| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Estelle Ayme-Dietrich, Halim Marzak, Roland Lawson, Walid Mokni, Olivia Wendling, Roy Combe, Julien Becker, Lahcen El Fertak, Marie-France Champy, Rachel Matz, Ramaroson Andriantsitohaina, Stéphane Doly, Katia Boutourlinsky, Luc Maroteaux, Laurent Monassie. Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats. Journal of hypertension. vol 33. issue 11. 2016-05-26. PMID:26259125. |
blockade of the serotonin 5-ht2b receptor (5-ht2br) has been shown to reduce cardiac hypertrophy, oxidative stress, and extracellular cell matrix activation. |
2016-05-26 |
2023-08-13 |
rat |
| Renpeng Zhou, Qi Zhang, Yun Zhang, Shibo Fu, Chen Wan. Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Experimental cell research. vol 339. issue 2. 2016-05-24. PMID:26500110. |
the post-traumatic hypertrophic scar (hs) is a fibrotic disease with excessive extracellular matrix (ecm) production by fibroblasts in response to tissue injury. |
2016-05-24 |
2023-08-13 |
Not clear |
| Shaohong Cheng, Weirong Xing, Sheila Pourteymoor, Jan Schulte, Subburaman Moha. Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology. vol 157. issue 1. 2016-05-17. PMID:26562260. |
dynamic histomorphometric analyses revealed increased longitudinal length and osteoid surface per bone surface in the primary spongiosa of the cko mice, suggesting elevated conversion rate from hypertrophic chondrocytes to mineralized bone matrix as well as increased bone formation in the primary spongiosa. |
2016-05-17 |
2023-08-13 |
mouse |
| Andrea Linz, Yvonne Knieper, Tobias Gronau, Uwe Hansen, Attila Aszodi, Natalio Garbi, Günter J Hämmerling, Thomas Pap, Peter Bruckner, Rita Dreie. ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 8. 2016-05-16. PMID:25704664. |
long-bone growth by endochondral ossification is cooperatively accomplished by chondrocyte proliferation, hypertrophic differentiation, and appropriate secretion of collagens, glycoproteins, and proteoglycans into the extracellular matrix (ecm). |
2016-05-16 |
2023-08-13 |
mouse |
| Andrea Linz, Yvonne Knieper, Tobias Gronau, Uwe Hansen, Attila Aszodi, Natalio Garbi, Günter J Hämmerling, Thomas Pap, Peter Bruckner, Rita Dreie. ER Stress During the Pubertal Growth Spurt Results in Impaired Long-Bone Growth in Chondrocyte-Specific ERp57 Knockout Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 8. 2016-05-16. PMID:25704664. |
together this results in a delay of long-bone growth with the following characteristics: (1) enlarged growth plates; (2) expanded hypertrophic zones; (3) retarded osteoclast recruitment; (4) delayed remodeling of the proteoglycan-rich matrix; and (5) reduced numbers of bone trabeculae. |
2016-05-16 |
2023-08-13 |
mouse |
| Yvonne Peck, Ling Yen Ng, Jie Yi Lois Goh, Changyou Gao, Dong-An Wan. A three-dimensionally engineered biomimetic cartilaginous tissue model for osteoarthritic drug evaluation. Molecular pharmaceutics. vol 11. issue 7. 2016-05-04. PMID:24579704. |
up-regulation of matrix metalloproteinase-1 (mmp-1) and mmp-3 genes suggested increased degradative activity, while chondrocytic hypertrophic differentiation was observed. |
2016-05-04 |
2023-08-12 |
Not clear |
| Stacey C Skaalure, Stanley Chu, Stephanie J Bryan. An enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineering. Advanced healthcare materials. vol 4. issue 3. 2016-05-03. PMID:25296398. |
in contrast, matrix deposition in the nondegradable hydrogels consists of aggrecan and collagens i, ii, and x, indicative of hypertrophic cartilage. |
2016-05-03 |
2023-08-13 |
cattle |
| Shuang Yang, Sumita Mishra, Lijun Chen, Jian-Ying Zhou, Daniel W Chan, Subroto Chatterjee, Hui Zhan. Integrated glycoprotein immobilization method for glycopeptide and glycan analysis of cardiac hypertrophy. Analytical chemistry. vol 87. issue 19. 2016-05-02. PMID:26378618. |
we identified 291 unique glycopeptides from 195 glycoproteins; the comparative studies between wt and tac mice indicate the overexpression of extracellular proteins for heart matrix remodeling and the down-regulation of proteins associated with energy metabolism in cardiac hypertrophy. |
2016-05-02 |
2023-08-13 |
mouse |
| T Akisaka, C V Ga. The plasma membrane and matrix vesicles of mouse growth plate chondrocytes during differentiation as revealed in freeze-fracture replicas. The American journal of anatomy. vol 173. issue 4. 2016-04-23. PMID:20726124. |
imp-aggregated and imp-free matrix vesicles became increasingly frequent in the later stages of differentiation, particularly in the late hypertrophic stage. |
2016-04-23 |
2023-08-12 |
mouse |
| Xiaozhi Bai, Ting He, Jiaqi Liu, Yunchuan Wang, Lei Fan, Ke Tao, Jihong Shi, Chaowu Tang, Linlin Su, Dahai H. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Experimental dermatology. vol 24. issue 5. 2016-04-22. PMID:25683490. |
loureirin b inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via tgf-β/smad pathway. |
2016-04-22 |
2023-08-13 |
human |
| Mario Notari, Julián Pulecio, Ángel Ray. Update on the Pathogenic Implications and Clinical Potential of microRNAs in Cardiac Disease. BioMed research international. vol 2015. 2016-04-21. PMID:26221581. |
for instance, acute myocardial infarction induces cardiac tissue necrosis and apoptosis but also initiates a pathological remodelling response of the left ventricle that includes hypertrophic growth of cardiomyocytes and fibrotic deposition of extracellular matrix components. |
2016-04-21 |
2023-08-13 |
Not clear |
| Chia-Li M Shih, Kolapo M Ajuwo. Inhibition of MMP-13 prevents diet-induced obesity in mice and suppresses adipogenesis in 3T3-L1 preadipocytes. Molecular biology reports. vol 42. issue 7. 2016-03-10. PMID:25682268. |
adipose tissue remodeling by the matrix metalloproteases (mmps) is critical for tissue hypertrophy and obesity. |
2016-03-10 |
2023-08-13 |
mouse |
| Jing-Jing Yang, Yan-ru Huang, Yi-gang Wan, Shan-mei Shen, Zhi-min Mao, Wei Wu, Jian Ya. [Regulative mechanisms of mammalian target of rapamycin signaling pathway in glomerular hypertrophy in diabetic nephropathy and interventional effects of Chinese herbal medicine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790279. |
rapamycin, the inhibitor of mtor, could suppress glomerular inherent cell hypertrophy, cell proliferation, glomerular basement membrane (gbm) thickening and mesangial matrix deposition in model rats with dn. |
2016-03-10 |
2023-08-13 |
rat |
| Wei-Jian Ni, Hai-Hua Ding, Li-Qin Tan. Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms. European journal of pharmacology. vol 760. 2016-03-08. PMID:25912800. |
diabetic nephropathy is a progressive kidney disorder and is pathologically characterized by thickened glomerular and tubular basement membranes, accumulation of the extracellular matrix and increased mesangial hypertrophy. |
2016-03-08 |
2023-08-13 |
Not clear |
| Koichi Matsuo, Yukiko Kuroda, Nobuhito Nango, Kouji Shimoda, Yoshiaki Kubota, Masatsugu Ema, Latifa Bakiri, Erwin F Wagner, Yoshihiro Takeda, Wataru Yashiro, Atsushi Momos. Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus. Development (Cambridge, England). vol 142. issue 22. 2016-03-04. PMID:26428006. |
terminally differentiated hypertrophic chondrocytes are calcified, vascularized, and removed by chondroclasts before bone matrix is laid down by osteoblasts. |
2016-03-04 |
2023-08-13 |
mouse |
| Hirohisa Kawahata, Daisuke Sotobayashi, Motokuni Aoki, Hideo Shimizu, Hironori Nakagami, Toshio Ogihara, Ryuichi Morishit. Continuous infusion of angiotensin II modulates hypertrophic differentiation and apoptosis of chondrocytes in cartilage formation in a fracture model mouse. Hypertension research : official journal of the Japanese Society of Hypertension. vol 38. issue 6. 2016-03-03. PMID:25693858. |
it was also confirmed by a significant increase in the mrna expression of sox9 and runt-related transcription factor 2 (runx2), which are genes related to chondrocyte differentiation, and type x collagen, matrix metalloproteinase (mmp)-13 and indian hedgehog (ihh), which are hypertrophic chondrocyte-specific molecular markers. |
2016-03-03 |
2023-08-13 |
mouse |
| Jianquan Chen, Nilsson Holguin, Yu Shi, Matthew J Silva, Fanxin Lon. mTORC2 signaling promotes skeletal growth and bone formation in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 2. 2016-02-22. PMID:25196701. |
subsequently, the embryonic skeletal elements are shortened due to a delay in chondrocyte hypertrophy, with no change in proliferation, apoptosis, cell size, or matrix production. |
2016-02-22 |
2023-08-13 |
mouse |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
high glucose enhances microrna-26a to activate mtorc1 for mesangial cell hypertrophy and matrix protein expression. |
2016-02-16 |
2023-08-13 |
Not clear |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
high glucose milieu inhibits pten expression to activate akt kinase and induces glomerular mesangial cell hypertrophy and matrix protein expression in diabetic nephropathy. |
2016-02-16 |
2023-08-13 |
Not clear |
| Nirmalya Dey, Amit Bera, Falguni Das, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression. Cellular signalling. vol 27. issue 7. 2016-02-16. PMID:25797045. |
akt-mediated phosphorylation of tuberin and pras40 regulates mtorc1, which is necessary for mesangial cell hypertrophy and matrix protein expression. |
2016-02-16 |
2023-08-13 |
Not clear |