All Relations between (2R)-amino-5-phosphonovaleric acid (AP5) and hippocampus

Publication Sentence Publish Date Extraction Date Species
Wendy K Adams, Adam L Halberstadt, Maarten van den Buus. Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses. Frontiers in pharmacology. vol 4. 2013-09-06. PMID:24009584. dorsal hippocampus lesions potentiated pcp-induced hyperlocomotion (0.5, 2.5 mg/kg), but not the effect of mk-801 (0.1 mg/kg). 2013-09-06 2023-08-12 rat
Wendy K Adams, Adam L Halberstadt, Maarten van den Buus. Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses. Frontiers in pharmacology. vol 4. 2013-09-06. PMID:24009584. given that pcp and mk-801 may induce different spatiotemporal patterns of locomotor behavior, together with the known role of the dorsal hippocampus in spatial processing, we also assessed whether the 5,7-dht-lesions caused any qualitative differences in locomotor responses. 2013-09-06 2023-08-12 rat
Wendy K Adams, Adam L Halberstadt, Maarten van den Buus. Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses. Frontiers in pharmacology. vol 4. 2013-09-06. PMID:24009584. taken together, serotonergic lesions targeting the dorsal hippocampus unmask a functional differentiation of the hyperlocomotor effects of pcp and mk-801. 2013-09-06 2023-08-12 rat
Jingyi Ma, Siew Kian Tai, L Stan Leun. Septohippocampal GABAergic neurons mediate the altered behaviors induced by n-methyl-D-aspartate receptor antagonists. Hippocampus. vol 22. issue 12. 2013-06-27. PMID:22592894. in sham-lesion rats, mk-801 induced an increase in locomotion and an impairment of prepulse inhibition (ppi), and ketamine (3 mg/kg s.c.) induced a loss of gating of hippocampal auditory evoked potentials. 2013-06-27 2023-08-12 rat
Jingyi Ma, Siew Kian Tai, L Stan Leun. Septohippocampal GABAergic neurons mediate the altered behaviors induced by n-methyl-D-aspartate receptor antagonists. Hippocampus. vol 22. issue 12. 2013-06-27. PMID:22592894. it is concluded that septohippocampal gabaergic neurons are important for the expression of hyperactive and psychotic symptoms an enhanced hippocampal gamma activity induced by ketamine and mk-801, and for generating an atropine-resistant theta. 2013-06-27 2023-08-12 rat
Takashi Uehara, Tomiki Sumiyoshi, Tomonori Seo, Tadasu Matsuoka, Hiroko Itoh, Masayoshi Kurach. T-817MA, but Not Haloperidol and Risperidone, Restores Parvalbumin-Positive γ -Aminobutyric Acid Neurons in the Prefrontal Cortex and Hippocampus of Rats Transiently Exposed to MK-801 at the Neonatal Period. ISRN psychiatry. vol 2012. 2013-06-06. PMID:23738215. t-817ma, but not haloperidol and risperidone, restores parvalbumin-positive γ -aminobutyric acid neurons in the prefrontal cortex and hippocampus of rats transiently exposed to mk-801 at the neonatal period. 2013-06-06 2023-08-12 rat
Takashi Uehara, Tomiki Sumiyoshi, Tomonori Seo, Tadasu Matsuoka, Hiroko Itoh, Masayoshi Kurach. T-817MA, but Not Haloperidol and Risperidone, Restores Parvalbumin-Positive γ -Aminobutyric Acid Neurons in the Prefrontal Cortex and Hippocampus of Rats Transiently Exposed to MK-801 at the Neonatal Period. ISRN psychiatry. vol 2012. 2013-06-06. PMID:23738215. rats were treated with mk-801 (0.2 mg/kg/day) or vehicle on postnatal days (pd) 7-10, and the number of pv-positive neurons in the mpfc and hippocampus were measured on pds 63. 2013-06-06 2023-08-12 rat
Michael L Berger, Thomas Pöhler, Oliver Schadt, Maximilian Stanger, Patrick Rebernik, Petra Scholze, Christian R No. Exploring the polyamine regulatory site of the NMDA receptor: a parallel synthesis approach. ChemMedChem. vol 8. issue 1. 2013-05-28. PMID:23225329. the obtained compounds were tested as modulators of [(3) h]mk-801 binding to rat brain membranes and of nmda-induced currents in cultured rat hippocampal neurons. 2013-05-28 2023-08-12 rat
Jaesoon Joo, Soojeong Lee, Seong-Su Nah, Young Ock Kim, Duk-Soo Kim, Se-Hoon Shim, Young Hwangbo, Hyung-Kee Kim, Jun-Tack Kwon, Jong Woo Kim, Ho-Yeon Song, Hak-Jae Ki. Lasp1 is down-regulated in NMDA receptor antagonist-treated mice and implicated in human schizophrenia susceptibility. Journal of psychiatric research. vol 47. issue 1. 2013-05-06. PMID:23040864. in the present study, we compared protein expression levels in the hippocampus of mice treated with mk-801 (0.6 mg/kg) or saline once daily for 7 days. 2013-05-06 2023-08-12 mouse
E M Anderson, A Y Del Valle-Pinero, S K Suckow, T A Nolan, J K Neubert, R M Caudl. Morphine and MK-801 administration leads to alternative N-methyl-D-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay. Neuroscience. vol 214. 2013-04-29. PMID:22531378. when combined, mk-801 and morphine had an additive effect which led to altered splicing in the accumbens, amy, and the hipp. 2013-04-29 2023-08-12 rat
Daniel R Thomases, Daryn K Cass, Kuei Y Tsen. Periadolescent exposure to the NMDA receptor antagonist MK-801 impairs the functional maturation of local GABAergic circuits in the adult prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 1. 2013-03-12. PMID:23283319. in vivo electrophysiological analyses revealed that mk-801 administration during periadolescence elicits an enduring disinhibited prefrontal local field potential (lfp) response to ventral hippocampal stimulation at 20 hz (beta) and 40 hz (gamma) in adulthood (p65-p85). 2013-03-12 2023-08-12 rat
Hui Jiang, Shunlian Tian, Yan Zeng, Jing Sh. Nerve growth factor inhibits Gd(3+)-sensitive calcium influx and reduces chemical anoxic neuronal death. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 28. issue 4. 2013-02-11. PMID:18704295. when combination of 20 micromol/l mk-801 (glutamate receptor antagonist), 40 micromol/l cnqx (ampa receptor antagonist) and 5 micromol/l nimodipine (voltage-gated calcium channel antagonist) (hereafter denoted as mcn) were administrated to hippocampal cultures, levels of [ca(2+)](i) and cell death rate induced by kcn were partially reduced by 35.9% and 47.5% respectively. 2013-02-11 2023-08-12 rat
H Ozdemir, A Ertugrul, K Basar, E Sak. Differential effects of antipsychotics on hippocampal presynaptic protein expressions and recognition memory in a schizophrenia model in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22640753. mk-801 did not change snap-25 and synaptophysin expressions in the hippocampus and frontal cortex. 2013-01-21 2023-08-12 mouse
Ling-yun Liu, Qing-jun Li, Yu-yan Hu, Xin-hua Guo, Sai-chun Chu, Wen-bin L. [Intrathecal injection of MK-801 inhibited the NOS activity and NO content of hippocampus in rat during the process of formalin-induced inflammatory pain]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 25. issue 3. 2013-01-10. PMID:21155253. [intrathecal injection of mk-801 inhibited the nos activity and no content of hippocampus in rat during the process of formalin-induced inflammatory pain]. 2013-01-10 2023-08-12 rat
Ling-yun Liu, Qing-jun Li, Yu-yan Hu, Xin-hua Guo, Sai-chun Chu, Wen-bin L. [Intrathecal injection of MK-801 inhibited the NOS activity and NO content of hippocampus in rat during the process of formalin-induced inflammatory pain]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 25. issue 3. 2013-01-10. PMID:21155253. to study the effect of intrathecal injection of mk-801, a nmda receptor antagonist, on the nos activity and no content of hippocampus in rat during the process of formalin-induced inflammatory pain as well as the pain behavior of rat. 2013-01-10 2023-08-12 rat
Leonardo Magno Rambo, Leandro Rodrigo Ribeiro, Vanessa Grigoletto Schramm, Andriely Moreira Berch, Daniel Neis Stamm, Iuri Domingues Della-Pace, Luiz Fernando Almeida Silva, Ana Flávia Furian, Mauro Schneider Oliveira, Michele Rechia Fighera, Luiz Fernando Freire Roye. Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway. Brain research bulletin. vol 88. issue 6. 2012-11-23. PMID:22742935. the incubation of hippocampal slices with n-methyl-d-aspartate (nmda; mk-801, 10 μm) and nmda receptor 2b (nr2b; ifenprodil, 3 μm) antagonists but not with the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampa)/kainate antagonist (dnqx, 10 μm) and nitric oxide synthase inhibitor (nos; l-name, 100 μm), blunted the effect of creatine on na(+),k(+)-atpase activity. 2012-11-23 2023-08-12 rat
Andrea J Hickey, James N Reynolds, Richard J Beninge. Post-weaning social isolation and subchronic NMDA glutamate receptor blockade: effects on locomotor activity and GABA signaling in the rat suggest independent mechanisms. Pharmacology, biochemistry, and behavior. vol 101. issue 2. 2012-09-24. PMID:22293110. si resulted in increased locomotor activity, gat-1 activity in frontal cortex and hippocampus and gaba(a) receptor expression in the frontal cortex; mk-801 increased gaba(a) receptor expression in the hippocampus. 2012-09-24 2023-08-12 rat
Maren Klug, Rachel A Hill, Kwok Ho Christopher Choy, Michael Kyrios, Anthony J Hannan, Maarten van den Buus. Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice. Neurobiology of disease. vol 46. issue 3. 2012-09-14. PMID:22426399. the nmda receptor effects in hippocampal sub-regions could be related to the spatial memory deficits and the loss of the effect of mk-801 on startle in these mice, respectively. 2012-09-14 2023-08-12 mouse
María Eugenia Bertotto, Noelia Martina Maldonado, Elena Anahi Bignante, Silvana Vanesa Gorosito, María Julia Cambiasso, Víctor Alejandro Molina, Irene Delia Martijen. ERK activation in the amygdala and hippocampus induced by fear conditioning in ethanol withdrawn rats: modulation by MK-801. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 12. 2012-08-20. PMID:21315561. erk activation in the amygdala and hippocampus induced by fear conditioning in ethanol withdrawn rats: modulation by mk-801. 2012-08-20 2023-08-12 rat
María Eugenia Bertotto, Noelia Martina Maldonado, Elena Anahi Bignante, Silvana Vanesa Gorosito, María Julia Cambiasso, Víctor Alejandro Molina, Irene Delia Martijen. ERK activation in the amygdala and hippocampus induced by fear conditioning in ethanol withdrawn rats: modulation by MK-801. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 12. 2012-08-20. PMID:21315561. in order to explore the neural substrates and the potential mechanism involved in this effect, we examined: 1) the erk1/2 activation in the central (cea) and basolateral (bla) nuclei of the amygdala and in the dorsal hippocampus (dhip), 2) the effect of the nmda receptor antagonist mk-801 on fear conditioning and erk activation and 3) the effect of the infusion of u0126, a mek inhibitor, into the bla on fear memory formation in ethanol withdrawn rats. 2012-08-20 2023-08-12 rat