| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Tchetina, F Mwale, A R Pool. Distinct phases of coordinated early and late gene expression in growth plate chondrocytes in relationship to cell proliferation, matrix assembly, remodeling, and cell differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 18. issue 5. 2004-01-16. PMID:12733723. |
this initial cluster of gene expression associated predominantly with matrix assembly and onset of cell proliferation is therefore characterized by expression of regulatory molecules distinct from those involved at hypertrophy. |
2004-01-16 |
2023-08-12 |
mouse |
| Shoko Miura, Isao Ohno, Jun Suzuki, Ko Suzuki, Shinji Okada, Akira Okuyama, Jun Nawata, Jun Ikeda, Kunio Shirat. Inhibition of matrix metalloproteinases prevents cardiac hypertrophy induced by beta-adrenergic stimulation in rats. Journal of cardiovascular pharmacology. vol 42. issue 2. 2004-01-13. PMID:12883319. |
inhibition of matrix metalloproteinases prevents cardiac hypertrophy induced by beta-adrenergic stimulation in rats. |
2004-01-13 |
2023-08-12 |
rat |
| Shoko Miura, Isao Ohno, Jun Suzuki, Ko Suzuki, Shinji Okada, Akira Okuyama, Jun Nawata, Jun Ikeda, Kunio Shirat. Inhibition of matrix metalloproteinases prevents cardiac hypertrophy induced by beta-adrenergic stimulation in rats. Journal of cardiovascular pharmacology. vol 42. issue 2. 2004-01-13. PMID:12883319. |
because matrix metalloproteinases (mmps) have been implicated in the degradation of igfbps, the authors investigated the role of mmps in the regulation of the igf-i action through the degradation of igfbps in cardiac hypertrophy induced by beta-adrenergic stimulation. |
2004-01-13 |
2023-08-12 |
rat |
| Hirofumi Nagai, Masami Aok. Inhibition of growth plate angiogenesis and endochondral ossification with diminished expression of MMP-13 in hypertrophic chondrocytes in FGF-2-treated rats. Journal of bone and mineral metabolism. vol 20. issue 3. 2004-01-06. PMID:11984696. |
expression of matrix metalloproteinase-13 (mmp-13) was detected in the chondrocytes in the last row of the hypertrophic zone of the growth plate in control animals. |
2004-01-06 |
2023-08-12 |
rat |
| R Tracy Ballock, Regis J O'Keef. Physiology and pathophysiology of the growth plate. Birth defects research. Part C, Embryo today : reviews. vol 69. issue 2. 2004-01-06. PMID:12955857. |
through a sequential process of cell proliferation, extracellular matrix synthesis, cellular hypertrophy, matrix mineralization, vascular invasion, and eventually apoptosis, the cartilage model is continually replaced by bone as length increases. |
2004-01-06 |
2023-08-12 |
human |
| Denise Merz, Ru Liu, Kristen Johnson, Robert Terkeltau. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 8. 2004-01-06. PMID:14530367. |
foci of chondrocyte hypertrophy that commonly develop in osteoarthritic (oa) cartilage can promote dysregulated matrix repair and pathologic calcification in oa. |
2004-01-06 |
2023-08-12 |
mouse |
| Denise Merz, Ru Liu, Kristen Johnson, Robert Terkeltau. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. Journal of immunology (Baltimore, Md. : 1950). vol 171. issue 8. 2004-01-06. PMID:14530367. |
il-8 and the selective cxcr2 ligand groalpha (10 ng/ml) induced tissue inhibitor of metalloproteinase-3 expression, markers of hypertrophy (type x collagen and mmp-13 expression, alkaline phosphatase activity), as well as matrix calcification. |
2004-01-06 |
2023-08-12 |
mouse |
| Antonio Pacifico, Philip D Henr. Structural pathways and prevention of heart failure and sudden death. Journal of cardiovascular electrophysiology. vol 14. issue 7. 2004-01-05. PMID:12930259. |
the microscopic myocardial anatomy of scd is incompletely defined but may include prevalent changes of advanced myocardial disease, including cardiomyocyte hypertrophy, cardiomyocyte apoptosis, fibroblast hyperplasia, diffuse and focal matrix protein accumulation, and recruitment of inflammatory cells. |
2004-01-05 |
2023-08-12 |
Not clear |
| F Bonnet, Z Cao, M E Cooper, A J Cox, D J Kelly, R E Gilber. Tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes. Diabetes & metabolism. vol 29. issue 4 Pt 1. 2003-12-24. PMID:14526266. |
tranilast attenuates vascular hypertrophy, matrix accumulation and growth factor overexpression in experimental diabetes. |
2003-12-24 |
2023-08-12 |
human |
| Harumi Kawaki, Satoshi Kubota, Masanao Minato, Norifumi H Moritani, Takako Hattori, Hiroshi Hanagata, Mamoru Kubota, Akira Miyauchi, Tohru Nakanishi, Masaharu Takigaw. Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line. DNA and cell biology. vol 22. issue 10. 2003-12-09. PMID:14611685. |
it stimulates proliferation, migration, and extracellular matrix production of mesenchymal cells, and is highly expressed in hypertrophic chondrocytes. |
2003-12-09 |
2023-08-12 |
human |
| Shinichi Okada, Kenichi Shikata, Mitsuhiro Matsuda, Daisuke Ogawa, Hitomi Usui, Yuichi Kido, Ryo Nagase, Jun Wada, Yasushi Shikata, Hirofumi Makin. Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes. Diabetes. vol 52. issue 10. 2003-12-03. PMID:14514644. |
urinary albumin excretion, glomerular hypertrophy, and mesangial matrix expansion were significantly lower in diabetic icam-1(-/-) mice than in diabetic icam-1(+/+) mice. |
2003-12-03 |
2023-08-12 |
mouse |
| Maria Angelica Binotto, Maria de Lourdes Higuchi, Vera Demarchi Aiell. Left ventricular remodeling in hearts with tricuspid atresia: morphologic observations and possible basis for ventricular dysfunction after surgery. The Journal of thoracic and cardiovascular surgery. vol 126. issue 4. 2003-12-02. PMID:14566242. |
this study was undertaken to assess the pattern of left ventricular hypertrophy, the myocardial capillary network, and the extracellular matrix in hearts with tricuspid atresia. |
2003-12-02 |
2023-08-12 |
Not clear |
| Tamás Huszár, András Masszi, István Mucsi, László Rosival. [Role of mitogen-activated protein kinase cascade in the intracellular signaling of angiotensin II]. Orvosi hetilap. vol 144. issue 31. 2003-11-05. PMID:14502868. |
it has been recently recognized that angiotensin ii (ang ii), in addition to its role in the regulation of the salt-fluid homeostasis is also a growth factor and contributes to the regulation of cellular hypertrophy or proliferation and extracellular matrix (ecm) formation. |
2003-11-05 |
2023-08-12 |
Not clear |
| Richard L Lieber, Eva Runesson, Fredrik Einarsson, Jan Fridé. Inferior mechanical properties of spastic muscle bundles due to hypertrophic but compromised extracellular matrix material. Muscle & nerve. vol 28. issue 4. 2003-10-29. PMID:14506719. |
inferior mechanical properties of spastic muscle bundles due to hypertrophic but compromised extracellular matrix material. |
2003-10-29 |
2023-08-12 |
Not clear |
| Andrey Sorokin, Donald E Koha. Physiology and pathology of endothelin-1 in renal mesangium. American journal of physiology. Renal physiology. vol 285. issue 4. 2003-10-10. PMID:12954590. |
mcs also express et receptors, activation of which leads to a complex signaling cascade with resultant stimulation of mc hypertrophy, proliferation, contraction, and extracellular matrix accumulation. |
2003-10-10 |
2023-08-12 |
Not clear |
| X H Guo, Z H Liu, C S Dai, H Li, D Liu, L S L. Rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1. Acta pharmacologica Sinica. vol 22. issue 10. 2003-10-02. PMID:11749778. |
rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1. |
2003-10-02 |
2023-08-12 |
Not clear |
| X H Guo, Z H Liu, C S Dai, H Li, D Liu, L S L. Rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1. Acta pharmacologica Sinica. vol 22. issue 10. 2003-10-02. PMID:11749778. |
to investigate the effects of rhein on cell hypertrophy and accumulation of extracellular matrix (ecm) in the renal tubular epithelial cells. |
2003-10-02 |
2023-08-12 |
Not clear |
| Dae Joong Kim, Sang Hee Park, Chol Seung Lim, Jang-Soo Chun, Jin-Kyu Kim, Woo Keun Son. Cellular localization of integrin isoforms in phenylephrine-induced hypertrophic cardiac myocytes. Cell biochemistry and function. vol 21. issue 1. 2003-09-16. PMID:12579520. |
cardiac hypertrophy is characterized by remodeling of the extracellular matrix (ecm). |
2003-09-16 |
2023-08-12 |
Not clear |
| J Bauersachs, D Fraccaroll. Aldosterone antagonism in addition to angiotensin-converting enzyme inhibitors in heart failure. Minerva cardioangiologica. vol 51. issue 2. 2003-09-09. PMID:12783071. |
while reduction of excessive extracellular matrix turnover leading to decreased fibrosis appears to be the most important effect of spironolactone in heart failure, other mechanisms such as regression of hypertrophy, improvement of endothelial function, enhanced renal sodium excretion and antiarrhythmic actions may contribute. |
2003-09-09 |
2023-08-12 |
Not clear |
| Rennolds S Ostrom, Jennifer E Naugle, Miki Hase, Caroline Gregorian, James S Swaney, Paul A Insel, Laurence L Brunton, J Gary Meszaro. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. The Journal of biological chemistry. vol 278. issue 27. 2003-08-18. PMID:12711600. |
cardiac fibroblasts regulate formation of extracellular matrix in the heart, playing key roles in cardiac remodeling and hypertrophy. |
2003-08-18 |
2023-08-12 |
Not clear |