| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Cappelli, Monica Manini, Salvatore Valenti, Federica Castriconi, Germano Giuliani, Maurizio Anzini, Simone Brogi, Stefania Butini, Sandra Gemma, Giuseppe Campiani, Gianluca Giorgi, Laura Mennuni, Marco Lanza, Antonio Giordani, Gianfranco Caselli, Ornella Letari, Francesco Makove. Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. European journal of medicinal chemistry. vol 63. 2013-11-27. PMID:23466604. |
a new class of serotonin 5-ht1a receptor ligands related to nan-190, buspirone and aripiprazole has been designed using our potent 5-ht3 receptor ligands as templates. |
2013-11-27 |
2023-08-12 |
Not clear |
| Siamak Eyhani-Rad, Alireza Mohajjel Nayebi, Javad Mahmoudi, Morteza Samini, Vahab Babapou. Role of 5-Hydroxytryptamine 1A Receptors in 6-Hydroxydopmaine-induced Catalepsy-like Immobilization in Rats: a Therapeutic Approach for Treating Catalepsy of Parkinson's Disease. Iranian journal of pharmaceutical research : IJPR. vol 11. issue 4. 2013-11-19. PMID:24250551. |
we have shown that buspirone, a partial agonist of 5-hydroxytryptamine 1a (5-ht1a) receptors, improves motor dysfunctions induced by 6-hydroxydopamine (6-ohda) and haloperidol in rats. |
2013-11-19 |
2023-08-12 |
rat |
| Stephen M Stahl, Clara Lee-Zimmerman, Sylvia Cartwright, Debbi Ann Morrissett. Serotonergic drugs for depression and beyond. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23531115. |
the original trend to do this selectively (e.g., with ssris or selective serotonin reuptake inhibitors) has given way to combining various additional pharmacologic mechanisms with sert inhibition, including dual actions by single drugs (e.g., snris or serotonin norepinephrine reuptake inhibitors), or by augmenting ssris with a second drug of a different mechanism (e.g., bupropion with dopamine and norepinephrine reuptake inhibition; trazodone with 5ht2a antagonism; mirtazapine with 5ht2a/5ht2c/5ht3/alpha2 antagonism; buspirone or some atypical antipsychotics with 5ht1a partial agonism; other atypical antipsychotics with 5ht2c/5ht7 antagonism and other mechanisms). |
2013-10-29 |
2023-08-12 |
Not clear |
| Nancy K Mello, Peter A Fivel, Stephen J Kohut, Jack Bergma. Effects of chronic buspirone treatment on cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 3. 2013-10-17. PMID:23072835. |
buspirone (buspar) is a clinically available, non-benzodiazepine anxiolytic medication that acts on both serotonin and dopamine systems. |
2013-10-17 |
2023-08-12 |
monkey |
| Yasuhiro Saito, Machiko Matsumoto, Yoshiki Yanagawa, Sachiko Hiraide, Sumiyoshi Inoue, Yasunori Kubo, Kei-Ichi Shimamura, Hiroko Togash. Facilitation of fear extinction by the 5-HT(1A) receptor agonist tandospirone: possible involvement of dopaminergic modulation. Synapse (New York, N.Y.). vol 67. issue 4. 2013-08-09. PMID:23152167. |
facilitation of fear extinction by the 5-ht(1a) receptor agonist tandospirone: possible involvement of dopaminergic modulation. |
2013-08-09 |
2023-08-12 |
rat |
| Yasuhiro Saito, Machiko Matsumoto, Yoshiki Yanagawa, Sachiko Hiraide, Sumiyoshi Inoue, Yasunori Kubo, Kei-Ichi Shimamura, Hiroko Togash. Facilitation of fear extinction by the 5-HT(1A) receptor agonist tandospirone: possible involvement of dopaminergic modulation. Synapse (New York, N.Y.). vol 67. issue 4. 2013-08-09. PMID:23152167. |
in this study, we elucidated the therapeutic potential of the serotonin 1a (5-ht(1a) ) receptor agonist tandospirone compared with the effects of the n-methyl-d-aspartate partial agonist d-cycloserine (dcs), focusing on the possible involvement of dopaminergic mechanisms. |
2013-08-09 |
2023-08-12 |
rat |
| Adam S Olsen, Christopher N Sozda, Jeffrey P Cheng, Ann N Hoffman, Anthony E Klin. Traumatic brain injury-induced cognitive and histological deficits are attenuated by delayed and chronic treatment with the 5-HT1A-receptor agonist buspirone. Journal of neurotrauma. vol 29. issue 10. 2013-05-22. PMID:22416854. |
the aim of this study was to evaluate the potential efficacy of the serotonin(1a) (5-ht(1a)) receptor agonist buspirone (bus) on behavioral and histological outcome after traumatic brain injury (tbi). |
2013-05-22 |
2023-08-12 |
rat |
| Masakuni Horiguchi, Kayleen E Hannaway, Adesewa E Adelekun, Mei Huang, Karu Jayathilake, Herbert Y Meltze. D(1) receptor agonists reverse the subchronic phencyclidine (PCP)-induced novel object recognition (NOR) deficit in female rats. Behavioural brain research. vol 238. 2013-05-17. PMID:23018127. |
we also examined the ability of tandospirone, a serotonin (5-ht)(1a) receptor partial agonist, and ly341495, a mglur2/3 receptor antagonist, to potentiate or block the effects of skf38393 on nor, respectively. |
2013-05-17 |
2023-08-12 |
rat |
| Lei Li, Sachio Morimoto, Sachiko Take, Dong-Yun Zhan, Cheng-Kun Du, Yuan-Yuan Wang, Xue-Li Fan, Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Toshihiko Katafuchi, Toshiyuki Sasagur. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. Journal of molecular and cellular cardiology. vol 53. issue 6. 2013-04-19. PMID:22921782. |
since depression is common and associated with poor prognosis in hf patients, we examined therapeutic effects of anti-depression drug paroxetine and anti-anxiety drug buspirone that could improve the brain serotonin function in mice. |
2013-04-19 |
2023-08-12 |
mouse |
| E K Morrison, A S Row. Probable drug-drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia. Journal of clinical pharmacy and therapeutics. vol 37. issue 5. 2013-04-03. PMID:22452676. |
probable drug-drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia. |
2013-04-03 |
2023-08-12 |
Not clear |
| C Loane, M Politi. Buspirone: what is it all about? Brain research. vol 1461. 2013-04-01. PMID:22608068. |
buspirone is an anxiolytic drug and is a partial agonist for the serotonin 5-ht(1a) receptors as well as possessing low affinity and is an antagonist for the dopamine d(2) autoreceptors, with some evidence of a weak affinity to 5-ht(2) receptors. |
2013-04-01 |
2023-08-12 |
Not clear |
| C Loane, M Politi. Buspirone: what is it all about? Brain research. vol 1461. 2013-04-01. PMID:22608068. |
the underlying mechanism of action of buspirone is not clear; however it is thought that its main pharmacology is mediated via the 5-ht(1a) receptors. |
2013-04-01 |
2023-08-12 |
Not clear |
| Jan Tack, Pieter Janssen, Tatsuhiro Masaoka, Ricard Farré, Lukas Van Oudenhov. Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. vol 10. issue 11. 2013-03-22. PMID:22813445. |
buspirone, a 5-hydroxytryptamine 1a receptor agonist, relaxes the proximal stomach in healthy individuals. |
2013-03-22 |
2023-08-12 |
Not clear |
| Peter Kranke, Kerstin D Röhm, Pierre Diemunsch, Tong J Gan, Christian C Apfel, Leopold Eberhart, Harold S Minkowitz, Jan Wallenborn, Dominique Chassard, Gilles Lebuffe, Gabriel M Fox, Martin R Tramè. Intravenous buspirone for the prevention of postoperative nausea and vomiting. European journal of clinical pharmacology. vol 68. issue 11. 2013-03-04. PMID:22546895. |
buspirone, a partial 5ht(1a) agonist and d₂ and d₃ antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy for the prevention of postoperative nausea and vomiting (ponv) is unknown. |
2013-03-04 |
2023-08-12 |
Not clear |
| Cheryl Shuang-wu Li, Liming Zhang, Taraneh Haske, Amy Dounay, David Gray, Nancy Barta, Joanne Brodfuehrer, Christopher Lepsy, Brian Campbel. Mechanism-based pharmacokinetic/pharmacodynamic modeling of rat prefrontal cortical dopamine response to dual acting norepinephrine reuptake inhibitor and 5-HT1A partial agonist. The AAPS journal. vol 14. issue 2. 2013-01-28. PMID:22454087. |
the objectives of the present study were first to characterize the pharmacokinetic/pharmacodynamic (pk/pd) relationship of the plasma concentrations of atomoxetine (nri) and buspirone (5-ht(1a) partial agonist), administered alone and in combination, on the prefrontal cortex dopamine levels in rats, and second to use the model developed to characterize the pk/pd relationship of novel nri/5-ht(1a) compounds, pf-04269339 and pf-03529936, in a nri/5-ht(1a) drug discovery program. |
2013-01-28 |
2023-08-12 |
rat |
| Cheryl Shuang-wu Li, Liming Zhang, Taraneh Haske, Amy Dounay, David Gray, Nancy Barta, Joanne Brodfuehrer, Christopher Lepsy, Brian Campbel. Mechanism-based pharmacokinetic/pharmacodynamic modeling of rat prefrontal cortical dopamine response to dual acting norepinephrine reuptake inhibitor and 5-HT1A partial agonist. The AAPS journal. vol 14. issue 2. 2013-01-28. PMID:22454087. |
after fixing three mechanism-specific pharmacodynamic parameters (i (max) and γ2 for nri and γ1 for 5-ht(1a)) based on the model for atomoxetine and/or buspirone, the model fitted the exposure-response profiles of pf-04269339 and pf-03529936 well. |
2013-01-28 |
2023-08-12 |
rat |
| Kah-Chung Leong, Jarid Goodman, Mark G Packar. Buspirone blocks the enhancing effect of the anxiogenic drug RS 79948-197 on consolidation of habit memory. Behavioural brain research. vol 234. issue 2. 2013-01-21. PMID:22800923. |
the present study examined the effect of concurrent administration of the anxiolytic serotonin 5-ht(1a) receptor partial agonist buspirone on anxiety-induced facilitation of habit memory. |
2013-01-21 |
2023-08-12 |
rat |
| Joanna García, Thomas Carlsson, Máté Döbrössy, Guido Nikkhah, Christian Winkle. Impact of dopamine versus serotonin cell transplantation for the development of graft-induced dyskinesia in a rat Parkinson model. Brain research. vol 1470. 2013-01-15. PMID:22759908. |
serotonin neurons, included into the dopaminergic cell suspension due to the nature of the dissection process, have been suggested as a key factor for the development of gid, since the administration of the serotonin (5-ht)(1a)-receptor agonist buspirone reduced dyskinesia in transplanted pd patients. |
2013-01-15 |
2023-08-12 |
rat |
| Masakuni Horiguchi, Kayleen E Hannaway, Adesewa E Adelekun, Karu Jayathilake, Herbert Y Meltze. Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22739469. |
prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-ht(1a) partial agonist. |
2013-01-09 |
2023-08-12 |
rat |
| Masakuni Horiguchi, Kayleen E Hannaway, Adesewa E Adelekun, Karu Jayathilake, Herbert Y Meltze. Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 10. 2013-01-09. PMID:22739469. |
we have tested the ability of lurasidone, an atypical apd with potent 5-ht(1a) partial agonist properties, tandospirone, a selective 5-ht(1a) partial agonist, haloperidol, a d(2) antagonist, and pimavanserin, a 5-ht(2a) inverse agonist, to prevent the development of the pcp-induced nor deficit. |
2013-01-09 |
2023-08-12 |
rat |