| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
recently it has been shown that matrix metalloproteinase-9 (mmp-9)/gelatinase b is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. |
2004-09-16 |
2023-08-12 |
Not clear |
| Thaís P Amadeu, André S Braune, Luís C Porto, Alexis Desmoulière, Andréa M A Cost. Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 12. issue 2. 2004-09-03. PMID:15086768. |
considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin-1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. |
2004-09-03 |
2023-08-12 |
Not clear |
| Bernhard Schmitt, Jochen Ringe, Thomas Häupl, Michael Notter, Rudi Manz, Gerd-Rüdiger Burmester, Michael Sittinger, Christian Kap. BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation; research in biological diversity. vol 71. issue 9-10. 2004-08-24. PMID:14686954. |
histologic staining of mineralized extracellular matrix with von kossa, immunostaining of type x collagen (typical for hypertrophic chondrocytes), and gene expression analysis of osteocalcin and adipocyte-specific fatty acid binding protein (ap2) further documented that bmp2 induced chondrogenic lineage development and not osteogenesis and/or adipogenesis in human mscs. |
2004-08-24 |
2023-08-12 |
human |
| Sandro Goruppi, John M Kyriaki. The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4. The Journal of biological chemistry. vol 279. issue 20. 2004-07-21. PMID:15016802. |
these changes include an excess deposition of extracellular matrix proteins into the glomerular basement membrane and renal mesangial cell hypertrophy. |
2004-07-21 |
2023-08-12 |
human |
| Brian G Petrich, Yibin Wan. Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies. Trends in cardiovascular medicine. vol 14. issue 2. 2004-07-13. PMID:15030789. |
a far more complex picture has been provided by recent observations from both cellular and transgenic models that have not only challenged their role in hypertrophy and cell death but have also pointed out novel functions of sapks in different aspects of cardiac pathology, including contractile function, extracellular matrix remodeling, intercellular communication, and metabolic regulation. |
2004-07-13 |
2023-08-12 |
Not clear |
| Marcy Wong, Mark Siegrist, Kelly Goodwi. Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes. Bone. vol 33. issue 4. 2004-07-06. PMID:14555274. |
the goal of this study was to test this hypothesis by examining the expression of hypertrophic chondrocyte markers (transcription factor cbfa1, mmp-13, type x collagen, vegf, ctgf) and cartilage matrix proteins under cyclic tension and cyclic hydrostatic pressure. |
2004-07-06 |
2023-08-12 |
Not clear |
| Young-Sook Kim, Marpadga A Reddy, Linda Lanting, Sharon G Adler, Rama Nataraja. Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice. Kidney international. vol 64. issue 5. 2004-06-24. PMID:14531803. |
the 12/15-lipoxygenase (12/15-lo) enzyme has been implicated in the pathogenesis of diabetic nephropathy since lipoxygenase products induce cellular hypertrophy and extracellular matrix deposition in mesangial cells. |
2004-06-24 |
2023-08-12 |
mouse |
| Nan Jia, Hiroshi Okamoto, Toshihiro Shimizu, Satoru Chiba, Yutaka Matsui, Takeshi Sugawara, Masatoshi Akino, Akira Kitabatak. A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expression. Hypertension research : official journal of the Japanese Society of Hypertension. vol 26. issue 9. 2004-06-24. PMID:14620930. |
previous studies have demonstrated that integrins link the extracellular matrix to the hypertrophic response pathway of cardiac myocytes in vitro. |
2004-06-24 |
2023-08-12 |
rat |
| Céline Colnot, Chuanyong Lu, Diane Hu, Jill A Helm. Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development. Developmental biology. vol 269. issue 1. 2004-06-14. PMID:15081357. |
during the initiation of endochondral ossification three events occur that are inextricably linked in time and space: chondrocytes undergo terminal differentiation and cell death, the skeletal vascular endothelium invades the hypertrophic cartilage matrix, and osteoblasts differentiate and begin to deposit a bony matrix. |
2004-06-14 |
2023-08-12 |
mouse |
| Céline Colnot, Chuanyong Lu, Diane Hu, Jill A Helm. Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development. Developmental biology. vol 269. issue 1. 2004-06-14. PMID:15081357. |
endothelial cells residing within the perichondrium are the first cells to participate in the invasion of the hypertrophic cartilage matrix, followed by endothelial cells derived from the host environment. |
2004-06-14 |
2023-08-12 |
mouse |
| Philippe H Tartaix, Marie Doulaverakis, Anne George, Larry W Fisher, William T Butler, Chunlin Qin, Erdjan Salih, Melin Tan, Yukiji Fujimoto, Lyudmila Spevak, Adele L Boske. In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14769788. |
dentin matrix protein-1 (dmp1) is a mineralized tissue matrix protein synthesized by osteoblasts, hypertrophic chondrocytes, and ameloblasts as well as odontoblasts. |
2004-06-10 |
2023-08-12 |
mouse |
| A Bakr M Rabie, Guo Hua Tang, Urban Häg. Cbfa1 couples chondrocytes maturation and endochondral ossification in rat mandibular condylar cartilage. Archives of oral biology. vol 49. issue 2. 2004-06-07. PMID:14693204. |
quantitative analysis demonstrated that both types of cbfa1 proteins reached their maximum level on day 56, which coincided with the terminal maturation of hypertrophic chondrocytes and the aggregation of mineralisation deposits in extracellular matrix. |
2004-06-07 |
2023-08-12 |
rat |
| Tatyana V Dudnakova, Vladimir L Lakomkin, Valerie G Tsyplenkova, Boris V Shekhonin, Vladimir P Shirinsky, Valeri I Kapelk. Alterations in myocardial ultrastructure and protein expression after a single injection of isoproterenol. Molecular and cellular biochemistry. vol 252. issue 1-2. 2004-06-03. PMID:14577591. |
obtained results indicate that even a single injection of isoproterenol creates long lasting structural alterations in cardiac muscle accompanied by the increased expression of extracellular matrix proteins and several sarcoplasmic proteins apparently involved in hypertrophic response of cardiomyocytes. |
2004-06-03 |
2023-08-12 |
rat |
| Jennifer L Gooch, Yves Gorin, Bin-Xian Zhang, Hanna E Abbou. Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation. The Journal of biological chemistry. vol 279. issue 15. 2004-06-01. PMID:14742441. |
inhibition of calcineurin prior to the addition of tgf-beta revealed that calcineurin is required for tgf-beta-mediated accumulation of extracellular matrix (ecm) proteins but not cell hypertrophy. |
2004-06-01 |
2023-08-12 |
Not clear |
| Fuad N Ziyade. Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator. Journal of the American Society of Nephrology : JASN. vol 15 Suppl 1. 2004-05-25. PMID:14684674. |
treatment of diabetic mice with neutralizing anti-tgf-beta antibodies prevents the development of renal hypertrophy, mesangial matrix expansion, and the decline in renal function. |
2004-05-25 |
2023-08-12 |
mouse |
| Fuad N Ziyade. Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator. Journal of the American Society of Nephrology : JASN. vol 15 Suppl 1. 2004-05-25. PMID:14684674. |
these studies argue strongly in support of the hypothesis that overactivity of the tgf-beta system in the kidney is a crucial mediator of diabetic renal hypertrophy and mesangial matrix expansion. |
2004-05-25 |
2023-08-12 |
mouse |
| Mohan R K Dasu, Hal K Hawkins, Robert E Barrow, Hui Xue, David N Herndo. Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. The Journal of pathology. vol 202. issue 4. 2004-05-20. PMID:15095275. |
it is hypothesized that changes in the genes of cytokines, extracellular matrix proteins, and proteins regulating programmed cell death are related to hypertrophic scar formation. |
2004-05-20 |
2023-08-12 |
Not clear |
| Mohan R K Dasu, Hal K Hawkins, Robert E Barrow, Hui Xue, David N Herndo. Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. The Journal of pathology. vol 202. issue 4. 2004-05-20. PMID:15095275. |
no change in these matrix metalloproteinases could be shown with il-6 stimulation in hypertrophic scar fibroblasts. |
2004-05-20 |
2023-08-12 |
Not clear |
| Mohan R K Dasu, Hal K Hawkins, Robert E Barrow, Hui Xue, David N Herndo. Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation. The Journal of pathology. vol 202. issue 4. 2004-05-20. PMID:15095275. |
the absence of any up-regulation of mmp-1 and mmp-3 in hypertrophic scar fibroblasts, in response to il-6, suggests that suppression of matrix metalloproteinases may play a role in the excessive accumulation of collagen formed in hypertrophic scars. |
2004-05-20 |
2023-08-12 |
Not clear |
| Cynthia M Coleman, Rocky S Tua. Growth/differentiation factor 5 enhances chondrocyte maturation. Developmental dynamics : an official publication of the American Association of Anatomists. vol 228. issue 2. 2004-05-19. PMID:14517992. |
exposure to gdf5 significantly enhanced chondrocyte hypertrophy and maturation, as determined by the presence of alkaline phosphatase activity, collagen type x protein production, and the presence of a sulfated proteoglycan-rich extracellular matrix. |
2004-05-19 |
2023-08-12 |
chicken |