| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justin Crawford, Karen Nygard, Bing Siang Gan, David Brian O'Gorma. Periostin induces fibroblast proliferation and myofibroblast persistence in hypertrophic scarring. Experimental dermatology. vol 24. issue 2. 2015-10-08. PMID:25421393. |
periostin induced significant increases in supermature focal adhesion formation, α smooth muscle actin levels and collagen contraction in fibroblasts cultured from hypertrophic scars under conditions of increased matrix tension in three-dimensional type-i collagen lattices. |
2015-10-08 |
2023-08-13 |
Not clear |
| Justin Crawford, Karen Nygard, Bing Siang Gan, David Brian O'Gorma. Periostin induces fibroblast proliferation and myofibroblast persistence in hypertrophic scarring. Experimental dermatology. vol 24. issue 2. 2015-10-08. PMID:25421393. |
depletion of endogenous periostin expression in hypertrophic scar myofibroblasts resulted in a sustained decrease in α smooth muscle actin levels under conditions of reducing matrix tension, while matrix-associated periostin levels caused the cells to retain high levels of a smooth muscle actin under these conditions. |
2015-10-08 |
2023-08-13 |
Not clear |
| Andreea Iren Serban, Loredana Stanca, Ovidiu Ionut Geicu, Maria Cristina Munteanu, Marieta Costache, Anca Dinischiot. Extracellular matrix is modulated in advanced glycation end products milieu via a RAGE receptor dependent pathway boosted by transforming growth factor-β1 RAGE. Journal of diabetes. vol 7. issue 1. 2015-09-22. PMID:24666836. |
we set out to identify the role of ages in producing alterations leading to matrix hypertrophy and the pathway through which aminoguanidine, as well as anti-rage and anti-transforming growth factor (tgf)-β1 antibody treatments could prevent these modifications. |
2015-09-22 |
2023-08-12 |
Not clear |
| Anna Filip, Arnaud Bianchi, Didier Mainard, Patrick Lacolley, Jacques Magdalou, Nathalie Mercie. A simple two dimensional culture method to study the hypertrophic differentiation of rat articular chondrocytes. Bio-medical materials and engineering. vol 25. issue 1 Suppl. 2015-09-21. PMID:25538060. |
hypertrophic chondrocytes synthesise collagen x and express matrix metalloproteinase 13 and alkaline phosphatase. |
2015-09-21 |
2023-08-13 |
human |
| Jingming Zhou, Qian Chen, Beate Lanske, Braden C Fleming, Richard Terek, Xiaochun Wei, Ge Zhang, Shaowei Wang, Kai Li, Lei We. Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis research & therapy. vol 16. issue 1. 2015-09-16. PMID:24428864. |
previous observations implicate indian hedgehog (ihh) signaling in osteoarthritis (oa) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (mmp-13) expression. |
2015-09-16 |
2023-08-12 |
mouse |
| Hongrui Liu, Jie Guo, Shanliang Wei, Shengyu Lv, Wei Feng, Jian Cui, Tomoka Hasegawa, Hiromi Hongo, Yang Yang, Xiangzhi Li, Kimimitsu Oda, Norio Amizuka, Minqi L. Expression of matrix Gla protein and osteocalcin in the developing tibial epiphysis of mice. Histology and histopathology. vol 30. issue 1. 2015-09-02. PMID:24956112. |
subsequently, mgp reactivity was seen on the cartilaginous lacunar walls of hypertrophic chondrocytes, while ocn reactivity was evenly found not only in the bone matrix, but also in the cartilaginous lacunar walls and on the bone surfaces. |
2015-09-02 |
2023-08-13 |
mouse |
| Yves Gorin, Rita C Cavaglieri, Khaled Khazim, Doug-Yoon Lee, Francesca Bruno, Sachin Thakur, Paolo Fanti, Cédric Szyndralewiez, Jeffrey L Barnes, Karen Block, Hanna E Abbou. Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes. American journal of physiology. Renal physiology. vol 308. issue 11. 2015-08-13. PMID:25656366. |
gkt137831 significantly reduced glomerular hypertrophy, mesangial matrix expansion, urinary albumin excretion, and podocyte loss in ove26 mice. |
2015-08-13 |
2023-08-13 |
mouse |
| Dylan E Lee, Ryan M Trowbridge, Nagi T Ayoub, Devendra K Agrawa. High-mobility Group Box Protein-1, Matrix Metalloproteinases, and Vitamin D in Keloids and Hypertrophic Scars. Plastic and reconstructive surgery. Global open. vol 3. issue 6. 2015-07-16. PMID:26180726. |
high-mobility group box protein-1, matrix metalloproteinases, and vitamin d in keloids and hypertrophic scars. |
2015-07-16 |
2023-08-13 |
Not clear |
| Dong Huang, Yingping Liu, Yongjun Huang, Youfu Xie, Kuanhong Shen, Dawei Zhang, Yong Mo. Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts. Connective tissue research. vol 55. issue 5-6. 2015-07-08. PMID:25166894. |
activation of transforming growth factor-β (tgf-β) signaling and matrix metalloproteinases are involved in hypertrophic scar (hs) formation. |
2015-07-08 |
2023-08-13 |
Not clear |
| Norikazu Hinamoto, Yohei Maeshima, Hiroko Yamasaki, Tatsuyo Nasu, Daisuke Saito, Hiroyuki Watatani, Haruyo Ujike, Katsuyuki Tanabe, Kana Masuda, Yuka Arata, Hitoshi Sugiyama, Yasufumi Sato, Hirofumi Makin. Exacerbation of diabetic renal alterations in mice lacking vasohibin-1. PloS one. vol 9. issue 9. 2015-06-22. PMID:25255225. |
furthermore, the renal and glomerular hypertrophy, glomerular accumulation of mesangial matrix and type iv collagen and activation of renal tgf-β1/smad3 signaling, a key mediator of renal fibrosis, were exacerbated in the diabetic vash1(+/-) mice compared with the diabetic wild-type littermates. |
2015-06-22 |
2023-08-13 |
mouse |
| Jennifer Fischer, Antje Aulmann, Verena Dexheimer, Tobias Grossner, Wiltrud Richte. Intermittent PTHrP(1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells. Stem cells and development. vol 23. issue 20. 2015-06-12. PMID:24836507. |
pulsed pthrp exposure of mscs stimulated chondrogenesis and reduced endochondral differentiation apparently uncoupling chondrogenic matrix deposition from hypertrophic marker expression. |
2015-06-12 |
2023-08-13 |
human |
| Samy L Habi. Alterations in tubular epithelial cells in diabetic nephropathy. Journal of nephrology. vol 26. issue 5. 2015-06-04. PMID:24052469. |
renal hypertrophy, matrix protein accumulation and tubulointerstitial fibrosis are major pathological features of diabetic nephropathy (dn) that eventuate in renal failure. |
2015-06-04 |
2023-08-12 |
human |
| Shao-Qing Zhang, Yi-Ting Sun, Tian-Hua Xu, Xue-Feng Zhang, Ying-Zhong Liu, Ma Jian-Fei Ma, Li-Ning Wang, Li Ya. Protective effect of metformin on renal injury of C57BL/6J mouse treated with high fat diet. Die Pharmazie. vol 69. issue 12. 2015-06-02. PMID:25951664. |
at the end of 12th week, compared with mice on low fat diet (lfd), body weight (bw), the levels of fasting insulin (fins), plasma and renal triglyceride (tg) were higher and plasma high density lipoprotein (hdl) and insulin sensitivity index (isi) were significantly lower, but the levels of fasting blood glycemia (fbg), plasma total cholesterol (tc) and renal tc had no changes; oil red o staining revealed renal lipids deposition, masson staining and he staining revealed glomerular hypertrophy, matrix increasing, and inflammatory cells infiltration in glomerular; the expression of p-ampkα protein decreased and the expression of srebp-1c, tnf-α, nox4 mrna increased significantly in mouse treated with high fat diet (hfd). |
2015-06-02 |
2023-08-13 |
mouse |
| Meiling Zhu, Qian Feng, Liming Bia. Differential effect of hypoxia on human mesenchymal stem cell chondrogenesis and hypertrophy in hyaluronic acid hydrogels. Acta biomaterialia. vol 10. issue 3. 2015-05-12. PMID:24342044. |
in addition, at a constant high ha concentration, increasing hydrogel crosslinking density promoted hmsc hypertrophy and matrix calcification. |
2015-05-12 |
2023-08-12 |
human |
| Chenyu Huang, Rei Ogaw. The link between hypertension and pathological scarring: does hypertension cause or promote keloid and hypertrophic scar pathogenesis? Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 22. issue 4. 2015-05-12. PMID:24899409. |
pathological scars, namely, keloids and hypertrophic scars (hss), are caused by excessive cutaneous wound healing that is characterized by histological extracellular matrix (ecm) accumulation, clinically relevant irritating symptoms, and frequent recurrence after surgical excision. |
2015-05-12 |
2023-08-13 |
Not clear |
| Laura C O'Brien, Eleonora Mezzaroma, Benjamin W Van Tassell, Carlo Marchetti, Salvatore Carbone, Antonio Abbate, Stefano Told. Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure. Molecular medicine (Cambridge, Mass.). vol 20. 2015-05-11. PMID:24804827. |
in animal models of acute myocardial infarction (ami), pressure overload, and lps-induced dysfunction, il-18 regulates cardiomyocyte hypertrophy and induces cardiac contractile dysfunction and extracellular matrix remodeling. |
2015-05-11 |
2023-08-13 |
human |
| Elen Rizzi, Danielle A Guimaraes, Carla S Ceron, Cibele M Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santo. β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free radical biology & medicine. vol 73. 2015-05-11. PMID:24933619. |
β1-adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. |
2015-05-11 |
2023-08-13 |
rat |
| Elen Rizzi, Danielle A Guimaraes, Carla S Ceron, Cibele M Prado, Lucas C Pinheiro, Alisson Martins-Oliveira, Raquel F Gerlach, Jose E Tanus-Santo. β1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy. Free radical biology & medicine. vol 73. 2015-05-11. PMID:24933619. |
hypertension induces left-ventricular hypertrophy (lvh) by mechanisms involving oxidative stress and unbalanced cardiac matrix metalloproteinase (mmp) activity. |
2015-05-11 |
2023-08-13 |
rat |
| Meenalakshmi M Mariappan, Sanjay Prasad, Kristin D'Silva, Esteban Cedillo, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. The Journal of biological chemistry. vol 289. issue 51. 2015-04-21. PMID:25339176. |
increase in protein synthesis contributes to kidney hypertrophy and matrix protein accumulation in diabetes. |
2015-04-21 |
2023-08-13 |
mouse |
| Meenalakshmi M Mariappan, Sanjay Prasad, Kristin D'Silva, Esteban Cedillo, Kavithalakshmi Sataranatarajan, Jeffrey L Barnes, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Activation of glycogen synthase kinase 3β ameliorates diabetes-induced kidney injury. The Journal of biological chemistry. vol 289. issue 51. 2015-04-21. PMID:25339176. |
snp administered for 3 weeks to mice with streptozotocin-induced type 1 diabetes ameliorated kidney hypertrophy, accumulation of matrix proteins, and albuminuria without changing blood glucose levels. |
2015-04-21 |
2023-08-13 |
mouse |