| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V A Mikhailenko, I P Butkevic. The Role of 5-HT1A Receptors in Long-Term Adaptation of Newborn Rats to Hypoxia. Bulletin of experimental biology and medicine. vol 161. issue 4. 2017-03-08. PMID:27591870. |
the protective effect of buspirone can result from strengthening of the adaptive potencies of the serotoninergic system via activation of 5-ht1a receptors that up-regulate secretion of trophic factor s100β under conditions of serotonin deficiency typical of rats exposed to neonatal hypoxia. |
2017-03-08 |
2023-08-13 |
rat |
| Zeyad T Sahli, Pradeep Banerjee, Frank I Taraz. The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder. Expert opinion on drug discovery. vol 11. issue 5. 2016-12-30. PMID:26971593. |
augmentation of the leading class of antidepressant treatment, selective serotonin reuptake inhibitors (ssris), with the 5-ht1a receptor agonist buspirone has been shown to be effective in treating patients that do not respond to initial ssri therapy. |
2016-12-30 |
2023-08-13 |
Not clear |
| Masakuni Horiguchi, Masanori Miyauchi, Nichole M Neugebauer, Yoshihiro Oyamada, Herbert Y Meltze. Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism. Behavioural brain research. vol 301. 2016-10-20. PMID:26342283. |
we examined the ability of post-pcp subchronic lurasidone, an atypical apd with potent serotonin (5-ht)1a partial agonism and subchronic tandospirone, a selective 5-ht1a partial agonist, to enable prolonged reversal of the subchronic pcp-induced nor deficit. |
2016-10-20 |
2023-08-13 |
rat |
| D Bakish, R Habib, C L Hoope. Mixed Anxiety and Depression : Diagnosis and Treatment Options. CNS drugs. vol 9. issue 4. 2016-08-17. PMID:27521010. |
of particular importance in the treatment of patients with anxiety and depressive symptoms are the selective serotonin (5-hydroxytryptamine; 5-ht) reuptake inhibitors, nefazodone and the azapirones (including buspirone). |
2016-08-17 |
2023-08-13 |
Not clear |
| Diane C Chugani, Harry T Chugani, Max Wiznitzer, Sumit Parikh, Patricia A Evans, Robin L Hansen, Ruth Nass, James J Janisse, Pamela Dixon-Thomas, Michael Behen, Robert Rothermel, Jacqueline S Parker, Ajay Kumar, Otto Muzik, David J Edwards, Deborah Hirt. Efficacy of Low-Dose Buspirone for Restricted and Repetitive Behavior in Young Children with Autism Spectrum Disorder: A Randomized Trial. The Journal of pediatrics. vol 170. 2016-07-26. PMID:26746121. |
to determine safety and efficacy of the 5ht1a serotonin partial agonist buspirone on core autism and associated features in children with autism spectrum disorder (asd). |
2016-07-26 |
2023-08-13 |
Not clear |
| D Piskulic, J Olver, P Maruff, T Norma. Assessment of serotonin function, memory and spatial working memory using buspirone and placebo. Acta neuropsychiatrica. vol 18. issue 6. 2016-07-12. PMID:27397319. |
assessment of serotonin function, memory and spatial working memory using buspirone and placebo. |
2016-07-12 |
2023-08-13 |
Not clear |
| A Sagarduy, J Llorente, C Miguelez, T Morera-Herreras, J A Ruiz-Ortega, L Uged. Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors. Experimental neurology. vol 277. 2016-06-27. PMID:26687972. |
cell-attached recordings in parasagittal slices from naïve rats showed that whilst serotonin excited the majority of stn neurons, buspirone showed an inhibitory main effect but only in 27% of the studied cells which was prevented by the 5-ht1a receptor selective antagonist way-100635. |
2016-06-27 |
2023-08-13 |
rat |
| Ken-Ichi Kasahara, Shinji Hashimoto, Tsuyoshi Hattori, Koh Kawasaki, Ryuichi Tsujita, Osamu Nakazono, Katsuyuki Takao, Hiromu Kawakubo, Tadashi Nagatan. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. Journal of pharmacological sciences. vol 127. issue 1. 2016-04-25. PMID:25704026. |
ap521 showed equal or more potent anxiolytic-like effects compared with diazepam, a benzodiazepine receptor agonist, or tandospirone, a partial 5-hydroxytryptamine (5-ht)1a receptor agonist, in three rat anxiety models; the vogel-type conflict test, elevated plus maze test, and conditioned fear stress test. |
2016-04-25 |
2023-08-13 |
human |
| Ken-Ichi Kasahara, Shinji Hashimoto, Tsuyoshi Hattori, Koh Kawasaki, Ryuichi Tsujita, Osamu Nakazono, Katsuyuki Takao, Hiromu Kawakubo, Tadashi Nagatan. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. Journal of pharmacological sciences. vol 127. issue 1. 2016-04-25. PMID:25704026. |
tandospirone, which can stimulate the presynaptic 5-ht1a receptors in the raphe, tended to decrease extracellular 5-ht concentration in the medial prefrontal cortex (mpfc) in rats. |
2016-04-25 |
2023-08-13 |
human |
| Ryuki Tsutsui, Kazuaki Shinomiya, Toshiaki Sendo, Yoshihisa Kitamura, Chiaki Kame. Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats. Biological & pharmaceutical bulletin. vol 38. issue 6. 2016-02-21. PMID:26027828. |
effects of the 5-ht(1a) receptor agonist tandospirone on acth-induced sleep disturbance in rats. |
2016-02-21 |
2023-08-13 |
rat |
| Ryuki Tsutsui, Kazuaki Shinomiya, Toshiaki Sendo, Yoshihisa Kitamura, Chiaki Kame. Effects of the 5-HT(1A) Receptor Agonist Tandospirone on ACTH-Induced Sleep Disturbance in Rats. Biological & pharmaceutical bulletin. vol 38. issue 6. 2016-02-21. PMID:26027828. |
the aim of this study was to compare the effect of the serotonin (5-ht)1a receptor agonist tandospirone versus that of the benzodiazepine hypnotic flunitrazepam in a rat model of long-term adrenocorticotropic hormone (acth)-induced sleep disturbance. |
2016-02-21 |
2023-08-13 |
rat |
| Elisabetta Tronci, Camino Fidalgo, Manolo Cart. Foetal Cell Transplantation for Parkinson's Disease: Focus on Graft-Induced Dyskinesia. Parkinson's disease. vol 2015. 2016-02-16. PMID:26881178. |
in agreement, clinical investigations have shown that grafted tissue may contain a large number of serotonin neurons, in the order of half of the da cells; moreover, the serotonin 5-ht1a receptor agonist buspirone has been found to produce significant dampening of gid in grafted patients. |
2016-02-16 |
2023-08-13 |
Not clear |
| Satoko Baba, Takeshi Murai, Tomokazu Nakako, Takeshi Enomoto, Michiko Ono, Isao Shimizu, Kazuhito Iked. The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets. Behavioural brain research. vol 287. 2016-01-19. PMID:25804359. |
the serotonin 5-ht₁a receptor agonist tandospirone improves executive function in common marmosets. |
2016-01-19 |
2023-08-13 |
Not clear |
| Satoko Baba, Takeshi Murai, Tomokazu Nakako, Takeshi Enomoto, Michiko Ono, Isao Shimizu, Kazuhito Iked. The serotonin 5-HT₁A receptor agonist tandospirone improves executive function in common marmosets. Behavioural brain research. vol 287. 2016-01-19. PMID:25804359. |
previous pilot clinical studies have shown that the serotonin 5-ht1a receptor agonist tandospirone has beneficial effect on cognitive deficits associated with schizophrenia. |
2016-01-19 |
2023-08-13 |
Not clear |
| Fosco Bernasconi, Michael Kometer, Thomas Pokorny, Erich Seifritz, Franz X Vollenweide. The electrophysiological effects of the serotonin 1A receptor agonist buspirone in emotional face processing. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25637265. |
the electrophysiological effects of the serotonin 1a receptor agonist buspirone in emotional face processing. |
2016-01-11 |
2023-08-13 |
Not clear |
| Paul W Czoty, Michael A Nade. Effects of oral and intravenous administration of buspirone on food-cocaine choice in socially housed male cynomolgus monkeys. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 5. 2015-12-31. PMID:25393717. |
moreover, it is noteworthy that the effects of buspirone were similar to those of the d3 receptor-selective antagonist pg01037 and qualitatively different than those of less selective drugs that act at d2-like or serotonin (5-ht)1a receptors, suggesting a d3 and possibly d4 receptor mechanism of action for buspirone. |
2015-12-31 |
2023-08-13 |
monkey |
| Nausheen Alam, Rahila Najam, Saira Saeed Kha. Attenuation of methylphenidate-induced tolerance on cognition by buspirone co-administration. Pakistan journal of pharmaceutical sciences. vol 28. issue 5. 2015-12-15. PMID:26408868. |
it is suggested that buspirone may oppose methylphenidate-induced cognitive tolerance by reducing the sensitivity of 5-ht 1a soma to dendritic receptors. |
2015-12-15 |
2023-08-13 |
rat |
| Yoshihiro Oyamada, Masakuni Horiguchi, Lakshmi Rajagopal, Masanori Miyauchi, Herbert Y Meltze. Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats. Behavioural brain research. vol 285. 2015-12-14. PMID:25448429. |
to further clarify the importance of these actions to the restoration of nor by atypical apds, sub-effective or non-effective doses of combinations of the 5-ht(1a) partial agonist (tandospirone), the 5-ht(2a) inverse agonist (pimavanserin), or the d2 antagonist (haloperidol), as well as the combination of all three agents, were studied in the acute reversal and prevention pcp models of cis. |
2015-12-14 |
2023-08-13 |
rat |
| Y H Youn, E J Choi, Y H Lee, T Oshima, H Miwa, H Par. The effects of 5-hydroxytryptamine1a receptor agonist, buspirone on the gastric fundus accommodation in an animal model using guinea pigs. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 27. issue 4. 2015-12-08. PMID:25677141. |
the aim of this study is to examine the effects and mechanisms of buspirone, 5-ht(1a) receptor agonist, in the accommodation of gastric fundus muscle in an animal experimental model using guinea pigs. |
2015-12-08 |
2023-08-13 |
Not clear |
| Eszter Kirilly, Xénia Gonda, György Bagd. [Antidepressants, stressors and the serotonin 1A receptor]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 17. issue 2. 2015-12-04. PMID:26192901. |
buspirone, an anxiolytic drug with a then yet unidentified mechanism of action had been marketed for years when it was discovered that it is a 5-ht(1a) partial agonist. |
2015-12-04 |
2023-08-13 |
human |