| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iku Tsutsui-Kimura, Yu Ohmura, Takayuki Yoshida, Mitsuhiro Yoshiok. Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner. Journal of pharmacological sciences. vol 134. issue 3. 2018-01-03. PMID:28694090. |
a milnacipran dose of 10 mg/kg suppressed all behaviors, which was accompanied by increased dopamine and serotonin levels in the medial prefrontal cortex (mpfc) but not in the nucleus accumbens (nac). |
2018-01-03 |
2023-08-13 |
mouse |
| Egemen Kaya, Oguz Gozen, Muzeyyen Ugur, Ersin O Koylu, Lutfiye Kanit, Burcu Balka. Nicotine regulates cocaine-amphetamine-Regulated Transcript (Cart) in the mesocorticolimbic system. Synapse (New York, N.Y.). vol 70. issue 7. 2017-12-22. PMID:26990424. |
cart mrna and peptide levels in medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum (dst), amygdala (amg), lateral hypothalamic area (lha), and ventral tegmental area (vta) were measured by quantitative real-time pcr (qpcr) and western blot analysis, respectively. |
2017-12-22 |
2023-08-13 |
rat |
| Chengji Piao, Xiaofei Deng, Xingyue Wang, Yiran Yuan, Zhengkui Liu, Jing Lian. Altered function in medial prefrontal cortex and nucleus accumbens links to stress-induced behavioral inflexibility. Behavioural brain research. vol 317. 2017-12-05. PMID:27616342. |
the medial prefrontal cortex (mpfc) and its output area, the nucleus accumbens (nac), are implicated in mediating attentional set-shifting. |
2017-12-05 |
2023-08-13 |
rat |
| Giannina Descalzi, Vasiliki Mitsi, Immanuel Purushothaman, Sevasti Gaspari, Kleopatra Avrampou, Yong-Hwee Eddie Loh, Li Shen, Venetia Zachario. Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression. Science signaling. vol 10. issue 471. 2017-11-28. PMID:28325815. |
using two mouse models of neuropathic pain and depression [spared nerve injury (sni) and chronic unpredictable stress (cus)], we performed next-generation rna sequencing and pathway analysis to monitor changes in gene expression in the nucleus accumbens (nac), the medial prefrontal cortex (mpfc), and the periaqueductal gray (pag). |
2017-11-28 |
2023-08-13 |
mouse |
| Karl T Schmidt, Jason P Schroeder, Stephanie L Foster, Katherine Squires, Brilee M Smith, Elizabeth G Pitts, Michael P Epstein, David Weinshenke. Norepinephrine regulates cocaine-primed reinstatement via α1-adrenergic receptors in the medial prefrontal cortex. Neuropharmacology. vol 119. 2017-08-31. PMID:28392265. |
furthermore, administration of the α1ar antagonist terazosin in the medial prefrontal cortex (mpfc), but not the ventral tegmental area (vta) or nucleus accumbens (nac) shell, attenuated cocaine-primed reinstatement. |
2017-08-31 |
2023-08-13 |
rat |
| Lauren N Beloate, Azar Omrani, Roger A Adan, Ian C Webb, Lique M Coole. Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 38. 2017-08-17. PMID:27656032. |
instead, cno prevented sexual experience-induced cross-sensitization of amphetamine cpp, Δfosb in the nac and medial prefrontal cortex, and decreases in vta dopamine soma size. |
2017-08-17 |
2023-08-13 |
rat |
| Julie A D Dela Cruz, Tricia Coke, Richard J Bodna. Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats. Journal of visualized experiments : JoVE. issue 114. 2017-08-14. PMID:27583636. |
thus, sugar intake elicits da release and increases c-fos-like immunoreactivity (fli) from individual vta da projection zones including the nucleus accumbens (nac), amygdala (amy) and medial prefrontal cortex (mpfc) as well as the dorsal striatum. |
2017-08-14 |
2023-08-13 |
rat |
| Jian-Feng Liu, Justin N Siemian, Robert Seaman, Yanan Zhang, Jun-Xu L. Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 4. 2017-08-01. PMID:28123023. |
here, using a local pharmacological activation method, we assessed the role of taar1 within the subregions of the mesocorticolimbic system: that is, the vta, the prelimbic cortex (prl), and infralimbic cortex of medial prefrontal cortex, the core and shell of nac, bla, and cea, on cue- and drug-induced cocaine-seeking in the rat cocaine reinstatement model. |
2017-08-01 |
2023-08-13 |
rat |
| Colby R Keistler, Emma Hammarlund, Jacqueline M Barker, Colin W Bond, Ralph J DiLeone, Christopher Pittenger, Jane R Taylo. Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 17. 2017-07-31. PMID:28336571. |
previous studies have demonstrated that the regulation of cue-guided alcohol seeking is mediated by the basolateral amygdala (bla), nucleus accumbens (nac), and medial prefrontal cortex (mpfc). |
2017-07-31 |
2023-08-13 |
rat |
| Luis Prado, Jorge Luis-Islas, Osvaldo I Sandoval, Liliana Puron, Moreno M Gil, Alvaro Luna, Mario A Arias-García, Elvira Galarraga, Sidney A Simon, Ranier Gutierre. Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 50. 2017-07-24. PMID:27974611. |
activation of glutamatergic fibers in the anterior nac shell modulates reward activity in the anacsh, the lateral hypothalamus, and medial prefrontal cortex and transiently stops feeding. |
2017-07-24 |
2023-08-13 |
mouse |
| Ellen M McGlinchey, Morgan H James, Stephen V Mahler, Caroline Pantazis, Gary Aston-Jone. Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 33. 2017-07-14. PMID:27535915. |
glutamate inputs to nucleus accumbens (nac) facilitate conditioned drug-seeking behavior and primarily originate from medial prefrontal cortex (mpfc), basolateral amygdala (bla), and ventral subiculum of the hippocampus (vsub). |
2017-07-14 |
2023-08-13 |
rat |
| Jennifer M Bossert, Sweta Adhikary, Robyn St Laurent, Nathan J Marchant, Hui-Ling Wang, Marisela Morales, Yavin Shaha. Role of projections from ventral subiculum to nucleus accumbens shell in context-induced reinstatement of heroin seeking in rats. Psychopharmacology. vol 233. issue 10. 2017-02-10. PMID:26344108. |
we previously demonstrated that the projections from ventral medial prefrontal cortex (vmpfc) to nucleus accumbens (nac) shell play a role in this reinstatement. |
2017-02-10 |
2023-08-13 |
rat |
| Sujan C Das, Yusuf S Althobaiti, Fahad S Alshehri, Youssef Sar. Binge ethanol withdrawal: Effects on post-withdrawal ethanol intake, glutamate-glutamine cycle and monoamine tissue content in P rat model. Behavioural brain research. vol 303. 2016-12-13. PMID:26821293. |
in addition, the expression of glt-1, glast and xct were determined in both medial prefrontal cortex (mpfc) and nucleus accumbens (nac). |
2016-12-13 |
2023-08-13 |
rat |
| D-L Jiao, Y Liu, J-D Long, J Du, Y-Y Ju, G-Y Zan, J-G Liu, M Zha. Involvement of dorsal striatal α1-containing GABAA receptors in methamphetamine-associated rewarding memories. Neuroscience. vol 320. 2016-12-13. PMID:26868969. |
in this study, using the rat-conditioned place preference (cpp) model, a classic animal model for the reward-associated effects of addictive drugs, we found that the expression level of gabaa α1 subunits was significantly decreased in the dorsal striatum (dstr) after conditioned methamphetamine (meth) pairing, and no significant differences were observed in the other four rewarding memory-associated areas (medial prefrontal cortex (mpfc), nucleus accumbens (nac), amygdala (amy), and dorsal hippocampus (dh)). |
2016-12-13 |
2023-08-13 |
Not clear |
| K A Kerstetter, A M Wunsch, K G Nakata, E Donckels, J F Neumaier, Susan M Ferguso. Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 4. 2016-11-08. PMID:26289144. |
the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) are both integral components of the corticobasal ganglia-thalamic circuitry that regulates addiction-related behaviors. |
2016-11-08 |
2023-08-13 |
Not clear |
| Yukihiko Shirayama, Chun Yang, Ji-chun Zhang, Qian Ren, Wei Yao, Kenji Hashimot. Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26419294. |
lh rats showed a reduction of bdnf in the medial prefrontal cortex (mpfc), ca3, and dentate gyrus (dg) of the hippocampus, whereas lh rats showed an increase in bdnf in the nucleus accumbens (nac). |
2016-10-05 |
2023-08-13 |
rat |
| Yi Zhang, Xiongzhao Zhu, Can Huang, Xiuwu Zhan. Molecular changes in the medial prefrontal cortex and nucleus accumbens are associated with blocking the behavioral sensitization to cocaine. Scientific reports. vol 5. 2016-09-23. PMID:26538265. |
previous studies have demonstrated that cocaine-induced behavioral sensitization is associated with persistent functional and structural alterations in the medial prefrontal cortex (mpfc) and nucleus accumbens (nac); however, the molecular mechanisms underlying these changes have not been elucidated. |
2016-09-23 |
2023-08-13 |
rat |
| Achikam Haim, Christopher Albin-Brooks, Morgan Sherer, Emily Mills, Benedetta Leune. The effects of gestational stress and Selective Serotonin reuptake inhibitor antidepressant treatment on structural plasticity in the postpartum brain--A translational model for postpartum depression. Hormones and behavior. vol 77. 2016-09-15. PMID:25997412. |
moreover, the effect of gestational stress on postpartum mood is accompanied by structural modifications within the nucleus accumbens (nac) and the medial prefrontal cortex (mpfc)-limbic regions that have been linked to ppd. |
2016-09-15 |
2023-08-13 |
rat |
| M A De Luca, Z Bimpisidis, M Melis, M Marti, P Caboni, V Valentini, G Margiani, N Pintori, I Polis, G Marsicano, L H Parsons, G Di Chiar. Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid. Neuropharmacology. vol 99. 2016-08-30. PMID:26327678. |
in order to investigate the neurobiological substrates of jwh-018 actions, we studied by microdialysis in freely moving rats the effect of jwh-018 on extracellular dopamine (da) levels in the nucleus accumbens (nac) shell and core and in the medial prefrontal cortex (mpfc). |
2016-08-30 |
2023-08-13 |
mouse |
| Nathan J Marchant, Erin J Campbell, Leslie R Whitaker, Brandon K Harvey, Konstantin Kaganovsky, Sweta Adhikary, Bruce T Hope, Robert C Heins, Thomas E Prisinzano, Eyal Vardy, Antonello Bonci, Jennifer M Bossert, Yavin Shaha. Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 11. 2016-07-26. PMID:26985037. |
here, we studied the role of projections to nucleus accumbens (nac) shell from ventral subiculum (vsub), basolateral amygdala, paraventricular thalamus, and ventral medial prefrontal cortex in context-induced relapse after punishment-imposed abstinence. |
2016-07-26 |
2023-08-13 |
human |