| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ramin Ataee, Soheila Ajdary, Mohammadreza Zarrindast, Mehdi Rezayat, Mohammad Ali Shokrgozar, Amin Atae. Y25130 hydrochloride, a selective 5HT3 receptor antagonist has potent antimitogenic and apoptotic effect on HT29 colorectal cancer cell line. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 19. issue 2. 2010-04-13. PMID:20010428. |
in cell culture, we investigated the effects of 5-ht, 5-ht3 and 5-ht4 receptor agonists and antagonists on proliferation of ht29 cells. |
2010-04-13 |
2023-08-12 |
Not clear |
| Erin R Slaten, Melissa C Hernandez, Ricardo Albay, Rachel Lavian, Skirmantas Janusoni. Transient expression of serotonin 5-HT4 receptors in the mouse developing thalamocortical projections. Developmental neurobiology. vol 70. issue 3. 2010-03-11. PMID:19998416. |
transient expression of serotonin 5-ht4 receptors in the mouse developing thalamocortical projections. |
2010-03-11 |
2023-08-12 |
mouse |
| O Mnie-Filali, M Gholi Amraei, S Benmbarek, E Archer-Lahlou, R Peñas-Cazorla, M T Vilaró, S M Boye, G Piñeyr. Serotonin 4 receptor (5-HT4R) internalization is isoform-specific: effects of 5-HT and RS67333 on isoforms A and B. Cellular signalling. vol 22. issue 3. 2010-03-08. PMID:19922792. |
the present study compared isoforms 5-ht4(a) and 5-ht4(b) in their ability to undergo endocytic regulation following exposure to 5-ht and to the putatively fast acting antidepressant rs67333. |
2010-03-08 |
2023-08-12 |
Not clear |
| Jeremy D Gal. The use of novel promotility and prosecretory agents for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. Advances in therapy. vol 26. issue 5. 2010-03-05. PMID:19444393. |
5-hydroxytryptamine receptor 4 (5-ht4) agonists stimulate gi motility and intestinal secretion, and tegaserod has demonstrated efficacy in improving bowel habit. |
2010-03-05 |
2023-08-12 |
Not clear |
| Łukasz Dobrek, Piotr J Tho. Pathophysiological concepts of functional dyspepsia and irritable bowel syndrome future pharmacotherapy. Acta poloniae pharmaceutica. vol 66. issue 5. 2009-12-17. PMID:19894640. |
some of them which seem to diminish visceral hypersensitivity acting via serotonin receptors are also used, including 5-ht4 agonists and 5-ht3 antagonists. |
2009-12-17 |
2023-08-12 |
Not clear |
| Hui-Rong Liu, Xiao-Mei Wang, En-Hua Zhou, Yin Shi, Na Li, Ling-Song Yuan, Huan-Gan W. Acupuncture at both ST25 and ST37 improves the pain threshold of chronic visceral hypersensitivity rats. Neurochemical research. vol 34. issue 11. 2009-11-25. PMID:19387829. |
after seven ea treatments, the concentrations of 5-hydroxytryptamine (5-ht), 5-ht3 receptor (5-ht3r) and 5-ht4 receptor (5-ht4r) in colon tissue were assayed quantitatively by enzyme-linked immunosorbent assay. |
2009-11-25 |
2023-08-12 |
rat |
| Alain M Gardier, Bruno P Guiard, Jean-Philippe Guilloux, Christelle Repérant, François Coudoré, Denis J Davi. Interest of using genetically manipulated mice as models of depression to evaluate antidepressant drugs activity: a review. Fundamental & clinical pharmacology. vol 23. issue 1. 2009-06-01. PMID:19267769. |
the present review will thus focus on ko mice lacking g protein-coupled monoaminergic receptors (e.g; 5-ht1b, 5-ht1a, and 5-ht4 receptors) and the 5-ht serotonin transporter, which is the main target of antidepressant drugs (or strategies). |
2009-06-01 |
2023-08-12 |
mouse |
| Johann Guillemot, Patricia Compagnon, Dorthe Cartier, Erwan Thouennon, Christian Bastard, Isabelle Lihrmann, Perrine Pichon, Christian Thuillez, Pierre-François Plouin, Jérôme Bertherat, Youssef Anouar, Jean-Marc Kuhn, Laurent Yon, Hervé Lefebvr. Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors. Endocrine-related cancer. vol 16. issue 1. 2009-05-11. PMID:18948374. |
metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-ht4) receptors. |
2009-05-11 |
2023-08-12 |
Not clear |
| Andrew Holme. Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18439676. |
serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-ht1a, 5-ht1b, 5-ht2a, 5-ht2c, 5-ht3a, 5-ht4, 5-ht5a, 5-ht6, 5-ht7), reuptake (serotonin transporter), and degradation (monoamine oxidase a). |
2009-02-19 |
2023-08-12 |
mouse |
| Gareth J Sange. 5-hydroxytryptamine and the gastrointestinal tract: where next? Trends in pharmacological sciences. vol 29. issue 9. 2009-01-30. PMID:19086255. |
in this review, i describe the background to 5-ht in gastrointestinal physiology and disease, and the actions of drugs that interact with 5-ht3 and 5-ht4 receptors. |
2009-01-30 |
2023-08-12 |
Not clear |
| Madeleine V King, Charles A Marsden, Kevin C F Fon. A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends in pharmacological sciences. vol 29. issue 9. 2009-01-30. PMID:19086256. |
a role for the 5-ht(1a), 5-ht4 and 5-ht6 receptors in learning and memory. |
2009-01-30 |
2023-08-12 |
mouse |
| Madeleine V King, Charles A Marsden, Kevin C F Fon. A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. Trends in pharmacological sciences. vol 29. issue 9. 2009-01-30. PMID:19086256. |
5-ht(1a), 5-ht4 and 5-ht6 receptors are densely expressed in brain regions innervated by serotonergic projections from the raphe nuclei and are associated with learning and memory. |
2009-01-30 |
2023-08-12 |
mouse |
| Emidio Scarpellini, Jan Tac. Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome. Expert opinion on investigational drugs. vol 17. issue 11. 2009-01-14. PMID:18922103. |
renzapride is a mixed 5-hydroxytryptamine type 4 (5-ht4) agonist and 5-ht3 receptor antagonist that has a stimulatory effect on gastrointestinal motility and transit, as established by in vivo and in vitro studies. |
2009-01-14 |
2023-08-12 |
Not clear |
| J A M Smith, D T Beattie, D Marquess, J P Shaw, R G Vickery, P P A Humphre. The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn-Schmiedeberg's archives of pharmacology. vol 378. issue 1. 2008-12-19. PMID:18415081. |
the high intrinsic activity and preferential binding of td-5108 to 5-ht4 over other 5-ht receptors may result in an improved clinical profile for the treatment of gastrointestinal disorders of reduced motility. |
2008-12-19 |
2023-08-12 |
human |
| Ravinder K Gill, Le Shen, Jerrold R Turner, Seema Saksena, Waddah A Alrefai, Nitika Pant, Ali Esmaili, Alka Dwivedi, Krishnamurthy Ramaswamy, Pradeep K Dudej. Serotonin modifies cytoskeleton and brush-border membrane architecture in human intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 4. 2008-11-26. PMID:18669621. |
5-ht induced basal stress fibers with prominent cortical actin filaments via 5-ht3 and 5-ht4 receptor subtypes. |
2008-11-26 |
2023-08-12 |
human |
| Boris Mlinar, Simona Mascalchi, Raffaella Morini, Filippo Giachi, Renato Corradett. MDMA induces EPSP-Spike potentiation in rat ventral hippocampus in vitro via serotonin and noradrenaline release and coactivation of 5-HT4 and beta1 receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 6. 2008-08-07. PMID:17653110. |
mdma induces epsp-spike potentiation in rat ventral hippocampus in vitro via serotonin and noradrenaline release and coactivation of 5-ht4 and beta1 receptors. |
2008-08-07 |
2023-08-12 |
human |
| S Cellek, R Thangiah, E M Jarvie, S Vivekanandan, O Lalude, G J Sange. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18194150. |
5-hydroxytryptamine (5-ht4) receptor agonists increase gastrointestinal (gi) motility by enhancing enteric acetylcholine release which is then metabolized by acetylcholinesterase (ache) to inactive metabolites. |
2008-08-06 |
2023-08-12 |
human |
| N van Lelyveld, J Ter Linde, M Schipper, M Samso. Serotonergic signalling in the stomach and duodenum of patients with gastroparesis. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18208480. |
neuroendocrine cells, specifically 5-ht producing cells, were counted after immunohistochemistry, and non-neuronal mrna expression levels of tryptophan hydroxylase (tph)-1, 5-ht transport protein (sert), 5-ht3 and 5-ht4 receptor were quantified by real time rt-pcr. |
2008-08-06 |
2023-08-12 |
Not clear |
| Rolf Postin. A closer look at alpha-secretase. Current Alzheimer research. vol 5. issue 2. 2008-05-15. PMID:18393803. |
agonists for m1 muscarinic acetylcholine receptors and serotonin 5-ht4 receptors are currently in clinical trials to test their efficiency in the treatment of ad. |
2008-05-15 |
2023-08-12 |
Not clear |
| b' Philippe Ducrott\\xc3\\xa. [Irritable bowel syndrome: current treatment options]. Presse medicale (Paris, France : 1983). vol 36. issue 11 Pt 2. 2008-02-19. PMID:17490849.' |
among the serotonergic drugs, serotonin 5-ht4 receptors agonists (tegaserod) may be available soon, but the development of 5-ht3 antagonists (alosetron, cilansetron) has been stopped for safety reasons (ischemic colitis and severe constipation). |
2008-02-19 |
2023-08-12 |
Not clear |