| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Di Stefano, A Papathanasopoulos, K Blondeau, R Vos, V Boecxstaens, R Farré, N Rommel, J Tac. Effect of buspirone, a 5-HT1A receptor agonist, on esophageal motility in healthy volunteers. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 25. issue 5. 2012-12-05. PMID:22050410. |
buspirone, an orally available 5-ht(1a) receptor agonist, was shown to modulate gastroduodenal motor function. |
2012-12-05 |
2023-08-12 |
human |
| Eunju Shin, Joanna Garcia, Christian Winkler, Anders Björklund, Manolo Cart. Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22579773. |
although the mechanism underlying the appearance of gid is unknown, in a recent clinical study the partial 5-ht(1a) agonist buspirone was found to markedly reduce gid in three grafted patients, who showed significant serotonin (5-ht) hyperinnervation in the grafted striatum in positron emission tomography scanning (politis et al., 2010, 2011). |
2012-11-29 |
2023-08-12 |
rat |
| Eunju Shin, Joanna Garcia, Christian Winkler, Anders Björklund, Manolo Cart. Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22579773. |
by contrast, removal of the host 5-ht innervation or pre-treatment with a 5-ht(1a) antagonist did not abolish the anti-gid effect of buspirone, showing that its effect is independent from activation of either pre- or post-synaptic 5-ht(1a) receptors. |
2012-11-29 |
2023-08-12 |
rat |
| M W Moore, S Chai, C B Gillombardo, A Carlo, L M Donovan, N Netzer, K P Stroh. Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL/6J mouse strain. Respiratory physiology & neurobiology. vol 183. issue 1. 2012-11-13. PMID:22595368. |
on day 17, 4 mice in each group were tested after buspirone and the 5-ht(1a) receptor antagonist, 4-iodo-n-{2-[4-(methoxyphenyl)-1-piperazinyl] ethyl}-n-2-pyridinyl-benzamide (p-mppi, 5 mg/kg). |
2012-11-13 |
2023-08-12 |
mouse |
| M W Moore, S Chai, C B Gillombardo, A Carlo, L M Donovan, N Netzer, K P Stroh. Two weeks of buspirone protects against posthypoxic ventilatory pauses in the C57BL/6J mouse strain. Respiratory physiology & neurobiology. vol 183. issue 1. 2012-11-13. PMID:22595368. |
in conclusion, buspirone administration after 2 weeks acts through the 5-ht(1a) receptor to reduce post-hypoxic ventilatory instability in the b6 strain. |
2012-11-13 |
2023-08-12 |
mouse |
| S K Ojha, M Nandave, C Sharm. Effect of buspirone: An anxiolytic drug on blood glucose in humans. Indian journal of clinical biochemistry : IJCB. vol 21. issue 2. 2012-10-30. PMID:23105615. |
the present study investigated the effect of an antianxiety drug, buspirone on blood glucose and plasma insulin level concerning the role of 5-ht(1a) receptors in blood glucose regulation in healthy humans. |
2012-10-30 |
2023-08-12 |
human |
| P H Silverstone, M D Lalies, A L Hudso. Quetiapine and Buspirone Both Elevate Cortical Levels of Noradrenaline and Dopamine In vivo, but Do Not have Synergistic Effects. Frontiers in psychiatry. vol 3. 2012-10-11. PMID:23049514. |
clinical studies have been mixed but there have been no studies specifically examining the effects of combining the atypical antipsychotic quetiapine with the 5ht(1a) receptor partial agonist, buspirone on monoamine release. |
2012-10-11 |
2023-08-12 |
rat |
| P H Silverstone, M D Lalies, A L Hudso. Quetiapine and Buspirone Both Elevate Cortical Levels of Noradrenaline and Dopamine In vivo, but Do Not have Synergistic Effects. Frontiers in psychiatry. vol 3. 2012-10-11. PMID:23049514. |
one possible explanation for these negative findings could be that the intrinsic 5ht(1a) agonist activity of quetiapine on its own is of such significance that it is not further enhanced by buspirone. |
2012-10-11 |
2023-08-12 |
rat |
| J E Barrett, S Gleeson, M A Nader, S M Hoffman. Anticonflict effects of the 5-HT1A compound flesinoxan. Journal of psychopharmacology (Oxford, England). vol 3. issue 2. 2012-10-02. PMID:22156500. |
in a second study flesinoxan substituted for the 5-ht(1a) anxiolytic buspirone under a drug discrimination procedure, providing further evidence that the behavioural effects offlesinoxan are mediated by 5-ht(1a) mechanisms. |
2012-10-02 |
2023-08-12 |
Not clear |
| C T Dourish, G A Kennett, G Curzo. The 5-HT1A agonists 8-OH-DPAT, buspirone and ipsapirone attenuate stress-induced anorexia in rats. Journal of psychopharmacology (Oxford, England). vol 1. issue 1. 2012-10-02. PMID:22158750. |
the selective 5-ht(1a) agonists 8-hydroxy-2-(di- n-propylamino)tetralin (8-oh-dpat), buspirone and ipsapirone, when injected 2 h after the termination of stress, attenuated stress-induced anor exia and body weight loss. |
2012-10-02 |
2023-08-12 |
rat |
| C T Dourish, G A Kennett, G Curzo. The 5-HT1A agonists 8-OH-DPAT, buspirone and ipsapirone attenuate stress-induced anorexia in rats. Journal of psychopharmacology (Oxford, England). vol 1. issue 1. 2012-10-02. PMID:22158750. |
the data suggest that 8-oh-dpat, buspirone and ipsapirone attenuate stress-induced anorexia in rodents by a hyperphagic action on 5-ht(1a) receptors. |
2012-10-02 |
2023-08-12 |
rat |
| R J Rauch, I P Stolerma. Midazolam cue in rats: effects of drugs acting on GABA and 5-hydroxytryptamine systems, anticonvulsants and sedatives. Journal of psychopharmacology (Oxford, England). vol 1. issue 2. 2012-10-02. PMID:22158887. |
there was no generalization to the gaba agonists muscimol and thip, to the 5-ht antagonists cyproheptadine and methergoline, to buspirone, cgs 9896, ethanol, ro 5-4864, promethazine, phenytoin sodium or sodium valproate. |
2012-10-02 |
2023-08-12 |
rat |
| S Ahlenius, K Larsso. Effects of the putative 5-HT agonist 5-OH-DPAC on male rat sexual behaviour: a comparison with effects produced by 8-OH-DPAT and buspirone. Journal of psychopharmacology (Oxford, England). vol 2. issue 1. 2012-10-02. PMID:22159669. |
effects of the putative 5-ht agonist 5-oh-dpac on male rat sexual behaviour: a comparison with effects produced by 8-oh-dpat and buspirone. |
2012-10-02 |
2023-08-12 |
rat |
| C Pantelis, T R Barne. Acute exacerbation of psychosis with buspirone? Journal of psychopharmacology (Oxford, England). vol 7. issue 3. 2012-10-02. PMID:22290846. |
the other case studies of psychosis due to buspirone are reviewed and possible mechanisms for this association are discussed, particularly the role of dopamine and serotonin. |
2012-10-02 |
2023-08-12 |
Not clear |
| E M Goodall, M Whittle, J Cookson, P J Cowen, T Silverston. Menstrual cycle effects on the action of buspirone on food intake in healthy female volunteers. Journal of psychopharmacology (Oxford, England). vol 9. issue 4. 2012-10-02. PMID:22298394. |
we studied the effect of single doses of the 5-ht(1a) agonist buspirone (10 mg and 20 mg) on food intake during the menstrual cycle of nine healthy women, none of whom were on a contraceptive pill. |
2012-10-02 |
2023-08-12 |
human |
| P A Barba-Escobedo, G G Goul. Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects. Genes, brain, and behavior. vol 11. issue 3. 2012-09-10. PMID:22288820. |
we examined the effects of the cannabinoid receptor agonist win 55,212-2 (1 mg/l), or serotonin 5-ht(1a) receptor agonist buspirone (10 mg/l) on petco short-fin social choice. |
2012-09-10 |
2023-08-12 |
mouse |
| A Mohajjel Nayebi A, H Sheidae. Buspirone improves haloperidol-induced Parkinson disease in mice through 5-HT(1A) recaptors. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 18. issue 1. 2012-08-23. PMID:22615592. |
buspirone improves haloperidol-induced parkinson disease in mice through 5-ht(1a) recaptors. |
2012-08-23 |
2023-08-12 |
mouse |
| A Mohajjel Nayebi A, H Sheidae. Buspirone improves haloperidol-induced Parkinson disease in mice through 5-HT(1A) recaptors. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 18. issue 1. 2012-08-23. PMID:22615592. |
this study aimed to investigate effect of buspirone, a partial agonist of 5ht(1a) receptor, on motor dysfunctions induced by haloperidol and involvement of 5ht(1a) receptors in this regard. |
2012-08-23 |
2023-08-12 |
mouse |
| Eunju Shin, Elisabetta Tronci, Manolo Cart. Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22762012. |
interestingly, the 5-ht(1a) receptor agonist buspirone has been shown to suppress gid in these patients, suggesting that serotonin neurons might be involved in the etiology of gid as for lid. |
2012-08-23 |
2023-08-12 |
rat |
| M Horiguchi, H Y Meltze. The role of 5-HT1A receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats. Psychopharmacology. vol 221. issue 2. 2012-08-15. PMID:22227609. |
atypical antipsychotic drugs (apds), many of which are direct or indirect serotonin (5-ht)(1a) agonists, and tandospirone, a 5-ht(1a) partial agonist, have been reported to improve cognition in schizophrenia. |
2012-08-15 |
2023-08-12 |
rat |