| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ioannis Sotiropoulos, Joana Silva, Tetsuya Kimura, Ana Joao Rodrigues, Patricio Costa, Osborne F X Almeida, Nuno Sousa, Akihiko Takashim. Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25159665. |
furthermore, stress elevates levels of caspase-3-truncated tau and insoluble tau aggregates exclusively in the female hippocampus while it also alters the expression of the molecular chaperones hsp90, hsp70, and hsp105, thus favoring accumulation of tau aggregates. |
2015-08-21 |
2023-08-13 |
mouse |
| Ioannis Sotiropoulos, Joana Silva, Tetsuya Kimura, Ana Joao Rodrigues, Patricio Costa, Osborne F X Almeida, Nuno Sousa, Akihiko Takashim. Female hippocampus vulnerability to environmental stress, a precipitating factor in Tau aggregation pathology. Journal of Alzheimer's disease : JAD. vol 43. issue 3. 2015-08-21. PMID:25159665. |
our data point to the exquisite sensitivity of the female hippocampus to stress-triggered tau pathology. |
2015-08-21 |
2023-08-13 |
mouse |
| Sarah M Ciupek, Jingheng Cheng, Yousuf O Ali, Hui-Chen Lu, Daoyun J. Progressive functional impairments of hippocampal neurons in a tauopathy mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019329. |
in rtg4510 mice, a tau-p301l tauopathy model, hippocampal place fields that support spatial memories are abnormal at old age (7-9 months) when tau tangles and neurodegeneration are extensive. |
2015-08-20 |
2023-08-13 |
mouse |
| Sarah M Ciupek, Jingheng Cheng, Yousuf O Ali, Hui-Chen Lu, Daoyun J. Progressive functional impairments of hippocampal neurons in a tauopathy mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 21. 2015-08-20. PMID:26019329. |
however, it is unclear how the abnormality in the hippocampal circuit function arises and progresses with the age-dependent progression of tau pathology. |
2015-08-20 |
2023-08-13 |
mouse |
| R W Paterson, J W Bartlett, K Blennow, N C Fox, L M Shaw, J Q Trojanowski, H Zetterberg, J M Schot. Cerebrospinal fluid markers including trefoil factor 3 are associated with neurodegeneration in amyloid-positive individuals. Translational psychiatry. vol 4. 2015-08-19. PMID:25072324. |
adjusting for tau, baseline volume, p-tau, age, sex and apoe4, 4/83 analytes were significantly independently associated with brain atrophy rate, 1/83 with ventricular expansion and 2/83 with hippocampal atrophy. |
2015-08-19 |
2023-08-13 |
human |
| Nicole Maphis, Guixiang Xu, Olga N Kokiko-Cochran, Shanya Jiang, Astrid Cardona, Richard M Ransohoff, Bruce T Lamb, Kiran Bhaska. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain : a journal of neurology. vol 138. issue Pt 6. 2015-08-07. PMID:25833819. |
second, cd45(+) microglial activation correlates with the spatial memory deficit and spread of tau pathology in the anatomically connected regions of the hippocampus. |
2015-08-07 |
2023-08-13 |
mouse |
| V Melis, C Zabke, K Stamer, M Magbagbeolu, K Schwab, P Marschall, R W Veh, S Bachmann, S Deiana, P-H Moreau, K Davidson, K A Harrington, J E Rickard, D Horsley, R Garman, M Mazurkiewicz, G Niewiadomska, C M Wischik, C R Harrington, G Riedel, F Theurin. Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration. Cellular and molecular life sciences : CMLS. vol 72. issue 11. 2015-07-31. PMID:25523019. |
l66 has abundant tau pathology widely distributed throughout the brain, with particularly high counts of affected neurons in hippocampus and entorhinal cortex. |
2015-07-31 |
2023-08-13 |
mouse |
| Panagiotis Alexopoulos, Laura Kriett, Bernhard Haller, Elisabeth Klupp, Katherine Gray, Timo Grimmer, Nikolaos Laskaris, Stefan Förster, Robert Perneczky, Alexander Kurz, Alexander Drzezga, Andreas Fellgiebel, Igor Yakushe. Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 6. 2015-07-30. PMID:24857233. |
here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (csf) in 585 subjects from all phases of the ad neuroimaging initiative. |
2015-07-30 |
2023-08-13 |
human |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease. vol 73. 2015-07-29. PMID:25220759. |
we show here that intracerebral injections of preformed synthetic tau fibrils into the hippocampus or frontal cortex of young tau transgenic mice expressing mutant human p301l tau induces tau hyperphosphorylation and aggregation around the site of injection, as well as a time-dependent propagation of tau pathology to interconnected brain areas distant from the injection site. |
2015-07-29 |
2023-08-13 |
mouse |
| Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A Kemp, Marc Mercken, Kurt R Brunden, John Q Trojanowski, Ilse Dewachter, Virginia M Y Lee, Diederik Moechar. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of disease. vol 73. 2015-07-29. PMID:25220759. |
furthermore, we show that the tau pathology as a consequence of injection of tau preformed fibrils into the hippocampus induces selective loss of ca1 neurons. |
2015-07-29 |
2023-08-13 |
mouse |
| Lourdes Orejana, Lucía Barros-Miñones, Joaquin Jordan, Angel Cedazo-Minguez, Rosa M Tordera, Norberto Aguirre, Elena Puert. Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 70. issue 6. 2015-07-20. PMID:25063079. |
cognitive impairments and increased levels of hyperphosphorylated tau are found in the hippocampus of samp8 mice along with an increased β-secretase activity and amyloid-β (aβ) depositions that increase in number and extent with age. |
2015-07-20 |
2023-08-13 |
mouse |
| Chang-E Zhang, Xifei Yang, Lingyun Li, Xiaojing Sui, Qing Tian, Wei Wei, Jianzhi Wang, Gongping Li. Hypoxia-induced tau phosphorylation and memory deficit in rats. Neuro-degenerative diseases. vol 14. issue 3. 2015-07-17. PMID:24993525. |
in this study, we demonstrate that rats exposed to a hypoxic condition (10% oxygen concentration) for 1, 2, 4 and 8 weeks (6 h each day) displayed spatial memory impairment and increased tau phosphorylation at ser198/199/202, thr205, ser262, ser396 and ser404 in the hippocampus. |
2015-07-17 |
2023-08-13 |
rat |
| Fehmida Bibi, Muhammad Yasir, Sayed S Sohrab, Esam I Azhar, Mohammed H Al-Qahtani, Adel M Abuzenadah, Mohammad A Kamal, Muhammad I Nasee. Link between chronic bacterial inflammation and Alzheimer disease. CNS & neurological disorders drug targets. vol 13. issue 7. 2015-07-13. PMID:25230225. |
alzheimer's disease (ad) is a degenerative disease of brain that is associated with dementia, brain atrophy, accumulation of hyperphosphorylated tau protein and amyloid-beta peptide in hippocampus and cortex region of the brain. |
2015-07-13 |
2023-08-13 |
Not clear |
| Min Xie, Ruihong Shi, Ying Pan, Tao Zeng, Qicai Chen, Shaohui Wang, Xiaomei Lia. Proteasome inhibition-induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice. Molecular neurobiology. vol 50. issue 3. 2015-07-08. PMID:24752588. |
proteasome inhibition-induced downregulation of akt/gsk-3β pathway contributes to abnormality of tau in hippocampal slice. |
2015-07-08 |
2023-08-13 |
Not clear |
| Min Xie, Ruihong Shi, Ying Pan, Tao Zeng, Qicai Chen, Shaohui Wang, Xiaomei Lia. Proteasome inhibition-induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice. Molecular neurobiology. vol 50. issue 3. 2015-07-08. PMID:24752588. |
in this study, proteasome inhibitor mg132 was used to treat hippocampal slices to explore the role and mechanism of akt/glycogen synthase kinase-3β (gsk-3β) in proteasome inhibition-induced tau abnormality. |
2015-07-08 |
2023-08-13 |
Not clear |
| Min Xie, Ruihong Shi, Ying Pan, Tao Zeng, Qicai Chen, Shaohui Wang, Xiaomei Lia. Proteasome inhibition-induced downregulation of Akt/GSK-3β pathway contributes to abnormality of tau in hippocampal slice. Molecular neurobiology. vol 50. issue 3. 2015-07-08. PMID:24752588. |
this current study establishes a hippocampal slice model targeting akt/gsk-3β signaling pathway to explore the pivotal role of proteasome inhibition in tau pathology. |
2015-07-08 |
2023-08-13 |
Not clear |
| Amina Chaalal, Roseline Poirier, David Blum, Brigitte Gillet, Pascale Le Blanc, Marie Basquin, Luc Buée, Serge Laroche, Valérie Enderli. PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments. Hippocampus. vol 24. issue 11. 2015-07-07. PMID:24978200. |
in the hippocampus, hypothyroidism resulted in tau hyperphosphorylation and increases in several proinflammatory cytokines. |
2015-07-07 |
2023-08-13 |
rat |
| Carmen Laura Sayas, Elena Tortosa, Flavia Bollati, Sacnicte Ramírez-Ríos, Isabelle Arnal, Jesús Avil. Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells. Journal of neurochemistry. vol 133. issue 5. 2015-06-24. PMID:25761518. |
tau and ebs partially colocalize at extending neurites of n1e-115 neuroblastoma cells and axons of primary hippocampal neurons, as shown by confocal immunofluorescence analyses. |
2015-06-24 |
2023-08-13 |
Not clear |
| Matthew J Kan, Jennifer E Lee, Joan G Wilson, Angela L Everhart, Candice M Brown, Andrew N Hoofnagle, Marilyn Jansen, Michael P Vitek, Michael D Gunn, Carol A Colto. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 15. 2015-06-18. PMID:25878270. |
we have previously described the unique cvn-ad mouse model of ad, in which immune-mediated nitric oxide is lowered to mimic human levels, resulting in a mouse model that demonstrates the cardinal features of ad, including amyloid deposition, hyperphosphorylated and aggregated tau, behavioral changes, and age-dependent hippocampal neuronal loss. |
2015-06-18 |
2023-08-13 |
mouse |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology. Journal of neuropathology and experimental neurology. vol 74. issue 4. 2015-06-15. PMID:25756588. |
hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology. |
2015-06-15 |
2023-08-13 |
Not clear |