| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tiong C Sia, Malcolm Whiting, Melinda Kyloh, Sarah J Nicholas, John Oliver, Simon J Brookes, Phil G Dinning, David A Wattchow, Nick J Spence. 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Frontiers in neuroscience. vol 7. 2013-08-12. PMID:23935564. |
5-ht3 and 5-ht4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-ht. |
2013-08-12 |
2023-08-12 |
Not clear |
| Tiong C Sia, Malcolm Whiting, Melinda Kyloh, Sarah J Nicholas, John Oliver, Simon J Brookes, Phil G Dinning, David A Wattchow, Nick J Spence. 5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT. Frontiers in neuroscience. vol 7. 2013-08-12. PMID:23935564. |
we suggest caution should be exercised when interpreting the effects of 5-ht3 and 5-ht4 antagonists; and the role of endogenous 5-ht, in the generation of distension-evoked colonic peristalsis. |
2013-08-12 |
2023-08-12 |
Not clear |
| Yukiko Mine, Seiko Oku, Naoyuki Yoshid. Anti-emetic effect of mosapride citrate hydrate, a 5-HT4 receptor agonist, on selective serotonin reuptake inhibitors (SSRIs)-induced emesis in experimental animals. Journal of pharmacological sciences. vol 121. issue 1. 2013-06-21. PMID:23257657. |
anti-emetic effect of mosapride citrate hydrate, a 5-ht4 receptor agonist, on selective serotonin reuptake inhibitors (ssris)-induced emesis in experimental animals. |
2013-06-21 |
2023-08-12 |
rat |
| Gakuji Hashimoto, Mikako Sakurai, Andrew F Teich, Faisal Saeed, Fahad Aziz, Ottavio Aranci. 5-HT₄ receptor stimulation leads to soluble AβPPα production through MMP-9 upregulation. Journal of Alzheimer's disease : JAD. vol 32. issue 2. 2013-04-23. PMID:22810092. |
serotonin 4 (5-ht4) receptor signaling does not only have the physiological function of improving cognition, but might also be helpful in the therapy of alzheimer's disease (ad) through regulation of the production of soluble amyloid-β protein precursor alpha (saβppα). |
2013-04-23 |
2023-08-12 |
mouse |
| Hans Jc Buiter, Albert D Windhorst, Marc C Huisman, Joris H De Maeyer, Jan Aj Schuurkes, Adriaan A Lammertsma, Josée E Leyse. Radiosynthesis and preclinical evaluation of [11C]prucalopride as a potential agonist PET ligand for the 5-HT4 receptor. EJNMMI research. vol 3. issue 1. 2013-04-15. PMID:23557209. |
serotonin 5-ht4 receptor (5-ht4-r) agonists are potential therapeutic agents for enterokinetic and cognitive disorders and are marketed for treatment of constipation. |
2013-04-15 |
2023-08-12 |
Not clear |
| Shinichi Kato, Narumi Matsuda, Kenjiro Matsumoto, Mai Wada, Naoki Onimaru, Masashi Yasuda, Kikuko Amagase, Syunji Horie, Koji Takeuch. Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Pharmacological research. vol 66. issue 3. 2012-12-11. PMID:22699012. |
dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-ht3 receptors and anti-ulcerogenic action via 5-ht4 receptors. |
2012-12-11 |
2023-08-12 |
mouse |
| Shinichi Kato, Narumi Matsuda, Kenjiro Matsumoto, Mai Wada, Naoki Onimaru, Masashi Yasuda, Kikuko Amagase, Syunji Horie, Koji Takeuch. Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. Pharmacological research. vol 66. issue 3. 2012-12-11. PMID:22699012. |
these findings suggest that endogenous 5-ht exerts a dual role in the pathogenesis of indomethacin-induced intestinal lesions: pro-ulcerogenic action via 5-ht3 receptors and anti-ulcerogenic action via 5-ht4 receptors, and the latter effect via 5-ht4 receptors may be mediated by activation of α7-nicotinic acetylcholine receptors. |
2012-12-11 |
2023-08-12 |
mouse |
| Jon Riise, Øivind Ørstavik, Eirik Qvigstad, Christen P Dahl, Jan-Bjørn Osnes, Tor Skomedal, Finn Olav Levy, Kurt A Krober. Prostaglandin E1 facilitates inotropic effects of 5-HT4 serotonin receptors and β-adrenoceptors in failing human heart. Basic research in cardiology. vol 107. issue 5. 2012-11-06. PMID:22923058. |
prostaglandin e1 facilitates inotropic effects of 5-ht4 serotonin receptors and β-adrenoceptors in failing human heart. |
2012-11-06 |
2023-08-12 |
human |
| Eamonn M M Quigle. Prucalopride: safety, efficacy and potential applications. Therapeutic advances in gastroenterology. vol 5. issue 1. 2012-08-23. PMID:22282705. |
among these approaches is the use of prokinetic agents; while prior molecules have been troubled by lack of selectivity and cardiac side effects, the new agent, prucalopride, appears to be highly selective for the serotonin 5-ht4 receptor and is, therefore, a potent stimulator of gut motility. |
2012-08-23 |
2023-08-12 |
Not clear |
| Lisbeth Marne. Communication among neurons. Danish medical journal. vol 59. issue 4. 2012-08-02. PMID:22459725. |
the novel serotonin 5-ht4 antagonist [11c]sb207145 was used as an example of the validation process for quantitative pet receptor imaging. |
2012-08-02 |
2023-08-12 |
human |
| Rudi Henriksen, Nishtman Dizeyi, Per-Anders Abrahamsso. Expression of serotonin receptors 5-HT1A, 5-HT1B, 5-HT2B and 5-HT4 in ovary and in ovarian tumours. Anticancer research. vol 32. issue 4. 2012-05-24. PMID:22493371. |
expression of serotonin receptors 5-ht1a, 5-ht1b, 5-ht2b and 5-ht4 in ovary and in ovarian tumours. |
2012-05-24 |
2023-08-12 |
Not clear |
| Isao Kawahara, Hiroki Kuniyasu, Hiroko Matsuyoshi, Kei Goto, Koji Obata, Hiromi Misawa, Hisao Fujii, Miyako Takak. Comparison of effects of a selective 5-HT reuptake inhibitor versus a 5-HT4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 6. 2012-05-04. PMID:22194416. |
comparison of effects of a selective 5-ht reuptake inhibitor versus a 5-ht4 receptor agonist on in vivo neurogenesis at the rectal anastomosis in rats. |
2012-05-04 |
2023-08-12 |
rat |
| Ramin Ataee, Soheila Ajdary, Mehdi Rezayat, Mohammad Ali Shokrgozar, Shadab Shahriari, Mohammad Reza Zarrindas. Study of 5HT3 and HT4 receptor expression in HT29 cell line and human colon adenocarcinoma tissues. Archives of Iranian medicine. vol 13. issue 2. 2011-06-13. PMID:20187666. |
in this study, the effects of 5ht, 5ht3 (1-phenylbiguanide hydrochloride) and 5ht4 (cisapride) agonists in promoting the growth of the ht29 cell line and the growth-inhibition effect of the 5ht3 receptor antagonist (y-25130 hydrochloride) and 5ht4 receptor antagonist (rs 23597-190) were investigated. |
2011-06-13 |
2023-08-12 |
human |
| H M Francis, N J Kraushaar, L R Hunt, J L Cornis. Serotonin 5-HT4 receptors in the nucleus accumbens are specifically involved in the appetite suppressant and not locomotor stimulant effects of MDMA ('ecstasy'). Psychopharmacology. vol 213. issue 2-3. 2011-05-24. PMID:20740276. |
serotonin 5-ht4 receptors in the nucleus accumbens are specifically involved in the appetite suppressant and not locomotor stimulant effects of mdma ('ecstasy'). |
2011-05-24 |
2023-08-12 |
Not clear |
| Maria S M Wai, Dietrich E Lorke, W H Kwong, Lihong Zhang, David T Ye. Profiles of serotonin receptors in the developing human thalamus. Psychiatry research. vol 185. issue 1-2. 2011-03-03. PMID:20538346. |
our observation that 5-ht1a, 5-ht2a, 5-ht2c and 5-ht4 receptors are present in the human thalamus prenatally indicates that 5-ht may play a role during fetal development. |
2011-03-03 |
2023-08-12 |
human |
| Andrea S Prause, Christophe T Guionaud, Michael H Stoffel, Christopher J Portier, Meike Mevisse. Expression and function of 5-hydroxytryptamine 4 receptors in smooth muscle preparations from the duodenum, ileum, and pelvic flexure of horses without gastrointestinal tract disease. American journal of veterinary research. vol 71. issue 12. 2011-03-01. PMID:21117994. |
to evaluate the expression of the 5-hydroxytryptamine 4 (5-ht4) receptor subtype and investigate the modulating function of those receptors on contractility in intestinal tissues obtained from horses without gastrointestinal tract disease. |
2011-03-01 |
2023-08-12 |
Not clear |
| Fritzi Siegert, Karen Niebe. [New therapeutical approaches for treatment of irritable bowel syndrome]. Medizinische Monatsschrift fur Pharmazeuten. vol 33. issue 8. 2011-01-25. PMID:21189648. |
new generation 5-ht4 receptor agonists, 5-ht, antagonists or partial antagonists are promising approaches to treat gastrointestinal dysmotility, particularly colonic diseases. |
2011-01-25 |
2023-08-12 |
Not clear |
| M N Modica, V Pittalà, G Romeo, L Salerno, M A Siracus. Serotonin 5-HT3 and 5-HT4 ligands: an update of medicinal chemistry research in the last few years. Current medicinal chemistry. vol 17. issue 4. 2010-09-07. PMID:20015043. |
serotonin 5-ht3 and 5-ht4 ligands: an update of medicinal chemistry research in the last few years. |
2010-09-07 |
2023-08-12 |
Not clear |
| Arnaud Goolaerts, Jérémie Roux, Michael T Ganter, Vadim Shlyonsky, Ahmed Chraibi, Renauld Stéphane, Frédérique Mies, Michael A Matthay, Robert Naeije, Sarah Sariban-Sohraby, Marybeth Howard, Jean-Francois Pitte. Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. American journal of respiratory cell and molecular biology. vol 43. issue 1. 2010-07-15. PMID:19717814. |
in addition, the stimulation of 5-ht1r (5-ht receptor 1), 5-ht2r (5-ht receptor 2), 5-ht4r (5-ht receptor 4), and 5-ht7r (5-ht receptor 7) failed to reproduce the 5-ht effect on amiloride-sensitive sodium transport. |
2010-07-15 |
2023-08-12 |
mouse |
| Cecilie L Licht, Lisbeth Kirkegaard, Maha Zueger, Sabine Chourbaji, Peter Gass, Susana Aznar, Gitte M Knudse. Changes in 5-HT4 receptor and 5-HT transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice. Neurochemistry international. vol 56. issue 4. 2010-05-25. PMID:20060867. |
changes in 5-ht4 receptor and 5-ht transporter binding in olfactory bulbectomized and glucocorticoid receptor heterozygous mice. |
2010-05-25 |
2023-08-12 |
mouse |