| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Suzuki, K Iwaoka, N Imanishi, Y Nagakura, K Miyata, H Nakahara, M Ohta, T Mas. Synthesis of the selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist (+)-(S)-2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-y l]aniline. Chemical & pharmaceutical bulletin. vol 47. issue 1. 1999-03-16. PMID:9987833. |
in a search for novel 5-hydroxytryptamine 4 (5-ht4) agonists focusing on the linker group of benzamide derivatives, 2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl]a niline (2) was prepared and its optical isomers were separated. |
1999-03-16 |
2023-08-12 |
human |
| M A Olsen, S P Nawoschik, B R Schurman, H L Schmitt, M Burno, D L Smith, L E Schechte. Identification of a human 5-HT6 receptor variant produced by alternative splicing. Brain research. Molecular brain research. vol 64. issue 2. 1999-03-12. PMID:9931499. |
the complexity of the 5-hydroxytryptamine (5-ht) (serotonin) receptor family has been increased by the findings that isoforms or splice variants exist for subtypes such as the 5-ht2b, 5-ht2c, 5-ht4 and 5-ht7 subtypes. |
1999-03-12 |
2023-08-12 |
mouse |
| A J Sleight, F G Boess, M Bös, A Bourso. The putative 5-ht6 receptor: localization and function. Annals of the New York Academy of Sciences. vol 861. 1999-02-25. PMID:9928244. |
until recently, the majority of actions of the neurotransmitter 5-hydroxytryptamine (5-ht) were generally believed to be mediated by members of the 5-ht1, 5-ht2, 5-ht3 and 5-ht4 receptor families. |
1999-02-25 |
2023-08-12 |
Not clear |
| J G Jin, A E Foxx-Orenstein, J R Gride. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862758. |
propulsion in guinea pig colon induced by 5-hydroxytryptamine (ht) via 5-ht4 and 5-ht3 receptors. |
1999-02-05 |
2023-08-12 |
human |
| J G Jin, A E Foxx-Orenstein, J R Gride. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862758. |
previous studies have shown that the intestinal peristaltic reflex initiated by mucosal stimulation is mediated by release of 5-hydroxytryptamine (ht) from enterochromaffin cells; 5-ht acts via 5-ht4 receptors in rat and human, and via both 5-ht4 and 5-ht3 receptors in guinea pig to activate intramural sensory neurons that release calcitonin gene-related peptide. |
1999-02-05 |
2023-08-12 |
human |
| J G Jin, A E Foxx-Orenstein, J R Gride. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862758. |
the selective 5-ht4 agonists, htf 919 and r093877, as well as 5-ht in the presence of the 5-ht2a antagonist, ketanserin, increased the velocity of propulsion in a concentration-dependent fashion with ec50s of 6.9 +/- 0.1 nm, 37.4 +/- 1.0 nm, and 3.9 +/- 0. |
1999-02-05 |
2023-08-12 |
human |
| J G Jin, A E Foxx-Orenstein, J R Gride. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862758. |
we conclude that the presence of fecal pellets triggers the release of 5-ht, which acts via both 5-ht3 and 5-ht4 receptors to regulate propulsive activity in guinea pig colon. |
1999-02-05 |
2023-08-12 |
human |
| B Arranz, P Rosel, L San, S Sarró, M A Navarro, J Marcusso. Characterization of the 5-HT4 binding site in human brain. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 6-7. 1999-01-26. PMID:9826103. |
5-ht, 5-ct, ondansetron, tropisetron, bimu 1 and bimu 8 (mixed 5-ht3 and 5-ht4 agonists). |
1999-01-26 |
2023-08-12 |
human |
| C M Villalón, F J López-Muñoz, M Perusquía, J A Terró. External carotid effects of 2-(2-aminoethyl)-quinoline (D-1997) in vagosympathectomized dogs. European journal of pharmacology. vol 356. issue 1. 1998-12-14. PMID:9761419. |
serotonin (5-hydroxytryptamine; 5-ht) elicits external carotid vasoconstriction in vagosympathectomized dogs via 5-ht1b/1d receptors and a mechanism unrelated to the 5-ht1, 5-ht2, 5-ht3 and 5-ht4 types. |
1998-12-14 |
2023-08-12 |
Not clear |
| K Hillsley, G M Maw. 5-HT is present in nerves of guinea pig sphincter of Oddi and depolarizes sphincter of Oddi neurons. The American journal of physiology. vol 275. issue 5. 1998-12-14. PMID:9815032. |
when 5-ht was applied to so neurons, it elicited three different responses: 1) a fast depolarization to 5-ht in 31 of 62 cells was mimicked by 2-methyl-5-ht and blocked by ly-278584 (1 microm); 2) a prolonged depolarization to 5-ht in 21 of 62 cells evoked an increase in input resistance and was attenuated by the 5-ht1p antagonist renzapride (1 microm) but not by the 5-ht4 antagonist sdz-205557 (0.1-10 microm); and 3) an indirect depolarization blocked by ttx or atropine was observed in 32 of 62 cells. |
1998-12-14 |
2023-08-12 |
Not clear |
| J Goldhill, M F Porquet, I Ange. The response of rat colonic mucosa to 5-hydroxytryptamine in health and following restraint stress. European journal of pharmacology. vol 353. issue 2-3. 1998-11-13. PMID:9726659. |
the colonic response to 5-ht was unaltered by methysergide (10 microm), ritanserin (0.1 microm), ondansetron (1 microm) or clozapine (10 microm), but was antagonized by the 5-ht4 receptor antagonists sb204070 (pd'2 = 9.32), gr113808 (pkb = 8.56), dau6285 (pkb = 6.07) and sdz205557 (pkb = 6.80). |
1998-11-13 |
2023-08-12 |
human |
| J Goldhill, M F Porquet, I Ange. The response of rat colonic mucosa to 5-hydroxytryptamine in health and following restraint stress. European journal of pharmacology. vol 353. issue 2-3. 1998-11-13. PMID:9726659. |
the response of colonic epithelial and oesophageal tunica muscularis mucosae to 5-ht is therefore mediated by a similar 5-ht4 receptor. |
1998-11-13 |
2023-08-12 |
human |
| K Thorré, G Ebinger, Y Michott. 5-HT4 receptor involvement in the serotonin-enhanced dopamine efflux from the substantia nigra of the freely moving rat: a microdialysis study. Brain research. vol 796. issue 1-2. 1998-10-29. PMID:9689461. |
intranigral perfusion of the 5-ht4 receptor antagonist, rs 39604 (10 microm, 3 h), did not affect da levels but significantly decreased nigral 5-ht levels to 74%. |
1998-10-29 |
2023-08-12 |
rat |
| H Lefebvre, V Contesse, C Delarue, H Vaudry, J M Kuh. Serotonergic regulation of adrenocortical function. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 30. issue 6-7. 1998-10-13. PMID:9694569. |
in the frog and the human, the effect of 5-ht on the adrenal cortex is mediated through a 5-ht4 receptor subtype positively coupled to adenylyl cyclase and calcium influx. |
1998-10-13 |
2023-08-12 |
mouse |
| H Lefebvre, V Contesse, C Delarue, H Vaudry, J M Kuh. Serotonergic regulation of adrenocortical function. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 30. issue 6-7. 1998-10-13. PMID:9694569. |
collectively, these findings suggest that intra-adrenal 5-ht stimulates the secretory activity of adrenocortical cells through a paracrine mode of communication involving a 5-ht4 receptor type. |
1998-10-13 |
2023-08-12 |
mouse |
| H Schwörer, G Ramador. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 5. 1998-09-28. PMID:9650808. |
the 5-ht4 receptor agonist 5-methoxytryptamine (0.3-30 micromol/l) reduced 5-ht release by about 50% in both species. |
1998-09-28 |
2023-08-12 |
human |
| H Schwörer, G Ramador. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn-Schmiedeberg's archives of pharmacology. vol 357. issue 5. 1998-09-28. PMID:9650808. |
the specific 5-ht4 receptor antagonist gr 113808 ((1-[2-methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-1-methyl-1h-ind ole-3-carboxylate) (0.1 micromol/l) which by itself did not significantly affect 5-ht release from human duodenal specimens blocked the inhibitory effect of 5-methoxytryptamine (30 micromol/l). |
1998-09-28 |
2023-08-12 |
human |
| M J Farthin. New drugs in the management of the irritable bowel syndrome. Drugs. vol 56. issue 1. 1998-09-28. PMID:9664195. |
for many patients, abdominal pain and bloating are the most distressing symptoms of this disease and the new drugs targeted at pain control, such as kappa agonists and serotonin antagonists (5-ht3) and possibly 5-ht4), may eventually find a place in the clinical management of this syndrome. |
1998-09-28 |
2023-08-12 |
Not clear |
| F C Albuquerque, E H Smith, J M Kellu. 5-HT induces cAMP production in crypt colonocytes at a 5-HT4 receptor. The Journal of surgical research. vol 77. issue 2. 1998-09-24. PMID:9733600. |
5-ht induces camp production in crypt colonocytes at a 5-ht4 receptor. |
1998-09-24 |
2023-08-12 |
rat |
| F C Albuquerque, E H Smith, J M Kellu. 5-HT induces cAMP production in crypt colonocytes at a 5-HT4 receptor. The Journal of surgical research. vol 77. issue 2. 1998-09-24. PMID:9733600. |
previous studies demonstrate that both 5-hydroxytryptamine (5-ht) and cyclic amp (camp) induce chloride efflux from crypt colonocytes in the rat distal colon; antagonist studies suggest that the 5-ht response is mediated primarily by the 5-ht4 receptor. |
1998-09-24 |
2023-08-12 |
rat |