Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
Peihua Zhang, Jin Li, Xudong Tang, Junlei Zhang, Jie Liang, Guofang Zen. Dracorhodin perchlorate induces apoptosis in primary fibroblasts from human skin hypertrophic scars via participation of caspase-3. European journal of pharmacology vol 728 issue 2015 24525335 |
hypertrophic scar (hs) is an abnormally proliferative disorder characterized by excessive proliferation of fibroblasts and redundant deposition of extracellular matrix. |
2015-03-02 |
2023-01-25 |
human |
M Fuers. [Chondrocalcinosis. Clinical impact of intra-articular calcium phosphate crystals]. Zeitschrift fur Rheumatologie vol 73 issue 5 2015 24924727 |
in the process of endochondral ossification, the link between hypertrophy and matrix mineralization is particularly well described. |
2015-02-23 |
2023-01-25 |
Not clear |
M Fuers. [Chondrocalcinosis. Clinical impact of intra-articular calcium phosphate crystals]. Zeitschrift fur Rheumatologie vol 73 issue 5 2015 24924727 |
hypertrophic chondrocytes in oa cartilage and at the growth line share certain features, not only hypertrophy but also a capability to mineralize the matrix. |
2015-02-23 |
2023-01-25 |
Not clear |
Waldemar Hoffmann, Sandra Feliciano, Ivan Martin, Michael de Wild, David Wend. Novel Perfused Compression Bioreactor System as an in vitro Model to Investigate Fracture Healing. Frontiers in bioengineering and biotechnology vol 3 issue 2015 25699254 |
our findings provide a proof-of-principle that dynamic mechanical loading applied by the pcb can enhance the maturation process of mesenchymal stromal cells toward late hypertrophic chondrocytes and the mineralization of the deposited extracellular matrix. |
2015-02-20 |
2023-01-25 |
human |
Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry vol 289 issue 47 2015 25288788 |
high glucose forces a positive feedback loop connecting akt kinase and foxo1 transcription factor to activate mtorc1 kinase for mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-01-25 |
mouse |
Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry vol 289 issue 47 2015 25288788 |
high glucose-induced akt acts as a signaling hub for mesangial cell hypertrophy and matrix expansion, which are recognized as cardinal signatures for the development of diabetic nephropathy. |
2015-02-12 |
2023-01-25 |
mouse |
Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Amit Bera, Meenalakshmi M Mariappan, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression. The Journal of biological chemistry vol 289 issue 47 2015 25288788 |
together, our results provide the first evidence for the presence of a positive feedback loop for the sustained activation of akt involving inactivated foxo1 and a decrease in catalase expression, leading to increased ros and mesangial cell hypertrophy and matrix protein expression. |
2015-02-12 |
2023-01-25 |
mouse |
Xu Yang, Samir K Trehan, Yingjie Guan, Changqi Sun, Douglas C Moore, Chathuraka T Jayasuriya, Qian Che. Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist. The Journal of biological chemistry vol 289 issue 50 2015 25331953 |
hence, as a novel bmp-2-binding protein and antagonist in the cartilage extracellular matrix, matn3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing bmp-2/smad1 activity. |
2015-02-12 |
2023-01-25 |
mouse |
Kristen L Lauing, Mauricio Cortes, Miriam S Domowicz, Judith G Henry, Alexis T Baria, Nancy B Schwart. Aggrecan is required for growth plate cytoarchitecture and differentiation. Developmental biology vol 396 issue 2 2015 25446537 |
aggrecan-null growth plates were devoid of matrix and lacked chondrocyte organization and differentiation, while those of the rescue embryos exhibited matrix production concomitant with partial zonation of chondrocytes having proliferative and hypertrophic morphologies. |
2015-02-05 |
2023-01-25 |
mouse |
Katsuhiko Amano, Michael Densmore, Riko Nishimura, Beate Lansk. Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions. The Journal of biological chemistry vol 289 issue 36 2015 25028519 |
independent of this function, we and others recently reported independent ihh functions to promote chondrocyte hypertrophy and matrix mineralization in vivo and in vitro. |
2015-01-28 |
2023-01-25 |
Not clear |
Tarek Hamdy Abd-Elhamid, Marianne L Conway, Allan R Sinnin. The hLAMP-1-positive particulate matrix involved in cardiac mesenchyme formation in the chick does not include BMP-2. Cells, tissues, organs vol 198 issue 5 2015 24503594 |
the particulate matrix causes a subset of endocardial cells to hypertrophy, lose their cell-cell contacts, form migratory processes, transform into mesenchymal cells, and migrate into the underlying endocardial cushions. |
2015-01-22 |
2023-01-25 |
chicken |
Malihe-Sadat Poormasjedi-Meibod, Ryan Hartwell, Ruhangiz Taghi Kilani, Aziz Ghahar. Anti-scarring properties of different tryptophan derivatives. PloS one vol 9 issue 3 2015 24637853 |
hypertrophic scars are associated with prolonged extracellular matrix (ecm) production, aberrant ecm degradation and high tissue cellularity. |
2015-01-13 |
2023-01-25 |
rabbit |
Trevi A Ramirez, Rugmani Padmanabhan Iyer, Omid Ghasemi, Elizabeth F Lopez, Daniel B Levin, Jianhua Zhang, Rogelio Zamilpa, Youn-Min Chou, Yu-Fang Jin, Merry L Lindse. Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects. Journal of molecular and cellular cardiology vol 72 issue 2015 24768766 |
the treatments influenced systolic function and hypertrophy index, as well as extracellular matrix (ecm) and inflammatory genes in the remote region, indicating that primary effects were on the viable myocardium. |
2015-01-13 |
2023-01-25 |
mouse |
Ana M Briones, Rosa Aras-L\\xc3\\xb3pez, Mar\\xc3\\xada J Alonso, Mercedes Salaice. Small artery remodeling in obesity and insulin resistance. Current vascular pharmacology vol 12 issue 3 2015 24846232 |
in general, vascular remodeling of small arteries associated to cardiometabolic diseases seems to be hypertrophic and it is associated to increased extracellular matrix deposition, although specific vascular beds might show different structural patterns. |
2015-01-05 |
2023-01-25 |
Not clear |
Zhenyu Zhang, Yan Wang, Mingchao Li, Jiaping Li, Jian W. Fibroblast growth factor 18 increases the trophic effects of bone marrow mesenchymal stem cells on chondrocytes isolated from late stage osteoarthritic patients. Stem cells international vol 2014 issue 2014 25544847 |
results from transwell coculture study showed that expression of matrix producing genes in oa chondrocytes increased when cocultured with mscs with fgf18 in culture medium, while hypertrophic genes were not changed by coculture. |
2014-12-29 |
2023-01-25 |
Not clear |
Nancy E Castro, Mitsuo Kato, Jung Tak Park, Rama Nataraja. Transforming growth factor \\xce\\xb21 (TGF-\\xce\\xb21) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells. The Journal of biological chemistry vol 289 issue 42 2014 25204661 |
increased expression of transforming growth factor-\xce\xb21 (tgf-\xce\xb21) in glomerular mesangial cells (mc) augments extracellular matrix accumulation and hypertrophy during the progression of diabetic nephropathy (dn), a debilitating renal complication of diabetes. |
2014-12-22 |
2023-01-25 |
mouse |
Qia Zhang, Sunil K Joshi, David H Lovett, Bryon Zhang, Sue Bodine, Hubert Kim, Xuhui Li. Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles, ligaments and tendons journal vol 4 issue 3 2014 25489556 |
matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. |
2014-12-09 |
2023-01-25 |
Not clear |
Shigenori Miura, Jun Kondo, Aki Takimoto, Hiroko Sano-Takai, Long Guo, Chisa Shukunami, Hideyuki Tanaka, Yuji Hirak. The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development. PloS one vol 9 issue 4 2014 24710035 |
taken together, our results suggest that intact 20-25 kda chm-i is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single n-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage. |
2014-12-03 |
2023-01-25 |
rat |
Katsuhito Fujiu, Ryozo Naga. Fibroblast-mediated pathways in cardiac hypertrophy. Journal of molecular and cellular cardiology vol 70 issue 2014 24492068 |
many growth factors and extracellular matrix components secreted by cardiac fibroblasts induce and modify cardiomyocyte hypertrophy. |
2014-12-01 |
2023-01-25 |
Not clear |
William M Yarbrough, Catalin Baicu, Rupak Mukherjee, An Van Laer, William T Rivers, Richard A McKinney, Corey B Prescott, Robert E Stroud, Parker D Freels, Kia N Zellars, Michael R Zile, Francis G Spinal. Cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following pressure overload-induced hypertrophy. American journal of physiology. Heart and circulatory physiology vol 307 issue 5 2014 24993046 |
cardiac-restricted overexpression or deletion of tissue inhibitor of matrix metalloproteinase-4: differential effects on left ventricular structure and function following pressure overload-induced hypertrophy. |
2014-11-07 |
2023-01-25 |
mouse |