinity and to the muscarinic m2 receptor with a low affinity, but not to dopamine d1 and d2 and serotonin 5-ht1 and 5-ht2 and muscarinic m1 and m3 receptors. |
1999-06-29 |
2023-08-12 |
rat |
| B Dean, E Tomaskovic-Crook, K Opeskin, N Keks, D Copolo. No change in the density of the serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia. Neurochemistry international. vol 34. issue 2. 1999-06-10. PMID:10213068. |
the binding of [3h]8-oh-dpat to serotonin1a receptor, [3h]gr113808 to the 5ht4 receptor and [3h]citalopram to serotonin transporter was not altered in subjects with schizophrenia. |
1999-06-10 |
2023-08-12 |
human |
| S Claeysen, M Sebben, C Becamel, J Bockaert, A Dumui. Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain. Molecular pharmacology. vol 55. issue 5. 1999-06-01. PMID:10220570. |
we have cloned new 5-hydroxytryptamine 4 (5-ht4) receptor splice variants from mouse (m5-ht4(e)r and m5-ht4(f)r), rat (r5-ht4(e)r), and human brain tissue (h5-ht4(e)r) which differ, as do the previously described 5-ht4 receptor variants, in the length and composition of their intracellular c termini after the common splicing site (l358). |
1999-06-01 |
2023-08-12 |
mouse |
| K Takemura, K Takada, S Mameya, M Kaibara, K Taniyam. Regional and functional differences of 5-hydroxytryptamine-receptor subtypes in guinea pig stomach. Japanese journal of pharmacology. vol 79. issue 1. 1999-05-04. PMID:10082316. |
the corpus possesses relaxant 5-ht1 receptors and relaxant receptors other than 5-ht1, 5-ht2, 5-ht3 and 5-ht4 receptors > contractile 5-ht4 receptor, and therefore 5-ht caused relaxations. |
1999-05-04 |
2023-08-12 |
Not clear |
| K Takemura, K Takada, S Mameya, M Kaibara, K Taniyam. Regional and functional differences of 5-hydroxytryptamine-receptor subtypes in guinea pig stomach. Japanese journal of pharmacology. vol 79. issue 1. 1999-05-04. PMID:10082316. |
the antrum possesses relaxant 5-ht1 receptor < contractile 5-ht2, 5-ht3 and 5-ht4 receptors, and thus 5-ht caused contractions. |
1999-05-04 |
2023-08-12 |
Not clear |
| C Delarue, V Contesse, H Lefebvre, S Lenglet, L Grumolato, J M Kuhn, H Vaudr. Pharmacological profile of serotonergic receptors in the adrenal gland. Endocrine research. vol 24. issue 3-4. 1999-04-13. PMID:9888560. |
in both frog and human adrenal gland, the benzamide derivative (r,s)-zacopride induces a robust increase in corticosteroid release suggesting that the effect of 5-ht on steroidogenesis is mediated through activation of 5-ht4 receptors. |
1999-04-13 |
2023-08-12 |
human |
| C Delarue, V Contesse, H Lefebvre, S Lenglet, L Grumolato, J M Kuhn, H Vaudr. Pharmacological profile of serotonergic receptors in the adrenal gland. Endocrine research. vol 24. issue 3-4. 1999-04-13. PMID:9888560. |
in contrast, in rat, the stimulatory effect of 5-ht on aldosterone secretion is clearly not mediated by 5-ht4 receptors. |
1999-04-13 |
2023-08-12 |
human |
| H Lefebvre, K N Gonzalez, V Contesse, C Delarue, H Vaudry, J M Kuhn. Effect of prolonged administration of the serotonin4 (5-HT4) receptor agonist cisapride on aldosterone secretion in healthy volunteers. Endocrine research. vol 24. issue 3-4. 1999-04-13. PMID:9888571. |
in man, serotonin (5-ht) has been shown to stimulate aldosterone secretion through activation of 5-ht4 receptors, in particular, we have observed that oral administration of a single dose of the 5-ht4 receptor agonist cisapride (10 mg) induces a 5-fold increase in plasma aldosterone levels in healthy volunteers. |
1999-04-13 |
2023-08-12 |
human |
| R H Mach, L Wu, T West, B R Whirrett, S R Childer. The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors. Life sciences. vol 64. issue 10. 1999-04-13. PMID:10096443. |
in the current study, in vitro studies were conducted in order to determine the affinity of (+/-)-sm 21 for serotonin 5-ht3, 5-ht4, and sigma receptors. |
1999-04-13 |
2023-08-12 |
Not clear |
| O Blondel, M Gastineau, M Langlois, R Fischmeiste. The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor. British journal of pharmacology. vol 125. issue 4. 1999-03-25. PMID:9831890. |
the 5-ht4 receptor antagonist 2-(cis-3,5-dimethylpiperidino)ethyl 4-amino-5-chloro-2-methoxybenzoate (ml10375) at 1 microm completely abolished the 5-ht (1 microm)-mediated increase in adenylyl cyclase activity in cos-7 cells expressing the h5-ht4(c) receptor. |
1999-03-25 |
2023-08-12 |
human |
| A Menese. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886142. |
emerging evidence also indicates that 5-ht1a and 5-ht4 receptor agonists, as well as, 5-ht1a antagonists, 5-ht2 antagonists, 5-ht3 antagonists and 5-ht uptake inhibitors may have therapeutic utility in the treatment of alzheimer's disease and amnesia. |
1999-03-23 |
2023-08-12 |
Not clear |
| T Suzuki, K Iwaoka, N Imanishi, Y Nagakura, K Miyata, H Nakahara, M Ohta, T Mas. Synthesis of the selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist (+)-(S)-2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-y l]aniline. Chemical & pharmaceutical bulletin. vol 47. issue 1. 1999-03-16. PMID:9987833. |
synthesis of the selective 5-hydroxytryptamine 4 (5-ht4) receptor agonist (+)-(s)-2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-y l]aniline. |
1999-03-16 |
2023-08-12 |
human |