| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adriana Alexandre S Tavares, Fabien Caillé, Olivier Barret, Caroline Papin, Hsiaoju Lee, Thomas J Morley, Krista Fowles, Daniel Holden, John P Seibyl, David Alagille, Gilles D Tamagna. Whole-body biodistribution and dosimetry estimates of a novel radiotracer for imaging of serotonin 4 receptors in brain: [¹⁸F]MNI-698. Nuclear medicine and biology. vol 41. issue 5. 2014-12-15. PMID:24674817. |
a new radiotracer for imaging the serotonin 4 receptors (5-ht4) in brain, [¹⁸f]mni-698, was recently developed by our group. |
2014-12-15 |
2023-08-12 |
Not clear |
| Toshiaki Ishizuka, Hazuki Goshima, Ayako Ozawa, Yasuhiro Watanab. Stimulation of 5-HT4 receptor enhances differentiation of mouse induced pluripotent stem cells into neural progenitor cells. Clinical and experimental pharmacology & physiology. vol 41. issue 5. 2014-12-09. PMID:24606396. |
pretreatment of eb cultures with either 1 μmol/l gr113808 (a selective 5-ht4 receptor antagonist) or 1 μmol/l h89 (a protein kinase (pka) inhibitor) significantly inhibited these effects of 5-ht. |
2014-12-09 |
2023-08-12 |
mouse |
| J Bushman, B Mishra, M Ezra, S Gul, C Schulze, S Chaudhury, D Ripoll, A Wallqvist, J Kohn, M Schachner, G Loer. Tegaserod mimics the neurostimulatory glycan polysialic acid and promotes nervous system repair. Neuropharmacology. vol 79. 2014-12-03. PMID:24067923. |
the psa mimicking activity of tegaserod was shown in cultures of central and peripheral nervous system cells of the mouse and found to be independent of its described function as a serotonin (5-ht4) receptor agonist. |
2014-12-03 |
2023-08-12 |
mouse |
| Kyung Hoon Oh, Yoonjin Nam, Ji Hoon Jeong, In Kyeom Kim, Uy Dong Soh. The effect of DA-9701 on 5-hydroxytryptamine-induced contraction of feline esophageal smooth muscle cells. Molecules (Basel, Switzerland). vol 19. issue 4. 2014-11-25. PMID:24759073. |
5-ht binds to the 5-ht2, 5-ht3 and 5-ht4 receptors to induce smooth muscle contraction in feline esmcs. |
2014-11-25 |
2023-08-13 |
cat |
| Noé Dumas, Marcelle Moulin-Sallanon, Nathalie Ginovart, Benjamin B Tournier, Peggy Suzanne, Thomas Cailly, Frédéric Fabis, Sylvain Rault, Yves Charnay, Philippe Mille. Small-animal single-photon emission computed tomographic imaging of the brain serotoninergic systems in wild-type and mdr1a knockout rats. Molecular imaging. vol 13. 2014-11-04. PMID:24622810. |
thus, we compared the performances of 123i-p-mppi, 123i-r91150, 123i-sb207710, and 123i-adam radioligands, for imaging of their respective targets (5-hydroxytryptamine [5-ht]1a, 5-ht2a, 5-ht4, and serotonin transporter [sert]), in wt and mdr1a knockout (ko) rats. |
2014-11-04 |
2023-08-12 |
rat |
| Natsumi Aoki, Hiroyuki Watanabe, Kazuya Okada, Kazuyuki Aoki, Takuma Imanishi, Daisuke Yoshida, Ryosuke Ishikawa, Shigenobu Shibat. Involvement of 5-HT₃ and 5-HT₄ receptors in the regulation of circadian clock gene expression in mouse small intestine. Journal of pharmacological sciences. vol 124. issue 2. 2014-10-13. PMID:24492464. |
injection of 5-ht and agonists of the 5-ht3 and 5-ht4 receptors increased per1/per2 expression and decreased bmal1 expression in a dose-dependent manner. |
2014-10-13 |
2023-08-12 |
mouse |
| Natsumi Aoki, Hiroyuki Watanabe, Kazuya Okada, Kazuyuki Aoki, Takuma Imanishi, Daisuke Yoshida, Ryosuke Ishikawa, Shigenobu Shibat. Involvement of 5-HT₃ and 5-HT₄ receptors in the regulation of circadian clock gene expression in mouse small intestine. Journal of pharmacological sciences. vol 124. issue 2. 2014-10-13. PMID:24492464. |
although treatment with antagonists of 5-ht3 and 5-ht4 alone did not affect clock gene expression, co-injection of these antagonists with 5-ht blocked the 5-ht-induced changes in clock gene expression. |
2014-10-13 |
2023-08-12 |
mouse |
| Hamid-Reza Chegini, Mohammad Nasehi, Mohammad-Reza Zarrindas. Differential role of the basolateral amygdala 5-HT3 and 5-HT4 serotonin receptors upon ACPA-induced anxiolytic-like behaviors and emotional memory deficit in mice. Behavioural brain research. vol 261. 2014-10-06. PMID:24333573. |
differential role of the basolateral amygdala 5-ht3 and 5-ht4 serotonin receptors upon acpa-induced anxiolytic-like behaviors and emotional memory deficit in mice. |
2014-10-06 |
2023-08-12 |
mouse |
| Rachel M Gwynne, Amanda J Clarke, John B Furness, Joel C Bornstei. Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro. Frontiers in neuroscience. vol 8. 2014-10-06. PMID:25285066. |
the roles of 5-ht3 and 5-ht4 receptors in the modulation of intestinal propulsion by luminal application of 5-ht and augmentation of endogenous 5-ht effects were studied in segments of guinea-pig ileum in vitro. |
2014-10-06 |
2023-08-13 |
Not clear |
| Rachel M Gwynne, Amanda J Clarke, John B Furness, Joel C Bornstei. Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro. Frontiers in neuroscience. vol 8. 2014-10-06. PMID:25285066. |
when 5-ht (30 nm), fluoxetine (selective serotonin reuptake inhibitor; 1 nm), 2-methyl-5-ht (5-ht3 receptor agonist; 1 mm), or rs 67506 (5-ht4 receptor agonist, 1 μm) was infused into the lumen, the pressure needed to initiate persistent propulsive activity fell significantly. |
2014-10-06 |
2023-08-13 |
Not clear |
| Rachel M Gwynne, Amanda J Clarke, John B Furness, Joel C Bornstei. Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro. Frontiers in neuroscience. vol 8. 2014-10-06. PMID:25285066. |
a specific 5-ht4 receptor antagonist, sb 207266 (10 nm in lumen), abolished the effects of 5-ht, fluoxetine, and rs 67506, but not those of 2-methyl-5-ht. |
2014-10-06 |
2023-08-13 |
Not clear |
| Rachel M Gwynne, Amanda J Clarke, John B Furness, Joel C Bornstei. Both exogenous 5-HT and endogenous 5-HT, released by fluoxetine, enhance distension evoked propulsion in guinea-pig ileum in vitro. Frontiers in neuroscience. vol 8. 2014-10-06. PMID:25285066. |
these results indicate that luminal application of exogenous 5-ht, or increased release of endogenous mucosal 5-ht above basal levels, acts to lower the threshold for propulsive contractions in the guinea-pig ileum via activation of 5-ht3 and 5-ht4 receptors and the release of tachykinins. |
2014-10-06 |
2023-08-13 |
Not clear |
| Matthias Wawra, Pawel Fidzinski, Uwe Heinemann, Istvan Mody, Joachim Beh. 5-HT4-receptors modulate induction of long-term depression but not potentiation at hippocampal output synapses in acute rat brain slices. PloS one. vol 9. issue 2. 2014-09-29. PMID:24505387. |
in the present study, we investigate the effect of 5-hydroxytryptamine type 4 (5-ht4) receptor activation and blockade on both forms of synaptic plasticity in burst-spiking cells. |
2014-09-29 |
2023-08-12 |
rat |
| Matthias Wawra, Pawel Fidzinski, Uwe Heinemann, Istvan Mody, Joachim Beh. 5-HT4-receptors modulate induction of long-term depression but not potentiation at hippocampal output synapses in acute rat brain slices. PloS one. vol 9. issue 2. 2014-09-29. PMID:24505387. |
since ltd is blocked in the presence of 5-ht4 receptor antagonists, our data are consistent with 5-ht4 receptor activation by ambient serotonin or intrinsically active 5-ht4 receptors. |
2014-09-29 |
2023-08-12 |
rat |
| Hirokazu Doi, Ryuji Sakakibara, Masahiko Kishi, Yohei Tsuyuzaki, Fuyuki Tateno, Shigekazu Hira. [Gastrointestinal dysfunction has important implications for plasma L-dopa concentrations in Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2014-09-19. PMID:24291998. |
serotonin 5-ht4 agonist and dopamine d2 antagonist are useful to improve ge impairment in pd. |
2014-09-19 |
2023-08-12 |
Not clear |
| Anna A Pimenova, Amantha Thathiah, Bart De Strooper, Ina Tesseu. Regulation of amyloid precursor protein processing by serotonin signaling. PloS one. vol 9. issue 1. 2014-09-15. PMID:24466315. |
upregulation of α-secretase activity through the 5-hydroxytryptamine 4 (5-ht4) receptor has been shown to reduce aβ production, amyloid plaque load and to improve cognitive impairment in transgenic mouse models of ad. |
2014-09-15 |
2023-08-12 |
mouse |
| Gillian M Keatin. Prucalopride: a review of its use in the management of chronic constipation. Drugs. vol 73. issue 17. 2014-08-02. PMID:24194435. |
the highly selective serotonin 5-ht4 receptor agonist prucalopride (resolor(®), resotran(®), resotrans(®)) is indicated for the treatment of chronic constipation. |
2014-08-02 |
2023-08-12 |
Not clear |
| Chi Yan, Liu Xin-Guang, Wang Hua-Hong, Li Jun-Xia, Li Yi-Xua. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 10. 2014-07-13. PMID:22832600. |
effect of the 5-ht4 receptor and serotonin transporter on visceral hypersensitivity in rats. |
2014-07-13 |
2023-08-12 |
rat |
| Shin Fukud. Stress and visceral pain: focusing on irritable bowel syndrome. Pain. vol 154 Suppl 1. 2014-07-03. PMID:24021863. |
serotonin (5-ht) is another likely candidate associated with brain-gut function in ibs, as 5-ht3 antagonists, 5-ht4 agonists, and antidepressants were demonstrated to regulate 5-ht neurotransmission in ibs patients. |
2014-07-03 |
2023-08-12 |
Not clear |
| Laura Grasa, Alejandro Ansón-Casaos, María Teresa Martínez, Raquel Albendea, Alba De Martino, Sergio Gonzalo, María Divina Murill. Single-walled carbon nanotubes (SWCNTs) enhance KCl-, acetylcholine-, and serotonin-induced contractions and evoke oxidative stress on rabbit ileum. Journal of biomedical nanotechnology. vol 10. issue 3. 2014-06-12. PMID:24730248. |
ondansetron and gr 113808 reduced the 5-ht response, indicating that serotonin 5-ht3 and 5-ht4 receptors are involved in this effect. |
2014-06-12 |
2023-08-13 |
rabbit |