| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fackson Mwale, Elena Tchetina, C William Wu, A Robin Pool. The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 17 issue 2 2002 11811558 |
at hypertrophy, when mineral content was maximal, type ii collagen was reduced maximally in content coincident with a peak of cleavage of this molecule by collagenase when matrix metalloproteinase 13 (mmp-13) expression was maximal. |
2002-08-02 |
2023-01-24 |
cattle |
| Fackson Mwale, Elena Tchetina, C William Wu, A Robin Pool. The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 17 issue 2 2002 11811558 |
taken together with earlier studies, these findings show that matrix remodeling after assembly is linked closely to initial changes in ca2+ and pi to subsequent cellular hypertrophy and mineralization. |
2002-08-02 |
2023-01-24 |
cattle |
| W Petersen, M Rafi. Immunolocalization of the angiogenetic factor pleiotrophin (PTN) in the growth plate of mice. Archives of orthopaedic and trauma surgery vol 121 issue 7 2002 11510908 |
within the zone of hypertrophic chondrocytes, immunolabelling for ptn was positive in the pericellular matrix of hypertrophic chondrocytes and within the opened lacunae of the apoptotic hypertrophic chondrocytes. |
2002-07-15 |
2023-01-24 |
mouse |
| Olena Jacenko, Douglas W Roberts, Michelle R Campbell, Patricia M McManus, Catherine J Gress, Zhuliang Ta. Linking hematopoiesis to endochondral skeletogenesis through analysis of mice transgenic for collagen X. The American journal of pathology vol 160 issue 6 2002 12057907 |
during this process of endochondral ossification, hypertrophic cartilage expresses a unique matrix molecule, collagen x. |
2002-07-15 |
2023-01-24 |
mouse |
| Giordano Stabellini, Francesco Carinci, Pier Luigi Bedani, Carla Calastrini, Monica De Mattei, Luca Scapoli, Angelo Caruso, Mario Calvitti, Paola Locc. Cyclosporin A and transforming growth factor beta modify the pattern of extracellular glycosaminoglycans without causing cytoskeletal changes in human gingival fibroblasts. Transplantation vol 73 issue 10 2002 12042659 |
our data suggest that the biochemical changes in the extracellular matrix are caused more by cytokine, and that cyclosporin a does not induce any morphological changes in fibroblast cultures derived from hypertrophic and normal gingiva. |
2002-06-26 |
2023-01-24 |
human |
| Jacek Rozg. Hepatocyte proliferation in health and in liver failure. Medical science monitor : international medical journal of experimental and clinical research vol 8 issue 2 2002 11859294 |
in normal animals and humans, it is a tightly regulated process of both hypertrophy and hyperplasia involving different liver cell populations and a finely tuned interplay between growth factors, cytokines, extracellular matrix components and other regulators. |
2002-06-24 |
2023-01-24 |
rat |
| Filippo Ren\\xc3\\xb2, Paola Grazianetti, Maurizio Stella, Gilberto Magliacani, Carla Pezzuto, Mario Canna. Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. Archives of dermatology vol 138 issue 4 2002 11939809 |
release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. |
2002-06-04 |
2023-01-24 |
Not clear |
| Filippo Ren\\xc3\\xb2, Paola Grazianetti, Maurizio Stella, Gilberto Magliacani, Carla Pezzuto, Mario Canna. Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. Archives of dermatology vol 138 issue 4 2002 11939809 |
to investigate induction of matrix metalloproteinases (mmps) during mechanical compression of hypertrophic scars. |
2002-06-04 |
2023-01-24 |
Not clear |
| Filippo Ren\\xc3\\xb2, Paola Grazianetti, Maurizio Stella, Gilberto Magliacani, Carla Pezzuto, Mario Canna. Release and activation of matrix metalloproteinase-9 during in vitro mechanical compression in hypertrophic scars. Archives of dermatology vol 138 issue 4 2002 11939809 |
mechanical pressure blocks hypertrophy inducted on extracellular matrix in scars by a mechanism that involves mmp-2 (gelatinase a) and mmp-9 (gelatinase b). |
2002-06-04 |
2023-01-24 |
Not clear |
| M Dangelo, D P Sarment, P C Billings, M Pacific. Activation of transforming growth factor beta in chondrocytes undergoing endochondral ossification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol 16 issue 12 2002 11760850 |
zymography of gelatin gels revealed that matrix metalloprotease 2 (mmp-2) and mmp-9 were expressed by each population and that mmp-13 characterized hypertrophic chondrocytes and to a lesser extent proliferating chondrocytes in late cultures. |
2002-06-03 |
2023-01-24 |
chicken |
| M V Nurminskaya, B Recheis, J Nimpf, Cordula Magee, T F Linsenmaye. Transglutaminase factor XIIIA in the cartilage of developing avian long bones. Developmental dynamics : an official publication of the American Association of Anatomists vol 223 issue 1 2002 11803567 |
by immunohistochemical analysis, the protein is detected in the zone of maturation, where it is mostly intracellular, and in the hypertrophic zone, where it is present both intracellularly and in the extracellular matrix. |
2002-05-24 |
2023-01-24 |
chicken |
| Yoshitaka Iwanaga, Takeshi Aoyama, Yasuki Kihara, Yoko Onozawa, Takeshi Yoneda, Shigetake Sasayam. Excessive activation of matrix metalloproteinases coincides with left ventricular remodeling during transition from hypertrophy to heart failure in hypertensive rats. Journal of the American College of Cardiology vol 39 issue 8 2002 11955860 |
excessive activation of matrix metalloproteinases coincides with left ventricular remodeling during transition from hypertrophy to heart failure in hypertensive rats. |
2002-05-10 |
2023-01-24 |
rat |
| Marpadga A Reddy, Pushpa-Rekha Thimmalapura, Linda Lanting, Jerry L Nadler, Soghra Fatima, Rama Nataraja. The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II effects. The Journal of biological chemistry vol 277 issue 12 2002 11786549 |
evidence suggests that the arachidonic acid metabolite of 12-lipoxygenase, 12(s)-hydroxyeicosatetraenoic acid (12(s)-hete), not only mediates the effects of angiotensin ii (angii), but also has direct effects on hypertrophy and matrix protein production in vascular smooth muscle cells (vsmcs). |
2002-04-29 |
2023-01-24 |
Not clear |
| Dengshun Miao, Andrew Scut. Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol 50 issue 3 2002 11850436 |
in the articular cartilage of the proximal tibia, alp activity was localized to the hypertrophic chondrocytes and cartilage matrix of the deep zone and the maturing chondrocytes of the intermediate zone. |
2002-04-15 |
2023-01-24 |
rat |
| Dengshun Miao, Andrew Scut. Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol 50 issue 3 2002 11850436 |
in tibial and vertebral growth plates, a progressive increase in alp expression was seen in chondrocytes and cartilage matrix, with activity being weakest in the proliferative zone, higher in the maturing zone, and highest in the hypertrophic zone. |
2002-04-15 |
2023-01-24 |
rat |
| Dengshun Miao, Andrew Scut. Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society vol 50 issue 3 2002 11850436 |
in adult rats, the thickness of the growth plates was less and alp activity was enhanced in maturing and hypertrophic chondrocytes, cartilage matrix in the hypertrophic zone, and primary spongiosa. |
2002-04-15 |
2023-01-24 |
rat |
| Ann L Armstrong, Hans J Barrach, Michael G Ehrlic. Identification of the metalloproteinase stromelysin in the physis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society vol 20 issue 2 2002 11918308 |
for long bone growth to occur, calcification of the matrix must commence in the lower hypertrophic zone of the growth plate. |
2002-04-11 |
2023-01-24 |
cattle |
| H Ohara, T Tamayama, K Maemura, K Kanbara, H Hayasaki, M Abe, M Watanab. Immunocytochemical demonstration of glucose transporters in epiphyseal growth plate chondrocytes of young rats in correlation with autoradiographic distribution of 2-deoxyglucose in chondrocytes of mice. Acta histochemica vol 103 issue 4 2002 11700943 |
however, in the hypertrophic zone, silver grain density was high in matrix and chondrocytes. |
2002-03-19 |
2023-01-24 |
rat |
| K Masutomo, N Makino, M S Fushik. Effects of losartan on the collagen degradative enzymes in hypertrophic and congestive types of cardiomyopathic hamsters. Molecular and cellular biochemistry vol 224 issue 1-2 2002 11693196 |
the present study was undertaken to determine the effects of at1 receptor blockade which occurred in response to losartan, on the extracellular matrix (ecm) degradation process in the bio 14.6 (n = 12) and bio 53.58 (n = 12) strains which are referred as models of hypertrophic and dilated cardiomyopathy, respectively. |
2002-03-15 |
2023-01-24 |
Not clear |
| J Turnay, N Olmo, M A Lizarbe, K von der Mar. Changes in the expression of annexin A5 gene during in vitro chondrocyte differentiation: influence of cell attachment. Journal of cellular biochemistry vol 84 issue 1 2002 11746522 |
as a major constituent of cartilage matrix vesicles, which are released from microvilli of hypertrophic chondrocytes, it is involved in calcium uptake necessary for the initial stages of cartilage calcification. |
2002-03-13 |
2023-01-24 |
chicken |